AR071111A1 - Derivados de amidas del acido 3-trifluorometil-pirazin-2-carboxilico como agentes para aumentar el hdl-colesterol, composiciones farmaceuticas y un metodo para su preparacion. - Google Patents
Derivados de amidas del acido 3-trifluorometil-pirazin-2-carboxilico como agentes para aumentar el hdl-colesterol, composiciones farmaceuticas y un metodo para su preparacion.Info
- Publication number
- AR071111A1 AR071111A1 ARP090101125A ARP090101125A AR071111A1 AR 071111 A1 AR071111 A1 AR 071111A1 AR P090101125 A ARP090101125 A AR P090101125A AR P090101125 A ARP090101125 A AR P090101125A AR 071111 A1 AR071111 A1 AR 071111A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- cholesterol
- agents
- preparation
- pirazin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Estos compuestos se utilizan para la preparacion de medicamentos para el tratamiento y/o la profilaxis de enfermedades que pueden tratarse con agentes para aumentar el HDL-colesterol, tal como, de una forma preferible, la dislipemia. Reivindicacion 1: Compuestos de la formula general (1) en donde, R1 es cicloalquilo, el cual se encuentra insustituido o sustituido por hidroxi o hidroxialquilo inferior, o CH2-CR9R10-cicloalquilo, R9 es hidrogeno o alquilo inferior; R10 es hidrogeno o hidroxi; R2, es hidrogeno; R3, se selecciona de entre el grupo consistente en cicloalquilalquilo inferior, alcoxialquilo inferior, halogenoalquilo inferior, heteroarilalquilo inferior, en donde, el grupo heteroarilo, se encuentra insustituido o mono- o disustituido por alquilo inferior; y fenilo, es cual se encuentra insustituido o mono- o di-sustituido por halogeno; R4 y R8, de una forma independiente la una con respecto a la otra, son hidrogeno o halogeno; R5, R6 y R7, de una forma independiente la una con respecto a la otra se seleccionan de entre el grupo consistente en hidrogeno, alquilo inferior, alcoxi inferior, halogeno, halogenoalquilo inferior, halogenoalcoxi inferior, alquilsulfonilamino inferior y ciano; y sus sales farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08153802 | 2008-03-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR071111A1 true AR071111A1 (es) | 2010-05-26 |
Family
ID=40585575
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP090101125A AR071111A1 (es) | 2008-03-31 | 2009-03-30 | Derivados de amidas del acido 3-trifluorometil-pirazin-2-carboxilico como agentes para aumentar el hdl-colesterol, composiciones farmaceuticas y un metodo para su preparacion. |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US8088920B2 (es) |
| EP (1) | EP2271632B1 (es) |
| JP (1) | JP5243596B2 (es) |
| KR (1) | KR101307066B1 (es) |
| CN (1) | CN101981015B (es) |
| AR (1) | AR071111A1 (es) |
| AU (1) | AU2009231376A1 (es) |
| CA (1) | CA2718645A1 (es) |
| ES (1) | ES2408961T3 (es) |
| IL (1) | IL208022A0 (es) |
| MX (1) | MX2010009999A (es) |
| PE (1) | PE20091711A1 (es) |
| TW (1) | TW200944514A (es) |
| WO (1) | WO2009121741A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2009003222A (es) * | 2006-10-04 | 2009-04-06 | Hoffmann La Roche | Derivados de 3-piridinocarboxamida y 2-pirazinocarboxamida como agentes elevadores de colesterol de lipoproteina de alta densidad. |
| WO2012031817A1 (en) * | 2010-09-09 | 2012-03-15 | F. Hoffmann-La Roche Ag | Determination of abca1 protein levels in cells |
| US8410107B2 (en) | 2010-10-15 | 2013-04-02 | Hoffmann-La Roche Inc. | N-pyridin-3-yl or N-pyrazin-2-yl carboxamides |
| US8669254B2 (en) | 2010-12-15 | 2014-03-11 | Hoffman-La Roche Inc. | Pyridine, pyridazine, pyrimidine or pyrazine carboxamides as HDL-cholesterol raising agents |
| EP2567959B1 (en) | 2011-09-12 | 2014-04-16 | Sanofi | 6-(4-hydroxy-phenyl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors |
| US9403808B2 (en) * | 2011-10-28 | 2016-08-02 | Hoffmann-La Roche Inc. | Pyrazine derivatives |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4293552A (en) * | 1978-02-27 | 1981-10-06 | Eli Lilly And Company | Novel 1-(mono-o-substituted benzoyl)-3-(substituted pyrazinyl) ureas |
| US6930111B2 (en) * | 2001-07-19 | 2005-08-16 | Cv Therapeutics, Inc. | Substituted heterocyclic compounds |
| JP4712865B2 (ja) * | 2005-04-06 | 2011-06-29 | エフ．ホフマン−ラ ロシュ アーゲー | Ｃｂ１逆アゴニストとしてのピリジン−３−カルボキサミド誘導体 |
| US7629346B2 (en) | 2006-06-19 | 2009-12-08 | Hoffmann-La Roche Inc. | Pyrazinecarboxamide derivatives as CB1 antagonists |
| US7781593B2 (en) * | 2006-09-14 | 2010-08-24 | Hoffmann-La Roche Inc. | 5-phenyl-nicotinamide derivatives |
| MX2009003316A (es) | 2006-10-04 | 2009-04-09 | Hoffmann La Roche | Derivados de pirazina-2-carboxamida como moduladores receptores de cb2. |
| MX2009003222A (es) | 2006-10-04 | 2009-04-06 | Hoffmann La Roche | Derivados de 3-piridinocarboxamida y 2-pirazinocarboxamida como agentes elevadores de colesterol de lipoproteina de alta densidad. |
-
2009
- 2009-03-16 US US12/404,365 patent/US8088920B2/en not_active Expired - Fee Related
- 2009-03-23 MX MX2010009999A patent/MX2010009999A/es active IP Right Grant
- 2009-03-23 AU AU2009231376A patent/AU2009231376A1/en not_active Abandoned
- 2009-03-23 EP EP09728270.1A patent/EP2271632B1/en not_active Not-in-force
- 2009-03-23 ES ES09728270T patent/ES2408961T3/es active Active
- 2009-03-23 JP JP2011502335A patent/JP5243596B2/ja not_active Expired - Fee Related
- 2009-03-23 CA CA2718645A patent/CA2718645A1/en not_active Abandoned
- 2009-03-23 WO PCT/EP2009/053344 patent/WO2009121741A1/en not_active Ceased
- 2009-03-23 KR KR1020107021710A patent/KR101307066B1/ko not_active Expired - Fee Related
- 2009-03-23 CN CN200980110553XA patent/CN101981015B/zh not_active Expired - Fee Related
- 2009-03-30 TW TW098110492A patent/TW200944514A/zh unknown
- 2009-03-30 PE PE2009000467A patent/PE20091711A1/es not_active Application Discontinuation
- 2009-03-30 AR ARP090101125A patent/AR071111A1/es unknown
-
2010
- 2010-09-06 IL IL208022A patent/IL208022A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN101981015B (zh) | 2013-08-21 |
| US20090247550A1 (en) | 2009-10-01 |
| EP2271632A1 (en) | 2011-01-12 |
| JP5243596B2 (ja) | 2013-07-24 |
| TW200944514A (en) | 2009-11-01 |
| ES2408961T3 (es) | 2013-06-24 |
| KR101307066B1 (ko) | 2013-09-11 |
| CN101981015A (zh) | 2011-02-23 |
| WO2009121741A1 (en) | 2009-10-08 |
| MX2010009999A (es) | 2010-09-30 |
| PE20091711A1 (es) | 2009-11-13 |
| AU2009231376A1 (en) | 2009-10-08 |
| IL208022A0 (en) | 2010-12-30 |
| CA2718645A1 (en) | 2009-10-08 |
| EP2271632B1 (en) | 2013-04-17 |
| KR20100119819A (ko) | 2010-11-10 |
| US8088920B2 (en) | 2012-01-03 |
| JP2011516445A (ja) | 2011-05-26 |
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Legal Events
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| FB | Suspension of granting procedure |