AR079849A1 - DERIVATIVES OF THIOCHROMAN, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, PROCEDURE FOR PREPARATION AND USE OF THE SAME IN THE TREATMENT OF DISEASES OF THE NERVOUS CENTRAL SYSTEM, SUCH AS ALZHEIMER AND PARKINSON, AMONG OTHERS. - Google Patents
DERIVATIVES OF THIOCHROMAN, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, PROCEDURE FOR PREPARATION AND USE OF THE SAME IN THE TREATMENT OF DISEASES OF THE NERVOUS CENTRAL SYSTEM, SUCH AS ALZHEIMER AND PARKINSON, AMONG OTHERS.Info
- Publication number
- AR079849A1 AR079849A1 ARP110100041A ARP110100041A AR079849A1 AR 079849 A1 AR079849 A1 AR 079849A1 AR P110100041 A ARP110100041 A AR P110100041A AR P110100041 A ARP110100041 A AR P110100041A AR 079849 A1 AR079849 A1 AR 079849A1
- Authority
- AR
- Argentina
- Prior art keywords
- branched
- linear
- substituted
- unsubstituted
- nitrogen atom
- Prior art date
Links
- WPWNEKFMGCWNPR-UHFFFAOYSA-N 3,4-dihydro-2h-thiochromene Chemical class C1=CC=C2CCCSC2=C1 WPWNEKFMGCWNPR-UHFFFAOYSA-N 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 20
- 229910052757 nitrogen Inorganic materials 0.000 abstract 10
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 10
- 125000005843 halogen group Chemical group 0.000 abstract 6
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 3
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 abstract 3
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 3
- 125000004442 acylamino group Chemical group 0.000 abstract 3
- 125000004423 acyloxy group Chemical group 0.000 abstract 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 3
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 2
- 125000001769 aryl amino group Chemical group 0.000 abstract 2
- 125000004658 aryl carbonyl amino group Chemical group 0.000 abstract 2
- 125000005129 aryl carbonyl group Chemical group 0.000 abstract 2
- 125000005199 aryl carbonyloxy group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000004657 aryl sulfonyl amino group Chemical group 0.000 abstract 2
- 125000005110 aryl thio group Chemical group 0.000 abstract 2
- 125000004104 aryloxy group Chemical group 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000005100 aryl amino carbonyl group Chemical group 0.000 abstract 1
- 125000005161 aryl oxy carbonyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Reivindicacion 1: Compuestos de formula (1): en la que R1, R2, R3 y R4 idénticos o diferentes, representan cada uno un átomo de hidrogeno, un átomo de halogeno, o un grupo ciano ; hidroxi ; tio ; nitro; alquilo C1-6 lineal o ramificado sustituido opcionalmente ; arilo ; alcoxi C1-6 lineal o ramificado no sustituido o sustituido con uno o varios átomos de halogeno ; ariloxi ; alquiltio C1-6 lineal o ramificado ; ariltio; carboxi; alcoxicarbonilo C1-6 lineal o ramificado ariloxicarbonilo ; aciloxi C1-6 lineal o ramificado ; arilcarboniloxi; acilo C1-6 lineal o ramificado ; arilcarbonilo; amino no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes ; arilamino no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado ; acilamino C1-6 lineal o ramificado no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado; arilcarbonilamino no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado; aminocarbonilo no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes arilaminocarbonilo no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado ; alquilsulfonilamino C1-6 lineal o ramificado no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado ; o arilsulfonilamino no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado; sus enantiomeros y sus diastereoisomeros, así como sus sales de adicion con un ácido o una base farmacéuticamente aceptable, entendiéndose que: el término ½arilo y el término ½aril contenido en los grupos ariloxi, ariltio, ariloxicarbonilo, arilcarboniloxi, arilcarbonilo, arilamino, arilcarbonilamino, arilaminocarbonilo, y arilsulfonilamino, representan el grupo fenilo no sustituido o sustituido con uno o varios grupos, idénticos o diferentes, elegidos entre un átomo de halogeno, o un grupo ciano ; hidroxi; tio; nitro; alquilo C1-6 lineal o ramificado sustituido opcionalmente ; alcoxi C1-6 lineal o ramificado no sustituido o sustituido con uno o varios átomos de halogeno ; alquiltio C1-6 lineal o ramificado ; carboxi; alcoxicarbonilo C1-6 lineal o ramificado ; amino no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes ; aciloxi C1-6 lineal o ramificado ; acilamino C1-6 lineal o ramificado no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado ; aminocarbonilo no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes aminosulfonilo no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes ; alquilsulfonilamino C1-6 lineal o ramificado no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado ; o N-hidroxicarboximidamida; la expresion ½sustituido opcionalmente destinada al término alquilo significa que este grupo puede estar sustituido con uno o varios átomos de halogeno, o con un grupo ciano; hidroxi; tio; nitro; arilo ; alcoxi C1-6 lineal o ramificado no sustituido o sustituido con uno o varios átomos de halogeno ; alquiltio C1-6 lineal o ramificado ; carboxi; alcoxicarbonilo C1-6 lineal o ramificado ; aciloxi C1-6 lineal o ramificado ; amino no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes ; acilamino C1-6 lineal o ramificado no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado ; aminocarbonilo no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes aminosulfonilo no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes ; alquilsulfonilamino C1-6 lineal o ramificado no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado ; o N-hidroxicarboximidamida.Claim 1: Compounds of formula (1): wherein R1, R2, R3 and R4 identical or different, each represent a hydrogen atom, a halogen atom, or a cyano group; hydroxy; uncle ; nitro; linear or branched C1-6 alkyl optionally substituted; aryl; linear or branched C1-6 alkoxy not substituted or substituted with one or more halogen atoms; aryloxy; linear or branched C1-6 alkylthio; arylthio; carboxy; linear or branched C 1-6 alkoxycarbonyl aryloxycarbonyl; linear or branched C1-6 acyloxy; arylcarbonyloxy; linear or branched C1-6 acyl; arylcarbonyl; amino unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different; unsubstituted or substituted arylamino in the nitrogen atom with a linear or branched C1-6 alkyl group; linear or branched C1-6 acylamino unsubstituted or substituted on the nitrogen atom with a linear or branched C1-6 alkyl group; unsubstituted or substituted arylcarbonylamino in the nitrogen atom with a linear or branched C1-6 alkyl group; aminocarbonyl unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different arylaminocarbonyl unsubstituted or substituted on the nitrogen atom with a linear or branched C1-6 alkyl group; linear or branched C1-6 alkylsulfonylamino unsubstituted or substituted on the nitrogen atom with a linear or branched C1-6 alkyl group; or unsubstituted or substituted arylsulfonylamino in the nitrogen atom with a linear or branched C1-6 alkyl group; their enantiomers and their diastereoisomers, as well as their addition salts with a pharmaceutically acceptable acid or base, it being understood that: the term ½aryl and the term ½aryl contained in the aryloxy, arylthio, aryloxycarbonyl, arylcarbonyloxy, arylcarbonyl, arylamino, arylcarbonylamino, arylaminocarbonylamino groups , and arylsulfonylamino, represent the phenyl group unsubstituted or substituted with one or more groups, identical or different, chosen from a halogen atom, or a cyano group; hydroxy; uncle; nitro; linear or branched C1-6 alkyl optionally substituted; linear or branched C1-6 alkoxy not substituted or substituted with one or more halogen atoms; linear or branched C1-6 alkylthio; carboxy; linear or branched C1-6 alkoxycarbonyl; amino unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different; linear or branched C1-6 acyloxy; linear or branched C1-6 acylamino unsubstituted or substituted on the nitrogen atom with a linear or branched C1-6 alkyl group; aminocarbonyl unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different aminosulfonyl unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different; linear or branched C1-6 alkylsulfonylamino unsubstituted or substituted on the nitrogen atom with a linear or branched C1-6 alkyl group; or N-hydroxycarboximidamide; the term "substituted" optionally intended for the term "alkyl" means that this group may be substituted with one or more halogen atoms, or with a cyano group; hydroxy; uncle; nitro; aryl; linear or branched C1-6 alkoxy not substituted or substituted with one or more halogen atoms; linear or branched C1-6 alkylthio; carboxy; linear or branched C1-6 alkoxycarbonyl; linear or branched C1-6 acyloxy; amino unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different; linear or branched C1-6 acylamino unsubstituted or substituted on the nitrogen atom with a linear or branched C1-6 alkyl group; aminocarbonyl unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different aminosulfonyl unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different; linear or branched C1-6 alkylsulfonylamino unsubstituted or substituted on the nitrogen atom with a linear or branched C1-6 alkyl group; or N-hydroxycarboximidamide.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1000070A FR2955107B1 (en) | 2010-01-08 | 2010-01-08 | NOVEL THIOCHROMAN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR079849A1 true AR079849A1 (en) | 2012-02-22 |
Family
ID=42935687
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110100041A AR079849A1 (en) | 2010-01-08 | 2011-01-07 | DERIVATIVES OF THIOCHROMAN, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM, PROCEDURE FOR PREPARATION AND USE OF THE SAME IN THE TREATMENT OF DISEASES OF THE NERVOUS CENTRAL SYSTEM, SUCH AS ALZHEIMER AND PARKINSON, AMONG OTHERS. |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR079849A1 (en) |
| FR (1) | FR2955107B1 (en) |
| WO (1) | WO2011083264A1 (en) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1088945A (en) | 1976-10-18 | 1980-11-04 | Pfizer Limited | Hydantoin derivatives as therapeutic agents |
| FR2722502B1 (en) | 1994-07-12 | 1996-08-23 | Adir | NOVEL BENZOTHIADIAZINE DERIVATIVE, ITS PREPARATION METHOD AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
| AU4345297A (en) * | 1996-09-17 | 1998-04-14 | Regents Of The University Of California, The | Benzothiadiazide derivatives and their use as allosteric up-modulators of the ampa receptor |
| ZA991301B (en) * | 1998-02-18 | 1999-09-13 | Neurosearch As | Glutamate receptor modulators. |
| JP2005508352A (en) * | 2001-10-10 | 2005-03-31 | ニューロサーチ、アクティーゼルスカブ | Novel benzothiazine derivative, method for producing the same and method for using the same |
-
2010
- 2010-01-08 FR FR1000070A patent/FR2955107B1/en not_active Expired - Fee Related
-
2011
- 2011-01-06 WO PCT/FR2011/000008 patent/WO2011083264A1/en not_active Ceased
- 2011-01-07 AR ARP110100041A patent/AR079849A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2955107A1 (en) | 2011-07-15 |
| FR2955107B1 (en) | 2012-03-02 |
| WO2011083264A1 (en) | 2011-07-14 |
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