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AR075196A1 - Un derivado de cianopirimidina para el tratamiento de una enfermedad ocular - Google Patents

Un derivado de cianopirimidina para el tratamiento de una enfermedad ocular

Info

Publication number
AR075196A1
AR075196A1 ARP100100213A ARP100100213A AR075196A1 AR 075196 A1 AR075196 A1 AR 075196A1 AR P100100213 A ARP100100213 A AR P100100213A AR P100100213 A ARP100100213 A AR P100100213A AR 075196 A1 AR075196 A1 AR 075196A1
Authority
AR
Argentina
Prior art keywords
cyanopirimidine
derivative
treatment
eye disease
group
Prior art date
Application number
ARP100100213A
Other languages
English (en)
Inventor
Norifumi Sato
Yohei Yuki
Hiroyuki Yamazaki
Hisashi Shinohara
Yasuhiro Takeji
Daisaku Michikami
Kuni Ito
Keisuke Hino
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of AR075196A1 publication Critical patent/AR075196A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

Compuesto de cianopirimidina, y una composicion farmacéutica la cual tiene actividad agonista del receptor A2a de adenosina. Reivindicacion 1: Un compuesto de cianopirimidina caracterizado por la formula (1): donde R es hidrogeno, grupo hidroxi (alquilo inferior), grupo (alquilo inferior) halogenado o grupo (alcoxi interior) carbonil (alquilo interior) o una sal de los mismos.
ARP100100213A 2009-02-03 2010-01-28 Un derivado de cianopirimidina para el tratamiento de una enfermedad ocular AR075196A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2009022339 2009-02-03

Publications (1)

Publication Number Publication Date
AR075196A1 true AR075196A1 (es) 2011-03-16

Family

ID=42112160

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP100100213A AR075196A1 (es) 2009-02-03 2010-01-28 Un derivado de cianopirimidina para el tratamiento de una enfermedad ocular

Country Status (23)

Country Link
US (1) US9708292B2 (es)
EP (1) EP2393552B1 (es)
JP (1) JP5145422B2 (es)
KR (1) KR101263074B1 (es)
CN (1) CN102307621B (es)
AR (1) AR075196A1 (es)
AU (1) AU2010211594B2 (es)
BR (1) BRPI1007893A2 (es)
CA (1) CA2749358C (es)
CO (1) CO6420321A2 (es)
DK (1) DK2393552T3 (es)
ES (1) ES2661047T3 (es)
IL (1) IL214028A (es)
MX (1) MX2011008149A (es)
MY (1) MY165572A (es)
NO (1) NO2393552T3 (es)
NZ (1) NZ593975A (es)
RU (1) RU2533115C2 (es)
SG (1) SG173093A1 (es)
TR (1) TR201802626T4 (es)
TW (1) TWI537260B (es)
UA (1) UA105919C2 (es)
WO (1) WO2010090299A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5823766B2 (ja) * 2010-07-30 2015-11-25 大塚製薬株式会社 医薬組成物
JP5574294B2 (ja) * 2010-11-04 2014-08-20 独立行政法人科学技術振興機構 光磁気記録媒体及び光磁気記録方法
CN106588696B (zh) * 2016-12-08 2018-12-25 西北师范大学 一种反式α,β-不饱和腈类化合物的制备方法
KR102316819B1 (ko) * 2018-04-20 2021-10-25 한미약품 주식회사 카라기난을 유효성분으로 포함하는 보존성이 개선된 액상 제제
CN110950774B (zh) * 2019-11-04 2021-04-13 北京大学 蛋白质定量标记试剂及其制备方法与应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3677421B2 (ja) * 1999-12-27 2005-08-03 扶桑薬品工業株式会社 涙液分泌促進組成物
DE10110754A1 (de) * 2001-03-07 2002-09-19 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung
DE10134481A1 (de) 2001-07-16 2003-01-30 Bayer Ag Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung
MXPA06000051A (es) 2003-07-02 2006-03-21 Vertex Pharma Pirimidinas utiles como moduladores de canales ionicos dependientes de voltaje.
JP4794200B2 (ja) * 2004-04-30 2011-10-19 大塚製薬株式会社 ４−アミノ−５−シアノピリミジン誘導体
TWI346109B (en) * 2004-04-30 2011-08-01 Otsuka Pharma Co Ltd 4-amino-5-cyanopyrimidine derivatives
JP5201817B2 (ja) * 2005-10-28 2013-06-05 大塚製薬株式会社 医薬組成物
US20070140897A1 (en) * 2005-12-21 2007-06-21 Hongna Wang Ph stable biguanide composition and method of treatment and prevention of infections

Also Published As

Publication number Publication date
AU2010211594A1 (en) 2011-07-28
NZ593975A (en) 2012-10-26
US9708292B2 (en) 2017-07-18
CN102307621A (zh) 2012-01-04
CA2749358A1 (en) 2010-08-12
KR101263074B1 (ko) 2013-05-09
BRPI1007893A2 (pt) 2016-02-16
IL214028A (en) 2015-11-30
DK2393552T3 (en) 2018-03-05
EP2393552B1 (en) 2017-12-20
SG173093A1 (en) 2011-08-29
AU2010211594B2 (en) 2016-05-12
WO2010090299A1 (en) 2010-08-12
ES2661047T3 (es) 2018-03-27
RU2533115C2 (ru) 2014-11-20
TWI537260B (zh) 2016-06-11
JP5145422B2 (ja) 2013-02-20
US20120022077A1 (en) 2012-01-26
CA2749358C (en) 2016-07-26
TW201033192A (en) 2010-09-16
JP2011509924A (ja) 2011-03-31
IL214028A0 (en) 2011-08-31
NO2393552T3 (es) 2018-05-19
TR201802626T4 (tr) 2018-03-21
EP2393552A1 (en) 2011-12-14
UA105919C2 (uk) 2014-07-10
MY165572A (en) 2018-04-05
RU2011136648A (ru) 2013-03-10
KR20100111687A (ko) 2010-10-15
CN102307621B (zh) 2014-10-01
CO6420321A2 (es) 2012-04-16
MX2011008149A (es) 2011-08-17

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