AR065039A1 - Una composicion farmaceutica de liberacion modificada, un proceso para su preparacion, un metodo para su utilizacion y su uso - Google Patents
Una composicion farmaceutica de liberacion modificada, un proceso para su preparacion, un metodo para su utilizacion y su usoInfo
- Publication number
- AR065039A1 AR065039A1 ARP080100316A ARP080100316A AR065039A1 AR 065039 A1 AR065039 A1 AR 065039A1 AR P080100316 A ARP080100316 A AR P080100316A AR P080100316 A ARP080100316 A AR P080100316A AR 065039 A1 AR065039 A1 AR 065039A1
- Authority
- AR
- Argentina
- Prior art keywords
- release
- weight
- active agent
- composition
- amount
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 7
- 239000013543 active substance Substances 0.000 abstract 6
- 230000002378 acidificating effect Effects 0.000 abstract 4
- 229920000642 polymer Polymers 0.000 abstract 3
- 239000003795 chemical substances by application Substances 0.000 abstract 2
- 230000001419 dependent effect Effects 0.000 abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 2
- 238000001879 gelation Methods 0.000 abstract 1
- 239000003349 gelling agent Substances 0.000 abstract 1
- 238000011065 in-situ storage Methods 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Inorganic Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Transplantation (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Composiciones farmacéuticas de liberacion modificada que comprenden por lo menos un agente(s) farmacéuticamente activo(s) que posee una solubilidad que depende del pH, por lo menos un polímero(s) controlador de la tasa de liberacion que predominantemente controla la liberacion de agente(s) activos en un medio acídico, un sistema modificador de la tasa de liberacion que controla la liberacion del agente(s) activo(s) en medios acídicos y básicos, y opcionalmente uno o más de otros excipientes farmacéuticamente aceptables. También se provee un proceso para la preparacion de tales composiciones y el método para su utilizacion. Las composiciones de liberacion modificada de la presente invencion son de utilidad para proveer niveles profilácticamente o terapéuticamente eficaces de agente(s) activo(s) durante un período de tiempo prolongado. Reivindicacion 1: Una composicion farmacéutica de liberacion modificada caracterizada porque comprende al menos un agente(s) farmacéuticamente activo que tiene una solubilidad dependiente del pH, un polímero controlador de la lasa de liberacion que predominantemente controla la liberacion del agente activo en un medio acídico en una cantidad de 3-80% peso/peso de la composicion, un sistema modificador de la tasa de liberacion que controla la liberacion del agente activo en los medios acídicos y básicos que consiste en una combinacion de al menos un agente gelificante in situ en una cantidad no menor de aproximadamente 0,5% peso/peso de la composicion, al menos un agente facilitador de la gelacion en una cantidad de 2-17,5% peso/peso de la composicion y opcionalmente al menos un polímero controlador de la tasa independiente del pH en una cantidad de hasta 40% peso/peso de la composicion y opcionalmente uno o más de otros excipientes farmacéuticamente aceptables.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN164DE2007 | 2007-01-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR065039A1 true AR065039A1 (es) | 2009-05-13 |
Family
ID=39644166
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP080100316A AR065039A1 (es) | 2007-01-25 | 2008-01-25 | Una composicion farmaceutica de liberacion modificada, un proceso para su preparacion, un metodo para su utilizacion y su uso |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100056493A1 (es) |
| EP (1) | EP2114380A1 (es) |
| JP (1) | JP2010532746A (es) |
| KR (1) | KR20090109113A (es) |
| CN (1) | CN101588794A (es) |
| AR (1) | AR065039A1 (es) |
| BR (1) | BRPI0807807A2 (es) |
| CL (1) | CL2008000219A1 (es) |
| MX (1) | MX2009007913A (es) |
| RU (1) | RU2009131931A (es) |
| WO (1) | WO2008090569A1 (es) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090087490A1 (en) | 2007-06-08 | 2009-04-02 | Addrenex Pharmaceuticals, Inc. | Extended release formulation and method of treating adrenergic dysregulation |
| EP2268283A2 (en) * | 2008-03-12 | 2011-01-05 | Dexcel Ltd. | Oral modified-release formulations containing thiazepines |
| GB2460915B (en) | 2008-06-16 | 2011-05-25 | Biovascular Inc | Controlled release compositions of agents that reduce circulating levels of platelets and methods therefor |
| WO2010001413A2 (en) * | 2008-07-01 | 2010-01-07 | Lupin Limited | Sustained release pharmaceutical compositions comprising quetiapine |
| DE102008046650A1 (de) * | 2008-09-10 | 2010-03-11 | Tiefenbacher Pharmachemikalien Alfred E. Tiefenbacher Gmbh & Co. Kg | Quetiapin enthaltende Retardtablette |
| EP2355804A1 (en) * | 2008-11-26 | 2011-08-17 | Krka | Quetiapine composition |
| AT10562U3 (de) * | 2008-12-05 | 2010-01-15 | Aop Orphan Pharmaceuticals Ag | Neuartige zusammensetzung zur behandlung einer essenziellen thrombozytämie |
| EP2373319B1 (en) * | 2009-01-05 | 2013-07-31 | Torrent Pharmaceuticals Limited | Sustained release pharmaceutical composition of quetiapine and process for preparation thereof |
| WO2010089259A2 (en) * | 2009-02-04 | 2010-08-12 | Woerwag R&D Gmbh | Sustained release composition containing quetiapine |
| EP2233130A1 (en) * | 2009-03-23 | 2010-09-29 | Genepharm (Europe) Trading Limited | A sustained release oral composition of an antipsychotic agent |
| CN102151242B (zh) * | 2010-02-11 | 2012-10-31 | 中国医学科学院药用植物研究所 | 一种抗结核药物的原位凝胶缓释制剂及其制备方法 |
| ME02118B (me) * | 2010-03-25 | 2015-10-20 | Aop Orphan Pharmaceuticals Ag | Nova kompozicija za tretman esencijalne trombocitemije |
| WO2011132008A2 (en) | 2010-04-22 | 2011-10-27 | EGIS Gyűgyszergyár Nyilvánosan Múködő Részvény társaság | Controlled release pharmaceutical composition |
| WO2011154118A1 (en) | 2010-06-07 | 2011-12-15 | Alfred E. Tiefenbacher (Gmbh & Co. Kg) | Quetiapine prolonged-release tablets |
| CN102939300A (zh) | 2010-06-07 | 2013-02-20 | 泰立克公司 | 无溶剂化晶体依泽替米贝盐酸盐d型的制备 |
| US8759303B2 (en) | 2010-06-07 | 2014-06-24 | Telik, Inc. | Compositions and methods for treating myelodysplastic syndrome |
| CN102917694A (zh) | 2010-06-07 | 2013-02-06 | 泰立克公司 | 依泽替米贝的片剂制剂 |
| CN102525983A (zh) * | 2010-12-31 | 2012-07-04 | 北京万全阳光医药科技有限公司 | 胍法新缓释片及其制备方法 |
| DE102011115690A1 (de) | 2011-10-11 | 2013-04-11 | Acino Pharma Ag | Quetiapin enthaltende Formulierungen |
| CN102335155B (zh) * | 2011-10-17 | 2013-03-27 | 苏州大学 | 一种富马酸喹硫平缓释片及其制备方法 |
| CN102579381B (zh) * | 2012-03-30 | 2013-07-10 | 河南中帅医药科技发展有限公司 | 盐酸胍法辛缓释制剂及其制备方法 |
| US9271937B2 (en) * | 2012-05-31 | 2016-03-01 | Covidien Lp | Oxidized cellulose microspheres |
| KR101462065B1 (ko) * | 2012-12-14 | 2014-11-14 | 박재돈 | 구안파신 함유 경구용 서방성 약제학적 조성물 |
| ES2619121T3 (es) | 2013-03-15 | 2017-06-23 | Warner Chilcott Company, Llc | Forma farmacéutica de dosificación en cápsula de gelatina blanda con goma guar modificada |
| JP6165970B2 (ja) * | 2013-05-02 | 2017-07-19 | カ−ディオノブーム ゲーエムベーハー | バルーン表面被覆 |
| EP3307248A1 (en) * | 2015-06-10 | 2018-04-18 | Disphar International B.V. | Improved pharmaceutical formulation |
| CN106038506A (zh) * | 2016-07-20 | 2016-10-26 | 南京正宽医药科技有限公司 | 一种富马酸喹硫平片及其制备方法 |
| KR20180062063A (ko) * | 2016-11-30 | 2018-06-08 | (주) 메티메디제약 | 서방형 항암용 약학 조성물 |
| CA3054817A1 (en) * | 2017-03-13 | 2018-09-20 | Okava Pharmaceuticals, Inc. | Methods and compositions for delivering mycophenolic acid active agents to non-human mammals |
| US10835489B2 (en) | 2018-03-09 | 2020-11-17 | University Of Saskatchewan | Modified release formulations of mycophenolate mofetil |
| CN115120590B (zh) * | 2022-06-07 | 2024-12-27 | 复旦大学 | 一种以难溶盐为pH调节剂的凝胶缓释制剂及其制备方法与应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5455046A (en) * | 1993-09-09 | 1995-10-03 | Edward Mendell Co., Inc. | Sustained release heterodisperse hydrogel systems for insoluble drugs |
| MX2008000084A (es) * | 2005-06-29 | 2008-03-18 | Panacea Biotec Ltd | Composiciones farmaceuticas de liberacion sostenida y procedimientos de las mismas. |
-
2008
- 2008-01-24 BR BRPI0807807-6A2A patent/BRPI0807807A2/pt not_active IP Right Cessation
- 2008-01-24 KR KR1020097017735A patent/KR20090109113A/ko not_active Ceased
- 2008-01-24 MX MX2009007913A patent/MX2009007913A/es not_active Application Discontinuation
- 2008-01-24 JP JP2009546864A patent/JP2010532746A/ja not_active Withdrawn
- 2008-01-24 WO PCT/IN2008/000046 patent/WO2008090569A1/en not_active Ceased
- 2008-01-24 RU RU2009131931/15A patent/RU2009131931A/ru not_active Application Discontinuation
- 2008-01-24 US US12/522,185 patent/US20100056493A1/en not_active Abandoned
- 2008-01-24 EP EP08702738A patent/EP2114380A1/en not_active Withdrawn
- 2008-01-24 CN CNA2008800031430A patent/CN101588794A/zh active Pending
- 2008-01-25 AR ARP080100316A patent/AR065039A1/es not_active Application Discontinuation
- 2008-01-25 CL CL200800219A patent/CL2008000219A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010532746A (ja) | 2010-10-14 |
| CN101588794A (zh) | 2009-11-25 |
| BRPI0807807A2 (pt) | 2014-06-17 |
| KR20090109113A (ko) | 2009-10-19 |
| CL2008000219A1 (es) | 2008-05-16 |
| MX2009007913A (es) | 2009-07-31 |
| RU2009131931A (ru) | 2011-02-27 |
| WO2008090569A1 (en) | 2008-07-31 |
| US20100056493A1 (en) | 2010-03-04 |
| EP2114380A1 (en) | 2009-11-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR065039A1 (es) | Una composicion farmaceutica de liberacion modificada, un proceso para su preparacion, un metodo para su utilizacion y su uso | |
| AR058620A1 (es) | Formulacion farmaceutica para el suministro de compuestos inhibidores del receptor de tirosina quinasa (rtki) al ojo | |
| ATE302616T1 (de) | Oral anzuwendende arzneizusammensetzungen mit gesteuerter wirkstoffabgabe | |
| MX2009003735A (es) | Composicion en deposito inyectable y su procedimiento de preparacion. | |
| ECSP105253A (es) | Derivados de 5-feniltiazol y uso como inhibidores de pi3 cinasa | |
| NZ604026A (en) | Injectable flowable composition comprising buprenorphine | |
| BRPI0516830A (pt) | composições de droga de liberação sustentada convenientemente implantáveis | |
| GT200700034A (es) | Composiciones farmaceuticas de antagonistas del anticuerpo anti-cd40 | |
| ATE391708T1 (de) | Verbindungen und gemische zur verabreichung eines aktiven agens | |
| BRPI0611400B8 (pt) | formulações contendo xiloglicano muco-adesivas úteis em dispositivos médicos e em formulações farmacêuticas | |
| UY31957A (es) | Metodo anticonceptivo mejorado | |
| PE20040418A1 (es) | Nuevas formulaciones farmaceuticas solidas que comprenden telmisartano y su preparacion | |
| WO2007084460A8 (en) | Pharmaceutical compositions with enhanced stability | |
| PE20080374A1 (es) | Composiciones farmaceuticas de ropinirol | |
| PE20080423A1 (es) | Formulaciones de flibanserina y metodo para fabricarlas | |
| EA200800161A1 (ru) | Новые фармацевтические композиции с модифицированным высвобождением и способ получения таких композиций | |
| BRPI0508579A (pt) | composto, composição farmacêutica, e, uso de um composto | |
| SG147450A1 (en) | Sustained release pharmaceutical compositions comprising aplindore and derivatives thereof | |
| PL1750862T3 (pl) | Kompozycja farmaceutyczna zawierająca irbesartan | |
| RU2011136636A (ru) | Фармацевтическая композиция для орального введения | |
| BR112013004455A2 (pt) | composições para fornecimento gástrico de agentes ativos | |
| CY1114311T1 (el) | Θεραπευτικα συστηματα αμεσης απελευθερωσης για βελτιωμενη απο του στοματος απορροφηση 7-[(ε)-τριτ-βουτυλοξυιμινομεθυλο]καμπτοθεκινης | |
| AR044200A1 (es) | Composicion de fondaparinux sodico de alta pureza ,un procedimiento de preparacion de esta composicion y composiciones farmaceuticas que la contienen como principio activo | |
| UY31343A1 (es) | Composicion con una combinacion de principios activos para el tratamiento del estrenimiento | |
| WO2004078111A3 (en) | Extended release minocycline compositions and processes for their preparation |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |