AR052150A1 - 5-amino-4-hidroxi-2-isopropil-7-[4-metoxi-3-(3-metoxipropoxi) bencil] -8-metil-nonamidas - Google Patents
5-amino-4-hidroxi-2-isopropil-7-[4-metoxi-3-(3-metoxipropoxi) bencil] -8-metil-nonamidasInfo
- Publication number
- AR052150A1 AR052150A1 ARP050105156A ARP050105156A AR052150A1 AR 052150 A1 AR052150 A1 AR 052150A1 AR P050105156 A ARP050105156 A AR P050105156A AR P050105156 A ARP050105156 A AR P050105156A AR 052150 A1 AR052150 A1 AR 052150A1
- Authority
- AR
- Argentina
- Prior art keywords
- amino
- alkylamino
- mono
- optionally
- nonamids
- Prior art date
Links
- -1 nitro, amino Chemical group 0.000 abstract 5
- 125000006624 (C1-C6) alkoxycarbonylamino group Chemical group 0.000 abstract 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 abstract 2
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 2
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 abstract 2
- 125000003806 alkyl carbonyl amino group Chemical group 0.000 abstract 2
- 125000005196 alkyl carbonyloxy group Chemical group 0.000 abstract 2
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000002461 renin inhibitor Substances 0.000 abstract 1
- 229940086526 renin-inhibitors Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
Abstract
Composiciones farmacéuticas que las contienen y uso como inhibidores de la renina. Reivindicacion 1: Compuesto de la formula (1), en la cual: R es heterociclilo que está unido a través de un átomo de carbono y está mono- o polisustituido con alquilo C1-6, trifluormetilo, nitro, amino, alquilamino C1-6, di-alquilaminoC1-6, alquenilo C2-6, alquinilo C2-6, alcoxilo C1-6, alquilcarboniloxilo C1-6, alquilcarbonilamino C0-6, alcoxicarbonilamino C1-6, hidroxilo, halogeno, oxido, ciano, carbamoilo opcionalmente N-mono- o N,N-di-alquiladoC1-8, carboxilo o alquilendioxilo C1-6 opcionalmente esterificados o está sustituido con oxo y mono- o polisustituido con alquilo C1-6, trifluormetilo, nitro, amino, alquilamino C1-6, di-alquilamino C1-6, alquenilo C2-6, alquinilo C2-6, alcoxilo C1-6, alquilcarboniloxilo C1-6, alquilcarbonilamino C0-6, alcoxicarbonilamino C1-6, hidroxilo,, halogeno, oxido, ciano, carbamoilo opcionalmente N-mono- o N,N-di-alquiladoC1-8, carboxilo o alquilendioxilo C1-6 opcionalmente esterificados, y su sal, especialmente sal util desde el punto de vista farmacéutico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH20492004 | 2004-12-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR052150A1 true AR052150A1 (es) | 2007-03-07 |
Family
ID=35668936
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050105156A AR052150A1 (es) | 2004-12-10 | 2005-12-09 | 5-amino-4-hidroxi-2-isopropil-7-[4-metoxi-3-(3-metoxipropoxi) bencil] -8-metil-nonamidas |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20080167381A1 (es) |
| EP (1) | EP1819675A1 (es) |
| JP (1) | JP2008523036A (es) |
| CN (1) | CN101076518A (es) |
| AR (1) | AR052150A1 (es) |
| BR (1) | BRPI0518963A2 (es) |
| CA (1) | CA2590252A1 (es) |
| IL (1) | IL183771A0 (es) |
| TW (1) | TW200633983A (es) |
| WO (1) | WO2006061427A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005095876A1 (en) | 2004-04-01 | 2005-10-13 | Cucumber Limited | Delivery and storage of goods |
| EP1937248B1 (en) | 2005-09-17 | 2010-06-02 | Novartis Ag | Alcanoic acid amides substituted by saturated o-heterocycles |
| EP1867329A3 (en) * | 2006-06-14 | 2008-05-07 | Speedel Experimenta AG | 5-Amino-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamides as therapeutic compounds |
| EP1958666A1 (en) * | 2007-02-13 | 2008-08-20 | Speedel Experimenta AG | Heterocyclic-substituted alkanamides as therapeutic compounds |
| EP2075244A1 (en) | 2007-12-24 | 2009-07-01 | DSMIP Assets B.V. | New route to building block for making renin inhibitors |
| EP2225200B1 (en) | 2007-12-24 | 2013-10-16 | DSM IP Assets B.V. | Convergent synthesis of renin inhibitors and intermediates useful therein |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY119161A (en) * | 1994-04-18 | 2005-04-30 | Novartis Ag | Delta-amino-gamma-hydroxy-omega-aryl-alkanoic acid amides with enzyme especially renin inhibiting activities |
| ATE421501T1 (de) * | 2004-03-19 | 2009-02-15 | Speedel Experimenta Ag | 2,7-substituierte 5-amino-4-hydroxy-8-(1h-indol-5-yl)-octanamid derivate als renin inhibitoren zur behandlung von bluthochdruck |
-
2005
- 2005-12-08 TW TW094143398A patent/TW200633983A/zh unknown
- 2005-12-09 WO PCT/EP2005/056623 patent/WO2006061427A1/en not_active Ceased
- 2005-12-09 US US11/792,676 patent/US20080167381A1/en not_active Abandoned
- 2005-12-09 AR ARP050105156A patent/AR052150A1/es not_active Application Discontinuation
- 2005-12-09 EP EP05821571A patent/EP1819675A1/en not_active Withdrawn
- 2005-12-09 BR BRPI0518963-2A patent/BRPI0518963A2/pt not_active Application Discontinuation
- 2005-12-09 CA CA002590252A patent/CA2590252A1/en not_active Abandoned
- 2005-12-09 JP JP2007544926A patent/JP2008523036A/ja active Pending
- 2005-12-09 CN CNA2005800424794A patent/CN101076518A/zh active Pending
-
2007
- 2007-06-07 IL IL183771A patent/IL183771A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| TW200633983A (en) | 2006-10-01 |
| WO2006061427A1 (en) | 2006-06-15 |
| CA2590252A1 (en) | 2006-06-15 |
| EP1819675A1 (en) | 2007-08-22 |
| US20080167381A1 (en) | 2008-07-10 |
| JP2008523036A (ja) | 2008-07-03 |
| BRPI0518963A2 (pt) | 2008-12-16 |
| CN101076518A (zh) | 2007-11-21 |
| IL183771A0 (en) | 2007-09-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR076171A1 (es) | Pirazolopirimidinonas 1,6-disustituidas, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento del alzheimer, epilepsia y otras enfermedades del sistema nervioso central. | |
| AR073689A1 (es) | Derivados de azaindazol, antagonistas de receptores ccr1, composiciones farmaceuticas que los contienen, metodo de preparacion de los mismos y de intermediarios, y uso para tratar enfermedades autoinmunes ,diabetes y alzheimer, entre otras. | |
| CR9690A (es) | 3-acilaminobenzanilidas insecticidas | |
| BRPI0606318A2 (pt) | composto, composição, e, uso de um composto | |
| ECSP088450A (es) | Derivados de pirimidina 4-(3-aminopirazol) para uso como inhibidores de tirosina quinasa en el tratamiento de cáncer | |
| CL2003002731A1 (es) | Compuesto derivado de quinazolina de formula definida, que actua como inhibidor de la kinasa aurora; procedimiento de preparacion del compuesto; composicion farmaceutica que comprende al compuesto y uso del compuesto; util para el tratamiento de enfe | |
| BRPI0910368A2 (pt) | "uso de um ou mais intensificadores escolhidos entre biointensificadores e fotointensificadores, composição para o uso de um ou mais intensificadores escolhidos entre biointensificadores e fotointensificadores e colírio para uso de um ou mais intensificadores escolhidos entre biointensificadores e fotointensificadores" | |
| CL2010000188A1 (es) | Metodo para el tratamiento de una infeccion en un sujeto que comprende la administracion de 9-[(2,2-dimetil-propilamino)-metil]-minociclina o de una sal de la misma; composicion farmaceutica que comprende dicho compuesto; y su uso. | |
| ES2422556T3 (es) | Tratamiento de hepatitis vírica | |
| AR062094A1 (es) | Derivados de n'-ciano-n-halogenoalquil-imidamida | |
| CL2008002295A1 (es) | Compuestos derivados de tiazolida sustituidos con alquilsulfonilos; composicion farmaceutica; y uso para el tratamiento de la hepatitis c. | |
| AR069899A1 (es) | Compuestos quimicos derivados de pirazol-triazina | |
| CY1114533T1 (el) | Φαρμακευτικες συνθεσεις οι οποιες περιεχουν ροζουβαστατινικο ασβεστιο | |
| AR072016A1 (es) | Derivados de isoxazol que funcionan como potenciadores de los receptores de glutamato | |
| CO5640151A2 (es) | Uso de una combinacion de un inhibidor de la cinasa del receptor del factor de crecimiento epidermico y agentes citotoxicos para el tratamiento e inhibicion del cancer | |
| CL2011001078A1 (es) | Compuestos derivados de espirodihidrotetraazabenzoazuleno; procedimiento de preparacion; composicion farmaceutica; y su uso para la prevencion o tratamiento de dismenorrea, disfuncion sexual, hipertension, cirrosis hepatica y esquizofrenia entre otras. | |
| GT201000047A (es) | Mejoras en compuestos organicos o relacionadas con los mismos | |
| CL2008002155A1 (es) | Composicion herbicida que contiene la sulfonamida inhibidor de acetolactato sintetasa piroxsulam y un ester alquilo de acidos grasos; metodo que emplea esta composicion para combatir plantas indeseadas. | |
| GT200400146A (es) | Derivados sustituidos del dioxido de tiazol-benzoisotiazol, procedimiento para su preparacion y su uso | |
| CR8451A (es) | Uso de derivados de n-arilhidracina para combatir pestes | |
| PA8575601A1 (es) | Procedimiento para su preparacion, medicamentos que comprenden estos compuestos y su uso | |
| CL2007002387A1 (es) | Uso de compuestos derivados de 2,5-dihidroxibenceno para el tratamiento de artritis y dolor. | |
| MX2023013542A (es) | Amidas heterociclicas nematicidas. | |
| BR112012021108A2 (pt) | composições biocidas, e, uso de valerolactona e/ou de seus derivados de amida | |
| UY27203A1 (es) | Bencimidazoles útiles en el tratamiento de la disfunción sexual |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |