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AR053577A1 - Piperazin-benzotiofenos sustituidos para el tratamiento de desordenes mentales - Google Patents

Piperazin-benzotiofenos sustituidos para el tratamiento de desordenes mentales

Info

Publication number
AR053577A1
AR053577A1 ARP060101451A ARP060101451A AR053577A1 AR 053577 A1 AR053577 A1 AR 053577A1 AR P060101451 A ARP060101451 A AR P060101451A AR P060101451 A ARP060101451 A AR P060101451A AR 053577 A1 AR053577 A1 AR 053577A1
Authority
AR
Argentina
Prior art keywords
group
lower alkyl
ring
alkylene group
alkylene
Prior art date
Application number
ARP060101451A
Other languages
English (en)
Inventor
H Yamashita
J Matsubara
K Oshima
H Kuroda
Shin Miyamura
S Shimizu
T Tanaka
Y Oshiro
J Shimada
K Maeda
Y Tadori
N Amada
H Akazawa
J Yamashita
A Mori
Y Uwahodo
T Masumoto
K Hashimoto
H Takahashi
Original Assignee
Otsuka Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36645750&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR053577(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Otsuka Pharma Co Ltd filed Critical Otsuka Pharma Co Ltd
Publication of AR053577A1 publication Critical patent/AR053577A1/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/32—Alcohol-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Composiciones farmacéuticas que los contienen, métodos de preparacion y usos para el tratamiento de desordenes mentales que incluyen desorden de sistema nervioso central, sin efecto colateral y con elevada seguridad. Reivindicacion 1: Un compuesto heterocíclico representado por la formula (1) [en donde el anillo Q representa la formula (2) (en donde ---Z---Y--- representa -NH-CH2-, -N=CH-, -CH2-NH- o -CH=N-; y el enlace C-C, ------ entre la posicion 3 y posicion 4 del esqueleto heterocíclico que contiene Z e Y representa un enlace simple o un enlace doble); el anillo Q puede tener por lo menos un sustituyente seleccionado del grupo que consiste de un grupo alquilo inferior, alquenilo inferior, alquinilo inferior, hidroxilo, alcoxilo inferior, alquilo inferior halogenado, arilo, arilalquilo inferior, arilalcoxilo inferior, arilcarbonilo, alqueniloxilo inferior, alcanoiloxilo inferior, alcanoilo inferior, alcanoiloxilo inferior, cicloalquilo, alquilo inferior cicloalquilo, un átomo halogeno, un grupo carbamoílo que puede tener un grupo alquilo inferior, carboxilo, alcoxicarbonilo inferior, amino que puede tener un grupo alcanoilo inferior, un grupo nitro, hidroxialquilo inferior, alquilo inferior amino que puede tener un grupo alquilo inferior, un grupo tienilo, un grupo heteromonocíclico de 5 a 6 miembros conteniendo 1 a 2 átomos de N sustituido por grupo alquilo inferior y un grupo oxo; R2 representa H o alquilo inferior; y A representa -O-A1- (en donde A1 representa un grupo alquileno que puede ser sustituido con un grupo hidroxilo (en donde el grupo alquileno puede contener un átomo de O) o un grupo alquenileno inferior) o un grupo alquileno inferior; con la condicion que cuando A representa un grupo alquileno inferior, el anillo Q representa un grupo bicíclico seleccionad del grupo que consiste de la formulas (3) (en donde el enlace C-C ----- representa un enlace simple o un enlace doble)] o una sal del mismo
ARP060101451A 2005-04-14 2006-04-12 Piperazin-benzotiofenos sustituidos para el tratamiento de desordenes mentales AR053577A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2005116698 2005-04-14

Publications (1)

Publication Number Publication Date
AR053577A1 true AR053577A1 (es) 2007-05-09

Family

ID=36645750

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060101451A AR053577A1 (es) 2005-04-14 2006-04-12 Piperazin-benzotiofenos sustituidos para el tratamiento de desordenes mentales

Country Status (26)

Country Link
US (14) USRE48059E1 (es)
EP (1) EP1869025B3 (es)
KR (1) KR100937623B1 (es)
CN (1) CN101155804B (es)
AR (1) AR053577A1 (es)
AT (1) ATE496911T3 (es)
AU (1) AU2006237905C1 (es)
BR (1) BRPI0609785B8 (es)
CA (1) CA2602247C (es)
CY (2) CY1111206T1 (es)
DE (1) DE602006019838D1 (es)
DK (1) DK1869025T6 (es)
ES (1) ES2358631T7 (es)
HU (2) HUE011611T6 (es)
IL (1) IL185909A (es)
IN (1) IN2012DN00855A (es)
LT (1) LTC1869025I2 (es)
LU (1) LUC00086I2 (es)
MY (1) MY142746A (es)
NL (1) NL300946I2 (es)
PL (1) PL1869025T6 (es)
PT (1) PT1869025E (es)
SI (1) SI1869025T1 (es)
TW (1) TWI320783B (es)
WO (1) WO2006112464A1 (es)
ZA (1) ZA200708686B (es)

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