AR079543A1 - Derivados de amino-heteroarilo - Google Patents
Derivados de amino-heteroariloInfo
- Publication number
- AR079543A1 AR079543A1 ARP100104763A ARP100104763A AR079543A1 AR 079543 A1 AR079543 A1 AR 079543A1 AR P100104763 A ARP100104763 A AR P100104763A AR P100104763 A ARP100104763 A AR P100104763A AR 079543 A1 AR079543 A1 AR 079543A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkyloxy
- halo
- pain
- amino
- Prior art date
Links
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 208000002193 Pain Diseases 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 229920006395 saturated elastomer Polymers 0.000 abstract 2
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 abstract 1
- 125000006164 6-membered heteroaryl group Chemical group 0.000 abstract 1
- 206010065390 Inflammatory pain Diseases 0.000 abstract 1
- 125000005214 aminoheteroaryl group Chemical group 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 208000004296 neuralgia Diseases 0.000 abstract 1
- 230000002981 neuropathic effect Effects 0.000 abstract 1
- 208000021722 neuropathic pain Diseases 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/73—Unsubstituted amino or imino radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Addiction (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- AIDS & HIV (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Composiciones farmacéuticas y usos para el tratamiento del dolor. Reivindicacion 1: Un derivado de amino-heteroarilo de acuerdo con la formula general (1) caracterizado porque: Ar representa fenilo o un grupo heteroarilo de 6 miembros que contiene 1 o 2 átomos de nitrogeno, cada uno de los cuales es substituido opcionalmente con uno o más substituyentes seleccionados entre halogeno, alquilo C1-4, halo-alquilo C1-4, alquiloxi C1-4, halo-alquiloxi C1-4, CN, alquiltio C1-4 y halo-alquiltio C1-4; X es O, S o NR1; R1 es H o alquilo C1-4; R2 es alquilo C1-4, halo-alquilo C1-4, alquiloxi C1-4-alquilo C1-4 o halo-alquiloxi C1-4-alquilo C1-4; R3 es H, alquilo C1-4, halo-alquilo C1-4, alquiloxi C1-4-alquilo C1-4 o halo-alquiloxi C1-4-alquilo C1-4; o R2 y R3 forman junto con el átomo de carbono al cual están unidos un anillo saturado de 3 a 7 miembros que contiene opcionalmente un átomo de oxígeno; Y1, Y2 e Y3 son independientemente CH o N; con la condicion de que por lo menos uno de Y1, Y2 e Y3 es N y que cuando Y3 es N, Y2 es N; R4 y R5 son independientemente H, alquilo C1-4, haloalquilo C1-4, alquiloxi C1-4-alquilo C1-4; o R4 y R5 forman junto con el nitrogeno al cual están unidos un anillo saturado de 3 a 7 miembros que contiene opcionalmente un átomo de oxígeno; o una sal farmacéuticamente aceptable del mismo, para usar en el tratamiento del dolor, tal como el dolor neuropático o inflamatorio.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09180321 | 2009-12-22 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR079543A1 true AR079543A1 (es) | 2012-02-01 |
Family
ID=42045216
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100104763A AR079543A1 (es) | 2009-12-22 | 2010-12-20 | Derivados de amino-heteroarilo |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8952001B2 (es) |
| EP (1) | EP2516397B1 (es) |
| JP (1) | JP5728024B2 (es) |
| KR (1) | KR20120095481A (es) |
| CN (1) | CN102884048B (es) |
| AR (1) | AR079543A1 (es) |
| AU (1) | AU2010335231C1 (es) |
| BR (1) | BR112012015170A8 (es) |
| CA (1) | CA2783209C (es) |
| MX (1) | MX2012007426A (es) |
| RU (1) | RU2549546C2 (es) |
| WO (1) | WO2011076723A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5917503B2 (ja) * | 2011-05-19 | 2016-05-18 | 株式会社東芝 | モリブデン造粒粉の製造方法 |
| JP5941546B2 (ja) | 2011-09-02 | 2016-06-29 | パーデュー、ファーマ、リミテッド、パートナーシップ | ナトリウムチャネル遮断剤としてのピリミジン |
| WO2013072758A1 (en) | 2011-11-15 | 2013-05-23 | Purdue Pharma L.P. | Pyrimidine diol amides as sodium channel blockers |
| RU2014150494A (ru) * | 2012-05-30 | 2016-07-20 | Ф. Хоффманн-Ля Рош Аг | Пирролидиногетероциклы |
| CN106588803A (zh) * | 2016-11-16 | 2017-04-26 | 西南科技大学 | 一种制备5‑乙酰基异噁唑的新方法 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4606757A (en) * | 1982-12-23 | 1986-08-19 | The Dow Chemical Company | Diphenoxymethylpyridines having herbicidal properties |
| KR100197583B1 (ko) | 1997-02-04 | 1999-06-15 | 이민화 | 환자용모니터를 구비한 초음파진단장치 |
| EP1297136A2 (en) | 2000-05-24 | 2003-04-02 | Akzo Nobel N.V. | Full length human hcn1 ih channel subunit and variants |
| EP1378237A4 (en) * | 2001-04-10 | 2009-03-25 | Nippon Shinyaku Co Ltd | THERAPEUTIC AGENT FOR CHRONIC JOINT RHEUMATISM |
| US6980419B2 (en) | 2003-03-12 | 2005-12-27 | Zonare Medical Systems, Inc. | Portable ultrasound unit and docking station |
| WO2006030378A1 (en) | 2004-09-17 | 2006-03-23 | Koninklijke Philips Electronics, N.V. | Wireless ultrasound system display |
| US20070135437A1 (en) * | 2005-03-04 | 2007-06-14 | Alsgen, Inc. | Modulation of neurodegenerative diseases |
| EP3048099A3 (en) * | 2006-11-15 | 2016-09-21 | YM BioSciences Australia Pty Ltd | Inhibitors of kinase activity |
| AR069813A1 (es) * | 2007-12-19 | 2010-02-17 | Palau Pharma Sa | Derivados de 2- amino-pirimidina, una composicion farmaceutica, un metodo de preparacion del compuesto y uso del mismo para preparar un medicamento |
| NZ736561A (en) * | 2008-02-28 | 2018-02-23 | Vertex Pharma | Heteroaryl derivatives as cftr modulators |
| TW201022233A (en) | 2008-11-04 | 2010-06-16 | Organon Nv | (Pyrrolidin-2-yl)phenyl derivatives |
-
2010
- 2010-12-20 WO PCT/EP2010/070213 patent/WO2011076723A1/en not_active Ceased
- 2010-12-20 CN CN201080064520.9A patent/CN102884048B/zh not_active Expired - Fee Related
- 2010-12-20 KR KR1020127019218A patent/KR20120095481A/ko not_active Withdrawn
- 2010-12-20 CA CA2783209A patent/CA2783209C/en not_active Expired - Fee Related
- 2010-12-20 BR BR112012015170A patent/BR112012015170A8/pt not_active Application Discontinuation
- 2010-12-20 US US13/518,427 patent/US8952001B2/en active Active
- 2010-12-20 EP EP10795690.6A patent/EP2516397B1/en not_active Not-in-force
- 2010-12-20 AR ARP100104763A patent/AR079543A1/es unknown
- 2010-12-20 RU RU2012131279/04A patent/RU2549546C2/ru not_active IP Right Cessation
- 2010-12-20 AU AU2010335231A patent/AU2010335231C1/en not_active Ceased
- 2010-12-20 MX MX2012007426A patent/MX2012007426A/es active IP Right Grant
- 2010-12-20 JP JP2012545268A patent/JP5728024B2/ja not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN102884048A (zh) | 2013-01-16 |
| EP2516397B1 (en) | 2016-07-13 |
| KR20120095481A (ko) | 2012-08-28 |
| US8952001B2 (en) | 2015-02-10 |
| AU2010335231C1 (en) | 2015-04-16 |
| EP2516397A1 (en) | 2012-10-31 |
| JP2013515031A (ja) | 2013-05-02 |
| CA2783209A1 (en) | 2011-06-30 |
| AU2010335231B2 (en) | 2014-09-11 |
| RU2012131279A (ru) | 2014-01-27 |
| CA2783209C (en) | 2017-03-14 |
| BR112012015170A8 (pt) | 2017-12-26 |
| JP5728024B2 (ja) | 2015-06-03 |
| CN102884048B (zh) | 2014-07-23 |
| AU2010335231A1 (en) | 2012-06-21 |
| MX2012007426A (es) | 2012-07-23 |
| WO2011076723A1 (en) | 2011-06-30 |
| US20120264728A1 (en) | 2012-10-18 |
| RU2549546C2 (ru) | 2015-04-27 |
| BR112012015170A2 (pt) | 2016-03-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |