AR072467A1 - Derivados de oxabispidina como ligandos de receptor de acetilcolina nicotinica neuronal - Google Patents
Derivados de oxabispidina como ligandos de receptor de acetilcolina nicotinica neuronalInfo
- Publication number
- AR072467A1 AR072467A1 ARP090102482A ARP090102482A AR072467A1 AR 072467 A1 AR072467 A1 AR 072467A1 AR P090102482 A ARP090102482 A AR P090102482A AR P090102482 A ARP090102482 A AR P090102482A AR 072467 A1 AR072467 A1 AR 072467A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- haloalkyl
- heteroaryl
- cycloalkyl
- aryl
- Prior art date
Links
- 230000001537 neural effect Effects 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 7
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- 150000002367 halogens Chemical group 0.000 abstract 4
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 abstract 2
- -1 - (CH2) q-aryl Chemical group 0.000 abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 1
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 abstract 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente se relaciona con compuestos que se unen y modulan la actividad de receptores de acetilcolina nicotínicos neuronales, con composiciones farmacéuticas que contienen estos compuestos y con métodos de uso de estos compuestos para tratar una amplia variedad de condiciones y trastornos, que incluyen aquellos asociados con la disfuncion del sistema nervioso central (SNC). Reivindicacion 1: Un compuesto de la formula (1), en donde: X1 es arilo (optativamente sustituido con uno o más grupos R) o heteroarilo (optativamente sustituido con uno o más grupos R); cada R es independientemente alquilo de C1-6, alquenilo de C2-6, alquinilo de C2-6, cicloalquilo de C3-8, -(CH2)q-cicloalquilo C3-8, heterociclilo, -(CH2)q-heterociclilo, arilo, -(CH2)q-arilo, heteroarilo, -(CH2)q-heteroarilo, halo, -ORI, -NRIRII, haloalquilo C1-6, -CN, -NO2, -C2RI, -SRI, -N3, -C(=O)NRIRII, -NRIC(=O)RII, -OC(=O)NRIRII, -NRIC(=O)ORII, -SO2RI, -SO2NRIRII, o -NRISO2RII; cada uno de RI y RII es independientemente hidrogeno, alquilo C1-6, haloalquilo C1-6, cicloalquilo C3-8, -(CH2)q-cicloalquilo C3-8, heterociclilo, -(CH2)q-heterociclilo, arilo (optativamente sustituido con uno o más alquilo C1-6, halogeno, o haloalquilo C1-6), -(CH2)q-arilo, (optativamente sustituido con uno o más alquilo C1-6, halogeno, o haloalquilo C1-6), heteroarilo (optativamente sustituido con uno o más alquilo C1-6, halogeno, o haloalquilo C1-6), o -(CH2)q-heteroarilo, (optativamente sustituido con uno o más alquilo C1-6, halogeno, o haloalquilo C1-6), o RI y RII se pueden cambiar junto con los átomos a los cuales están unidos para formar un anillo de tres a diez miembros; cada q es independientemente 1, 2, 3, 4, 5 o 6; X2 es hidrogeno, alquilo C1-6, cicloalquilo, -(CH2)q-cicloalquilo C3-8, -(CH2)q-arilo, o -(CH2)q-heteroarilo; o una sal farmacéuticamente aceptable de él.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7800508P | 2008-07-03 | 2008-07-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR072467A1 true AR072467A1 (es) | 2010-09-01 |
Family
ID=41131776
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090102482A AR072467A1 (es) | 2008-07-03 | 2009-07-02 | Derivados de oxabispidina como ligandos de receptor de acetilcolina nicotinica neuronal |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20110257168A1 (es) |
| EP (1) | EP2356125A1 (es) |
| KR (1) | KR20110038093A (es) |
| CN (1) | CN102131816A (es) |
| AR (1) | AR072467A1 (es) |
| AU (1) | AU2009266994A1 (es) |
| CA (1) | CA2731790A1 (es) |
| CL (1) | CL2009001515A1 (es) |
| RU (1) | RU2011103776A (es) |
| TW (1) | TW201004963A (es) |
| WO (1) | WO2010002971A1 (es) |
| ZA (1) | ZA201100805B (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW201311698A (zh) * | 2011-08-22 | 2013-03-16 | Targacept Inc | 作為神經元菸鹼乙醯膽鹼受體配位體之１，４－二氮雜雙環［３．２．２］壬烷 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1147112E (pt) * | 1999-01-29 | 2004-03-31 | Abbott Lab | Derivados diazabiciclicos como liganos nicotinicos do receptor de acetilcolina |
| ATE261448T1 (de) * | 1999-05-04 | 2004-03-15 | Neurosearch As | Heteroaryl diazabicycloalkene, deren herstellung und verwendung |
| SE9903759D0 (sv) * | 1999-10-18 | 1999-10-18 | Astra Ab | Pharmaceutically active compounds |
| WO2001044243A2 (en) * | 1999-12-14 | 2001-06-21 | Neurosearch A/S | Novel heteroaryl-diazabicycloalkanes |
| DE60203007T2 (de) * | 2001-06-01 | 2005-07-07 | Neurosearch A/S | Heteroaryl-diazabicycloalkanderivaten als cns-modulatoren |
| DE10232572A1 (de) * | 2002-07-18 | 2004-02-05 | Bayer Ag | Neue 2,5-disubstituierte Pyrimidinderivate |
| SE0401539D0 (sv) * | 2004-06-15 | 2004-06-15 | Astrazeneca Ab | New compounds |
| SE0401540D0 (sv) * | 2004-06-15 | 2004-06-15 | Astrazeneca Ab | New compounds |
| EP1863819B1 (en) * | 2005-02-16 | 2011-01-12 | NeuroSearch A/S | Diazabicyclic aryl derivatives and their use as chinolinergic ligands at the nicotinic acetylcholine receptors |
| CA2609938A1 (en) * | 2005-06-13 | 2006-12-21 | Astrazeneca Ab | New oxabispidine compounds for the treatment of cardiac arrhythmias |
| WO2007090888A1 (en) * | 2006-02-10 | 2007-08-16 | Neurosearch A/S | 3-heteroaryl- 3,9-diazabicyclo[3.3.1]nonane derivatives as nicotinic acetylcholine receptor agonists |
| AU2008312631A1 (en) * | 2007-10-16 | 2009-04-23 | Wyeth Llc | Thienopyrimidine and pyrazolopyrimidine compounds and their use as mTOR kinase and PI3 kinase inhibitors |
-
2009
- 2009-06-23 TW TW098120944A patent/TW201004963A/zh unknown
- 2009-07-01 CA CA2731790A patent/CA2731790A1/en not_active Abandoned
- 2009-07-01 AU AU2009266994A patent/AU2009266994A1/en not_active Abandoned
- 2009-07-01 EP EP09774421A patent/EP2356125A1/en not_active Withdrawn
- 2009-07-01 RU RU2011103776/04A patent/RU2011103776A/ru unknown
- 2009-07-01 KR KR1020117002496A patent/KR20110038093A/ko not_active Ceased
- 2009-07-01 WO PCT/US2009/049373 patent/WO2010002971A1/en not_active Ceased
- 2009-07-01 CN CN2009801329352A patent/CN102131816A/zh active Pending
- 2009-07-01 US US13/055,085 patent/US20110257168A1/en not_active Abandoned
- 2009-07-02 AR ARP090102482A patent/AR072467A1/es unknown
- 2009-07-02 CL CL2009001515A patent/CL2009001515A1/es unknown
-
2011
- 2011-01-31 ZA ZA2011/00805A patent/ZA201100805B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20110038093A (ko) | 2011-04-13 |
| US20110257168A1 (en) | 2011-10-20 |
| TW201004963A (en) | 2010-02-01 |
| ZA201100805B (en) | 2011-10-26 |
| CN102131816A (zh) | 2011-07-20 |
| CL2009001515A1 (es) | 2009-08-28 |
| WO2010002971A1 (en) | 2010-01-07 |
| CA2731790A1 (en) | 2010-01-07 |
| EP2356125A1 (en) | 2011-08-17 |
| AU2009266994A1 (en) | 2010-01-07 |
| RU2011103776A (ru) | 2012-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |