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AR067528A1 - Eteres heterociclicos sustituidos y su uso en trastornos del snc - Google Patents

Eteres heterociclicos sustituidos y su uso en trastornos del snc

Info

Publication number
AR067528A1
AR067528A1 ARP080103007A ARP080103007A AR067528A1 AR 067528 A1 AR067528 A1 AR 067528A1 AR P080103007 A ARP080103007 A AR P080103007A AR P080103007 A ARP080103007 A AR P080103007A AR 067528 A1 AR067528 A1 AR 067528A1
Authority
AR
Argentina
Prior art keywords
alkyl
haloalkyl
cyano
halo
hydrogen
Prior art date
Application number
ARP080103007A
Other languages
English (en)
Inventor
Andrew P Degnan
George O Tora
John E Macor
Derek John Denhart
Vivekananda Y Vrudhula
Joanne J Bronson
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of AR067528A1 publication Critical patent/AR067528A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Reivindicacion 1: Un compuesto caracterizado porque tiene la formula (1) en la que R1 es hidrogeno o alquilo; R2 es hidrogeno o alquilo, cianoalquilo, haloalquilo, hidroxilalquilo, alcoxialquilo, aminoalquilo, alquilaminoalquilo, dialquilaminoalquilo, ciano, carboxi, alcoxicarbonilo, aminocarbonilo, N-alquilaminocarbonilo o N,N-dialquilaminocarbonilo; R3 es hidrogeno o alquilo; Ar1 es fenilo o piridinilo y está sustituido con 0-3 sustituyentes seleccionados del grupo constituido por halo, alquilo, haloalquilo y ciano; Ar2 es indolilo, indazolilo, bencimidazolilo o benzotriazolilo y está sustituido con 0-3 sustituyentes seleccionados del grupo constituido por halo, alquilo, cicloalquilo, (cicloalquil)alquilo, haloalquilo, cianoalquilo, hidroxi, alcoxi, haloalcoxi, ciano, amino, alquilamino, dialquilamino, pirrolidinilo, piperidinilo, piperazinilo, (alquiI)piperazinilo, morfolinilo, tiomorfolinilo y Ar3, y Ar3 es fenilo sustituido con 0-3 sustituyentes seleccionados del grupo constituido por halo, alquilo, haloalquilo, alcoxi, haloalcoxi y ciano; o una de sus sales farmacéuticamente aceptables.
ARP080103007A 2007-07-11 2008-07-11 Eteres heterociclicos sustituidos y su uso en trastornos del snc AR067528A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94901307P 2007-07-11 2007-07-11
US12/165,967 US8026257B2 (en) 2007-07-11 2008-07-01 Substituted heterocyclic ethers and their use in CNS disorders

Publications (1)

Publication Number Publication Date
AR067528A1 true AR067528A1 (es) 2009-10-14

Family

ID=39764827

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080103007A AR067528A1 (es) 2007-07-11 2008-07-11 Eteres heterociclicos sustituidos y su uso en trastornos del snc

Country Status (6)

Country Link
US (1) US8026257B2 (es)
AR (1) AR067528A1 (es)
CL (1) CL2008002041A1 (es)
PE (1) PE20090444A1 (es)
TW (1) TW200906407A (es)
WO (1) WO2009009411A1 (es)

