[go: up one dir, main page]

AR077546A1 - Formulaciones de comprimidos de 3-cianoquinolina y usos de los mismos - Google Patents

Formulaciones de comprimidos de 3-cianoquinolina y usos de los mismos

Info

Publication number
AR077546A1
AR077546A1 ARP100102373A ARP100102373A AR077546A1 AR 077546 A1 AR077546 A1 AR 077546A1 AR P100102373 A ARP100102373 A AR P100102373A AR P100102373 A ARP100102373 A AR P100102373A AR 077546 A1 AR077546 A1 AR 077546A1
Authority
AR
Argentina
Prior art keywords
weight
composition
cyanoquinoline
methoxy
microcrystalline cellulose
Prior art date
Application number
ARP100102373A
Other languages
English (en)
Original Assignee
Wyeth Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Llc filed Critical Wyeth Llc
Publication of AR077546A1 publication Critical patent/AR077546A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente proporciona composiciones solidas que comprenden una 3-cianoquinolina, SKI-606, y que comprenden adicionalmente croscarmelosa sodica, Tween, o ambos. Reivindicacion 1: Una composicion farmacéuticamente aceptable que comprende: componentes intragranulares (a) 20-80 por ciento en peso de 4-(2,4-dicloro-5-metoxi-fenilamino)-6-metoxi-7-[3-(4-metil-piperazin-1-iI)-propoxi]-quinolin-3-carbonitrilo basado en el peso de la composicion; (b) povidona; (c) celulosa microcristalina; (d) 0,25-5 por ciento en peso de croscarmelosa sodica basado en el peso de la composicion; (e) poloxámero y componentes extraganulares; (f) celulosa microcristalina; y (g) estearato de magnesio. Reivindicacion 19: La composicion de acuerdo con la reivindicacion 1 o la reivindicacion 11, en forma de un comprimido granulado en humedo, revestido con una película, o en forma de un comprimido revestido en recipiente. Reivindicacion 20: Un procedimiento para tratar el cáncer que comprende administrar una cantidad eficaz de una composicion de acuerdo con la reivindicacion 1 o la reivindicacion 11.
ARP100102373A 2009-07-02 2010-07-02 Formulaciones de comprimidos de 3-cianoquinolina y usos de los mismos AR077546A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US22253709P 2009-07-02 2009-07-02

Publications (1)

Publication Number Publication Date
AR077546A1 true AR077546A1 (es) 2011-09-07

Family

ID=42732381

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100102373A AR077546A1 (es) 2009-07-02 2010-07-02 Formulaciones de comprimidos de 3-cianoquinolina y usos de los mismos

Country Status (15)

Country Link
EP (1) EP2448563A2 (es)
JP (1) JP2011012063A (es)
KR (1) KR20120046216A (es)
CN (1) CN102470109A (es)
AR (1) AR077546A1 (es)
AU (1) AU2010266342A1 (es)
BR (1) BRPI1015941A2 (es)
CA (1) CA2766067A1 (es)
IL (1) IL217298A0 (es)
MX (1) MX2012000048A (es)
RU (1) RU2011152105A (es)
SG (1) SG177309A1 (es)
TW (1) TW201113050A (es)
WO (1) WO2011002857A2 (es)
ZA (1) ZA201200366B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK1848414T3 (da) 2005-02-03 2011-07-25 Gen Hospital Corp Fremgangsmåde til behandling af gefitinib-resistent cancer
AU2006311877A1 (en) 2005-11-04 2007-05-18 Wyeth Llc Antineoplastic combinations with mTOR inhibitor, herceptin, and/orHKI-272
US8022216B2 (en) 2007-10-17 2011-09-20 Wyeth Llc Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
SI2310011T1 (sl) 2008-06-17 2013-10-30 Wyeth Llc Antineoplastične kombinacije, ki vsebujejo HKI-272 in vinorelbin
BRPI0916694B1 (pt) 2008-08-04 2021-06-08 Wyeth Llc uso de neratinibe em combinação com capecitabina para tratar câncer de mama metastático de erbb-2 positivo, kit e produto compreendendo os mesmos
CA2755789C (en) 2009-04-06 2016-01-19 Wyeth Llc Treatment regimen utilizing neratinib for breast cancer
CN107441058A (zh) 2009-11-09 2017-12-08 惠氏有限责任公司 包衣药物球状体及消除或减少病症如呕吐和腹泻的用途
ES2757882T5 (es) 2009-11-09 2023-05-10 Wyeth Llc Formulaciones de comprimidos de maleato de neratinib
CN104447541A (zh) * 2013-09-16 2015-03-25 天津市汉康医药生物技术有限公司 博舒替尼化合物
CN105384686B (zh) * 2014-09-04 2019-07-26 连云港润众制药有限公司 一种博舒替尼结晶方法
WO2017175855A1 (en) * 2016-04-08 2017-10-12 Shionogi & Co., Ltd. Stabilized solid dosage form
KR102297116B1 (ko) 2017-03-31 2021-09-01 닛세이 에이. 에스. 비 기카이 가부시키가이샤 수지제 용기

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6297258B1 (en) 1998-09-29 2001-10-02 American Cyanamid Company Substituted 3-cyanoquinolines
CA2476587C (en) * 2002-02-26 2010-05-04 Astrazeneca Ab Pharmaceutical formulation of iressa comprising a water-soluble cellulose derivative
EP1660453A2 (en) 2003-08-19 2006-05-31 Wyeth Holdings Corporation Process for the preparation of 4-amino-3-quinolinecarbonitriles
EP1797881B1 (en) * 2004-09-17 2009-04-15 Eisai R&D Management Co., Ltd. Medicinal composition with improved stability and reduced gelation properties
RU2007148072A (ru) * 2005-07-01 2009-08-10 Вайет (Us) Кристаллические формы 4-[(2,4-дихлор-5-метоксифинил)амино]-6- меокси-7-[3-(4-метил-1-пиперазинил)пропокси]-3-хиналинкарбонитрил и способы их получения
WO2008053295A2 (en) * 2006-10-30 2008-05-08 Wockhardt Research Centre Pharmaceutical compositions of benzoquinolizine-2-carboxylic acid
CN101224185A (zh) * 2007-12-11 2008-07-23 山东蓝金生物工程有限公司 一种治疗实体肿瘤的伯舒替尼缓释植入剂

Also Published As

Publication number Publication date
IL217298A0 (en) 2012-02-29
KR20120046216A (ko) 2012-05-09
WO2011002857A3 (en) 2011-03-10
JP2011012063A (ja) 2011-01-20
SG177309A1 (en) 2012-02-28
RU2011152105A (ru) 2013-08-10
WO2011002857A2 (en) 2011-01-06
CN102470109A (zh) 2012-05-23
AU2010266342A1 (en) 2012-01-19
BRPI1015941A2 (pt) 2016-04-19
CA2766067A1 (en) 2011-01-06
ZA201200366B (en) 2012-10-31
MX2012000048A (es) 2012-01-27
TW201113050A (en) 2011-04-16
EP2448563A2 (en) 2012-05-09

Similar Documents

Publication Publication Date Title
AR077546A1 (es) Formulaciones de comprimidos de 3-cianoquinolina y usos de los mismos
HRP20192026T4 (hr) Formulacija tableta od neratinib maleata
AR122580A2 (es) Forma de dosificación de doxilamina y piridoxina y/o sus metabolitos o sales
BR112012024019A2 (pt) forma de dosagem de liberação controlada, e, método para liberar uma droga
UY33183A (es) Compuestos inhibidores de virus flaviviridae, composición farmaceutica que los contiene y su uso en la manufactura de un medicamento
NO20091501L (no) Farmasoytiske sammensetninger
CL2013000713A1 (es) Compuestos pirazin-2-cabonil-imino-1,3,8-triaza-espiro-[4.5]-decan-sustituidos, bloqueadores del canal de sodio epitelial (enac); composicion farmaceutica que los incluye; metodo de prevencion o tratamiento; y su uso para tratar una enfermedad o condicion mediada por el bloqueo del canal de sodio epitelial.
CU24619B1 (es) Letermovir amorfo y formulaciones farmacéuticas sólidas del mismo para administración por via oral
GT200600096A (es) Composicion farmaceutica para el tratamiento del cancer
CO6440564A2 (es) Composiciones farmacéuticas de liberación inmediata que comprenden oxicodona y naloxona
CL2015003072A1 (es) Formulaciones de liberación prolongada de colchicina y métodos de uso de las mismas.
CO2018005842A2 (es) Composición farmacéutica que comprende un potente inhibidor de urat 1
AR077284A1 (es) Composiciones de dosis fija farmaceuticas solidas que comprenden irbesartan y amlodipina, su preparacion y su aplicacion terapeutica
WO2014016754A3 (en) Pharmaceutical compositions of proton pump inhibitor
BR112014014795A2 (pt) sistema de pélete de multiunidade de liberação imediata
PE20151607A1 (es) Formulaciones de compuestos organicos
AR100977A1 (es) Formulación compuesta para la administración oral que comprende ezetimiba y rosuvastatina, y un proceso para su preparación
AR094146A1 (es) Unidad solida con alto contenido en fexofenadina y su procedimiento de preparacion
MX2013001279A (es) Composicion farmaceutica con un inhibidor selectivo de la enzima fosfodiesterasa en forma de gel oral.
PH12016500693B1 (en) Slow-release solid oral compositions
AR080256A1 (es) Formulaciones farmaceuticas solidas de ramipril y besilato de amlodipino y su preparacion
ECSP16005208A (es) Composición farmacéutica anti-tuberculosis estable en una forma de un comprimido recubierto que comprende gránulos de isoniazid y gránulos de rifapentina y su proceso de preparación
AR080895A1 (es) Formulacion de comprimido de ezatiostat
PE20160245A1 (es) Composicion farmaceutica anti-tuberculosis estable en una forma de un comprimido dispersable que comprende granulos de isoniazid y granulos de rifapentina y su proceso de preparacion
BR112013000870A2 (pt) forma de dosagem farmacêutica oral em comprimidos

Legal Events

Date Code Title Description
FA Abandonment or withdrawal