AR078135A1 - Un proceso para la preparacion de derivados de cianoalquilpropionato. - Google Patents
Un proceso para la preparacion de derivados de cianoalquilpropionato.Info
- Publication number
- AR078135A1 AR078135A1 ARP100102305A ARP100102305A AR078135A1 AR 078135 A1 AR078135 A1 AR 078135A1 AR P100102305 A ARP100102305 A AR P100102305A AR P100102305 A ARP100102305 A AR P100102305A AR 078135 A1 AR078135 A1 AR 078135A1
- Authority
- AR
- Argentina
- Prior art keywords
- formula
- compound
- neutralization
- followed
- carbon atoms
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- 239000000725 suspension Substances 0.000 abstract 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- -1 alkaline salt compound Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000000706 filtrate Substances 0.000 abstract 2
- LTYRAPJYLUPLCI-UHFFFAOYSA-N glycolonitrile Chemical compound OCC#N LTYRAPJYLUPLCI-UHFFFAOYSA-N 0.000 abstract 2
- JMANVNJQNLATNU-UHFFFAOYSA-N glycolonitrile Natural products N#CC#N JMANVNJQNLATNU-UHFFFAOYSA-N 0.000 abstract 2
- 238000006386 neutralization reaction Methods 0.000 abstract 2
- MLIREBYILWEBDM-UHFFFAOYSA-M 2-cyanoacetate Chemical compound [O-]C(=O)CC#N MLIREBYILWEBDM-UHFFFAOYSA-M 0.000 abstract 1
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 abstract 1
- SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 abstract 1
- 229930040373 Paraformaldehyde Natural products 0.000 abstract 1
- KXZJHVJKXJLBKO-UHFFFAOYSA-N chembl1408157 Chemical compound N=1C2=CC=CC=C2C(C(=O)O)=CC=1C1=CC=C(O)C=C1 KXZJHVJKXJLBKO-UHFFFAOYSA-N 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 238000004821 distillation Methods 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 229920002866 paraformaldehyde Polymers 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- QDRKDTQENPPHOJ-UHFFFAOYSA-N sodium ethoxide Chemical compound [Na+].CC[O-] QDRKDTQENPPHOJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente solicitud se relaciona al proceso de preparar un compuesto de la formula [1] y sales de la misma en donde R representa un alquilo de cadena recta o ramificada que contenga de 1 a 18 átomos de carbono, dicho proceso comprende i) reaccion de cianuro de sodio y paraformaldehído en un solvente seleccionado de un grupo compuesto por etanol anhidro, sulfoxido de dimetilo, N-metilpirrolidona, dimetilacetamida y dimetilformamida para obtener una suspension que contiene glicolonitrilo seguida de una neutralizacion de la suspension por medio de HCI gaseoso; ii) mezclando la suspension neutralizada que contiene glicolonitrilo con etoxido de sodio y cianoacetato de la formula [2] ROOC-CH2CN en donde R representa un alquilo de cadena recta o ramificada que contenga de 1 a 18 átomos de carbono; para obtener un compuesto de sal alcalina de la formula [1]; iii) neutralizacion del compuesto de sal alcalina de la formula [1] utilizando HCI gaseoso seco, con la posterior eliminacion de cloruro de sodio por filtracion para obtener un filtrado claro, y iv) concentracion del filtrado a una temperatura de aproximadamente 55°C a 60°C para la eliminacion de alcohol, seguida de una destilacion a presion reducida para obtener un compuesto de la formula [1].
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN129MU2010 | 2010-01-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR078135A1 true AR078135A1 (es) | 2011-10-19 |
Family
ID=42173704
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100102305A AR078135A1 (es) | 2010-01-18 | 2010-06-28 | Un proceso para la preparacion de derivados de cianoalquilpropionato. |
Country Status (5)
| Country | Link |
|---|---|
| AR (1) | AR078135A1 (es) |
| AU (1) | AU2010100309A4 (es) |
| BR (1) | BRPI1002090A2 (es) |
| CH (1) | CH702298B1 (es) |
| WO (1) | WO2011086570A1 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BR112013027291B1 (pt) * | 2011-04-25 | 2021-01-19 | Keki Hormusji Gharda | processo para a preparação de derivados de dicianocarboxilato |
| CN103214395B (zh) * | 2013-03-26 | 2014-04-30 | 南通市海圣药业有限公司 | 2,3-二氰基丙酸乙酯的合成工艺 |
| CN105481721B (zh) * | 2015-12-24 | 2017-06-20 | 湖南化工研究院有限公司 | 一种2,3‑二氰基丙酸乙酯的制备方法 |
| CN106631889B (zh) * | 2016-12-16 | 2018-08-21 | 阳泉煤业（集团）有限责任公司 | 一种羟基乙腈的分离提纯方法 |
| CN113149823B (zh) * | 2021-03-29 | 2023-12-08 | 上海青平药业有限公司 | 一种2-r1戊酸的制备方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9604691D0 (en) * | 1996-03-05 | 1996-05-01 | Rhone Poulenc Agriculture | New processes for preparing pesticidal intermediates |
| GB0414890D0 (en) * | 2004-07-02 | 2004-08-04 | Pfizer Ltd | Process for preparing synthetic intermediates useful in preparing pyrazole compounds |
| CN100391936C (zh) * | 2005-11-07 | 2008-06-04 | 栾忠岳 | 一种合成2、3-二氰基丙酸乙酯的工艺 |
-
2010
- 2010-04-02 AU AU2010100309A patent/AU2010100309A4/en not_active Expired
- 2010-06-08 WO PCT/IN2010/000382 patent/WO2011086570A1/en not_active Ceased
- 2010-06-24 BR BRPI1002090-0A patent/BRPI1002090A2/pt not_active Application Discontinuation
- 2010-06-28 AR ARP100102305A patent/AR078135A1/es active IP Right Grant
- 2010-07-05 CH CH01096/10A patent/CH702298B1/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| AU2010100309A4 (en) | 2010-05-20 |
| BRPI1002090A2 (pt) | 2011-09-06 |
| CH702298B1 (de) | 2011-05-13 |
| WO2011086570A1 (en) | 2011-07-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration |