AR070079A1 - Derivados de morfolino pirimidina usados en enfermedades relacionadas con mtor quinasa y/o p13k - Google Patents
Derivados de morfolino pirimidina usados en enfermedades relacionadas con mtor quinasa y/o p13kInfo
- Publication number
- AR070079A1 AR070079A1 ARP080105784A ARP080105784A AR070079A1 AR 070079 A1 AR070079 A1 AR 070079A1 AR P080105784 A ARP080105784 A AR P080105784A AR P080105784 A ARP080105784 A AR P080105784A AR 070079 A1 AR070079 A1 AR 070079A1
- Authority
- AR
- Argentina
- Prior art keywords
- 6alkyl
- amino
- bis
- 6alkoxy
- aminoc1
- Prior art date
Links
- 201000010099 disease Diseases 0.000 title abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 3
- 101150097381 Mtor gene Proteins 0.000 title 1
- 102100023085 Serine/threonine-protein kinase mTOR Human genes 0.000 title 1
- ORXTYTVXABMVJS-UHFFFAOYSA-N morpholine;pyrimidine Chemical class C1COCCN1.C1=CN=CN=C1 ORXTYTVXABMVJS-UHFFFAOYSA-N 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 45
- -1 carbocyclylC1-6alkyl Chemical group 0.000 abstract 14
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 12
- 125000005843 halogen group Chemical group 0.000 abstract 10
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 9
- 125000000623 heterocyclic group Chemical group 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 7
- 125000001424 substituent group Chemical group 0.000 abstract 7
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 abstract 5
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 5
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 5
- 125000004452 carbocyclyl group Chemical group 0.000 abstract 5
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 4
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 abstract 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102000038030 PI3Ks Human genes 0.000 abstract 1
- 108091007960 PI3Ks Proteins 0.000 abstract 1
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 abstract 1
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002062 proliferating effect Effects 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Una sal aceptable para uso farmacéutico del mismo, con los procesos para su preparacion, con composiciones farmacéuticas que los contienen y con su uso en terapias, por ejemplo en el tratamiento de enfermedades proliferativas tal como el cáncer y en particular de enfermedades mediadas por una mTOR quinasa y/o una o más enzimas PI3K. Reivindicacion 1: Un compuesto caracterizado porque es de la formula (1) o una sal aceptable para uso farmacéutico del mismo; en donde m es 0,1 , 2, 3 o 4; 1Y y Y2 son en forma independiente N o CR8 con la salvedad de que uno de 1Y y Y2 sea N y el otro sea CR8; X es un grupo de union seleccionado entre -CR4=CR5-, -CR4=CR5CR6R7-, -CR6R7CR5=CR4-, -C:::C-, -C:::CCR6R7-, -CR6R7C:::C-, -NR4CR6R7-, -OCR6R7-, -SCR6R7-, -S(O)CR6R7-, -S(O)2CR6R7-, -C(O)NR4CR6R7-, -NR4C(O)CR6R7-, -NR4C(O)NR5CR6R7-, -NR4S(O)2CR6R7-, -S(O)2NR4CR6R7-, -C(O)NR4-, -NR4C(O)-, -NR4C(O)NR5-, -S(O)2NR4- y - NR4S(O)2-; R1 es un grupo seleccionado entre hidrogeno, C1-6alquilo, C2-6aIquenilo, C2-6aIquinilo, carbociclilo, carbociclilC1-6alquilo, heterociclilo y heterociclilC1-6alquilo, donde dicho grupo está sustituido optativamente con uno o más grupos sustituyentes seleccionados entre halo, ciano, nitro, R9, -OR9, -SR9, -SOR9, -SO2R9, -COR9, -CO2R9, -CONR9R10, -NR9R10, -NR9COR10, -NR9CO2R10, -NR9CONR10R15, -NR9COCONR10R15 y -NR9SO2R10; R2 es un grupo seleccionado entre C1-6alquilo, carbociclilo y heterociclilo, donde dicho grupo está sustituido con -NR17CSNR18R19 y está sustituido optativamente con uno o más grupos sustituyentes seleccionados en forma independiente entre halo, ciano, nitro, -R11, -OR11, -SR11, -SOR11, -SO2R11, -COR11, -CO2R11, -CONR11R12, -NR11R12, -NR11COR12, y -NR11COCONR12R16 cada R3, cuando está presente, se selecciona en forma independiente entre halo, ciano, nitro, -R13, -OR13, -SR13, -SOR13, -SO2R13, -COR13, -CO2R13, -CONR13R14, -NR13R14, -NR13COR14, -NR13CO2R14 y -NR13SO2R14; R4 y R5 son en forma independiente hidrogeno o C1-6alquilo; o R1 y R4 junto con el átomo o los átomos a los cuales se encuentran unidos forman un anillo carbocíclico o heterocíclico de 4 a 10 miembros donde 1, 2 o 3 átomos de carbono del anillo se reemplazan optativamente con N, O o S y dicho anillo está sustituido optativamente con uno o más grupos sustituyentes seleccionados entre halo, ciano, nitro, hidroxi, oxo, C1-6alquilo, C1-6alcoxi, haIoC1-6alquilo, haloC1-6alcoxi, hidroxiC1-6alquilo, hidroxiC1-6alcoxi, C1-6alcoxiC1-6alquilo, C1-6alcoxiC1-6alcoxi, amino, C1-6alquilamino, bis(C1-6alquil)amino, aminoC1-6alquilo, (C1-6alquil)aminoC1-6alquilo, bis(C1-6alquil)aminoC1-6alquilo, cianoC1-6alquilo, C1-6alquilsulfonilo, C1-6alquilsulfonilamino, C1-6alquilsulfonil(C1-6alquil)amino, sulfamoílo, C1-6alquilsulfamoilo, bis(C1-6alquil)sulfamoílo, C1-6alcanoilamino, C1-6alcanoil(C1-6alquil)amino, carbamoilo, C1-6alquilcarbamoilo y bis(C1-6alquil)carbamoilo; R6 y R7 se seleccionan en forma independiente entre hidrogeno, halo, ciano, nitro y C1-6alquilo; R8 se selecciona entre hidrogeno, halo, ciano y C1-6alquilo; R9 y R10 son en forma independiente hidrogeno o un grupo seleccionado entre C1-6alquilo, carbociclilo, carbociclilC1-6alquilo, heterociclilo y heterociclilC1-6alquilo, donde dicho grupo está sustituido optativamente con uno o más grupos sustituyentes seleccionados entre halo, ciano, nitro, hidroxi, C1-6alquiIo, C1-6alcoxi, haloC1-6alquilo, haloC1-6alcoxi, hidroxiC1-6alquilo, hidroxiC1-6alcoxi, C1-6alcoxiC1-6alquilo, C1-6alcoxiC1-6aIcoxi, amino, C1-6alquilamino, bis(C1-6alquil)amino, aminoC1-6aIquilo, (C1-6alquil)aminoC1-6alquilo, bis(C1-6alquil)aminoC1-6alquilo, cianoC1-6aIquiIo, C1-6alquilsulfonilo, C1-6alquilsulfonilamino, C1-6alquiIsulfonil(C1-6aIquil)amino, sulfamoílo, C1-6alquilsulfamoilo, bis(C1-6alquil)sulfamoílo, C1-6aIcanoilamino, C1-6alcanoil(C1-6alquil)amino, carbamoilo, C1-6alquilcarbamoilo y bis(C1-6aquil)carbamoilo; R11, R12, R17 y R18 