AR063061A1 - Metodo de generacion de anticuerpos activos contra un antigeno de resistencia, anticuerpos obtenidos por dicho metodo y sus utilizaciones - Google Patents
Metodo de generacion de anticuerpos activos contra un antigeno de resistencia, anticuerpos obtenidos por dicho metodo y sus utilizacionesInfo
- Publication number
- AR063061A1 AR063061A1 ARP070104320A ARP070104320A AR063061A1 AR 063061 A1 AR063061 A1 AR 063061A1 AR P070104320 A ARP070104320 A AR P070104320A AR P070104320 A ARP070104320 A AR P070104320A AR 063061 A1 AR063061 A1 AR 063061A1
- Authority
- AR
- Argentina
- Prior art keywords
- resistance
- antibodies
- antigen
- generation
- tumor
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 206010028980 Neoplasm Diseases 0.000 abstract 5
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 239000013592 cell lysate Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012634 fragment Substances 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/515—Animal cells
- A61K2039/5152—Tumor cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Cell Biology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Developmental Biology & Embryology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Zoology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Utilizacion de un homogenizado y/o de una suspension y/o de un lisado celular procedente de un tumor resistente por lo menos a un compuesto antitumoral para inmunizar y generar in vitro un anticuerpo, o uno de sus fragmentos funcionales, dirigido contra un antígeno tumoral expresado específicamente en la superficie de dicho tumor resistente y susceptible de estar implicado en la resistencia de dicho tumor resistente. Más particularmente, se refiere a dichos anticuerpos obtenidos utilizando dicho método, corno anticuerpos 1A6, 1A9, 2E11, 3C11 y 3G7, así como su utilizacion para el tratamiento del cáncer.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0608514A FR2906533B1 (fr) | 2006-09-28 | 2006-09-28 | Procede de generation d'anticorps actifs contre un antigene de resistance,anticorps obtenus par ledit procede et leurs utilisations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR063061A1 true AR063061A1 (es) | 2008-12-23 |
Family
ID=38164542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070104320A AR063061A1 (es) | 2006-09-28 | 2007-09-28 | Metodo de generacion de anticuerpos activos contra un antigeno de resistencia, anticuerpos obtenidos por dicho metodo y sus utilizaciones |
Country Status (21)
| Country | Link |
|---|---|
| US (2) | US8241646B2 (es) |
| EP (4) | EP2491945B9 (es) |
| JP (1) | JP5774276B2 (es) |
| KR (1) | KR101504770B1 (es) |
| CN (1) | CN101516394B (es) |
| AR (1) | AR063061A1 (es) |
| AU (1) | AU2007312437C1 (es) |
| BR (1) | BRPI0717246A2 (es) |
| CA (1) | CA2663561A1 (es) |
| FR (1) | FR2906533B1 (es) |
| IL (1) | IL197790A (es) |
| MA (1) | MA30954B1 (es) |
| MX (1) | MX2009003245A (es) |
| NO (1) | NO20091613L (es) |
| NZ (1) | NZ576420A (es) |
| RU (1) | RU2515904C2 (es) |
| TN (1) | TN2009000102A1 (es) |
| TW (1) | TWI516276B (es) |
| UA (1) | UA102812C2 (es) |
| WO (1) | WO2008046724A1 (es) |
| ZA (1) | ZA200902697B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7241444B2 (en) * | 2002-01-18 | 2007-07-10 | Pierre Fabre Medicament | Anti-IGF-IR antibodies and uses thereof |
| CU23736A1 (es) * | 2009-05-04 | 2011-11-15 | Centro Inmunologia Molecular | Anticuerpos que reconocen sulfatidos y proteoglicanos sulfatados y su uso |
| WO2011004899A1 (en) * | 2009-07-06 | 2011-01-13 | Takeda Pharmaceutical Company Limited | Cancerous disease modifying antibodies |
| US20120282211A1 (en) * | 2009-11-24 | 2012-11-08 | Carnegie Mellon University | Antibodies and conjugates for modulators of angiogenesis |
| BR122014027420A2 (pt) | 2010-11-03 | 2019-08-20 | Argenx Bvba | Anticorpos anti c-met |
| US9255595B2 (en) * | 2011-04-29 | 2016-02-09 | Bae Systems Information And Electronic Systems Integration Inc. | Optical dome bezel |
| EP2773660A2 (en) | 2011-11-03 | 2014-09-10 | Argen-X B.V. | Chimeric human-camel antigens and their use |
| WO2014152006A2 (en) * | 2013-03-15 | 2014-09-25 | Intrinsic Lifesciences, Llc | Anti-hepcidin antibodies and uses thereof |
| CN106794194A (zh) * | 2014-06-30 | 2017-05-31 | 中央研究院 | 用于癌症治疗的介白素‑17受体b（il‑17rb）及其配体il‑17b之拮抗剂 |
| CA2961917A1 (en) | 2014-09-22 | 2016-03-31 | Intrinsic Lifesciences Llc | Humanized anti-hepcidin antibodies and uses thereof |
| TWI740824B (zh) * | 2015-04-27 | 2021-10-01 | 法商皮爾法伯製藥公司 | 新穎的ｉｇｆ－１ｒ抗體及其用於癌症診斷之用途（一） |
| TWI716400B (zh) * | 2015-04-27 | 2021-01-21 | 法商皮爾法伯製藥公司 | 新穎的igf-1r抗體及其用於癌症診斷之用途（二） |
| JP6976241B2 (ja) * | 2015-08-14 | 2021-12-08 | メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. | 抗ｔｉｇｉｔ抗体 |
| CA3000638C (en) * | 2015-09-29 | 2024-02-27 | Asia Biotech Pte. Ltd. | Pd-1 antibodies and uses thereof |
| GB2547179A (en) * | 2015-10-26 | 2017-08-16 | Quethera Ltd | Genetic construct |
| WO2025111382A2 (en) * | 2023-11-21 | 2025-05-30 | Board Of Regents, The University Of Texas System | Anti-lamp5 antibodies, engineered immune cells expressing anti-lamp5 antibodies, and uses thereof |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6261596A (ja) * | 1985-09-11 | 1987-03-18 | Japan Found Cancer Res | 薬剤耐性癌に関するモノクロ−ナル抗体およびその製造 |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8924581D0 (en) | 1989-11-01 | 1989-12-20 | Pa Consulting Services | Bleaching of hair |
| ATE139258T1 (de) | 1990-01-12 | 1996-06-15 | Cell Genesys Inc | Erzeugung xenogener antikörper |
| GB9014932D0 (en) | 1990-07-05 | 1990-08-22 | Celltech Ltd | Recombinant dna product and method |
| US5814318A (en) | 1990-08-29 | 1998-09-29 | Genpharm International Inc. | Transgenic non-human animals for producing heterologous antibodies |
| WO1994004679A1 (en) | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
| JPH05244982A (ja) | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化ｂ−ｂ１０ |
| DE69304895T2 (de) * | 1992-02-06 | 1997-02-06 | Merrell Pharma Inc | Aufhebung von Multi-Drug-Resistenz durch Tetraarylethylene |
| IT1257893B (it) | 1992-06-17 | 1996-02-16 | Ist Superiore Sanita | Anticorpi monoclonali che riconoscono un epitopo della p-glicoproteina umana. |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US5503984A (en) * | 1993-04-13 | 1996-04-02 | Health Research, Inc. | Hybridoma producing monoclonal antibody F4 which specifically binds to multidrug resistant P-glycoprotein and assays for detection of P-glycoprotein |
| AU4441799A (en) * | 1998-06-15 | 2000-01-05 | Research Foundation Of The State University Of New York, The | Monoclonal antibodies that recognize antigens associated with tumor metastasis |
| US7303760B2 (en) | 1999-04-23 | 2007-12-04 | Alza Corporation | Method for treating multi-drug resistant tumors |
| MXPA04006980A (es) | 2002-01-18 | 2004-11-10 | Pf Medicament | Anticuerpos novedosos anti-receptor del factor de crecimiento i tipo insulina, y usos de los mismos. |
| WO2004026293A2 (en) | 2002-09-20 | 2004-04-01 | Wyeth Holdings Corporation | Hemiasterlin derivatives for treating resistant tumors |
| MXPA06003886A (es) * | 2003-10-08 | 2006-08-11 | Ebioscience | Reactivos de enlace de inmunoglobulina naturales y metodos de fabricacion y uso de los mismos. |
| ATE397924T1 (de) | 2004-02-18 | 2008-07-15 | Gpc Biotech Ag | Satraplatin zur behandlung von resistenten oder refrkatären tumoren |
| EP1742060A1 (en) * | 2005-01-24 | 2007-01-10 | DIGILAB BioVisioN GmbH | TIF1-beta peptides and nucleic acids for diagnosis and therapy of cancer and colorectal cancerous disorders. |
-
2006
- 2006-09-28 FR FR0608514A patent/FR2906533B1/fr not_active Expired - Fee Related
-
2007
- 2007-09-27 UA UAA200904020A patent/UA102812C2/ru unknown
- 2007-09-27 EP EP12159083.0A patent/EP2491945B9/en active Active
- 2007-09-27 BR BRPI0717246-0A2A patent/BRPI0717246A2/pt not_active IP Right Cessation
- 2007-09-27 MX MX2009003245A patent/MX2009003245A/es active IP Right Grant
- 2007-09-27 NZ NZ576420A patent/NZ576420A/en not_active IP Right Cessation
- 2007-09-27 KR KR1020097008469A patent/KR101504770B1/ko not_active Expired - Fee Related
- 2007-09-27 EP EP12159086.3A patent/EP2497491B1/en active Active
- 2007-09-27 US US12/442,918 patent/US8241646B2/en not_active Expired - Fee Related
- 2007-09-27 EP EP12159077.2A patent/EP2494984B1/en active Active
- 2007-09-27 WO PCT/EP2007/060243 patent/WO2008046724A1/en not_active Ceased
- 2007-09-27 CA CA002663561A patent/CA2663561A1/en not_active Abandoned
- 2007-09-27 RU RU2009114682/10A patent/RU2515904C2/ru not_active IP Right Cessation
- 2007-09-27 JP JP2009529701A patent/JP5774276B2/ja not_active Expired - Fee Related
- 2007-09-27 AU AU2007312437A patent/AU2007312437C1/en not_active Ceased
- 2007-09-27 CN CN200780035523.8A patent/CN101516394B/zh not_active Expired - Fee Related
- 2007-09-27 EP EP07820636.4A patent/EP2081592B1/en active Active
- 2007-09-28 TW TW096136193A patent/TWI516276B/zh not_active IP Right Cessation
- 2007-09-28 AR ARP070104320A patent/AR063061A1/es unknown
-
2009
- 2009-03-24 IL IL197790A patent/IL197790A/en not_active IP Right Cessation
- 2009-03-26 TN TN2009000102A patent/TN2009000102A1/fr unknown
- 2009-04-17 MA MA31800A patent/MA30954B1/fr unknown
- 2009-04-20 ZA ZA200902697A patent/ZA200902697B/xx unknown
- 2009-04-22 NO NO20091613A patent/NO20091613L/no not_active Application Discontinuation
-
2012
- 2012-07-09 US US13/544,672 patent/US8808667B2/en not_active Expired - Fee Related
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |