AR060299A1 - Procedimiento para preparar linezolid,un agente antibacteriano derivado de oxazolidinona - Google Patents
Procedimiento para preparar linezolid,un agente antibacteriano derivado de oxazolidinonaInfo
- Publication number
- AR060299A1 AR060299A1 ARP070101433A ARP070101433A AR060299A1 AR 060299 A1 AR060299 A1 AR 060299A1 AR P070101433 A ARP070101433 A AR P070101433A AR P070101433 A ARP070101433 A AR P070101433A AR 060299 A1 AR060299 A1 AR 060299A1
- Authority
- AR
- Argentina
- Prior art keywords
- oxazolidinona
- procedure
- antibacterial agent
- agent derived
- linezolid
- Prior art date
Links
- TYZROVQLWOKYKF-ZDUSSCGKSA-N linezolid Chemical compound O=C1O[C@@H](CNC(=O)C)CN1C(C=C1F)=CC=C1N1CCOCC1 TYZROVQLWOKYKF-ZDUSSCGKSA-N 0.000 title abstract 3
- 229960003907 linezolid Drugs 0.000 title abstract 3
- 239000003242 anti bacterial agent Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000004201 2,4-dichlorophenyl group Chemical group [H]C1=C([H])C(*)=C(Cl)C([H])=C1Cl 0.000 abstract 2
- 125000004799 bromophenyl group Chemical group 0.000 abstract 2
- 125000000068 chlorophenyl group Chemical group 0.000 abstract 2
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D263/18—Oxygen atoms
- C07D263/20—Oxygen atoms attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C251/06—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
- C07C251/08—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton being acyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/08—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un procedimiento para preparar linezolid que comprende: a) hacer reaccionar un compuesto de estructura (1) en la que X es clorofenilo, bromofenilo o 2,4-diclorofenilo; con un compuesto de estructura (2) a una temperatura en el intervalo de temperatura ambiente a aproximadamente 65°C, en la que R es bencilo o alquilo C1-8, proporcionando un compuesto de estructura (3): en la que X es clorofenilo, bromofenilo o 2,4-diclorofenilo; b) hidrolizar el compuesto de estructura (3) y aciIar posteriormente, proporcionando linezolid.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US79036006P | 2006-04-07 | 2006-04-07 | |
| US81698306P | 2006-06-28 | 2006-06-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR060299A1 true AR060299A1 (es) | 2008-06-04 |
Family
ID=38308763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070101433A AR060299A1 (es) | 2006-04-07 | 2007-04-04 | Procedimiento para preparar linezolid,un agente antibacteriano derivado de oxazolidinona |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP2007740A1 (es) |
| JP (1) | JP2007277243A (es) |
| KR (1) | KR20080104178A (es) |
| AR (1) | AR060299A1 (es) |
| AU (1) | AU2007235635A1 (es) |
| BR (1) | BRPI0710312A2 (es) |
| CA (1) | CA2648178A1 (es) |
| MX (1) | MX2008012941A (es) |
| RU (1) | RU2008139612A (es) |
| TW (1) | TW200808782A (es) |
| WO (1) | WO2007116284A1 (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010084514A2 (en) * | 2009-01-02 | 2010-07-29 | Neuland Laboratories Ltd. | A process for the preparation of (5s)-(n)-[[3-[3-fluoro-4-(4-morpholinyl) phenyl]-2-oxo-5-oxazolidinyl] methyl] acetamide |
| CN101774978B (zh) | 2009-01-13 | 2011-09-21 | 联化科技股份有限公司 | 一种利奈唑胺的制备方法及其中间体 |
| US9206141B2 (en) * | 2010-04-30 | 2015-12-08 | Indiana University Research And Technology Corporation | Processes for preparing linezolid |
| EP2603506A1 (en) | 2010-08-11 | 2013-06-19 | Synthon BV | Process for making linezolid |
| WO2012019632A1 (en) | 2010-08-11 | 2012-02-16 | Synthon B.V. | Process for making linezolid |
| ES2395304B1 (es) * | 2011-05-20 | 2014-01-16 | Interquim, S.A. | Procedimiento de obtención de una tiofen-2-carboxamida. |
| CN102827154B (zh) * | 2011-06-14 | 2015-04-22 | 上海科胜药物研发有限公司 | 一种合成利伐沙班中间体4-{4-[(5s)-5-(氨基甲基)-2-氧代-1,3-恶唑烷-3-基]苯基}吗啉-3-酮的方法 |
| WO2013072923A1 (en) | 2011-09-19 | 2013-05-23 | Cadila Healthcare Limited | Process for the preparation of crystalline linezolid |
| CN103254148B (zh) | 2012-02-15 | 2016-04-13 | 浙江海正药业股份有限公司 | 利奈唑胺中间体的制备方法 |
| CZ2012111A3 (cs) | 2012-02-16 | 2013-08-28 | Zentiva, K.S. | Zpusob prípravy rivaroxabanu zalozený na vyuzití (S)-epichlorhydrinu |
| WO2014071990A1 (en) | 2012-11-09 | 2014-05-15 | Synthon Bv | Process for making linezolid |
| US9643939B1 (en) | 2016-04-18 | 2017-05-09 | Optimus Drugs Private Limited | Process for the preparation of linezolid |
| USRE47606E1 (en) | 2016-04-21 | 2019-09-17 | Optimus Drugs Private Limited | Process for the preparation of linezolid |
| CN110579556B (zh) * | 2018-06-08 | 2024-11-05 | 四川科伦药物研究院有限公司 | 利奈唑胺产品的检测方法 |
| CN115236236A (zh) * | 2022-07-26 | 2022-10-25 | 上海市食品药品检验研究院 | 一种利奈唑胺及其制剂中对映异构体的分离分析方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5688792A (en) * | 1994-08-16 | 1997-11-18 | Pharmacia & Upjohn Company | Substituted oxazine and thiazine oxazolidinone antimicrobials |
| CZ298060B6 (cs) * | 1996-04-11 | 2007-06-06 | Pharmacia & Upjohn Company | Zpusob prípravy oxazolidinonu |
| HUP0004388A3 (en) * | 1997-11-07 | 2001-10-29 | Upjohn Co | Process for the preparation of oxazolidinones, intermediates and preparation thereof |
-
2007
- 2007-03-26 KR KR1020087024348A patent/KR20080104178A/ko not_active Ceased
- 2007-03-26 CA CA002648178A patent/CA2648178A1/en not_active Abandoned
- 2007-03-26 AU AU2007235635A patent/AU2007235635A1/en not_active Abandoned
- 2007-03-26 MX MX2008012941A patent/MX2008012941A/es unknown
- 2007-03-26 RU RU2008139612/04A patent/RU2008139612A/ru not_active Application Discontinuation
- 2007-03-26 EP EP07734203A patent/EP2007740A1/en not_active Withdrawn
- 2007-03-26 BR BRPI0710312-3A patent/BRPI0710312A2/pt not_active IP Right Cessation
- 2007-03-26 WO PCT/IB2007/000882 patent/WO2007116284A1/en not_active Ceased
- 2007-04-04 AR ARP070101433A patent/AR060299A1/es not_active Application Discontinuation
- 2007-04-04 TW TW096112188A patent/TW200808782A/zh unknown
- 2007-04-06 JP JP2007099953A patent/JP2007277243A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| RU2008139612A (ru) | 2010-04-20 |
| WO2007116284A1 (en) | 2007-10-18 |
| JP2007277243A (ja) | 2007-10-25 |
| EP2007740A1 (en) | 2008-12-31 |
| AU2007235635A1 (en) | 2007-10-18 |
| MX2008012941A (es) | 2008-10-15 |
| BRPI0710312A2 (pt) | 2011-08-09 |
| CA2648178A1 (en) | 2007-10-18 |
| KR20080104178A (ko) | 2008-12-01 |
| TW200808782A (en) | 2008-02-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |