AR082257A1 - Composicion de inmunoglobulinas humanas concentradas, procedimiento - Google Patents
Composicion de inmunoglobulinas humanas concentradas, procedimientoInfo
- Publication number
- AR082257A1 AR082257A1 ARP110102592A ARP110102592A AR082257A1 AR 082257 A1 AR082257 A1 AR 082257A1 AR P110102592 A ARP110102592 A AR P110102592A AR P110102592 A ARP110102592 A AR P110102592A AR 082257 A1 AR082257 A1 AR 082257A1
- Authority
- AR
- Argentina
- Prior art keywords
- pharmaceutical composition
- immunoglobulins
- liquid pharmaceutical
- human
- surfactant
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title abstract 5
- 102000018358 immunoglobulin Human genes 0.000 title abstract 5
- 229940072221 immunoglobulins Drugs 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 5
- 239000007788 liquid Substances 0.000 abstract 4
- 239000004094 surface-active agent Substances 0.000 abstract 3
- 101000887490 Homo sapiens Guanine nucleotide-binding protein G(z) subunit alpha Proteins 0.000 abstract 2
- 102000052301 human GNAZ Human genes 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 238000000108 ultra-filtration Methods 0.000 abstract 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 229960000502 poloxamer Drugs 0.000 abstract 1
- 229920001983 poloxamer Polymers 0.000 abstract 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 abstract 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 abstract 1
- 229920000136 polysorbate Polymers 0.000 abstract 1
- 229950008882 polysorbate Drugs 0.000 abstract 1
- 229920000053 polysorbate 80 Polymers 0.000 abstract 1
- 229940068968 polysorbate 80 Drugs 0.000 abstract 1
- 239000007974 sodium acetate buffer Substances 0.000 abstract 1
- 238000007920 subcutaneous administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Dermatology (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Transplantation (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
Abstract
La solicitud se refiere a una composición de inmunoglobulinas G humanas caracterizada porque la concentración en inmunoglobulinas G humanas es de al menos 230 g/L, de utilidad en particular para una administración por vía subcutánea.Reivindicación 1: Procedimiento de preparación de una composición farmacéutica líquida que comprende inmunoglobulinas G humanas (IgG), que comprende las siguientes etapas: a) proporcionar una preparación de lgG; b) añadir a la preparación al menos un tensioactivo y/o al menos un aminoácido; c) proceder a una concentración de lgG por ultrafiltración, d) después añadir un tensioactivo, que puede ser idéntico o diferente al tensioactivo de la etapa b). Reivindicación 13: Procedimiento de preparación de una composición farmacéutica líquida de acuerdo con una de las reivindicaciones 1 a 12, caracterizado porque la ultrafiltración de la etapa c) se realiza a una temperatura inferior a 30ºC, con preferencia inferior a 25ºC. Reivindicación 16: Composición farmacéutica líquida susceptible de ser obtenida por el procedimiento de acuerdo con una de las reivindicaciones 1 a 15, en la que la composición farmacéutica obtenida está en un pH comprendido entre 4,2 y 5,5. Reivindicación 19: Composición farmacéutica líquida de acuerdo con la reivindicación 18 que comprende inmunoglobulinas G humanas concentradas entre 230 y 350 g/L, con preferencia a aproximadamente 250 g/L, con preferencia a aproximadamente 250 g/L; glicina; eventualmente tampón de acetato de sodio; polisorbato, con preferencia polisorbato 80, o un poloxámero.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1055825A FR2962650B1 (fr) | 2010-07-19 | 2010-07-19 | Composition d'immunoglobulines humaines concentrees |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR082257A1 true AR082257A1 (es) | 2012-11-21 |
Family
ID=43530307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110102592A AR082257A1 (es) | 2010-07-19 | 2011-07-18 | Composicion de inmunoglobulinas humanas concentradas, procedimiento |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9186401B2 (es) |
| EP (2) | EP3150225A1 (es) |
| JP (1) | JP2013534540A (es) |
| KR (1) | KR20140012011A (es) |
| CN (1) | CN103118705A (es) |
| AR (1) | AR082257A1 (es) |
| AU (1) | AU2011287458A1 (es) |
| BR (1) | BR112013001301A2 (es) |
| CA (1) | CA2805685A1 (es) |
| FR (1) | FR2962650B1 (es) |
| WO (1) | WO2012017156A1 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2977893B1 (fr) | 2011-07-11 | 2015-02-20 | Lab Francais Du Fractionnement | Procede de preparation d'un concentre d'immunoglobulines polyvalentes |
| FR2995213A1 (fr) * | 2012-09-12 | 2014-03-14 | Lfb Biotechnologies | Seringue contenant une composition, notamment pharmaceutique, comprenant des immunoglobulines, son procede de fabrication et son utilisation |