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* Cited by examiner, † Cited by third party
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US7861969B2 (en) 2007-05-24 2011-01-04 The Boeing Company Shaped composite stringers and methods of making
US7879276B2 (en) 2007-11-08 2011-02-01 The Boeing Company Foam stiffened hollow composite stringer
US7632861B2 (en) * 2007-11-13 2009-12-15 Bristol-Myers Squibb Company Substituted heterocyclic ethers and their use in CNS disorders
DK2358676T3 (da) * 2008-11-14 2013-01-14 Theravance Inc Krystallinsk form af en 4-[2-(2-fluorphenoxymethyl)phenyl]-piperidinforbindelse
US8500066B2 (en) 2009-06-12 2013-08-06 The Boeing Company Method and apparatus for wireless aircraft communications and power system using fuselage stringers
US8617687B2 (en) 2009-08-03 2013-12-31 The Boeing Company Multi-functional aircraft structures
EP2308866A1 (de) 2009-10-09 2011-04-13 Bayer CropScience AG Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide
JP5705239B2 (ja) 2010-01-11 2015-04-22 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー セロトニンおよびノルエピネフリン再取込みインヒビターとしての１−（２−フェノキシメチルフェニル）ピペラジン化合物
US8530663B2 (en) * 2010-03-22 2013-09-10 Theravance, Inc. 1-(2-phenoxymethylheteroaryl)piperidine and piperazine compounds
JP6219523B2 (ja) 2013-12-13 2017-10-25 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ ブルトンチロシンキナーゼの阻害剤
US9802920B2 (en) 2013-12-13 2017-10-31 Hoffman-La Roche Inc. Inhibitors of bruton's tyrosine kinase
WO2016198908A1 (en) 2015-06-09 2016-12-15 Abbvie Inc. Ror nuclear receptor modulators
AU2016276316B2 (en) 2015-06-09 2020-01-23 Abbvie Inc. Nuclear receptor modulators
KR101966736B1 (ko) * 2015-09-15 2019-04-09 주식회사 엘지화학 변성 폴리이미드 및 이를 포함하는 경화성 수지 조성물
WO2018095953A1 (de) 2016-11-23 2018-05-31 Bayer Cropscience Aktiengesellschaft 2-[3-(alkylsulfonyl)-2h-indazol-2-yl]-3h-imidazo[4,5-b]pyridin-derivate und ähnliche verbindungen als schädlingsbekämpfungsmittel
CN116003325B (zh) * 2023-01-09 2025-04-25 南方医科大学 吲唑类化合物或其药学上可接受的盐及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1337418C (en) 1988-03-28 1995-10-24 Engelbert Ciganek 4-aryl-4-piperiding (or pyrrolidine or hexahydroazepine) carbinols and heterocyclic analogs thereof
US5620989A (en) 1992-10-28 1997-04-15 Merck Sharp & Dohme Limited 4-Arylmethyloxymethyl piperidines as tachykinin antagonsits
EP0739336B1 (en) 1994-01-13 1998-08-26 MERCK SHARP & DOHME LTD. Gem-disubstituted azacyclic tachykinin antagonists
ES2345437T3 (es) 2002-03-13 2010-09-23 Schering Corporation Antagonistas de nk1.
ATE358482T1 (de) 2002-07-03 2007-04-15 Schering Corp 1-amido-4-phenyl-4-benzyloxymethyl-piperidin derivative und verwandte verbindungen als neurokinin-1 (nk-1) antagonsisten zur behandlung von erbrechen, depressionen, angstzustände und husten
AU2003258937A1 (en) 2002-09-09 2004-03-29 Astrazeneca Ab Naphthyl ether compounds and their use
US7494986B2 (en) 2004-07-20 2009-02-24 Bristol-Myers Squibb Company Cycloalkylamine derivatives as NK-1/SSRI antagonists
FR2883876B1 (fr) 2005-03-30 2007-05-04 Servier Lab Derives d'indanyl-piperazines, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
US20070249607A1 (en) 2006-04-17 2007-10-25 Bristol-Myers Squibb Company Nk-1 and serotonin transporter inhibitors
CN101495470A (zh) 2006-07-27 2009-07-29 百时美施贵宝公司 4-芳基烷氧基甲基-4-苯基哌啶及其作为神经激肽受体拮抗剂治疗cns疾病的用途

Also Published As

Publication number Publication date
US8026257B2 (en) 2011-09-27
CL2008002041A1 (es) 2009-01-09
PE20090444A1 (es) 2009-04-18
WO2009009411A1 (en) 2009-01-15
US20090018132A1 (en) 2009-01-15
TW200906407A (en) 2009-02-16

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