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AR081427A1 - Metodo para preparar anticuerpos con propiedades mejoradas - Google Patents

Metodo para preparar anticuerpos con propiedades mejoradas

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Publication number
AR081427A1
AR081427A1 ARP110101823A ARP110101823A AR081427A1 AR 081427 A1 AR081427 A1 AR 081427A1 AR P110101823 A ARP110101823 A AR P110101823A AR P110101823 A ARP110101823 A AR P110101823A AR 081427 A1 AR081427 A1 AR 081427A1
Authority
AR
Argentina
Prior art keywords
improved properties
preparing antibodies
mutations
region
group
Prior art date
Application number
ARP110101823A
Other languages
English (en)
Original Assignee
Merck Sharp & Dohme
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of AR081427A1 publication Critical patent/AR081427A1/es

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Abstract

Reivindicacion 1: Un polipéptido, que contiene una region Fc que comprende las mutaciones en las posiciones aminoácidas 243 y 264 de la region Fc, en donde las mutaciones en las posiciones 243 se seleccionan a partir del grupo que consta de: F243A, F243G, F243S, F243T, F243V, F243L, F243I, F243D, F243Y, F243E, F243R, F243W y F243K y las mutaciones en la posicion 264 se seleccionan a partir del grupo que consta de: V264A, V264G, V264S, V264T, V264D, V264E, V264K, V264W, V264H, V264P, V264N, V264Q y V264L, en donde la numeracion es segun el índice EU de Kabat.
ARP110101823A 2010-05-27 2011-05-27 Metodo para preparar anticuerpos con propiedades mejoradas AR081427A1 (es)

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