AR084399A1 - USEFUL QUINOLINE ESTERS FOR THE TREATMENT OF CUTANEOUS DISORDERS - Google Patents
USEFUL QUINOLINE ESTERS FOR THE TREATMENT OF CUTANEOUS DISORDERSInfo
- Publication number
- AR084399A1 AR084399A1 ARP110102445A AR084399A1 AR 084399 A1 AR084399 A1 AR 084399A1 AR P110102445 A ARP110102445 A AR P110102445A AR 084399 A1 AR084399 A1 AR 084399A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- aryl
- heteroaryl
- halogen
- independently
- Prior art date
Links
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical class N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 16
- 125000003118 aryl group Chemical group 0.000 abstract 7
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical class 0.000 abstract 4
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 abstract 2
- 206010012438 Dermatitis atopic Diseases 0.000 abstract 1
- 206010051246 Photodermatosis Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 201000008937 atopic dermatitis Diseases 0.000 abstract 1
- 125000000592 heterocycloalkyl group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000008845 photoaging Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 208000017520 skin disease Diseases 0.000 abstract 1
- 230000037303 wrinkles Effects 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Esteres de quinolina de la fórmula (1). También composiciones farmacéuticas que contienen ésteres de quinolina de la fórmula (1). Los compuestos de la presente son útiles para tratar trastornos cutáneos como psoriasis, dermatitis atópicas, fotoenvejecimiento de la piel y arrugas.Reivindicación 1: Un compuesto caracterizado porque tiene la fórmula (1) o una sal de este farmacéuticamente aceptable, en donde Z es halógeno o alquilo; en donde cada alquilo se sustituye, opcionalmente, con halógeno; Y es H, alquilo, arilo, heteroarilo, cicloalquilo, heterocicloalquilo, CN; en donde cada alquilo o arilo se sustituye, opcionalmente, con alquilo o arilo; Q1, Q2, Q3 son cada uno, independientemente, H, halógeno, alquilo o arilo; en donde cada alquilo o arilo se sustituye, opcionalmente, con alquilo o arilo; L es OC(O), C(O)O, CH2C(O)O, OC(O)CH2; W es H, halógeno o alquilo; X es H, alquilo, S(O)nR1, SO2NR2R3, CONR4R5, C(R6)2OR7, CN; en donde cada alquilo, S(O)nR1, SO2NR2R3, CONR4R5, o C(R6)2OR7 se sustituye, opcionalmente, con alquilo, SO2-alquilo o SO2-arilo, o SO2-heteroarilo; en donde R1 es alquilo, arilo, heteroarilo o cicloalquilo; R2 y R3 son cada uno, independientemente, H, alquilo o heteroarilo; R4 y R5 son cada uno, independientemente, H o alquilo; R6 y R7 son cada uno, independientemente, H o alquilo; y n es 1 ó 2.Quinoline esters of the formula (1). Also pharmaceutical compositions containing quinoline esters of the formula (1). The compounds herein are useful for treating skin disorders such as psoriasis, atopic dermatitis, skin photoaging and wrinkles. Claim 1: A compound characterized in that it has the formula (1) or a pharmaceutically acceptable salt thereof, wherein Z is halogen or alkyl; wherein each alkyl is optionally substituted with halogen; Y is H, alkyl, aryl, heteroaryl, cycloalkyl, heterocycloalkyl, CN; wherein each alkyl or aryl is optionally substituted with alkyl or aryl; Q1, Q2, Q3 are each, independently, H, halogen, alkyl or aryl; wherein each alkyl or aryl is optionally substituted with alkyl or aryl; L is OC (O), C (O) O, CH2C (O) O, OC (O) CH2; W is H, halogen or alkyl; X is H, alkyl, S (O) nR1, SO2NR2R3, CONR4R5, C (R6) 2OR7, CN; wherein each alkyl, S (O) nR1, SO2NR2R3, CONR4R5, or C (R6) 2OR7 is optionally substituted with alkyl, SO2-alkyl or SO2-aryl, or SO2-heteroaryl; wherein R1 is alkyl, aryl, heteroaryl or cycloalkyl; R2 and R3 are each, independently, H, alkyl or heteroaryl; R4 and R5 are each, independently, H or alkyl; R6 and R7 are each, independently, H or alkyl; and n is 1 or 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP110102445 AR084399A1 (en) | 2011-07-07 | 2011-07-07 | USEFUL QUINOLINE ESTERS FOR THE TREATMENT OF CUTANEOUS DISORDERS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP110102445 AR084399A1 (en) | 2011-07-07 | 2011-07-07 | USEFUL QUINOLINE ESTERS FOR THE TREATMENT OF CUTANEOUS DISORDERS |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR084399A1 true AR084399A1 (en) | 2013-05-15 |
Family
ID=51520309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110102445 AR084399A1 (en) | 2011-07-07 | 2011-07-07 | USEFUL QUINOLINE ESTERS FOR THE TREATMENT OF CUTANEOUS DISORDERS |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR084399A1 (en) |
-
2011
- 2011-07-07 AR ARP110102445 patent/AR084399A1/en unknown
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| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |