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AR065498A1 - Co- critales de vx-950 (un inhibidor del virus de la hepatitis c) y composiciones farmaceuticas que los comprenden - Google Patents

Co- critales de vx-950 (un inhibidor del virus de la hepatitis c) y composiciones farmaceuticas que los comprenden

Info

Publication number
AR065498A1
AR065498A1 ARP080100809A ARP080100809A AR065498A1 AR 065498 A1 AR065498 A1 AR 065498A1 AR P080100809 A ARP080100809 A AR P080100809A AR P080100809 A ARP080100809 A AR P080100809A AR 065498 A1 AR065498 A1 AR 065498A1
Authority
AR
Argentina
Prior art keywords
critals
hepatitis
understand
pharmaceutical compositions
acid
Prior art date
Application number
ARP080100809A
Other languages
English (en)
Inventor
Patrick R Connelly
Irina Kadiyala
Yuegang Zhang
Steve Johnston
Kathy Stavropolus
Bhisetti Govinda Rao
Peter Rose
Valas Jurkauskas
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of AR065498A1 publication Critical patent/AR065498A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/07—Tetrapeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

Composiciones y co-cristales cada uno de los cuales comprende VX-950 y un formador de co-cristal seleccionado del grupo consistente en ácido 4-hidroxibenzoico, ácido 4-aminosalicílico, fenilalamina, teonlina, ácido tartárico, ácido adípico, acetatosuccínico, prolina, metil 4-hidroxibenzoato, ácido antranílico y d-Biotina. También comprende, dentro de su alcance métodos para preparar y usar dichas composiciones y cristales.
ARP080100809A 2007-02-27 2008-02-27 Co- critales de vx-950 (un inhibidor del virus de la hepatitis c) y composiciones farmaceuticas que los comprenden AR065498A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US90358707P 2007-02-27 2007-02-27

Publications (1)

Publication Number Publication Date
AR065498A1 true AR065498A1 (es) 2009-06-10

Family

ID=39672669

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP080100809A AR065498A1 (es) 2007-02-27 2008-02-27 Co- critales de vx-950 (un inhibidor del virus de la hepatitis c) y composiciones farmaceuticas que los comprenden

Country Status (28)

Country Link
US (1) US8759353B2 (es)
EP (3) EP2114924B1 (es)
JP (1) JP2010519330A (es)
KR (1) KR20090115970A (es)
CN (1) CN101687856A (es)
AP (1) AP2009004960A0 (es)
AR (1) AR065498A1 (es)
AT (1) ATE542815T1 (es)
AU (1) AU2008219607B2 (es)
BR (1) BRPI0807907A2 (es)
CA (1) CA2679312A1 (es)
CO (1) CO6220963A2 (es)
CY (1) CY1112865T1 (es)
DK (1) DK2114924T3 (es)
EA (1) EA200970806A1 (es)
EC (1) ECSP099600A (es)
ES (1) ES2379905T3 (es)
GE (1) GEP20125645B (es)
HR (1) HRP20120330T1 (es)
IL (1) IL200616A0 (es)
MX (1) MX2009009182A (es)
NZ (1) NZ579442A (es)
PL (1) PL2114924T3 (es)
PT (1) PT2114924E (es)
RS (1) RS52306B (es)
SI (1) SI2114924T1 (es)
TW (1) TW200846343A (es)
WO (1) WO2008106151A2 (es)

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CN102215816A (zh) * 2008-09-03 2011-10-12 沃泰克斯药物股份有限公司 共晶和包含所述共晶的药物制剂
WO2010093843A2 (en) 2009-02-12 2010-08-19 Vertex Pharmaceuticals Incorporated Hcv combination therapies
EP2496077B1 (en) * 2009-11-06 2014-08-20 Basf Se Crystalline complexes of 4-hydroxy benzoic acid and selected pesticides
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WO2011112922A2 (en) * 2010-03-11 2011-09-15 Vertex Pharmaceuticals Incorporated Co-crystals and pharmaceutical formulations comprising the same
WO2011156545A1 (en) 2010-06-09 2011-12-15 Vertex Pharmaceuticals Incorporated Viral dynamic model for hcv combination therapy
AR082215A1 (es) 2010-07-14 2012-11-21 Vertex Pharma Composicion farmaceutica agradable al paladar
CA2815416A1 (en) 2010-10-21 2012-04-26 Vertex Pharmaceuticals Incorporated Biomarkers for hcv infected patients
WO2012109646A1 (en) 2011-02-11 2012-08-16 Vertex Pharmaceuticals Incorporated Treatment of hcv in hiv infection patients
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EP2583680A3 (en) 2011-10-21 2013-06-12 Abbvie Inc. Mono (PSI-7977) or combination treatment of DAAs for use in treating HCV
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US20130195797A1 (en) 2012-01-31 2013-08-01 Vertex Pharmaceuticals Incorporated High potency formulations of vx-950
WO2014015217A1 (en) 2012-07-19 2014-01-23 Vertex Pharmaceuticals Incorporated Biomarkers for hcv infected patients
US9556216B2 (en) * 2012-08-31 2017-01-31 Novartis Ag 2′-Ethynyl nucleoside derivatives for treatment of viral infections
ITMI20131839A1 (it) * 2013-11-06 2015-05-07 Dipharma Francis Srl Co-cristallo di un farmaco antidepressivo
CN103819379A (zh) * 2014-02-18 2014-05-28 中国科学院上海药物研究所 维生素d3的胆甾烷醇共结晶及其制备方法和应用
CN105696066B (zh) * 2015-10-26 2018-07-03 西北大学 一种压片法制备共晶的方法
WO2017189978A1 (en) 2016-04-28 2017-11-02 Emory University Alkyne containing nucleotide and nucleoside therapeutic compositions and uses related thereto
CN113295723B (zh) * 2021-07-27 2021-09-28 西南石油大学 一种岩石中粘土矿物的分子模拟表征方法

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