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AR083672A1 - Inmunoglobulinas con dominio variable dual y usos de las mismas - Google Patents

Inmunoglobulinas con dominio variable dual y usos de las mismas

Info

Publication number
AR083672A1
AR083672A1 ARP110104046A ARP110104046A AR083672A1 AR 083672 A1 AR083672 A1 AR 083672A1 AR P110104046 A ARP110104046 A AR P110104046A AR P110104046 A ARP110104046 A AR P110104046A AR 083672 A1 AR083672 A1 AR 083672A1
Authority
AR
Argentina
Prior art keywords
variable domain
immunoglobulins
heavy chain
same
dual variable
Prior art date
Application number
ARP110104046A
Other languages
English (en)
Inventor
Tariq Ghayur
Junjian Liu
Jijie Gu
Maria C Harris
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of AR083672A1 publication Critical patent/AR083672A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
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    • C07K16/2875—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF/TNF superfamily, e.g. CD70, CD95L, CD153, CD154
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    • C12P21/00—Preparation of peptides or proteins
    • A—HUMAN NECESSITIES
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Abstract

Proteínas de unión multivalentes y multiespecíficas modificadas, métodos para elaborarlas y sus usos en la prevención, el diagnóstico y/o el tratamiento de enfermedades.Reivindicación 1: Una proteína de unión que se une a un par de antígenos, caracterizada porque comprende una cadena de polipéptidos, en donde dicha cadena de polipéptidos comprende VD1-(X1)n-VD2-C-(X2)n, en donde: VD1 es un primer dominio variable de la cadena pesada; VD2 es un segundo dominio variable de la cadena pesada; C es un dominio constante de la cadena pesada; X1 es un conector con la salvedad que no es CH1; X2 es una región Fc; (X1)n es (X1)0 o (X1)1; y (X2)n es (X2)0 o (X2)1 en donde el par de antígenos es TNF y PGE2 o VEGF y DLL4, y en donde VD1 y VD2 comprenden de manera independiente tres CDR de las SEQ ID Nº 30, 32, 34, 36, 38, 40, 42, 44, 46, 48, 50, 52, 54, 56, 58, 60, 62, 64, 66, 68, 70, 72, 74, 76, 78, 80, 82, 84, 86, 88, 90, 92, 94, 96, 98, 100, 102, 104, 106, 108, 110, 112, 114, 116, 118, 120, 122, 124, 126, 128, 130, 132, 280, 282, 284, 286, 288, 290, 292, 294, 296, 298, 300 ó 302.
ARP110104046A 2010-11-02 2011-11-01 Inmunoglobulinas con dominio variable dual y usos de las mismas AR083672A1 (es)

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