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AR068768A1 - Derivados de tetrahidroquinolina para tratar trastornos por estres post - traumatico - Google Patents

Derivados de tetrahidroquinolina para tratar trastornos por estres post - traumatico

Info

Publication number
AR068768A1
AR068768A1 ARP080104422A ARP080104422A AR068768A1 AR 068768 A1 AR068768 A1 AR 068768A1 AR P080104422 A ARP080104422 A AR P080104422A AR P080104422 A ARP080104422 A AR P080104422A AR 068768 A1 AR068768 A1 AR 068768A1
Authority
AR
Argentina
Prior art keywords
traumatico
tetrahydroquinoline derivatives
treat disorders
4alkyl
post stress
Prior art date
Application number
ARP080104422A
Other languages
English (en)
Original Assignee
Actelion Pharmaceuticals Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40467356&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR068768(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd filed Critical Actelion Pharmaceuticals Ltd
Publication of AR068768A1 publication Critical patent/AR068768A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La invencion se relaciona con el uso de derivados de tetrahidroquinolina de formula 1 donde R1 y R2 representan independientemente alcoxi C1-4, R3 representa aril-C1-4alquil o heteroaril-C1-4alquil, y R4 representa hidrogeno o alquil C1-4, o las sales farmacéuticamente aceptables de ellos, para la preparacion de un medicamento para prevenir o tratar trastornos por estrés post-traumático.
ARP080104422A 2007-10-10 2008-10-09 Derivados de tetrahidroquinolina para tratar trastornos por estres post - traumatico AR068768A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IB2007054130 2007-10-10

Publications (1)

Publication Number Publication Date
AR068768A1 true AR068768A1 (es) 2009-12-02

Family

ID=40467356

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080104422A AR068768A1 (es) 2007-10-10 2008-10-09 Derivados de tetrahidroquinolina para tratar trastornos por estres post - traumatico

Country Status (27)

Country Link
US (1) US9532985B2 (es)
EP (1) EP2207550B1 (es)
JP (1) JP5883222B2 (es)
KR (1) KR101733247B1 (es)
CN (1) CN101820878B (es)
AR (1) AR068768A1 (es)
AU (1) AU2008309194B2 (es)
BR (1) BRPI0818617A2 (es)
CA (1) CA2699504C (es)
CY (1) CY1114799T1 (es)
DK (1) DK2207550T3 (es)
EA (1) EA017443B1 (es)
ES (1) ES2444418T3 (es)
HR (1) HRP20140214T1 (es)
IL (1) IL204838A (es)
MA (1) MA31800B1 (es)
MX (1) MX2010003711A (es)
MY (1) MY153044A (es)
NZ (1) NZ585086A (es)
PE (1) PE20091010A1 (es)
PL (1) PL2207550T3 (es)
PT (1) PT2207550E (es)
SI (1) SI2207550T1 (es)
TW (1) TWI428129B (es)
UA (1) UA99150C2 (es)
WO (1) WO2009047723A2 (es)
ZA (1) ZA201003251B (es)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2380391T3 (es) 2006-12-22 2012-05-11 Actelion Pharmaceuticals Ltd. Derivados de 5,6,7,8-tetrahidro-imidazo[1,5-a]pirazina
KR20110036069A (ko) 2008-06-25 2011-04-06 액테리온 파마슈티칼 리미티드 5,6,7,8-테트라히드로-이미다조[1,5-ａ]피라진 화합물
EP2402322A1 (en) 2010-07-02 2012-01-04 Actelion Pharmaceuticals Ltd. 1,2,3,4-tetrahydroisoquinoline derivative and its use as orexin receptor antagonist
TW201209037A (en) 2010-08-24 2012-03-01 Actelion Pharmaceuticals Ltd Proline sulfonamide derivatives as orexin receptor antagonists
SI2626350T1 (sl) 2010-09-22 2015-09-30 Eisai R&D Management Co., Ltd. Spojina ciklopropana
JP5847830B2 (ja) 2010-11-10 2016-01-27 アクテリオン ファーマシューティカルズ リミテッドＡｃｔｅｌｉｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｌｔｄ オレキシン受容体拮抗薬として有用なラクタム誘導体
WO2012085852A1 (en) 2010-12-22 2012-06-28 Actelion Pharmaceuticals Ltd 3,8-diaza-bicyclo[4.2.0]oct-8-yl amides
US9303023B2 (en) 2011-02-18 2016-04-05 Actelion Pharmaceuticals Ltd. Pyrazole and imidazole derivatives useful as orexin antagonists
WO2012114252A1 (en) 2011-02-21 2012-08-30 Actelion Pharmaceuticals Ltd Novel indole and pyrrolopyridine amides
WO2013050938A1 (en) 2011-10-04 2013-04-11 Actelion Pharmaceuticals Ltd 3,7-diazabicyclo[3.3.1]nonane and 9-oxa-3,7-diazabicyclo[3.3.1]nonane derivatives
TWI565703B (zh) 2011-11-08 2017-01-11 艾克泰聯製藥有限公司 ２-（１，２，３-三唑-２-基）苯甲醯胺及３-（１，２，３-三唑-２-基）吡啶醯胺衍生物
KR101995683B1 (ko) 2012-06-04 2019-07-02 이도르시아 파마슈티컬스 리미티드 벤즈이미다졸-프롤린 유도체
CA2885180C (en) 2012-10-10 2021-03-02 Actelion Pharmaceuticals Ltd Orexin receptor antagonists which are [ortho bi-(hetero-)aryl]-[2-(meta bi-(hetero-)aryl)-pyrrolidin-1-yl]-methanone derivatives
CN105051040A (zh) 2013-03-12 2015-11-11 埃科特莱茵药品有限公司 作为食欲素受体拮抗剂的氮杂环丁烷酰胺衍生物
MY179862A (en) 2013-12-03 2020-11-18 Idorsia Pharmaceuticals Ltd Crystalline form of (s)-(2-(6-chloro-7-methyl-1h-benzo[d]imidazol-2-yl)-2-methylpyrrolidin-1 -yl)(5-methoxy-2-(2h-1,2,3-triazol-2-yl)phenyl)methanone and its use as orexin receptor antagonists
UA119151C2 (uk) 2013-12-03 2019-05-10 Ідорсія Фармасьютікалз Лтд КРИСТАЛІЧНА СОЛЬОВА ФОРМА (S)-(2-(6-ХЛОР-7-МЕТИЛ-1H-БЕНЗО[d]ІМІДАЗОЛ-2-ІЛ)-2-МЕТИЛПІРОЛІДИН-1-ІЛ)(5-МЕТОКСИ-2-(2H-1,2,3-ТРИАЗОЛ-2-ІЛ)ФЕНІЛ)МЕТАНОНУ ЯК АНТАГОНІСТ ОРЕКСИНОВОГО РЕЦЕПТОРА
UA116053C2 (uk) 2013-12-04 2018-01-25 Ідорсія Фармасьютікалз Лтд Застосування похідних бензоімідазолу-проліну
CA2964504C (en) 2014-10-23 2022-08-23 Eisai R&D Management Co., Ltd. Oral dosage form comprising a cyclopropanecarboxamide derivative for use in treating insomnia
JP7179049B2 (ja) * 2017-08-01 2022-11-28 ベルゲン ファーマシューティカル、 エルエルシー オレキシン受容体拮抗薬の結晶形及びその製造方法並びに用途
WO2020007964A1 (en) 2018-07-05 2020-01-09 Idorsia Pharmaceuticals Ltd 2-(2-azabicyclo[3.1.0]hexan-1-yl)-1h-benzimidazole derivatives
WO2020007977A1 (en) 2018-07-06 2020-01-09 Idorsia Pharmaceuticals Ltd 7-trifluoromethyl-[1,4]diazepan derivatives
WO2020099511A1 (en) 2018-11-14 2020-05-22 Idorsia Pharmaceuticals Ltd Benzimidazole-2-methyl-morpholine derivatives
AR129309A1 (es) 2022-05-13 2024-08-07 Idorsia Pharmaceuticals Ltd Derivados de hidrazina-n-carboxamida cíclica sustituida con tiazoloaril-metilo

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100393703C (zh) * 2000-03-14 2008-06-11 埃科特莱茵药品有限公司 1,2,3,4-四氢异喹啉的衍生物
DE602004021786D1 (de) * 2003-03-26 2009-08-13 Actelion Pharmaceuticals Ltd Tetrahydroisochinolylacetamidderivate zur verwendung als orexinrezeptorantagonisten
BRPI0508263B8 (pt) * 2004-03-01 2021-05-25 Idorsia Pharmaceuticals Ltd derivados de 1, 2, 3, 4-tetra-hidro-isoquinolina, composição farmacêutica, e, uso de derivado de 1, 2, 3, 4-tetra-hidro-isoquinolina
US7501395B2 (en) * 2005-04-25 2009-03-10 Eisai R & D Management Co., Ltd. Method of screening for antianxiety drugs
JP4582722B2 (ja) * 2006-03-15 2010-11-17 アクテリオン ファーマシューティカルズ リミテッド 記憶機能を向上させるテトラヒドロイソキノリン誘導体
EP2402322A1 (en) 2010-07-02 2012-01-04 Actelion Pharmaceuticals Ltd. 1,2,3,4-tetrahydroisoquinoline derivative and its use as orexin receptor antagonist

Also Published As

Publication number Publication date
IL204838A0 (en) 2010-11-30
PT2207550E (pt) 2014-02-07
KR20100065203A (ko) 2010-06-15
MA31800B1 (fr) 2010-10-01
EA017443B1 (ru) 2012-12-28
ZA201003251B (en) 2011-07-27
IL204838A (en) 2014-09-30
TWI428129B (zh) 2014-03-01
UA99150C2 (ru) 2012-07-25
MY153044A (en) 2014-12-31
NZ585086A (en) 2012-03-30
JP2011500550A (ja) 2011-01-06
US20100234420A1 (en) 2010-09-16
ES2444418T3 (es) 2014-02-25
US9532985B2 (en) 2017-01-03
MX2010003711A (es) 2010-04-30
EP2207550A2 (en) 2010-07-21
JP5883222B2 (ja) 2016-03-09
PE20091010A1 (es) 2009-08-08
WO2009047723A3 (en) 2009-05-28
CN101820878A (zh) 2010-09-01
CA2699504C (en) 2015-11-24
EA201000557A1 (ru) 2010-10-29
BRPI0818617A2 (pt) 2015-04-07
CA2699504A1 (en) 2009-04-16
AU2008309194A1 (en) 2009-04-16
PL2207550T3 (pl) 2014-05-30
SI2207550T1 (sl) 2014-03-31
AU2008309194B2 (en) 2013-10-03
HRP20140214T1 (hr) 2014-04-11
TW200932231A (en) 2009-08-01
CN101820878B (zh) 2012-02-01
HK1145440A1 (en) 2011-04-21
KR101733247B1 (ko) 2017-05-08
DK2207550T3 (da) 2014-01-27
WO2009047723A2 (en) 2009-04-16
CY1114799T1 (el) 2016-12-14
EP2207550B1 (en) 2013-12-11

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