son en forma independiente hidrogeno o un grupo seleccionado entre C1-6alquilo, carbociclilo, carbociclilC1-6alquilo, heterociclilo y heterocicIilC1-6alquilo, donde dicho grupo está sustituido optativamente con uno o más grupos sustituyentes seleccionados entre halo, ciano, nitro, hidroxi, C1 6alquilo, C1-6alcoxi, haIoC1-6alquilo, haloC1-6alcoxi, hidroxiC1-6alquilo, hidroxiC1-6alcoxi, C1-6alcoxiC1-6alquilo, C1-6aIcoxiC1-6aIcoxi, amino, C1-6alquilamino, bis(C1-6alquil)amino, aminoC1-6alquilo, (C1-6alquiI)aminoC1-6alquilo, bis(C1-6alquil)aminoC1-6alquilo, cianoC1-6alquilo, C1-6aIquilsuIfoniIo, C1-6alcanoilamino, C1-6alcanoil(C1-6alquil)amino, carbamoilo, C1-6alquilcarbamoilo y bis(C1-6alquil)carbamoilo; R13, R14, R15, R16 y R19 son en forma independiente hidrogeno o un grupo seleccionado entre C1-6alquilo, carbociclilo, carbociclilC1-6alquilo, heterociclilo y heterocicIiIC1-6alquilo, donde dicho grupo está sustituido optativamente con uno o más grupos sustituyentes seleccionados entre halo, ciano, nitro, hidroxi, C1-6alquilo, C1-6aIcoxi, haloC1-6aIquilo, haloC1-6alcoxi, hidroxiC1-6alquilo, hidroxiC1-6alcoxi, C1-6alcoxiC1-6alquilo, C1-6alcoxiC1-6alcoxi, amino C1-6aIquilamino, bis(C1-6alquil)amino, aminoC1-6alquilo, (C1- 6alquil)aminoC1-6alquilo, bis(C1-6alquil)aminoC1-6alquilo, cianoC1-6aIquilo, C1-6alquilsulfonilo, C1-6alquilsulfonilamino, C1-6alquiIsulfonil(C1-6alquiI)amino, sulfamoílo, C1-6alquilsulfamoilo, bis(C1-6alquil)sulfamoílo, C1-6alcanoilamino, C1-6alcanoiI(C1-6alquil)amino, carbamoilo, C1-6alquilcarbamoilo y bis(C1-6alquil)carbamoilo; o R18 y R19 junto con el átomo de nitrogeno al cual se encuentran unidos forman un anillo heterocíclico de 3 a 10 miembros donde 1 o 2 átomos de carbono del anillo se reemplazan optativamente con N, O o S y dicho anillo está sustituido optativamente con uno o más grupos sustituyentes seleccionados entre halo, ciano, nitro, hidroxi, C1-6alquilo, C1-6alcoxi, haloC1-6alquilo, haloC1-6alcoxi, hidroxiC1-6aIquiIo, hidroxiC1-6alcoxi, C1-6alcoxiC1-6alquilo, C1-6alcoxiC1-6alcoxi, amino, C1-6alquilamino, bis(C1-6alquil)amino, aminoC1-6alquilo, (C1-6alquil)aminoC1-6alquilo, bis(C1-6alquil)aminoC1-6alquiIo, cianoC1-6alquilo, C1-6alquilsulfonilo, C1-6alquilsulfonilamino, C1-6alquilsultonil(C1-6alquil)amino, sulfamoilo, C1-6aIquilsulfamoilo, bis(C1-6alquiI)sulfamoilo, C1-6alcanoilamino, C1-6alcanoil(C1-6alquil)amino, carbamoilo, C1-6alquilcarbamoilo y bis(C1-6alquil)carbamoilo
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94853907P | 2007-07-09 | 2007-07-09 | |
| PCT/GB2008/050548 WO2009007750A1 (en) | 2007-07-09 | 2008-07-08 | Morpholino pyrimidine derivatives used in diseases linked to mtor kinase and/or pi3k |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR070079A1 true AR070079A1 (es) | 2010-03-10 |
Family
ID=39791229
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080105784A AR070079A1 (es) | 2007-07-09 | 2008-12-30 | Derivados de morfolino pirimidina usados en enfermedades relacionadas con mtor quinasa y/o p13k |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US8138183B2 (es) |
| EP (1) | EP2176238B1 (es) |
| JP (1) | JP5508260B2 (es) |
| KR (1) | KR20100042280A (es) |
| CN (1) | CN101809002B (es) |
| AR (1) | AR070079A1 (es) |
| AT (1) | ATE554075T1 (es) |
| AU (1) | AU2008273891B2 (es) |
| BR (1) | BRPI0814688A2 (es) |
| CA (1) | CA2692720A1 (es) |
| CL (1) | CL2008003940A1 (es) |
| CO (1) | CO6251364A2 (es) |
| CR (1) | CR11200A (es) |
| DO (1) | DOP2010000012A (es) |
| EA (1) | EA018708B1 (es) |
| EC (1) | ECSP109935A (es) |
| ES (1) | ES2385692T3 (es) |
| NI (1) | NI201000002A (es) |
| PE (1) | PE20100138A1 (es) |
| WO (1) | WO2009007750A1 (es) |
| ZA (1) | ZA200909224B (es) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008273889B2 (en) * | 2007-07-09 | 2012-03-08 | Astrazeneca Ab | Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases |
| MX315904B (es) | 2008-05-30 | 2013-11-29 | Amgen Inc | Inhibidores de fosfoinosituro-3 cinasa. |
| US8785457B2 (en) | 2009-03-13 | 2014-07-22 | Cellzome Limited | Pyrimidine derivatives as mTOR inhibitors |
| UY32582A (es) | 2009-04-28 | 2010-11-30 | Amgen Inc | Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero |
| AR077628A1 (es) | 2009-07-02 | 2011-09-14 | Sanofi Aventis | Derivados de 6-(morfolin-4-il)-pirimidin-4(3h)-ona, su preparacion y su utilizacion farmaceutica como inhibidores de la fosforilacion de akt(pkb) |
| JP5680638B2 (ja) | 2009-07-02 | 2015-03-04 | サノフイ | 新規な（６−オキソ−１，６−ジヒドロピリミジン−２−イル）アミド誘導体、この調製およびａｋｔ（ｐｋｂ）リン酸化インヒビターとしてのこの医薬的な使用 |
| MX2012005023A (es) | 2009-10-30 | 2012-06-19 | Ariad Pharma Inc | Metodos y composiciones para tratar cancer. |
| EP2992878A1 (en) | 2010-02-03 | 2016-03-09 | Signal Pharmaceuticals, LLC | Identification of lkb1 mutation as a predictive biomarker for sensitivity to tor kinase inhibitors |
| ES2535116T3 (es) | 2010-03-04 | 2015-05-05 | Cellzome Limited | Derivados de urea sustituida con morfolino como inhibidores de mtor |
| JO2998B1 (ar) | 2010-06-04 | 2016-09-05 | Amgen Inc | مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان |
| ES2612492T3 (es) | 2010-12-28 | 2017-05-17 | Sanofi | Nuevos derivados de piridiminas, su preparación y su utilización farmacéutica como inhibidores de fosforilación de AKT (PKB) |
| US20140163023A1 (en) | 2011-04-04 | 2014-06-12 | Cellzome Limited | Dihydropyrrolo pyrimidine derivatives as mtor inhibitors |
| MX373641B (es) | 2011-04-29 | 2020-05-04 | Selecta Biosciences Inc | Nanoportadores sintéticos tolerogénicos para la terapia contra alergias. |
| AU2012290056B2 (en) | 2011-08-03 | 2015-03-19 | Signal Pharmaceuticals, Llc | Identification of gene expression profile as a predictive biomarker for LKB1 status |
| RU2616619C2 (ru) | 2011-09-21 | 2017-04-18 | Селлзоум Лимитед | Морфолино-замещенные производные мочевины или карбамата в качестве ингибиторов mtor |
| WO2013049250A1 (en) | 2011-09-27 | 2013-04-04 | Amgen Inc. | Heterocyclic compounds as mdm2 inhibitors for the treatment of cancer |
| BR112014008241A2 (pt) | 2011-10-07 | 2017-04-18 | Cellzome Ltd | composto, composição farmacêutica, métodos para tratar, controlar, retardar ou prevenir doenças e distúrbios, e para preparar um composto, e, uso de um composto |
| CA2871112C (en) | 2012-07-04 | 2020-05-12 | F. Hoffmann-La Roche Ag | Covalently linked antigen-antibody conjugates |
| FR2994572B1 (fr) * | 2012-08-17 | 2015-04-17 | Centre Nat Rech Scient | Pyrido[3,2-d]pyrimidines trisubstituees, leurs procedes de preparation et leurs utilisation en therapeutique |
| AU2013203714B2 (en) | 2012-10-18 | 2015-12-03 | Signal Pharmaceuticals, Llc | Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity |
| US11407721B2 (en) | 2013-02-19 | 2022-08-09 | Amgen Inc. | CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer |
| JP6417338B2 (ja) * | 2013-02-19 | 2018-11-07 | アムジエン・インコーポレーテツド | 癌の治療のためのｍｄｍ２阻害剤としてのシス−モルホリノン及び他の化合物 |
| EP2970237B1 (en) | 2013-03-14 | 2017-09-27 | Amgen Inc. | Heteroaryl acid morpholinone compounds as mdm2 inhibitors for the treatment of cancer |
| WO2014172432A1 (en) | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and a cytidine analog for treating cancer |
| JP6382945B2 (ja) | 2013-04-17 | 2018-08-29 | シグナル ファーマシューティカルズ，エルエルシー | ジヒドロピラジノ−ピラジンによる癌治療 |
| KR102459285B1 (ko) | 2013-04-17 | 2022-10-27 | 시그날 파마소티칼 엘엘씨 | 1-에틸-7-(2-메틸-6-(1H-1,2,4-트리아졸-3-일)피리딘-3-일)-3,4-디하이드로피라지노[2,3-b]피라진-2(1H)-온에 관한 약학 제제, 제조방법, 고체 형태 및 사용 방법 |
| TWI654979B (zh) | 2013-04-17 | 2019-04-01 | 美商標誌製藥公司 | 使用ｔｏｒ激酶抑制劑組合療法以治療癌症之方法 |
| KR102221029B1 (ko) | 2013-04-17 | 2021-02-26 | 시그날 파마소티칼 엘엘씨 | 디하이드로피라지노-피라진을 사용한 암의 치료 |
| CA2909579A1 (en) | 2013-04-17 | 2014-10-23 | Signal Pharmaceuticals, Llc | Combination therapy comprising a tor kinase inhibitor and n-(3-(5-fluoro-2-(4-(2-methoxyethoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide for treating cancer |
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- 2008-07-08 KR KR1020107002942A patent/KR20100042280A/ko not_active Ceased
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| EA018708B1 (ru) | 2013-10-30 |
| CN101809002B (zh) | 2013-03-27 |
| JP5508260B2 (ja) | 2014-05-28 |
| AU2008273891A1 (en) | 2009-01-15 |
| ZA200909224B (en) | 2011-05-25 |
| ECSP109935A (es) | 2010-03-31 |
| BRPI0814688A2 (pt) | 2017-06-06 |
| EP2176238B1 (en) | 2012-04-18 |
| CO6251364A2 (es) | 2011-02-21 |
| ES2385692T3 (es) | 2012-07-30 |
| CN101809002A (zh) | 2010-08-18 |
| NI201000002A (es) | 2010-10-12 |
| HK1142906A1 (en) | 2010-12-17 |
| AU2008273891B2 (en) | 2012-01-12 |
| CA2692720A1 (en) | 2009-01-15 |
| CR11200A (es) | 2010-06-17 |
| JP2010533160A (ja) | 2010-10-21 |
| ATE554075T1 (de) | 2012-05-15 |
| DOP2010000012A (es) | 2010-01-31 |
| CL2008003940A1 (es) | 2010-09-24 |
| US8138183B2 (en) | 2012-03-20 |
| EA201000091A1 (ru) | 2010-06-30 |
| PE20100138A1 (es) | 2010-03-20 |
| US20100249131A1 (en) | 2010-09-30 |
| EP2176238A1 (en) | 2010-04-21 |
| WO2009007750A1 (en) | 2009-01-15 |
| KR20100042280A (ko) | 2010-04-23 |
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