AR079848A1 - CYCLOPROPILATED BENZOTIADIAZIN DERIVATIVES, THEIR PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM - Google Patents
CYCLOPROPILATED BENZOTIADIAZIN DERIVATIVES, THEIR PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEMInfo
- Publication number
- AR079848A1 AR079848A1 ARP110100040A ARP110100040A AR079848A1 AR 079848 A1 AR079848 A1 AR 079848A1 AR P110100040 A ARP110100040 A AR P110100040A AR P110100040 A ARP110100040 A AR P110100040A AR 079848 A1 AR079848 A1 AR 079848A1
- Authority
- AR
- Argentina
- Prior art keywords
- branched
- linear
- substituted
- unsubstituted
- different
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 11
- 229910052757 nitrogen Inorganic materials 0.000 abstract 4
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 4
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 2
- 125000004845 (C1-C6) alkylsulfonylamino group Chemical group 0.000 abstract 2
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 2
- 125000004442 acylamino group Chemical group 0.000 abstract 2
- 125000004423 acyloxy group Chemical group 0.000 abstract 2
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 abstract 1
- 102000003678 AMPA Receptors Human genes 0.000 abstract 1
- 108090000078 AMPA Receptors Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
- C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
- C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Como moduladores de los receptores AMPA. Reivindicacion 1: Compuestos de formula (1) en la que R1 y R2, idénticos o diferentes, representan cada uno un átomo de hidrogeno, halogeno, o un grupo ciano; hidroxi; tio; nitro; alquilo C1-6 lineal o ramificado sustituido opcionalmente; alcoxi C1-6 lineal o ramificado no sustituido o sustituido con uno o varios átomos de halogeno; alquiltio C1-6 lineal o ramificado; carboxi; alcoxicarbonilo C1-6 lineal o ramificado; aciloxi C1-6 lineal o ramificado; amino no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes; acilamino C1-6 lineal o ramificado no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado; aminocarbonilo no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes; aminosulfonilo no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes; alquilsulfonilamino C1-6 lineal o ramificado no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado; o N-hidroxicarboximidamida, entendiéndose que la expresion ôsustituido opcionalmenteö destinada al término alquilo significa que este grupo puede estar sustituido con uno o varios átomos de halogeno, o con un grupo ciano; hidroxi; tio; nitro; alcoxi C1-6 lineal o ramificado no sustituido o sustituido con uno o varios átomos de halogeno; alquiltio C1-6 lineal o ramificado; carboxi; alcoxicarbonilo C1-6 lineal o ramificado; aciloxi C1-6 lineal o ramificado; amino no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes; acilamino C1-6 lineal o ramificado no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado; aminocarbonilo no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes aminosulfonilo no sustituido o sustituido con uno o dos grupos alquilo C1-6 lineal o ramificado, idénticos o diferentes; alquilsulfonilamino C1-6 lineal o ramificado no sustituido o sustituido en el átomo de nitrogeno con un grupo alquilo C1-6 lineal o ramificado; o N-hidroxicarboximidamida, sus enantiomeros y sus diastereoisomeros cuando existen, así como sus sales de adicion con un ácido o una base farmacéuticamente aceptable.As modulators of AMPA receptors. Claim 1: Compounds of formula (1) wherein R1 and R2, identical or different, each represent a hydrogen atom, halogen, or a cyano group; hydroxy; uncle; nitro; linear or branched C1-6 alkyl optionally substituted; linear or branched C1-6 alkoxy not substituted or substituted with one or more halogen atoms; linear or branched C1-6 alkylthio; carboxy; linear or branched C1-6 alkoxycarbonyl; linear or branched C1-6 acyloxy; amino unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different; linear or branched C1-6 acylamino unsubstituted or substituted on the nitrogen atom with a linear or branched C1-6 alkyl group; aminocarbonyl unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different; aminosulfonyl unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different; linear or branched C1-6 alkylsulfonylamino unsubstituted or substituted on the nitrogen atom with a linear or branched C1-6 alkyl group; or N-hydroxycarboximidamide, it being understood that the term "optionally substituted" for the term "alkyl" means that this group may be substituted with one or more halogen atoms, or with a cyano group; hydroxy; uncle; nitro; linear or branched C1-6 alkoxy not substituted or substituted with one or more halogen atoms; linear or branched C1-6 alkylthio; carboxy; linear or branched C1-6 alkoxycarbonyl; linear or branched C1-6 acyloxy; amino unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different; linear or branched C1-6 acylamino unsubstituted or substituted on the nitrogen atom with a linear or branched C1-6 alkyl group; aminocarbonyl unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different aminosulfonyl unsubstituted or substituted with one or two linear or branched C1-6 alkyl groups, identical or different; linear or branched C1-6 alkylsulfonylamino unsubstituted or substituted on the nitrogen atom with a linear or branched C1-6 alkyl group; or N-hydroxycarboximidamide, its enantiomers and diastereoisomers when they exist, as well as their addition salts with a pharmaceutically acceptable acid or base.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1000068A FR2955106B1 (en) | 2010-01-08 | 2010-01-08 | NOVEL CYCLOPROPYLATED BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR079848A1 true AR079848A1 (en) | 2012-02-22 |
Family
ID=42111755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP110100040A AR079848A1 (en) | 2010-01-08 | 2011-01-07 | CYCLOPROPILATED BENZOTIADIAZIN DERIVATIVES, THEIR PREPARATION PROCEDURE AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
Country Status (3)
| Country | Link |
|---|---|
| AR (1) | AR079848A1 (en) |
| FR (1) | FR2955106B1 (en) |
| WO (1) | WO2011083265A1 (en) |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2722502B1 (en) | 1994-07-12 | 1996-08-23 | Adir | NOVEL BENZOTHIADIAZINE DERIVATIVE, ITS PREPARATION METHOD AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
| ZA991301B (en) | 1998-02-18 | 1999-09-13 | Neurosearch As | Glutamate receptor modulators. |
| FR2833956B1 (en) * | 2001-12-21 | 2004-01-30 | Servier Lab | NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
| FR2856065B1 (en) * | 2003-06-13 | 2005-08-19 | Servier Lab | NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
| FR2877338B1 (en) * | 2004-11-03 | 2007-01-26 | Servier Lab | NOVEL BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
| FR2879201B1 (en) * | 2004-12-10 | 2007-02-16 | Servier Lab | NOVEL BENZOTHIAZINE AND BENZOTHIADIAZINE DERIVATIVES, PROCESS FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME |
-
2010
- 2010-01-08 FR FR1000068A patent/FR2955106B1/en not_active Expired - Fee Related
-
2011
- 2011-01-06 WO PCT/FR2011/000009 patent/WO2011083265A1/en not_active Ceased
- 2011-01-07 AR ARP110100040A patent/AR079848A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2955106A1 (en) | 2011-07-15 |
| WO2011083265A1 (en) | 2011-07-14 |
| FR2955106B1 (en) | 2011-12-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |