AR066509A1 - Derivados de tiazol, medicamentos que los contienen, proceso de preparacion y usos como moduladores de beta amiloide. - Google Patents
Derivados de tiazol, medicamentos que los contienen, proceso de preparacion y usos como moduladores de beta amiloide.Info
- Publication number
- AR066509A1 AR066509A1 ARP080101972A ARP080101972A AR066509A1 AR 066509 A1 AR066509 A1 AR 066509A1 AR P080101972 A ARP080101972 A AR P080101972A AR P080101972 A ARP080101972 A AR P080101972A AR 066509 A1 AR066509 A1 AR 066509A1
- Authority
- AR
- Argentina
- Prior art keywords
- halogen
- lower alkyl
- chr
- optionally substituted
- substituted
- Prior art date
Links
- 102000013455 Amyloid beta-Peptides Human genes 0.000 title abstract 3
- 108010090849 Amyloid beta-Peptides Proteins 0.000 title abstract 3
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 238000002360 preparation method Methods 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 19
- 229910052736 halogen Inorganic materials 0.000 abstract 19
- 150000002367 halogens Chemical group 0.000 abstract 19
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 150000002431 hydrogen Chemical group 0.000 abstract 4
- HCUARRIEZVDMPT-UHFFFAOYSA-N Indole-2-carboxylic acid Chemical compound C1=CC=C2NC(C(=O)O)=CC2=C1 HCUARRIEZVDMPT-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000001072 heteroaryl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 208000024827 Alzheimer disease Diseases 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 210000004556 brain Anatomy 0.000 abstract 1
- 230000008021 deposition Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
Se ha descubierto que los presentes compuestos de la formula 1 son moduladores del amiloide beta y, por tanto, pueden ser utiles para el tratamiento o prevencion de una enfermedad asociada con la deposicion de beta-amiloide en el cerebro, enparticular la enfermedad de Alzheimer. Reivindicacion 1: Un compuesto de la formula general (1) en la que hetarilo 1 es como en formulas (2), hetarilo 2 es como en formulas (3), R1 es hidrogeno, alcoxi inferior o ciano; R2/R3 con independenciaentre sí son hidrogeno, alquilo inferior, alquilo inferior sustituido por halogeno, CHO, fenilo o -CRR'-fenilo, dichos anillos fenilo están sin sustituir o sustituidos por uno o más halogeno, ciano, alquilo inferior, alquilo inferior sustituido porhalogeno, alcoxi inferior sustituido por halogeno o alcoxi inferior, o son -C(O)O-alquilo inferior, -CH2-C(O)O-alquilo inferior, -CH2-C(O)-piperidin-1-ilo, -CH2-C(O)NH-alquilo inferior, -CH2-C(O)NH-fenilo opcionalmente sustituido por halogeno, -CHR-NHC(O)O-alquilo inferior, -CHR-NH, -CHR-NH-CH-fenilo opcionalmente sustituido por halogeno, -CHR-NH-(CH292-fenilo opcionalmente sustituido por halogeno, -CHR-NH-fenilo opcionalmente sustituido por halogeno, -CHR-NH-cicloalquilo, -CHR-NHC(O)-CH2-fenilo opcionalmente sustituido por halogeno, -CHR-NHC(O)-CH2O-alquilo inferior, -CHR-NHC(O)-alquilo inferior, -CHR-NHC(O)O-alquilo inferior sustituido por halogeno, -CHR-NHC(O)-fenilo opcionalmente sustituido por halogeno, -CHR-NHCH2CH2O-alquiloinferior, -CHR-NH-S(O)2-fenilo opcionalmente sustituido por halogeno o alquilo inferior, -CHR-NH-S(O)2-CH2-fenilo opcionalmente sustituido por halogeno, -CHR-NH-S(O)2-alquilo inferior, - CH2-piperidin-1-ilo, -CH2-morfolinilo o - (3,4-difluor-fenil)amida del ácido indol-2-carboxílico; R/R' con independencia entre sí son hidrogeno, alquilo inferior, bencilo o hidroxi; R4 es hidrogeno, -C(O)O-alquilo inferior, -C(O)-fenilo opcionalmente sustituido por halogeno, -C(O)-alquilo inferiorsustituido por halogeno, -C(O)-alquilo inferior, -S(O)2-fenilo opcionalmente sustituido por halogeno, -S(O)2-alquilo inferior, -S(O)2-CH2-fenilo, -bencilo opcionalmente sustituido por halogeno, -CH2-CH2-fenilo, -C(O)-CH2-fenilo opcionalmentesustituido por halogeno o -C(O)-CH2-alcoxi inferior; R5 es hidrogeno, halogeno, alquilo inferior sustituido por hidroxi, o es alquilo inferior; n es el numero 0 o 1; o sus sales de adicion de ácido farmacéuticamente activas.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP07108004 | 2007-05-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR066509A1 true AR066509A1 (es) | 2009-08-26 |
Family
ID=39758855
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080101972A AR066509A1 (es) | 2007-05-11 | 2008-05-09 | Derivados de tiazol, medicamentos que los contienen, proceso de preparacion y usos como moduladores de beta amiloide. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US7910740B2 (es) |
| EP (1) | EP2155740B1 (es) |
| JP (1) | JP5264890B2 (es) |
| KR (1) | KR101138045B1 (es) |
| CN (1) | CN101675045B (es) |
| AR (1) | AR066509A1 (es) |
| AT (1) | ATE496915T1 (es) |
| AU (1) | AU2008250436B2 (es) |
| BR (1) | BRPI0811993A2 (es) |
| CA (1) | CA2686754C (es) |
| CL (1) | CL2008001347A1 (es) |
| DE (1) | DE602008004769D1 (es) |
| ES (1) | ES2358863T3 (es) |
| IL (1) | IL201566A (es) |
| MX (1) | MX2009012163A (es) |
| PE (1) | PE20090248A1 (es) |
| RU (1) | RU2009140182A (es) |
| TW (1) | TW200904420A (es) |
| WO (1) | WO2008138753A1 (es) |
| ZA (1) | ZA200907585B (es) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY149038A (en) * | 2004-05-26 | 2013-07-15 | Eisai R&D Man Co Ltd | Cinnamide compound |
| ES2338904T3 (es) * | 2004-10-26 | 2010-05-13 | EISAI R&D MANAGEMENT CO., LTD. | Forma amorfa de compuestos de cinamida. |
| JPWO2007058305A1 (ja) * | 2005-11-18 | 2009-05-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | シンナミド誘導体の製造方法 |
| US20090048448A1 (en) * | 2005-11-18 | 2009-02-19 | Ikuo Kushida | Salts of cynnamide compound or solvates thereof |
| JP5221144B2 (ja) * | 2005-11-24 | 2013-06-26 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | モルホリンタイプ・シンナミド化合物 |
| TWI370130B (en) * | 2005-11-24 | 2012-08-11 | Eisai R&D Man Co Ltd | Two cyclic cinnamide compound |
| TWI378091B (en) * | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
| US7737141B2 (en) * | 2006-07-28 | 2010-06-15 | Eisai R&D Management Co., Ltd. | Prodrug of cinnamide compound |
| EP2097376A2 (en) | 2006-12-22 | 2009-09-09 | F. Hoffmann-Roche AG | Spiro-piperidine derivatives |
| PE20081791A1 (es) * | 2007-02-28 | 2009-02-07 | Eisai Randd Man Co Ltd | Dos derivados ciclicos de oxomorfolina |
| CA2687262A1 (en) * | 2007-05-16 | 2008-11-20 | Naoyuki Shimomura | One-pot production process for cinnamide derivative |
| US7935815B2 (en) * | 2007-08-31 | 2011-05-03 | Eisai R&D Management Co., Ltd. | Imidazoyl pyridine compounds and salts thereof |
| AR068121A1 (es) | 2007-08-31 | 2009-11-04 | Eisai R&D Man Co Ltd | Compuestos multiciclicos para tratar enfermedades neurodegenerativas |
| KR101204213B1 (ko) * | 2007-12-21 | 2012-11-26 | 에프. 호프만-라 로슈 아게 | 오렉신 수용체 길항제로서의 헤테로아릴 유도체 |
| ES2375919T3 (es) * | 2008-01-11 | 2012-03-07 | F. Hoffmann-La Roche Ag | Moduladores de beta-amiloide. |
| CA2712095A1 (en) * | 2008-01-28 | 2009-08-06 | Eisai R&D Management Co., Ltd. | Crystalline cinnamide compounds or salts thereof |
| CN101952275B (zh) * | 2008-02-22 | 2014-06-18 | 弗·哈夫曼-拉罗切有限公司 | β-淀粉样蛋白的调节剂 |
| MX2011003246A (es) * | 2008-10-09 | 2011-04-21 | Hoffmann La Roche | Moduladores de beta amiloide. |
| KR20110082189A (ko) * | 2008-11-06 | 2011-07-18 | 아스트라제네카 아베 | 아밀로이드 베타의 조절제 |
| BRPI0921348A2 (pt) * | 2008-11-10 | 2019-09-24 | Hoffmann La Roche | moduladores heterocíclicos da gama secretase |
| PA8854101A1 (es) * | 2008-12-18 | 2010-07-27 | Ortho Mcneil Janssen Pharm | Derivados de imidazol bicíclicos sustituidos como moduladores de gamma secretasa |
| TW201030002A (en) | 2009-01-16 | 2010-08-16 | Bristol Myers Squibb Co | Bicyclic compounds for the reduction of beta-amyloid production |
| KR20110113197A (ko) | 2009-02-06 | 2011-10-14 | 오르토-맥닐-얀센 파마슈티칼스 인코포레이티드 | 감마 세크레타제 조절제로서의 신규 치환된 비사이클릭 헤테로사이클릭 화합물 |
| TWI461425B (zh) * | 2009-02-19 | 2014-11-21 | Janssen Pharmaceuticals Inc | 作為伽瑪分泌酶調節劑之新穎經取代的苯并唑、苯并咪唑、唑并吡啶及咪唑并吡啶衍生物類 |
| EP2427453B1 (en) * | 2009-05-07 | 2013-07-17 | Janssen Pharmaceuticals, Inc. | Substituted indazole and aza-indazole derivatives as gamma secretase modulators |
| UY32622A (es) * | 2009-05-12 | 2010-12-31 | Astrazeneca Ab | Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta) |
| CN102482227A (zh) | 2009-07-15 | 2012-05-30 | 杨森制药公司 | 作为γ分泌酶调节剂的取代的三唑和咪唑衍生物 |
| EP2523949B1 (en) | 2010-01-15 | 2014-08-20 | Janssen Pharmaceuticals Inc. | Novel substituted triazole derivatives as gamma secretase modulators |
| US20110190269A1 (en) * | 2010-02-01 | 2011-08-04 | Karlheinz Baumann | Gamma secretase modulators |
| US8486967B2 (en) | 2010-02-17 | 2013-07-16 | Hoffmann-La Roche Inc. | Heteroaryl substituted piperidines |
| ES2536442T3 (es) | 2011-03-24 | 2015-05-25 | Janssen Pharmaceuticals, Inc. | Derivados novedosos de triazolil piperazina y triazolil piperidina como moduladores de la gamma secretasa |
| ES2602794T3 (es) | 2011-03-31 | 2017-02-22 | Pfizer Inc | Piridinonas bicíclicas novedosas |
| JP6068464B2 (ja) | 2011-07-15 | 2017-01-25 | ヤンセン ファーマシューティカルズ，インコーポレーテッド | γ−セクレターゼ調節剤としての新規な置換インドール誘導体 |
| MX355164B (es) | 2012-05-16 | 2018-04-06 | Janssen Pharmaceuticals Inc | Derivados de 3,4-dihidro-2h-pirido[1,2-a]pirazin-1,6-diona sustituidos utiles para el tratamiento de la enfermedad de alzheimer (inter alia). |
| UA110688C2 (uk) | 2012-09-21 | 2016-01-25 | Пфайзер Інк. | Біциклічні піридинони |
| KR102209418B1 (ko) | 2012-12-20 | 2021-01-29 | 얀센 파마슈티카 엔.브이. | 감마 세크레타제 조절 인자로서의 신규 삼환 3,4-디하이드로-2H-피리도[1,2-α]피라진-1,6-디온 유도체 |
| CN104936958B (zh) | 2013-01-17 | 2019-07-26 | 詹森药业有限公司 | 作为γ分泌酶调节剂的新颖的经取代的吡啶并-哌嗪酮衍生物 |
| CN103664819A (zh) * | 2013-12-16 | 2014-03-26 | 山东汇海医药化工有限公司 | 一种2-氨基-4-甲基噻唑-5-甲酸乙酯的制备方法 |
| US10562897B2 (en) | 2014-01-16 | 2020-02-18 | Janssen Pharmaceutica Nv | Substituted 3,4-dihydro-2H-pyrido[1,2-a]pyrazine-1,6-diones as gamma secretase modulators |
| CN107406445B (zh) | 2015-02-03 | 2019-12-24 | 辉瑞公司 | 新颖环丙苯并呋喃基吡啶并吡嗪二酮类 |
| JP2019512491A (ja) * | 2016-03-11 | 2019-05-16 | エーシー・イミューン・エス・アー | 診断及び療法のための二環式化合物 |
| EP3523304B1 (en) * | 2016-10-04 | 2021-01-27 | H. Hoffnabb-La Roche Ag | Bicyclic heteroaryl derivatives |
| CN110194764B (zh) * | 2018-02-26 | 2022-08-16 | 云南大学 | 酰胺类化合物、其制备方法及用途 |
| CR20210104A (es) | 2018-09-03 | 2021-04-19 | Hoffmann La Roche | Derivados de heteroarilo bicíclicos |
| PT3894411T (pt) | 2018-12-13 | 2024-08-08 | Hoffmann La Roche | Derivados da 7-fenoxi-n-(3-azabiciclo[3.2.1]octan-8-il)-6,7-dihidro-5h-pirrolo[1,2-b][1,2,4]triazol-2-amina e compostos relacionados enquanto moduladores da gama-secretase para o tratamento da doença de alzheimer |
| CN114222732B (zh) * | 2019-10-28 | 2023-04-04 | 南京明德新药研发有限公司 | 一种尿酸促排剂及其合成方法和其在医药上的应用 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2256968T3 (es) * | 1997-10-27 | 2006-07-16 | Agouron Pharmaceuticals, Inc. | Derivados de 4-aminotiazol, su preparacion y su uso como inhibidores de quinasas dependientes de ciclina. |
| ATE288904T1 (de) * | 1998-06-18 | 2005-02-15 | Bristol Myers Squibb Co | Durch kohlenstoff substituierte aminothiazole als inhibitoren von zyclin-abhägigen kinasen |
| US20030176454A1 (en) * | 2000-05-15 | 2003-09-18 | Akira Yamada | N-coating heterocyclic compounds |
| CA2525547C (en) * | 2003-05-14 | 2012-07-03 | Torreypines Therapeutics, Inc. | Compounds and uses thereof in modulating amyloid beta |
| MY149038A (en) | 2004-05-26 | 2013-07-15 | Eisai R&D Man Co Ltd | Cinnamide compound |
| US20080125432A1 (en) * | 2004-12-01 | 2008-05-29 | Devgen Nv | 5-Carboxamido Substituted Thiazole Derivatives that Interact With Ion Channels, In Particular With Ion Channels From the Kv Family |
| US20060241038A1 (en) | 2005-04-20 | 2006-10-26 | Eisai Co., Ltd. | Therapeutic agent for Abeta related disorders |
| US20090048448A1 (en) | 2005-11-18 | 2009-02-19 | Ikuo Kushida | Salts of cynnamide compound or solvates thereof |
| JPWO2007058305A1 (ja) | 2005-11-18 | 2009-05-07 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | シンナミド誘導体の製造方法 |
| US20070117839A1 (en) | 2005-11-24 | 2007-05-24 | Eisai R&D Management Co., Ltd. | Two cyclic cinnamide compound |
| JP5221144B2 (ja) | 2005-11-24 | 2013-06-26 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | モルホリンタイプ・シンナミド化合物 |
| EP1992618B1 (en) | 2006-03-09 | 2012-01-18 | Eisai R&D Management Co., Ltd. | Polycyclic cinnamide derivative |
| TWI378091B (en) | 2006-03-09 | 2012-12-01 | Eisai R&D Man Co Ltd | Multi-cyclic cinnamide derivatives |
-
2008
- 2008-04-30 RU RU2009140182/04A patent/RU2009140182A/ru unknown
- 2008-04-30 MX MX2009012163A patent/MX2009012163A/es active IP Right Grant
- 2008-04-30 JP JP2010507876A patent/JP5264890B2/ja not_active Expired - Fee Related
- 2008-04-30 WO PCT/EP2008/055290 patent/WO2008138753A1/en not_active Ceased
- 2008-04-30 AU AU2008250436A patent/AU2008250436B2/en not_active Ceased
- 2008-04-30 KR KR1020097025780A patent/KR101138045B1/ko not_active Expired - Fee Related
- 2008-04-30 DE DE602008004769T patent/DE602008004769D1/de active Active
- 2008-04-30 BR BRPI0811993-7A2A patent/BRPI0811993A2/pt not_active Application Discontinuation
- 2008-04-30 CN CN2008800140851A patent/CN101675045B/zh not_active Expired - Fee Related
- 2008-04-30 ES ES08749887T patent/ES2358863T3/es active Active
- 2008-04-30 AT AT08749887T patent/ATE496915T1/de active
- 2008-04-30 CA CA2686754A patent/CA2686754C/en not_active Expired - Fee Related
- 2008-04-30 EP EP08749887A patent/EP2155740B1/en not_active Not-in-force
- 2008-05-05 US US12/114,852 patent/US7910740B2/en not_active Expired - Fee Related
- 2008-05-08 CL CL2008001347A patent/CL2008001347A1/es unknown
- 2008-05-08 TW TW097117052A patent/TW200904420A/zh unknown
- 2008-05-09 PE PE2008000822A patent/PE20090248A1/es not_active Application Discontinuation
- 2008-05-09 AR ARP080101972A patent/AR066509A1/es unknown
-
2009
- 2009-10-15 IL IL201566A patent/IL201566A/en active IP Right Grant
- 2009-10-28 ZA ZA200907585A patent/ZA200907585B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2008250436A1 (en) | 2008-11-20 |
| RU2009140182A (ru) | 2011-06-20 |
| TW200904420A (en) | 2009-02-01 |
| IL201566A0 (en) | 2010-05-31 |
| EP2155740A1 (en) | 2010-02-24 |
| KR20100008791A (ko) | 2010-01-26 |
| ZA200907585B (en) | 2010-07-28 |
| MX2009012163A (es) | 2009-12-01 |
| EP2155740B1 (en) | 2011-01-26 |
| AU2008250436B2 (en) | 2013-03-28 |
| CN101675045A (zh) | 2010-03-17 |
| JP2010526847A (ja) | 2010-08-05 |
| CA2686754A1 (en) | 2008-11-20 |
| WO2008138753A1 (en) | 2008-11-20 |
| ATE496915T1 (de) | 2011-02-15 |
| US20080280948A1 (en) | 2008-11-13 |
| DE602008004769D1 (en) | 2011-03-10 |
| US7910740B2 (en) | 2011-03-22 |
| KR101138045B1 (ko) | 2012-04-24 |
| BRPI0811993A2 (pt) | 2014-11-18 |
| CL2008001347A1 (es) | 2009-05-29 |
| JP5264890B2 (ja) | 2013-08-14 |
| CN101675045B (zh) | 2012-11-28 |
| IL201566A (en) | 2013-08-29 |
| PE20090248A1 (es) | 2009-03-27 |
| ES2358863T3 (es) | 2011-05-16 |
| CA2686754C (en) | 2014-10-28 |
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