AR086653A1 - COMPOUNDS FOR REDUCTION OF PRODUCTION OF B-AMYLOID - Google Patents
COMPOUNDS FOR REDUCTION OF PRODUCTION OF B-AMYLOIDInfo
- Publication number
- AR086653A1 AR086653A1 ARP120101953A ARP120101953A AR086653A1 AR 086653 A1 AR086653 A1 AR 086653A1 AR P120101953 A ARP120101953 A AR P120101953A AR P120101953 A ARP120101953 A AR P120101953A AR 086653 A1 AR086653 A1 AR 086653A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- haloalkyl
- cycloalkyl
- group
- compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 3
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 2
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 2
- 125000006650 (C2-C4) alkynyl group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- -1 hydroxy, amino Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 1
- 125000006583 (C1-C3) haloalkyl group Chemical group 0.000 abstract 1
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 125000001786 isothiazolyl group Chemical group 0.000 abstract 1
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 1
- 125000001715 oxadiazolyl group Chemical group 0.000 abstract 1
- 125000002971 oxazolyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D279/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D279/04—1,3-Thiazines; Hydrogenated 1,3-thiazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Los compuestos de la fórmula (1), que incluyen sales aceptables para el uso farmacéutico de los mismos, se exponen en la presente, donde R1 y R2 son independientemente hidrógeno, alquilo C1-6 o cicloalquilo; o R1 y R2 pueden unirse juntos en un anillo mediante la adición de -(CH2)m-, en donde m es 3, 4, ó 5; R3 es hidrógeno, alquilo C1-3, haloalquilo C1-3 o ciclopropilo; Y y Z son independientemente un grupo arilo C6-10 o un grupo heterocíclico de 5 a 10 miembros que además puede sustituirse con de 0 a 3 sustituyentes seleccionados del grupo de halógeno, hidroxi, amino, alquilamino C1-4, dialquilamino C1-4, haloalquilo C1-4, CN, alquilo C1-6 o cicloalquilo, alcoxi C1-6, - C=O-alquilo C1-4, -SO2-alquilo C1-4, y alquinilo C2-4; A se selecciona de los grupos de fenilo, bencilo, furanilo, oxazolilo, tiazolilo, isoxazolilo, isotiazolilo, oxadiazolilo, triazolilo, imidazolilo, pirazolilo, piridilo, pirimidinilo, pirazinilo, y piridazinilo que además pueden sustituirse con de 0 a 3 sustituyentes seleccionados del grupo de halógeno, hidroxi, amino, alquilamino C1-4, dialquilamino C1-4, haloalquilo C1-4, hidroxialquilo C1-6, CN, alquilo C1-6 o cicloalquilo, alcoxi C1-6, y alquinilo C2-4; L es -NHCO-, es un enlace simple; y L y Z juntos pueden estar ausentes.The compounds of the formula (1), which include salts acceptable for pharmaceutical use thereof, are set forth herein, where R 1 and R 2 are independently hydrogen, C 1-6 alkyl or cycloalkyl; or R1 and R2 can be joined together in a ring by the addition of - (CH2) m-, where m is 3, 4, or 5; R3 is hydrogen, C1-3 alkyl, C1-3 haloalkyl or cyclopropyl; Y and Z are independently a C6-10 aryl group or a 5-10 membered heterocyclic group which can also be substituted with 0 to 3 substituents selected from the halogen, hydroxy, amino, C1-4 alkylamino, C1-4 dialkylamino group, C1-4 haloalkyl, CN, C1-6 alkyl or cycloalkyl, C1-6 alkoxy, -C = O-C1-4 alkyl, -SO2-C1-4 alkyl, and C2-4 alkynyl; A is selected from the groups of phenyl, benzyl, furanyl, oxazolyl, thiazolyl, isoxazolyl, isothiazolyl, oxadiazolyl, triazolyl, imidazolyl, pyrazolyl, pyridyl, pyrimidinyl, pyrazinyl, and pyridazinyl which can also be substituted with 0 to 3 substituents selected from the group halogen, hydroxy, amino, C1-4 alkylamino, C1-4 dialkylamino, C1-4 haloalkyl, C1-6 hydroxyalkyl, CN, C1-6 alkyl or cycloalkyl, C1-6 alkoxy, and C2-4 alkynyl; L is -NHCO-, it is a simple link; and L and Z together may be absent.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161492856P | 2011-06-03 | 2011-06-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR086653A1 true AR086653A1 (en) | 2014-01-15 |
Family
ID=46275993
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101953A AR086653A1 (en) | 2011-06-03 | 2012-06-01 | COMPOUNDS FOR REDUCTION OF PRODUCTION OF B-AMYLOID |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR086653A1 (en) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9550762B2 (en) | 2014-08-08 | 2017-01-24 | Amgen, Inc. | Cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use |
| US9611261B2 (en) | 2013-03-08 | 2017-04-04 | Amgen Inc. | Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use |
| US11926616B2 (en) | 2018-03-08 | 2024-03-12 | Incyte Corporation | Aminopyrazine diol compounds as PI3K-γ inhibitors |
| US12421197B2 (en) | 2018-07-02 | 2025-09-23 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
-
2012
- 2012-06-01 AR ARP120101953A patent/AR086653A1/en unknown
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9611261B2 (en) | 2013-03-08 | 2017-04-04 | Amgen Inc. | Perfluorinated cyclopropyl fused 1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use |
| US9550762B2 (en) | 2014-08-08 | 2017-01-24 | Amgen, Inc. | Cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use |
| US11926616B2 (en) | 2018-03-08 | 2024-03-12 | Incyte Corporation | Aminopyrazine diol compounds as PI3K-γ inhibitors |
| US12365668B2 (en) | 2018-03-08 | 2025-07-22 | Incyte Corporation | Aminopyrazine diol compounds as PI3K-y inhibitors |
| US12421197B2 (en) | 2018-07-02 | 2025-09-23 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |