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AR078085A1 - Peptidos tau antigenicos y usos de los mismos - Google Patents

Peptidos tau antigenicos y usos de los mismos

Info

Publication number
AR078085A1
AR078085A1 ARP100102753A ARP100102753A AR078085A1 AR 078085 A1 AR078085 A1 AR 078085A1 AR P100102753 A ARP100102753 A AR P100102753A AR P100102753 A ARP100102753 A AR P100102753A AR 078085 A1 AR078085 A1 AR 078085A1
Authority
AR
Argentina
Prior art keywords
tau
phospho
epitope
pser
pthr
Prior art date
Application number
ARP100102753A
Other languages
English (en)
Original Assignee
Pfizer Vaccines Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Vaccines Llc filed Critical Pfizer Vaccines Llc
Publication of AR078085A1 publication Critical patent/AR078085A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/0005—Vertebrate antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4711—Alzheimer's disease; Amyloid plaque core protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente divulgacion se refiere a inmunogenos y composiciones que comprenden un péptido tau antigénico, preferentemente unido a un vehículo inmunogénico para su uso en el tratamiento de trastornos neurologicos relacionados con tau. La divulgacion se refiere además a procedimientos para la produccion de estos inmunogenos y composiciones y a su uso en medicina. Reivindicacion 1: Un inmunogeno que comprende al menos un péptido tau antigénico unido a un vehículo inmunogénico, en el que dicho péptido tau antigénico comprende un fosfo-epítope de tau seleccionado de un fosfo-epítope de tau pSer-396, un fosfo-epítope de tau pThr-231/pSer-235, un fosfo-epítope de tau pThr-231, un fosfo-epítope de tau pSer-235, un fosfo-epítope de tau pThr-212/pSer-214, un fosfo-epítope de tau pSer-202/pThr-205 y un fosfo-epítope de tau pTyr 18.
ARP100102753A 2009-07-30 2010-07-29 Peptidos tau antigenicos y usos de los mismos AR078085A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22986009P 2009-07-30 2009-07-30

Publications (1)

Publication Number Publication Date
AR078085A1 true AR078085A1 (es) 2011-10-12

Family

ID=42941871

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100102753A AR078085A1 (es) 2009-07-30 2010-07-29 Peptidos tau antigenicos y usos de los mismos

Country Status (17)

Country Link
US (1) US20110177109A1 (es)
EP (1) EP2459214A1 (es)
JP (1) JP2013500326A (es)
KR (2) KR20120049900A (es)
CN (1) CN102596236B (es)
AR (1) AR078085A1 (es)
AU (1) AU2010277254B2 (es)
CA (1) CA2768346A1 (es)
CO (1) CO6612199A2 (es)
IN (1) IN2012DN00446A (es)
MX (1) MX2012001194A (es)
NZ (2) NZ598356A (es)
PE (1) PE20120817A1 (es)
RU (2) RU2518291C2 (es)
SG (1) SG177637A1 (es)
TW (2) TWI461209B (es)
WO (1) WO2011013034A1 (es)

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CA2768346A1 (en) 2011-02-03
AU2010277254A1 (en) 2012-02-09
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WO2011013034A1 (en) 2011-02-03
CN102596236A (zh) 2012-07-18
KR20120049900A (ko) 2012-05-17
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JP2013500326A (ja) 2013-01-07
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WO2011013034A4 (en) 2011-04-28
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AU2010277254B2 (en) 2015-05-07
KR20130127547A (ko) 2013-11-22
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CO6612199A2 (es) 2013-02-01
NZ598356A (en) 2014-06-27

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