| KR102473791B1 (ko) * | 2014-09-08 | 2022-12-02 | 미츠비시 가스 가가쿠 가부시키가이샤 | 열가소성 수지 조성물 및 그것을 이용한 성형체 |
| FR3045387A1 (fr) * | 2015-12-18 | 2017-06-23 | Lab Francais Du Fractionnement | Composition d’immunoglobulines humaines concentrees |
| EP3254671B1 (en) | 2016-06-10 | 2019-11-13 | Octapharma AG | High concentration immunoglobulin composition for pharmaceutical application |
| CN110167531B (zh) * | 2017-01-11 | 2025-06-03 | 赛特瑞恩股份有限公司 | 稳定的液体调配物 |
| EP3612221A1 (en) * | 2017-04-21 | 2020-02-26 | CSL Behring AG | Immunoglobulin products for use in the treatment of chronic inflammatory demyelinating polyneuropathy |
| KR102208378B1 (ko) * | 2017-08-17 | 2021-01-28 | 주식회사 녹십자 | 항-egfr 항체를 포함하는 약학 제제 |
| GB201719447D0 (en) | 2017-11-23 | 2018-01-10 | Ucb Biopharma Sprl | Pharmaceutical composition |
| FR3081328B1 (fr) * | 2018-05-24 | 2021-01-01 | Lab Francais Du Fractionnement | Composition d'immunoglobulines humaines concentrees |
| CN120241997A (zh) | 2019-02-18 | 2025-07-04 | 伊莱利利公司 | 治疗性抗体制剂 |
| EP4199966A4 (en) * | 2020-08-20 | 2024-09-25 | Momenta Pharmaceuticals, Inc. | SIALYLATED GLYCOPROTEINS |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5945098A (en) * | 1990-02-01 | 1999-08-31 | Baxter International Inc. | Stable intravenously-administrable immune globulin preparation |
| SE501476C2 (sv) | 1992-10-21 | 1995-02-27 | Nilsson Carl O Lennart | Cylinderbultmekanism vid repetergevär |
| FR2824568B1 (fr) * | 2001-05-11 | 2004-04-09 | Lab Francais Du Fractionnement | Procede de preparation de concentres d'immunoglobulines humaines a usage therapeutique |
| US6893639B2 (en) * | 2001-10-19 | 2005-05-17 | Hemacare Corporation | Method for high yield purification of immune globulins from blood plasma and blood plasma intermediates |
| FR2853551B1 (fr) * | 2003-04-09 | 2006-08-04 | Lab Francais Du Fractionnement | Formulation stabilisante pour compositions d'immunoglobulines g sous forme liquide et sous forme lyophilisee |
| DE10327634B4 (de) | 2003-06-20 | 2005-06-09 | Sennheiser Electronic Gmbh & Co Kg | Mikrofon |
| FR2895263B1 (fr) * | 2005-12-26 | 2008-05-30 | Lab Francais Du Fractionnement | Concentre d'immunoglobines g (lg) appauvri en anticorps anti-a et anti-b, et en igg polyreactives |
| JP5099930B2 (ja) * | 2007-06-19 | 2012-12-19 | 旭化成株式会社 | 免疫グロブリン１量体の分離方法 |
| US20100189721A1 (en) * | 2007-07-06 | 2010-07-29 | Smithkline Beecham Corporation | Antibody formulations |
| CA2721037C (en) * | 2008-04-15 | 2018-05-22 | Talecris Biotherapeutics, Inc. | Methods for preparing a concentrated plasma product formulation using ultrafiltration/diafiltration |
| FR2940617B1 (fr) | 2008-12-30 | 2012-04-20 | Fractionnement Et Des Biotechonologies Lab Franc | Composition d'immunoglobulines g |
| MX2011012576A (es) * | 2009-05-27 | 2012-05-08 | Baxter Int | Metodo para producir una preparacion altamente concentrada de inmunoglobulina de uso subcutaneo. |
| EP2361636A1 (en) * | 2010-02-26 | 2011-08-31 | CSL Behring AG | Immunoglobulin preparation and storage system for an immunoglobulin preparation |
-
2010
- 2010-07-19 FR FR1055825A patent/FR2962650B1/fr not_active Expired - Fee Related
-
2011
- 2011-07-18 EP EP16197817.6A patent/EP3150225A1/fr not_active Withdrawn
- 2011-07-18 BR BR112013001301A patent/BR112013001301A2/pt not_active IP Right Cessation
- 2011-07-18 EP EP11754440.3A patent/EP2595654A1/fr not_active Withdrawn
- 2011-07-18 US US13/810,759 patent/US9186401B2/en not_active Expired - Fee Related
- 2011-07-18 KR KR1020137004204A patent/KR20140012011A/ko not_active Withdrawn
- 2011-07-18 AR ARP110102592A patent/AR082257A1/es unknown
- 2011-07-18 CA CA2805685A patent/CA2805685A1/fr not_active Abandoned
- 2011-07-18 AU AU2011287458A patent/AU2011287458A1/en not_active Abandoned
- 2011-07-18 CN CN2011800357460A patent/CN103118705A/zh active Pending
- 2011-07-18 JP JP2013520185A patent/JP2013534540A/ja active Pending
- 2011-07-18 WO PCT/FR2011/051712 patent/WO2012017156A1/fr not_active Ceased
-
2015
- 2015-10-09 US US14/879,673 patent/US20160030563A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20140012011A (ko) | 2014-01-29 |
| CN103118705A (zh) | 2013-05-22 |
| FR2962650B1 (fr) | 2013-04-05 |
| US20130121991A1 (en) | 2013-05-16 |
| US20160030563A1 (en) | 2016-02-04 |
| EP3150225A1 (fr) | 2017-04-05 |
| WO2012017156A1 (fr) | 2012-02-09 |
| US9186401B2 (en) | 2015-11-17 |
| CA2805685A1 (fr) | 2012-02-09 |
| FR2962650A1 (fr) | 2012-01-20 |
| JP2013534540A (ja) | 2013-09-05 |
| EP2595654A1 (fr) | 2013-05-29 |
| BR112013001301A2 (pt) | 2016-05-17 |
| AU2011287458A1 (en) | 2013-02-28 |
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