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AR060622A1 - Proceso para la preparcion del ester 2-[ 4-(4- fluoro-2 - metil-1h -indol-5- iloxi)-5-metil pirrolo [2,1-f] [ 1,2,4] triazin -6-iloxi] -1- metiletilico del acido [(1r),2s ] -2- aminopropinoico - Google Patents

Proceso para la preparcion del ester 2-[ 4-(4- fluoro-2 - metil-1h -indol-5- iloxi)-5-metil pirrolo [2,1-f] [ 1,2,4] triazin -6-iloxi] -1- metiletilico del acido [(1r),2s ] -2- aminopropinoico

Info

Publication number
AR060622A1
AR060622A1 ARP070101727A ARP070101727A AR060622A1 AR 060622 A1 AR060622 A1 AR 060622A1 AR P070101727 A ARP070101727 A AR P070101727A AR P070101727 A ARP070101727 A AR P070101727A AR 060622 A1 AR060622 A1 AR 060622A1
Authority
AR
Argentina
Prior art keywords
compound
formula
iloxi
methyl
give
Prior art date
Application number
ARP070101727A
Other languages
English (en)
Inventor
Jaan A Pesti
Zhongmin Xu
Paul C Lobben
David K Leahy
Jale Musiehiddinoglu
Chiajen Lai
Lori Ann Sprangler
Robert P Discordia
Gerard A Crispino
Mourad Hamedi
Thomas L Laporte
John E Thornton
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38357966&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR060622(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR060622A1 publication Critical patent/AR060622A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

El compuesto 1 se ha mostrado que va a ser util para el tratamiento de ciertos tipos de cáncer. Reivindicacion 1: Un proceso para la preparacion del compuesto de la formula (1) caracterizado porque comprende las etapas de: (a) hacer reaccionar el compuesto de la formula (2) con un agente de metilacion en un solvente adecuado para producir el compuesto de formula (3), b) el cual se hace reaccionar en una oxidacion continua seguido por una reaccion de apagado para preparar el compuesto de formula (4) y proteccion para convertir el compuesto de formula (4) al compuesto de formula (5), c) clorar el compuesto de formula (5) para dar el compuesto de formula (6), d) el cual es unido con el compuesto de formula (7) para dar el compuesto de formula (8), que es cristalizado opcionalmente para mejorar la calidad, y e) el cual es desprotegido subsiguientemente y se hace reaccionar con el oxido de (R)-(+)-propileno en un solvente adecuado, y opcionalmente recristalizado para mejorar la calidad, para dar el compuesto de formula (9), f) el cual se hace reaccionar con una Cbz-L-alanina y un agente de union para dar el compuesto de la formula (10).
ARP070101727A 2006-04-21 2007-04-20 Proceso para la preparcion del ester 2-[ 4-(4- fluoro-2 - metil-1h -indol-5- iloxi)-5-metil pirrolo [2,1-f] [ 1,2,4] triazin -6-iloxi] -1- metiletilico del acido [(1r),2s ] -2- aminopropinoico AR060622A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US74530006P 2006-04-21 2006-04-21

Publications (1)

Publication Number Publication Date
AR060622A1 true AR060622A1 (es) 2008-07-02

Family

ID=38357966

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070101727A AR060622A1 (es) 2006-04-21 2007-04-20 Proceso para la preparcion del ester 2-[ 4-(4- fluoro-2 - metil-1h -indol-5- iloxi)-5-metil pirrolo [2,1-f] [ 1,2,4] triazin -6-iloxi] -1- metiletilico del acido [(1r),2s ] -2- aminopropinoico

Country Status (23)

Country Link
US (1) US7671199B2 (es)
EP (1) EP2010538B1 (es)
JP (1) JP5203353B2 (es)
KR (1) KR101423789B1 (es)
CN (1) CN101472927B (es)
AR (1) AR060622A1 (es)
AU (1) AU2007240453B2 (es)
BR (1) BRPI0710691A2 (es)
CA (1) CA2650059A1 (es)
CL (2) CL2007001141A1 (es)
DK (1) DK2010538T3 (es)
EA (1) EA019693B1 (es)
ES (1) ES2399379T3 (es)
HR (1) HRP20130099T1 (es)
IL (1) IL194715A (es)
MX (1) MX2008013232A (es)
NO (1) NO20084326L (es)
PE (1) PE20080193A1 (es)
PL (1) PL2010538T3 (es)
PT (1) PT2010538E (es)
SI (1) SI2010538T1 (es)
TW (1) TWI378100B (es)
WO (1) WO2007124332A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007038648A1 (en) * 2005-09-27 2007-04-05 Bristol-Myers Squibb Company Crystalline forms of [(1r), 2s]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1h-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester
US20120135875A1 (en) * 2008-02-29 2012-05-31 Bristol-Myers Squibb Company Methods for determining sensitivity to vascular endothelial growth factor receptor-2 modulators
AR074830A1 (es) 2008-12-19 2011-02-16 Cephalon Inc Pirrolotriazinas como inhibidores de alk y jak2
EP3864418A1 (en) 2018-10-08 2021-08-18 Applied Photophysics Limited System and method for analysing the composition of a quenched flow reaction liquid

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6982265B1 (en) * 1999-05-21 2006-01-03 Bristol Myers Squibb Company Pyrrolotriazine inhibitors of kinases
TWI272271B (en) * 2002-07-19 2007-02-01 Bristol Myers Squibb Co Process for preparing certain pyrrolotriazine compounds
TWI329112B (en) * 2002-07-19 2010-08-21 Bristol Myers Squibb Co Novel inhibitors of kinases
US7173031B2 (en) * 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
US7432373B2 (en) * 2004-06-28 2008-10-07 Bristol-Meyers Squibb Company Processes and intermediates useful for preparing fused heterocyclic kinase inhibitors
US7393667B2 (en) * 2005-05-31 2008-07-01 Bristol-Myers Squibb Company Stereoselective reduction process for the preparation of pyrrolotriazine compounds
WO2007038648A1 (en) * 2005-09-27 2007-04-05 Bristol-Myers Squibb Company Crystalline forms of [(1r), 2s]-2-aminopropionic acid 2-[4-(4-fluoro-2-methyl-1h-indol-5-yloxy)-5-methylpyrrolo[2,1-f][1,2,4]triazin-6-yloxy]-1-methylethyl ester

Also Published As

Publication number Publication date
CN101472927B (zh) 2012-07-04
EA200802171A1 (ru) 2009-08-28
PL2010538T3 (pl) 2013-04-30
AU2007240453B2 (en) 2012-04-12
JP2009534413A (ja) 2009-09-24
KR101423789B1 (ko) 2014-07-30
NO20084326L (no) 2008-11-18
SI2010538T1 (sl) 2013-06-28
EP2010538B1 (en) 2012-12-05
CL2007001141A1 (es) 2008-01-18
PE20080193A1 (es) 2008-03-10
EA019693B1 (ru) 2014-05-30
IL194715A (en) 2013-10-31
US7671199B2 (en) 2010-03-02
TWI378100B (en) 2012-12-01
AU2007240453A1 (en) 2007-11-01
KR20090008246A (ko) 2009-01-21
EP2010538A1 (en) 2009-01-07
JP5203353B2 (ja) 2013-06-05
US20070249610A1 (en) 2007-10-25
MX2008013232A (es) 2008-10-21
BRPI0710691A2 (pt) 2011-08-23
WO2007124332A1 (en) 2007-11-01
CN101472927A (zh) 2009-07-01
TW200808799A (en) 2008-02-16
HRP20130099T1 (hr) 2013-03-31
CA2650059A1 (en) 2007-11-01
ES2399379T3 (es) 2013-04-01
PT2010538E (pt) 2013-02-22
CL2010000554A1 (es) 2010-10-15
DK2010538T3 (da) 2013-03-18

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