AR075438A1 - FUSIONATED BENZAZEPINS AS LEGANDS OF NEURONAL NICOTINIC ACETILCOLINE RECEIVER - Google Patents
FUSIONATED BENZAZEPINS AS LEGANDS OF NEURONAL NICOTINIC ACETILCOLINE RECEIVERInfo
- Publication number
- AR075438A1 AR075438A1 ARP100100445A AR075438A1 AR 075438 A1 AR075438 A1 AR 075438A1 AR P100100445 A ARP100100445 A AR P100100445A AR 075438 A1 AR075438 A1 AR 075438A1
- Authority
- AR
- Argentina
- Prior art keywords
- independently
- alkyl
- compounds
- aryl
- halogen
- Prior art date
Links
- 230000001537 neural effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000001072 heteroaryl group Chemical group 0.000 abstract 4
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- 210000003169 central nervous system Anatomy 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 1
- -1 C1-6 alkyl halogen Chemical class 0.000 abstract 1
- 101100240516 Caenorhabditis elegans nhr-10 gene Proteins 0.000 abstract 1
- 101001043818 Mus musculus Interleukin-31 receptor subunit alpha Proteins 0.000 abstract 1
- 102000019315 Nicotinic acetylcholine receptors Human genes 0.000 abstract 1
- 108050006807 Nicotinic acetylcholine receptors Proteins 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 230000004064 dysfunction Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
La presente se relaciona con compuestos que se unen y modulan la actividad de receptores de acetilcolina nicotínica neuronal, con procesos para preparar estos compuestos, con composiciones farmacéuticas que contienen estos compuestos, y con métodos para usar estos compuestos para tratar una amplia variedad de condiciones y trastornos, que incluyen aquellos asociados con la disfuncion del sistema nervioso central (SNC). Reivindicacion 1: Un compuesto de la Formula 1 o de la Formula 2 en donde: cada X1 es independientemente N o CR10; X2 es NR10 u O; cada Z es independientemente H, R10, OR10, NHR10, NR10R11, halogeno; cada R1 es independientemente H o alquilo de C1-6 cada R2 es independientemente H, alquilo de C1-6, arilo, heteroarilo, cuyos grupos arilo y heteroarilo se pueden sustituir opcionalmente con uno o más de alquilo de C1-6 halogeno, hidroxilo, alcoxi de C1-6, amino o haloalquilo de C1-6 y cada uno de R10 o R11 es independientemente H, alquilo de C1-6 arilo, o heteroarilo; cuyos grupos arilo y heteroarilo se pueden sustituir opcionalmente con uno o más de alquilo C1-6, halogeno, hidroxilo, alcoxi de C1-6, amino, o haloalquil de C1-6 o una sal farmacéuticamente aceptable de ellos.This is related to compounds that bind and modulate the activity of neuronal nicotinic acetylcholine receptors, with processes to prepare these compounds, with pharmaceutical compositions containing these compounds, and with methods to use these compounds to treat a wide variety of conditions and disorders, which include those associated with dysfunction of the central nervous system (CNS). Claim 1: A compound of Formula 1 or Formula 2 wherein: each X1 is independently N or CR10; X2 is NR10 or O; each Z is independently H, R10, OR10, NHR10, NR10R11, halogen; each R1 is independently H or C1-6 alkyl each R2 is independently H, C1-6 alkyl, aryl, heteroaryl, whose aryl and heteroaryl groups may optionally be substituted with one or more of C1-6 alkyl halogen, hydroxyl, C1-6 alkoxy, C1-6 amino or haloalkyl and each of R10 or R11 is independently H, C1-6 aryl alkyl, or heteroaryl; whose aryl and heteroaryl groups may optionally be substituted with one or more of C1-6 alkyl, halogen, hydroxyl, C1-6 alkoxy, amino, or C1-6 haloalkyl or a pharmaceutically acceptable salt thereof.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP100100445 AR075438A1 (en) | 2010-02-16 | 2010-02-16 | FUSIONATED BENZAZEPINS AS LEGANDS OF NEURONAL NICOTINIC ACETILCOLINE RECEIVER |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ARP100100445 AR075438A1 (en) | 2010-02-16 | 2010-02-16 | FUSIONATED BENZAZEPINS AS LEGANDS OF NEURONAL NICOTINIC ACETILCOLINE RECEIVER |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR075438A1 true AR075438A1 (en) | 2011-03-30 |
Family
ID=43857555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP100100445 AR075438A1 (en) | 2010-02-16 | 2010-02-16 | FUSIONATED BENZAZEPINS AS LEGANDS OF NEURONAL NICOTINIC ACETILCOLINE RECEIVER |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR075438A1 (en) |
-
2010
- 2010-02-16 AR ARP100100445 patent/AR075438A1/en unknown
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Legal Events
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| FB | Suspension of granting procedure |