AR084537A1 - AMBROXOL WATER SOLUTION - Google Patents
AMBROXOL WATER SOLUTIONInfo
- Publication number
- AR084537A1 AR084537A1 ARP110104880A ARP110104880A AR084537A1 AR 084537 A1 AR084537 A1 AR 084537A1 AR P110104880 A ARP110104880 A AR P110104880A AR P110104880 A ARP110104880 A AR P110104880A AR 084537 A1 AR084537 A1 AR 084537A1
- Authority
- AR
- Argentina
- Prior art keywords
- ambroxol
- water solution
- content
- aqueous solution
- polyols
- Prior art date
Links
- JBDGDEWWOUBZPM-XYPYZODXSA-N ambroxol Chemical compound NC1=C(Br)C=C(Br)C=C1CN[C@@H]1CC[C@@H](O)CC1 JBDGDEWWOUBZPM-XYPYZODXSA-N 0.000 title abstract 3
- 229960005174 ambroxol Drugs 0.000 title abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 title 1
- 239000007864 aqueous solution Substances 0.000 abstract 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 2
- 229920005862 polyol Polymers 0.000 abstract 2
- 150000003077 polyols Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- 150000007529 inorganic bases Chemical class 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 229920001515 polyalkylene glycol Polymers 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Dermatology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Chemical And Physical Treatments For Wood And The Like (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Abstract
Una solución acuosa que comprende una sal de adición de ácido de ambroxol, en la que el contenido de ambroxol está comprendido entre 0,1% y 7% (p/v), el contenido total de polialcoholes seleccionados de entre polioles y polialquilenglicoles es de por lo menos 20% (p/v), el contenido de alcoholes es inferior a 1% (p/v) y dicha solución acuosa está exenta de ácido benzoico y/o sus sales con bases orgánicas o inorgánicas.An aqueous solution comprising an ambroxol acid addition salt, in which the ambroxol content is comprised between 0.1% and 7% (w / v), the total content of polyols selected from polyols and polyalkylene glycols is at least 20% (w / v), the alcohol content is less than 1% (w / v) and said aqueous solution is free of benzoic acid and / or its salts with organic or inorganic bases.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10196711 | 2010-12-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR084537A1 true AR084537A1 (en) | 2013-05-22 |
Family
ID=45094329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110104880A AR084537A1 (en) | 2010-12-23 | 2011-12-22 | AMBROXOL WATER SOLUTION |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP2654719A1 (en) |
| JP (1) | JP2014503542A (en) |
| KR (1) | KR20130140042A (en) |
| CN (1) | CN103269685A (en) |
| AR (1) | AR084537A1 (en) |
| AU (1) | AU2011347257A1 (en) |
| BR (1) | BR112013012815A2 (en) |
| CA (1) | CA2817453A1 (en) |
| CL (1) | CL2013001297A1 (en) |
| EA (1) | EA201300535A1 (en) |
| MX (1) | MX2013005500A (en) |
| NZ (1) | NZ609742A (en) |
| WO (1) | WO2012085185A1 (en) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102083621B1 (en) * | 2013-06-13 | 2020-03-02 | 한미약품 주식회사 | Oral liquid formulation having improved stability comprising ambroxol and levodropropizine |
| CN103462942B (en) * | 2013-08-20 | 2016-12-28 | 湖南赛隆药业有限公司 | A kind of suction ambroxol hydrochloride solution |
| CN104316482A (en) * | 2014-08-15 | 2015-01-28 | 河北菲尼斯生物技术有限公司 | A quality control method for ambroxol hydrochloride particles |
| CN105287367B (en) * | 2015-10-13 | 2018-07-10 | 华润三九（南昌）药业有限公司 | A kind of oral liquid of ambroxol hydrochloride and preparation method and application |
| CN109060473B (en) * | 2018-07-27 | 2021-03-05 | 商洛学院 | Preparation method of ambroxol hydrochloride impurity reference substance |
| CN113995721A (en) * | 2020-07-27 | 2022-02-01 | 德国吉麦医疗技术有限公司 | Ambroxol hydrochloride oral spray solution and preparation method thereof |
| CN112168783A (en) * | 2020-10-26 | 2021-01-05 | 山东裕欣药业有限公司 | Oral medicine spray for respiratory system and preparation method thereof |
| CN112168782A (en) * | 2020-10-26 | 2021-01-05 | 山东裕欣药业有限公司 | Preparation method of respiratory system medicine oral spray |
| CN114129510A (en) * | 2021-12-03 | 2022-03-04 | 聊城大学 | A kind of compound sulfonamide injection and preparation method thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU574360B2 (en) * | 1983-05-13 | 1988-07-07 | Reichert, D. | Antisnoring agent |
| JP2000007561A (en) * | 1998-06-18 | 2000-01-11 | Nissho Corp | Ambroxol hydrochloride aqueous solution preparation |
| DE19933148A1 (en) | 1999-07-20 | 2001-01-25 | Boehringer Ingelheim Int | Lozenge containing ambroxol |
| US7138133B2 (en) | 2001-10-10 | 2006-11-21 | The Procter & Gamble Company | Orally administered liquid compositions |
| US20030171391A1 (en) | 2002-01-25 | 2003-09-11 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ambroxol for the treatment of chronic pain |
| DE10240802A1 (en) | 2002-08-30 | 2004-04-15 | W.L. Gore & Associates Gmbh | IR reflective material |
| DE10332486A1 (en) | 2003-07-16 | 2005-02-10 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ambroxol for the treatment of acute pain |
| WO2005023023A1 (en) * | 2003-09-09 | 2005-03-17 | 3M Innovative Properties Company | Concentrated antimicrobial compositions and methods |
| US20050075403A1 (en) | 2003-10-02 | 2005-04-07 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ambroxol for the treatment of inflammation in the pharynx |
| ITMI20032463A1 (en) | 2003-12-16 | 2005-06-17 | Advance Holdings Ltd | AQUEOUS CONCENTRATED AMBROXOL SOLUTION |
| DE102004021992A1 (en) | 2004-05-03 | 2005-11-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Topical preparation containing ambroxol |
| CN101961307B (en) * | 2010-09-14 | 2012-07-25 | 武汉人福药业有限责任公司 | Oral liquid for treating respiratory disease and preparation method thereof |
-
2011
- 2011-12-22 AR ARP110104880A patent/AR084537A1/en not_active Application Discontinuation
- 2011-12-22 EP EP11799722.1A patent/EP2654719A1/en not_active Withdrawn
- 2011-12-22 NZ NZ609742A patent/NZ609742A/en not_active IP Right Cessation
- 2011-12-22 AU AU2011347257A patent/AU2011347257A1/en not_active Abandoned
- 2011-12-22 JP JP2013545397A patent/JP2014503542A/en active Pending
- 2011-12-22 EA EA201300535A patent/EA201300535A1/en unknown
- 2011-12-22 MX MX2013005500A patent/MX2013005500A/en not_active Application Discontinuation
- 2011-12-22 CA CA2817453A patent/CA2817453A1/en not_active Abandoned
- 2011-12-22 CN CN2011800583550A patent/CN103269685A/en active Pending
- 2011-12-22 KR KR1020137013725A patent/KR20130140042A/en not_active Withdrawn
- 2011-12-22 BR BR112013012815A patent/BR112013012815A2/en not_active Application Discontinuation
- 2011-12-22 WO PCT/EP2011/073754 patent/WO2012085185A1/en not_active Ceased
-
2013
- 2013-05-10 CL CL2013001297A patent/CL2013001297A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CL2013001297A1 (en) | 2013-10-11 |
| CN103269685A (en) | 2013-08-28 |
| CA2817453A1 (en) | 2012-06-28 |
| MX2013005500A (en) | 2013-09-26 |
| EP2654719A1 (en) | 2013-10-30 |
| WO2012085185A1 (en) | 2012-06-28 |
| JP2014503542A (en) | 2014-02-13 |
| NZ609742A (en) | 2015-01-30 |
| BR112013012815A2 (en) | 2016-09-13 |
| KR20130140042A (en) | 2013-12-23 |
| EA201300535A1 (en) | 2013-08-30 |
| AU2011347257A1 (en) | 2013-05-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |