AR082965A1 - Metodo de preparacion de amidas de acido hialuronico altamente sustituidas - Google Patents
Metodo de preparacion de amidas de acido hialuronico altamente sustituidasInfo
- Publication number
- AR082965A1 AR082965A1 ARP110103318A ARP110103318A AR082965A1 AR 082965 A1 AR082965 A1 AR 082965A1 AR P110103318 A ARP110103318 A AR P110103318A AR P110103318 A ARP110103318 A AR P110103318A AR 082965 A1 AR082965 A1 AR 082965A1
- Authority
- AR
- Argentina
- Prior art keywords
- hyaluronic acid
- preparation
- highly substituted
- amidas
- forming
- Prior art date
Links
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 6
- 229920002674 hyaluronan Polymers 0.000 title abstract 6
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 3
- RIFGWPKJUGCATF-UHFFFAOYSA-N ethyl chloroformate Chemical compound CCOC(Cl)=O RIFGWPKJUGCATF-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 150000003141 primary amines Chemical class 0.000 abstract 1
- 239000012048 reactive intermediate Substances 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0072—Hyaluronic acid, i.e. HA or hyaluronan; Derivatives thereof, e.g. crosslinked hyaluronic acid (hylan) or hyaluronates
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Materials Engineering (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Polymers & Plastics (AREA)
- Organic Chemistry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Método de preparación de amidas de ácido hialurónico altamente sustituidas con un grado de sustitución controlable, que se preparan en un entorno aprótico polar a partir de una forma ácida de ácido hialurónico en presencia de cloroformiato de etilo, por medio de una amina parimaria.Reivindicación 1: Un método de preparación de derivados amida de ácido hialurónico, caracterizado porque primero se activa el grupo COOH del ácido hialurónico con cloroformiato de etilo en presencia de una base, formando un intermediario reactivo que luego reacciona con una amina primaria R-NH2, formando una amida de ácido hialurónico de acuerdo con el Esquema 1, donde R es una cadena alquilo lineal o ramificada C1-30, que contiene opcionalmente grupos aromáticos o heteroaromáticos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ2010-687A CZ305040B6 (cs) | 2010-09-14 | 2010-09-14 | Způsob přípravy vysoce substituovaných amidů kyseliny hyaluronové |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR082965A1 true AR082965A1 (es) | 2013-01-23 |
Family
ID=45047494
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110103318A AR082965A1 (es) | 2010-09-14 | 2011-09-13 | Metodo de preparacion de amidas de acido hialuronico altamente sustituidas |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR082965A1 (es) |
| CZ (1) | CZ305040B6 (es) |
| WO (1) | WO2012034544A2 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ2014451A3 (cs) | 2014-06-30 | 2016-01-13 | Contipro Pharma A.S. | Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití |
| CZ309295B6 (cs) | 2015-03-09 | 2022-08-10 | Contipro A.S. | Samonosný, biodegradabilní film na bázi hydrofobizované kyseliny hyaluronové, způsob jeho přípravy a použití |
| CZ2015398A3 (cs) | 2015-06-15 | 2017-02-08 | Contipro A.S. | Způsob síťování polysacharidů s využitím fotolabilních chránicích skupin |
| CZ306662B6 (cs) | 2015-06-26 | 2017-04-26 | Contipro A.S. | Deriváty sulfatovaných polysacharidů, způsob jejich přípravy, způsob jejich modifikace a použití |
| CZ307511B6 (cs) | 2015-12-23 | 2018-10-31 | Contipro A.S. | Fluorescenční konjugát kyseliny hyaluronové nebo jeho sůl, hydrofobizovaný konjugát, způsoby jejich přípravy a použití |
| CZ308106B6 (cs) | 2016-06-27 | 2020-01-08 | Contipro A.S. | Nenasycené deriváty polysacharidů, způsob jejich přípravy a jejich použití |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITPD980169A1 (it) | 1998-07-06 | 2000-01-06 | Fidia Advanced Biopolymers Srl | Ammidi dell'acido ialuronico e dei suoi derivati e processo per la loro preparazione. |
| KR20040009891A (ko) * | 2002-07-26 | 2004-01-31 | 주식회사 엘지생명과학 | 히알루론산의 유도체 겔 및 그 제조방법 |
| TW200612991A (en) * | 2004-09-07 | 2006-05-01 | Chugai Pharmaceutical Co Ltd | Process for producing water-soluble hyaluronic acid modification |
| ITMI20061726A1 (it) * | 2006-09-11 | 2008-03-12 | Fidia Farmaceutici | Derivati crosslinkati a base di acido ialuronico reticolato via click chemistry |
| CN101367884A (zh) * | 2008-09-25 | 2009-02-18 | 复旦大学 | 一种半胱胺修饰的巯基化透明质酸偶合物及其制备方法和应用 |
-
2010
- 2010-09-14 CZ CZ2010-687A patent/CZ305040B6/cs not_active IP Right Cessation
-
2011
- 2011-09-08 WO PCT/CZ2011/000089 patent/WO2012034544A2/en not_active Ceased
- 2011-09-13 AR ARP110103318A patent/AR082965A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012034544A3 (en) | 2012-05-03 |
| CZ2010687A3 (cs) | 2012-03-21 |
| CZ305040B6 (cs) | 2015-04-08 |
| WO2012034544A2 (en) | 2012-03-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |