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AR050648A1 - DERIVATIVES OF QUATERNAL ALCALOIDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IN THE TREATMENT OF METABOLIC, IMMUNOLOGICAL AND CANCER DYSFUNCTIONS - Google Patents

DERIVATIVES OF QUATERNAL ALCALOIDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IN THE TREATMENT OF METABOLIC, IMMUNOLOGICAL AND CANCER DYSFUNCTIONS

Info

Publication number
AR050648A1
AR050648A1 ARP050103885A ARP050103885A AR050648A1 AR 050648 A1 AR050648 A1 AR 050648A1 AR P050103885 A ARP050103885 A AR P050103885A AR P050103885 A ARP050103885 A AR P050103885A AR 050648 A1 AR050648 A1 AR 050648A1
Authority
AR
Argentina
Prior art keywords
residue
alkaloid
immunological
cancer
pharmaceutical compositions
Prior art date
Application number
ARP050103885A
Other languages
Spanish (es)
Inventor
Ddr Nowicky Wassyl Dipl-Ing
Original Assignee
Ddr Nowicky Wassyl Dipl-Ing
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ddr Nowicky Wassyl Dipl-Ing filed Critical Ddr Nowicky Wassyl Dipl-Ing
Publication of AR050648A1 publication Critical patent/AR050648A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Los productos de reaccion precipitados comprenden al menos un derivado de un alcaloide cuaternario y son adecuados como drogas para aplicaciones profilácticas o terapéuticas en composiciones farmacéuticas que los contienen, en particular en el tratamiento de disfunciones inmunologicas o metabolicas, y cáncer. Reivindicacion 1: Un producto de reaccion de alcaloides que comprende al menos un derivado de alcaloides fisiologicamente activo obtenido mediante la reaccion química de uno o más alcaloides con un agente de derivatizacion, caracterizado porque dicho al menos un derivado de alcaloides posee un nitrogeno cuaternario al cual se une, como cuarto ligando, un residuo de tipo base de Lewis, donde dicho residuo se selecciona del grupo formado por un residuo hidroxi (-OH), sulf-hidrilo (-SH), sulfoxi, sulfato, fosfato, éster, tioéster, éter, tioéter, alquilo, arilo, aralquilo, alquiloxi, ariloxi o un residuo o producto de descomposicion del agente de derivatizacion que no está comprendido en el grupo de compuestos mencionado precedentemente, con la condicion que dicho residuo no sea un residuo de hidrogeno, metilo o etilo.The precipitated reaction products comprise at least one derivative of a quaternary alkaloid and are suitable as drugs for prophylactic or therapeutic applications in pharmaceutical compositions containing them, in particular in the treatment of immunological or metabolic dysfunctions, and cancer. Claim 1: An alkaloid reaction product comprising at least one physiologically active alkaloid derivative obtained by the chemical reaction of one or more alkaloids with a derivatization agent, characterized in that said at least one alkaloid derivative possesses a quaternary nitrogen to which as a fourth ligand, a Lewis base type residue is attached, wherein said residue is selected from the group consisting of a hydroxy (-OH), sulf-hydroxy (-SH), sulfoxy, sulfate, phosphate, ester, thioester residue, ether, thioether, alkyl, aryl, aralkyl, alkyloxy, aryloxy or a residue or decomposition product of the derivatization agent that is not included in the group of compounds mentioned above, with the proviso that said residue is not a hydrogen, methyl residue or ethyl.

ARP050103885A 2004-09-20 2005-09-19 DERIVATIVES OF QUATERNAL ALCALOIDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IN THE TREATMENT OF METABOLIC, IMMUNOLOGICAL AND CANCER DYSFUNCTIONS AR050648A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP04022299 2004-09-20

Publications (1)

Publication Number Publication Date
AR050648A1 true AR050648A1 (en) 2006-11-08

Family

ID=35501129

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP050103885A AR050648A1 (en) 2004-09-20 2005-09-19 DERIVATIVES OF QUATERNAL ALCALOIDS, PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM AND THEIR USE IN THE TREATMENT OF METABOLIC, IMMUNOLOGICAL AND CANCER DYSFUNCTIONS

Country Status (5)

Country Link
EP (1) EP1833839A1 (en)
AR (1) AR050648A1 (en)
CA (1) CA2593202A1 (en)
TW (1) TW200610763A (en)
WO (1) WO2006032380A1 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITMI20131495A1 (en) 2013-09-10 2015-03-11 Ce R C Ar Di Paolo Maestri USEFUL COMPOSITIONS FOR CHEMOTHERAPY-RESISTANT CANCER TREATMENT
CN106535939B (en) 2014-07-17 2020-08-18 益生菌股份公司 Compositions comprising melatonin and flavonoids for the treatment of chemotherapy-resistant tumors
US11096975B2 (en) 2015-03-05 2021-08-24 Probiotical S.P.A. Compositions for use in the treatment of tumors resistant to chemotherapy
US20240139162A1 (en) * 2019-10-17 2024-05-02 Chengdu Anticancer Bioscience, Ltd. Benzophenanthridine Alkaloids and Their Methods of Use
CN115607549A (en) * 2021-07-15 2023-01-17 复旦大学 Application of sanguinarine and its derivatives in the preparation of drugs for preventing and treating multiple sclerosis
CN113549085B (en) * 2021-07-16 2022-11-22 湖北科技学院 A kind of synthetic method of natural product 6-HHC

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2670347A (en) * 1952-01-08 1954-02-23 American Cyanamid Co Thiophosphoric acid derivatives and method of preparing the same
AT407833B (en) * 1995-06-01 2001-06-25 Nowicky Wassyl Dr AGENTS FOR THE TREATMENT OF RADIATION DAMAGES

Also Published As

Publication number Publication date
EP1833839A1 (en) 2007-09-19
CA2593202A1 (en) 2006-03-30
TW200610763A (en) 2006-04-01
WO2006032380A1 (en) 2006-03-30

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