AR071955A1 - Compuestos utiles en terapia para el dolor - Google Patents
Compuestos utiles en terapia para el dolorInfo
- Publication number
- AR071955A1 AR071955A1 ARP090101937A ARP090101937A AR071955A1 AR 071955 A1 AR071955 A1 AR 071955A1 AR P090101937 A ARP090101937 A AR P090101937A AR P090101937 A ARP090101937 A AR P090101937A AR 071955 A1 AR071955 A1 AR 071955A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- compounds
- fluoro
- optionally substituted
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 5
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 5
- 125000001153 fluoro group Chemical group F* 0.000 abstract 4
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000006274 (C1-C3)alkoxy group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- -1 cyano, hydroxy Chemical group 0.000 abstract 2
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 abstract 1
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 1
- 125000004176 4-fluorobenzyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1F)C([H])([H])* 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000001041 indolyl group Chemical group 0.000 abstract 1
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 1
- MXNOZCVIVDJSIP-UHFFFAOYSA-N n-[(2-chlorophenyl)methyl]-2-[1-(1h-indol-3-yl)propan-2-yl]-3-oxo-1h-isoindole-1-carboxamide Chemical compound C=1NC2=CC=CC=C2C=1CC(C)N(C(C1=CC=CC=C11)=O)C1C(=O)NCC1=CC=CC=C1Cl MXNOZCVIVDJSIP-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000003373 pyrazinyl group Chemical group 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 125000001425 triazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Se reivindican compuestos de formula (1), en la que R1 es hidrogeno, alquilo C1-3, alcoxi C1-3, ciano, hidroxi o halo; en el que alquilo C1-3 puede estar opcionalmente sustituido con uno o m s sustituyentes seleccionados independientemente de hidroxi, alcoxi C1-3 o fluoro; y en el que alcoxi C1-3 puede estar opcionalmente sustituido con uno o m s fluoro; m es 1 o 2; R2 y R3 se seleccionan cada uno independientemente de hidrogeno, haloalquilo C1-4, haloalcoxi C1-4, halo, alcoxi C1-4, alquilo C1-4 y cicloalcoxi C3-7 y en los que dicho cicloalquiloxi C3-7 puede estar opcionalmente sustituido con uno o m s fluoro; y mientras que R2 y R3 no pueden ser ambos hidrogeno; Het se selecciona de cualquiera de piridinilo, pirazinilo, isoxazolilo, pirazolilo, indolilo, triazolilo y pirimidinilo, en el que cada uno de tal heteroarilo puede estar opcionalmente sustituido con uno o m s X4, X4 es halo, alquilo C1-3, alquil C1-3-O-alquilo C1-3, -CH(CH3)-O-C(CH3)3, alcoxi C1-4, ciano, o hidroxilo, o hidroxialquilo C1-2; y en el que dicho alquilo C1-3, alquil C1-3-O-alquilo C1-3, -CH(CH3)-O-C(CH3)3, o alcoxi C1-4 puede estar cada uno sustituido independientemente con uno o m s fluoro; L1 es alquileno C1-4, que puede estar opcionalmente fluorado o hidroxilado; y L2 es alquileno C1-3 con la excepcion de los compuestos: 2-[1-(1,5-dimetil-1H-pirazol-4-il)etil]-5,7-dimetoxi-3-oxo-N-[2- (trifluorometil)bencil]isoindolin-1-carboxamida; N-(4-fluorobencil)-3-oxo-2-(2-piridin-4-iletil)isoindolin-1-carboxamida; y N-(2-clorobencil)-2-[2-( 1H-indol-3-il)-1-metiletil]-3-oxoisoindolin-1-carboxamida; La presente se refiere adem s a composiciones farmaceuticas que contienen dichos compuestos, y al uso de dichos compuestos en terapia.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5731508P | 2008-05-30 | 2008-05-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR071955A1 true AR071955A1 (es) | 2010-07-28 |
Family
ID=41377343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090101937A AR071955A1 (es) | 2008-05-30 | 2009-05-29 | Compuestos utiles en terapia para el dolor |
Country Status (6)
| Country | Link |
|---|---|
| AR (1) | AR071955A1 (es) |
| CL (1) | CL2009001329A1 (es) |
| PE (1) | PE20091945A1 (es) |
| TW (1) | TW201000461A (es) |
| UY (1) | UY31852A (es) |
| WO (1) | WO2009145718A1 (es) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200613272A (en) * | 2004-08-13 | 2006-05-01 | Astrazeneca Ab | Isoindolone compounds and their use as metabotropic glutamate receptor potentiators |
| EP2044019A1 (en) * | 2006-07-12 | 2009-04-08 | Astra Zeneca AB | 3-oxoisoindoline-1-carboxamide derivatives as analgesic agents |
| TW200812962A (en) * | 2006-07-12 | 2008-03-16 | Astrazeneca Ab | New compounds I/418 |
| GB0705882D0 (en) * | 2007-03-27 | 2007-05-02 | Glaxo Group Ltd | Novel compounds |
-
2009
- 2009-05-26 TW TW098117489A patent/TW201000461A/zh unknown
- 2009-05-29 PE PE2009000756A patent/PE20091945A1/es not_active Application Discontinuation
- 2009-05-29 CL CL2009001329A patent/CL2009001329A1/es unknown
- 2009-05-29 WO PCT/SE2009/050615 patent/WO2009145718A1/en not_active Ceased
- 2009-05-29 AR ARP090101937A patent/AR071955A1/es not_active Application Discontinuation
- 2009-05-29 UY UY0001031852A patent/UY31852A/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009145718A1 (en) | 2009-12-03 |
| CL2009001329A1 (es) | 2010-01-04 |
| UY31852A (es) | 2010-01-05 |
| PE20091945A1 (es) | 2010-01-28 |
| TW201000461A (en) | 2010-01-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |