AR083832A1 - DERIVADOS DE TETRAHIDROPIRIDO[3,2-F][1,4]OXAZEPIN-8-AMINA PARA EL TRATAMIENTO DE ENFERMEDADES Ab-RELACIONADAS - Google Patents
DERIVADOS DE TETRAHIDROPIRIDO[3,2-F][1,4]OXAZEPIN-8-AMINA PARA EL TRATAMIENTO DE ENFERMEDADES Ab-RELACIONADASInfo
- Publication number
- AR083832A1 AR083832A1 ARP110104205A ARP110104205A AR083832A1 AR 083832 A1 AR083832 A1 AR 083832A1 AR P110104205 A ARP110104205 A AR P110104205A AR P110104205 A ARP110104205 A AR P110104205A AR 083832 A1 AR083832 A1 AR 083832A1
- Authority
- AR
- Argentina
- Prior art keywords
- methyl
- oxazepin
- phenyl
- pyridin
- methoxy
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- -1 6-methoxy-5- (4-methyl-1H-imidazol-1-yl) pyridin-2-yl Chemical group 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 3
- 125000006570 (C5-C6) heteroaryl group Chemical group 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000006706 (C3-C6) carbocyclyl group Chemical group 0.000 abstract 2
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052731 fluorine Inorganic materials 0.000 abstract 2
- 239000011737 fluorine Substances 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- IKUXSEKKQNIOCQ-NRFANRHFSA-N (2r)-n-[6-methoxy-5-(1-methylpyrazol-4-yl)pyridin-2-yl]-4-methyl-2-phenyl-3,5-dihydro-2h-pyrido[3,2-f][1,4]oxazepin-8-amine Chemical compound C1([C@@H]2CN(C)CC3=CC=C(N=C3O2)NC=2N=C(C(=CC=2)C2=CN(C)N=C2)OC)=CC=CC=C1 IKUXSEKKQNIOCQ-NRFANRHFSA-N 0.000 abstract 1
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 1
- 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 abstract 1
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Derivados de tetrahidropirido[3,2-f][1,4]oxazepin-8-amina, composición farmacéutica.Reivindicación 1: Un compuesto de fórmula (1) donde: R1 se selecciona de hidrógeno, alquilo C1-3, -C(O)CH3, -CH2CH2OCH3, -C(O)N(CH3)2 y -CH2CN; R2 se selecciona de alquilo C2-4 (opcionalmente sustituido con uno o varios sustituyentes seleccionados independientemente de flúor e hidroxi), fenilo, heteroarilo de 5 ó 6 miembros, carbociclilo C3-6 y heterociclilo C4-6 (donde el fenilo, heteroarilo de 5 ó 6 miembros, carbociclilo C3-6 y heterociclilo C4-6 están opcionalmente sustituidos con uno o varios sustituyentes seleccionados independientemente de halógeno, alquilo C1-3 y alcoxi C1-3); R3 es un grupo heteroarilo de 5 ó 6 miembros que comprenden por lo menos un átomo de nitrógeno, donde el grupo heteroarilo de 5 ó 6 miembros está opcionalmente sustituido con uno o varios sustituyentes seleccionados independientemente de alquilo C1-3, cloro, oxo, -CH2OH, -CH2OCH3, -CHF2 y -CH2F; R4 es hidrógeno, metoxi o ciano; R5 es hidrógeno o flúor; R6, R7 y R8 se seleccionan cada uno independientemente de hidrógeno y alquilo C1-3; o una sal farmacéuticamente aceptable de éste; con la condición de que el compuesto no se seleccione entre (R)-N-(6-metoxi-5-(4-metil-1H-imidazol-1-il)piridin-2-il)-4-metil-2-fenil-2,3,4,5-tetrahidropirido[3,2-f][1,4]oxazepin-8-amina; (R)-1-(8-(6-metoxi-5-(4-metil-1H-imidazol-1-il)piridin-2-ilamino)-2-fenil-2,3-dihidropirido[3,2-f][1,4]oxazepin-4(5H)-il)etanona; (R)-N-(6-metoxi-5-(1-metil-1H-pirazol-4-il)piridin-2-il)-4-metil-2-fenil-2,3,4,5-tetrahidropirido[3,2-f][1,4]oxazepin-8-amina; N-(6-metoxi-5-(1-metil-1H-pirazol-4-il)piridin-2-il)-4-metil-2-(6-metilpiridin-2-il)-2,3,4,5-tetrahidropirido[3,2-f][1,4]oxazepin-8-amina; (R)-N-(6-metoxi-5-(1-metil-1H-pirazol-4-il)piridin-2-il)-2-fenil-2,3,4,5-tetrahidropirido[3,2-f][1,4]oxazepin-8-amina; y (R)-N-(5-(1-metil-1H-pirazol-4-il)piridin-2-il)-2-fenil- 2,3,4,5-tetrahidropirido[3,2-f][1,4]oxazepin-8-amina.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41247210P | 2010-11-11 | 2010-11-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR083832A1 true AR083832A1 (es) | 2013-03-27 |
Family
ID=46048351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110104205A AR083832A1 (es) | 2010-11-11 | 2011-11-10 | DERIVADOS DE TETRAHIDROPIRIDO[3,2-F][1,4]OXAZEPIN-8-AMINA PARA EL TRATAMIENTO DE ENFERMEDADES Ab-RELACIONADAS |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20120122843A1 (es) |
| AR (1) | AR083832A1 (es) |
| TW (1) | TW201300396A (es) |
| UY (1) | UY33723A (es) |
| WO (1) | WO2012064269A1 (es) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103351410B (zh) * | 2013-07-09 | 2016-02-10 | 陕西科技大学 | 1-二茂铁基-3-[（n-(2-取代苯并咪唑基)]-2-丙烯-1-酮及其制备方法和应用 |
| US9267221B2 (en) | 2014-01-16 | 2016-02-23 | Uno & Company, Ltd. | Phosphonate flame-retardant polyester artificial hair and method of preparing same |
| GB201714740D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714734D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714745D0 (en) * | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201714736D0 (en) | 2017-09-13 | 2017-10-25 | Atrogi Ab | New compounds and uses |
| GB201903832D0 (en) | 2019-03-20 | 2019-05-01 | Atrogi Ab | New compounds and methods |
| JP7784542B2 (ja) * | 2021-10-29 | 2025-12-11 | ジアンスー カニョン ファーマシューティカル カンパニー リミテッド | ５－置換のピリジン－２（１ｈ）－オン系化合物及びその使用 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101910142B (zh) * | 2008-01-11 | 2013-07-10 | 弗·哈夫曼-拉罗切有限公司 | β-淀粉状蛋白的调节剂 |
| EP2367826A4 (en) * | 2008-11-06 | 2012-07-04 | Astrazeneca Ab | MODULATORS OF THE PROTEIN -AMYLOID |
| UY32622A (es) * | 2009-05-12 | 2010-12-31 | Astrazeneca Ab | Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta) |
-
2011
- 2011-11-09 US US13/292,582 patent/US20120122843A1/en not_active Abandoned
- 2011-11-10 TW TW100141112A patent/TW201300396A/zh unknown
- 2011-11-10 AR ARP110104205A patent/AR083832A1/es not_active Application Discontinuation
- 2011-11-10 WO PCT/SE2011/051341 patent/WO2012064269A1/en not_active Ceased
- 2011-11-11 UY UY0001033723A patent/UY33723A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| TW201300396A (zh) | 2013-01-01 |
| US20120122843A1 (en) | 2012-05-17 |
| UY33723A (es) | 2012-06-29 |
| WO2012064269A1 (en) | 2012-05-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |