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AR053561A1 - Compuestos novedosos, isomeros de los mismos o las sales farmaceuticamente aceptables de los mismos como el antagonista del receptor vaniloide y las composiciones farmaceuticas que contienen los mismos - Google Patents

Compuestos novedosos, isomeros de los mismos o las sales farmaceuticamente aceptables de los mismos como el antagonista del receptor vaniloide y las composiciones farmaceuticas que contienen los mismos

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Publication number
AR053561A1
AR053561A1 ARP060101059A ARP060101059A AR053561A1 AR 053561 A1 AR053561 A1 AR 053561A1 AR P060101059 A ARP060101059 A AR P060101059A AR P060101059 A ARP060101059 A AR P060101059A AR 053561 A1 AR053561 A1 AR 053561A1
Authority
AR
Argentina
Prior art keywords
alkoxy
alkyl
haloc1
alkenyl
phenyl
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Application number
ARP060101059A
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English (en)
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Amorepacific Corp
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Publication date
Application filed by Amorepacific Corp filed Critical Amorepacific Corp
Publication of AR053561A1 publication Critical patent/AR053561A1/es

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    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
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    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/155—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Vascular Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La presente se refiere a los compuestos novedosos, los isomeros de los mismos o las sales farmacéuticamente aceptables de los mismos como el antagonista del receptor vaniloide (Receptor Vaniloide 1; VR1; TRPV1), y una composicion farmacéutica que contiene a los mismos. La presente proporciona una composicion farmacéutica para prevenir o tratar una enfermedad tal como dolor, migrana, artralgia, neuralgia, neuropatías, herida en los nervios, skin disorder, hipersensibilidad de la vejiga urinaria, síndrome del intestino irritable, urgencia fecal, a desorden respiratorio, irritacion de la piel, membrana del ojo o mucosa, ulcera duodenal-estomacal, la enfermedad inflamatoria s, ear disease, y heart disease. Reivindicacion 1: Un compuesto de la formula (1), un isomero del mismo, o una sal farmacéuticamente aceptable del mismo en donde: X es NHCH2, CR11=CR12, NH, CHR11CHR12, o C:::C, en donde R11 y R12 son independientemente H, halogeno, alquilo C1-5, alcoxi C1-5, halo C1-5- alquilo o fenilo; R1 es alquenilo C2-5 o alquinilo C2-5; R2 es H, halogeno, nitro, ciano, alquilo C1-5, alcoxi C1-5, haloC1-5-alquilo, alquenilo C2-5, alquinilo C2-5, carboxi, alcoxicarbonilo C1-5, alquiltio C1-5, fenilo, o fenilC1-3alquilo, en donde, cada fenilo puede estar sustituido o no sustituido con uno o más sustituyentes seleccionados de carboxi, alquilo C1-5, halogeno, nitro, alquenilo C2-5, alcoxi C1-5, haloC1-5alquilo, alquilcarbonilo C1-5, alquiltio C1-5, alquilsulfonilo C1-5 y alcoxicarbonilo C1-5; R3 es H, alquilo C1-5, alcoxi C1-5, o haloC1-5alquilo; R4, R5, R6, R7, y R8 son independientemente H, carboxi, alquilo C1-5, nitro, alquenilo C2-5, alcoxi C1-5, alquinilo C2-5, haloC1-5alquilo, alquiltio C1-5, alquilsulfonilo C1-5, alquilcarbonilo C1-5, alcoxicarbonilo C1-5, hidroxi, alqueniloxi C2-5, alcoxi C1-5-alcoxi C1-5, alcoxi C1-5-alcoxiC1-5-alquilo C1-5, alquilpiperazinilo C1-3, piperazinilo C1-5alcoxi, piperidiniloC1-5alcoxi, alcoxi C1-5-alquilamino C1-5, alquilamino C1-7, morfolinilo, morfoliniloC1-5alquiloxi, tetrahidropiraniloxi, fenilo o halogeno, en donde fenilo puede estar sustituido o no sustituido con uno o más sustituyentes seleccionados de carboxi, alquilo C1-5, halogeno, nitro, alquenilo C2-5, alcoxi C1-5, haloC1-5alquilo, alquilcarbonilo C1-5, alquiltio C1-5, alquilsulfonilo C1-5, alcoxicarbonilo C1-5, o piperidiniloxi no sustituido o sustituido con alcoxicarbonilo C1-5, y R9 y 10 son independientemente H, -SO2R13, -SOR13, alquilo C1-5, alcoxi C1-5, haloC1-5alquilo, alquenilo C2-5, alcoxicarbonilo C1-5, alquiltio C1-5, fenilo, o fenilC1-3alquilo, en donde, cada fenilo puede estar sustituido o no sustituido con uno o más sustituyentes seleccionados de carboxi alquilo C1-5, halogeno, nitro, alquenilo C2-5, alcoxi C1-5, haloC1-5alquilo, alquilcarbonilo C1-5, alquiltio C1-5, alquilsulfonilo C1-5 y alcoxicarbonilo C1-5, y R13 es H, amino, alquilo C1-5, alquenilo C2-5, alcoxi C1-5, haloC1-5alquilo, trifluormetilo, fenilo o fenilC1-3alquilo.
ARP060101059A 2005-03-19 2006-03-17 Compuestos novedosos, isomeros de los mismos o las sales farmaceuticamente aceptables de los mismos como el antagonista del receptor vaniloide y las composiciones farmaceuticas que contienen los mismos AR053561A1 (es)

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KR20050022986 2005-03-19
US66326905P 2005-03-21 2005-03-21

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ARP060101059A AR053561A1 (es) 2005-03-19 2006-03-17 Compuestos novedosos, isomeros de los mismos o las sales farmaceuticamente aceptables de los mismos como el antagonista del receptor vaniloide y las composiciones farmaceuticas que contienen los mismos
ARP060101058A AR056943A1 (es) 2005-03-19 2006-03-17 DERIVADOS DE AMIDAS, ISoMEROS DE LOS MISMOS O LAS SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS COMO EL ANTAGONISTA DEL RECEPTOR VANILOIDE Y LAS COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LOS MISMOS

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ARP060101058A AR056943A1 (es) 2005-03-19 2006-03-17 DERIVADOS DE AMIDAS, ISoMEROS DE LOS MISMOS O LAS SALES FARMACÉUTICAMENTE ACEPTABLES DE LOS MISMOS COMO EL ANTAGONISTA DEL RECEPTOR VANILOIDE Y LAS COMPOSICIONES FARMACÉUTICAS QUE CONTIENEN LOS MISMOS

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US (2) US7763657B2 (es)
EP (2) EP1861357B1 (es)
JP (2) JP5159604B2 (es)
KR (2) KR101304981B1 (es)
AR (2) AR053561A1 (es)
AU (2) AU2006225496A1 (es)
BR (2) BRPI0608714A2 (es)
CA (2) CA2601871A1 (es)
EA (2) EA200702020A1 (es)
IL (2) IL185892A0 (es)
MX (2) MX2007011466A (es)
NO (2) NO20075354L (es)
TW (2) TW200716523A (es)
WO (2) WO2006101318A1 (es)

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