AR050540A1 - Derivados de adamantilamida triciclica como inhibidores de deshidrogenasa 11- beta hidroxiesteroide - Google Patents
Derivados de adamantilamida triciclica como inhibidores de deshidrogenasa 11- beta hidroxiesteroideInfo
- Publication number
- AR050540A1 AR050540A1 ARP050103613A ARP050103613A AR050540A1 AR 050540 A1 AR050540 A1 AR 050540A1 AR P050103613 A ARP050103613 A AR P050103613A AR P050103613 A ARP050103613 A AR P050103613A AR 050540 A1 AR050540 A1 AR 050540A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- phenyl
- alkyloxy
- hydroxycarbonyl
- alkylcarbonyl
- Prior art date
Links
- KVUXYQHEESDGIJ-UHFFFAOYSA-N 10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1h-cyclopenta[a]phenanthrene-3,16-diol Chemical compound C1CC2CC(O)CCC2(C)C2C1C1CC(O)CC1(C)CC2 KVUXYQHEESDGIJ-UHFFFAOYSA-N 0.000 title 1
- 101710088194 Dehydrogenase Proteins 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 9
- 125000003545 alkoxy group Chemical group 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 125000004448 alkyl carbonyl group Chemical group 0.000 abstract 6
- 125000001475 halogen functional group Chemical group 0.000 abstract 6
- ORTFAQDWJHRMNX-UHFFFAOYSA-N hydroxidooxidocarbon(.) Chemical group O[C]=O ORTFAQDWJHRMNX-UHFFFAOYSA-N 0.000 abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 6
- -1 cyano, amino, phenyl Chemical group 0.000 abstract 4
- 125000001424 substituent group Chemical group 0.000 abstract 4
- 125000000815 N-oxide group Chemical group 0.000 abstract 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000002541 furyl group Chemical group 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- 125000002883 imidazolyl group Chemical group 0.000 abstract 2
- 125000001786 isothiazolyl group Chemical group 0.000 abstract 2
- 125000000842 isoxazolyl group Chemical group 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 125000002911 monocyclic heterocycle group Chemical group 0.000 abstract 2
- 125000002971 oxazolyl group Chemical group 0.000 abstract 2
- 125000004193 piperazinyl group Chemical group 0.000 abstract 2
- 125000002098 pyridazinyl group Chemical group 0.000 abstract 2
- 125000000714 pyrimidinyl group Chemical group 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000000335 thiazolyl group Chemical group 0.000 abstract 2
- 125000001544 thienyl group Chemical group 0.000 abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 208000010412 Glaucoma Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 230000019771 cognition Effects 0.000 abstract 1
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 235000020824 obesity Nutrition 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/62—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles
- C07D209/64—Naphtho [c] pyrroles; Hydrogenated naphtho [c] pyrroles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Obesity (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Las formas de N-oxido, las sales de adicion farmacéuticamente aceptables y sus formas estereoquímicamente isoméricas, en las que X representa C o N; Y representa C o N; L representa un metilo o un enlace directo; Z1 representa un enlace directo, alquilo de C1-2 o un radical divalente de formula -CH2-CH= (a) o -CH= (b); Z2 representa un enlace directo, alquilo C1-2 o un radical divalente de formula -CH2-CH= (a) o -CH= (b); R1 representa H, halo, ciano, amino, fenilo, hidroxi, alquiloxicarbonilo C1-4, hidroxicarbonilo, NR3R4 o alquilo C1-4 opcionalmente sustituidos con uno o más sustituyentes seleccionados a partir de hidroxicarbonilo, fenilo, alquiloxi C1-4 o NR5R6 o R1 representa alquiloxi C1-4 opcionalmente sustituido con uno o más sustituyentes seleccionados a partir de hidroxicarbonilo, fenilo, alquiloxi C1-4 o NR7R8; R2 representa H, halo, alquilo C1-4 o alquiloxi C1-4; R3 y R4 representan cada uno independientemente H, alquilo C1-4 o alquilcarbonilo C1-4; R5 y R6 representan cada uno independientemente H, alquilo C1-4 o alquilcarbonilo C1-4; R7 y R8 representan cada uno independientemente H, alquilo C1-4 o alquilcarbonilo C1-4; A representa fenilo o un heterociclo monocíclico seleccionado a partir del grupo consistente de tiofenilo, furanilo, oxazolilo, tiazolilo, imidazolilo, isoxazolilo, isotiazolilo, pirridinilo, piridazinilo, pirimidinilo y piperazinilo. También reivindica composicion farmacéutica, uso de los compuestos para preparar medicamentos utiles para obesidad, diabetes, enfermedades cardiovasculares, demencia, cognicion, osteoporosis, estrés y glaucoma. Reivindicacion1: Un compuesto que tiene la formula (1), las formas de N-oxidos, las sales de adicion farmacéuticamente aceptables y las formas estereoquímicamente isoméricas del mismo, en donde: X representa C o N; Y representa C o N; L representa un metilo o un enlace directo; Z1 representa un enlace directo, alquilo C1-2 o un radical divalente de formula -CH2-CH= (a) o -CH= (b); Z2 representa un enlace directo, alquilo C1-2 o un radical divalente de formula -CH2-CH= (a) o -CH= (b); R1 representa H, halo, ciano, amino, fenilo, hidroxi, alquiloxicarbonilo C1-4, -O-(C=O)-alquilo C1-4, hidroxicarbonilo, NR3R4 o alquilo C1-4 donde dicho alquilo C1-4 o -O-(C=O)-alquilo C1-4 están opcionalmente sustituidos con uno o más sustituyentes seleccionados a partir de halo, hidroxicarbonilo, fenilo, alquiloxi C1-4 o NR5R6 o R1 representa alquiloxi C1-4 opcionalmente sustituido con uno o más sustituyentes seleccionados a partir de halo, hidroxicarbonilo, fenilo, alquiloxi C1-4 o NR7R8; R2 representa H, halo, alquilo C1-4 o alquiloxi C1-4; R3 y R4 representan cada uno independientemente H, alquilo C1-4 o alquilcarbonilo C1-4; R5 y R6 representan cada uno independientemente H, alquilo C1-4 o alquilcarbonilo C1-4; R7 y R8 representan cada uno independientemente H, alquilo C1-4 o alquilcarbonilo C1-4; A representa fenilo o un heterociclo monocíclico seleccionado a partir del grupo consistente de tiofenilo, furanilo, oxazolilo, tiazolilo, imidazolilo, isoxazolilo, isotiazolilo, pirridinilo, piridazinilo, pirimidinilo y piperazinilo.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP04104147 | 2004-08-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR050540A1 true AR050540A1 (es) | 2006-11-01 |
Family
ID=34929502
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP050103613A AR050540A1 (es) | 2004-08-30 | 2005-08-29 | Derivados de adamantilamida triciclica como inhibidores de deshidrogenasa 11- beta hidroxiesteroide |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8563591B2 (es) |
| EP (1) | EP1786774B1 (es) |
| JP (1) | JP5137574B2 (es) |
| KR (1) | KR101197672B1 (es) |
| CN (1) | CN101039908B (es) |
| AR (1) | AR050540A1 (es) |
| AT (1) | ATE445600T1 (es) |
| AU (1) | AU2005279209B2 (es) |
| CA (1) | CA2576850C (es) |
| ES (1) | ES2334246T3 (es) |
| IL (1) | IL181581A0 (es) |
| MY (1) | MY141198A (es) |
| RU (1) | RU2386617C2 (es) |
| TW (1) | TWI365871B (es) |
| WO (1) | WO2006024628A1 (es) |
Families Citing this family (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8415354B2 (en) | 2004-04-29 | 2013-04-09 | Abbott Laboratories | Methods of use of inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US7880001B2 (en) | 2004-04-29 | 2011-02-01 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase Type 1 enzyme |
| US20100222316A1 (en) | 2004-04-29 | 2010-09-02 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| EA011097B1 (ru) * | 2004-05-07 | 2008-12-30 | Янссен Фармацевтика Н.В. | Производные пирролидин-2-она и пиперидин-2-она, используемые в качестве ингибиторов 11-бета-гидроксистероид-дегидрогеназы |
| DE602005017159D1 (de) | 2004-08-30 | 2009-11-26 | Janssen Pharmaceutica Nv | Oxysteroid-dehydrogenase-inhibitoren |
| AU2005279208B2 (en) * | 2004-08-30 | 2011-02-24 | Janssen Pharmaceutica N.V. | N-2 adamantanyl-2-phenoxy-acetamide derivatives as 11-beta hydroxysteroid dehydrogenase inhibitors |
| CN102816081A (zh) | 2005-01-05 | 2012-12-12 | 雅培制药有限公司 | 11-β-羟甾类脱氢酶1型酶的抑制剂 |
| ATE555081T1 (de) | 2005-01-05 | 2012-05-15 | Abbott Lab | Adamantyl-derivate als inhibitoren des 11-beta- hydroxysteroid-dehydrogenase-1-enzyms |
| US8198331B2 (en) | 2005-01-05 | 2012-06-12 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| US20090192198A1 (en) | 2005-01-05 | 2009-07-30 | Abbott Laboratories | Inhibitors of the 11-beta-hydroxysteroid dehydrogenase type 1 enzyme |
| AU2006246930C1 (en) | 2005-05-19 | 2012-01-19 | Merck Canada Inc. | Quinoline derivatives as EP4 antagonists |
| WO2006132197A1 (ja) | 2005-06-07 | 2006-12-14 | Shionogi & Co., Ltd. | I型11βヒドロキシステロイド脱水素酵素阻害活性を有するヘテロ環化合物 |
| EP1953145B1 (en) | 2005-11-21 | 2015-11-04 | Shionogi & Co., Ltd. | Heterocyclic compound having inhibitory activity on 11-b-hydroxysteroid dehydrogenase type i |
| US8017638B2 (en) | 2006-03-30 | 2011-09-13 | Shionogi & Co., Ltd. | Isoxazole derivative and isothiazole derivative having inhibitory activity on 11β-hydroxysteroid dehydrogenase type 1 |
| DK2035379T3 (da) * | 2006-04-25 | 2010-09-06 | Lilly Co Eli | Inhibitorer af 11-beta-hydroxysteroiddehydrogenase 1 |
| PE20080251A1 (es) | 2006-05-04 | 2008-04-25 | Boehringer Ingelheim Int | Usos de inhibidores de dpp iv |
| US8318941B2 (en) | 2006-07-06 | 2012-11-27 | Bristol-Myers Squibb Company | Pyridone/hydroxypyridine 11-beta hydroxysteroid dehydrogenase type I inhibitors |
| WO2008046758A2 (en) * | 2006-10-19 | 2008-04-24 | F. Hoffmann-La Roche Ag | Imidazolone and imidazolidinone derivatives as 11b-hsd1 inhibitors for diabetes |
| EP1935420A1 (en) | 2006-12-21 | 2008-06-25 | Merck Sante | 2-Adamantyl-butyramide derivatives as selective 11beta-HSD1 inhibitors |
| EP2125750B1 (en) * | 2007-02-26 | 2014-05-21 | Vitae Pharmaceuticals, Inc. | Cyclic urea and carbamate inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| CA2689659C (en) | 2007-05-18 | 2012-10-23 | Shionogi And Co., Ltd. | Nitrogen-containing heterocyclic derivative having 11.beta.-hydroxysteroid dehydrogenase type 1 inhibitory activity |
| WO2009001817A1 (ja) | 2007-06-27 | 2008-12-31 | Taisho Pharmaceutical Co., Ltd. | １１β－ＨＳＤ１阻害活性を有する化合物 |
| JP5189165B2 (ja) | 2007-07-17 | 2013-04-24 | エフ．ホフマン−ラ ロシュ アーゲー | １１β−ヒドロキシステロイドデヒドロゲナーゼの阻害剤 |
| JP5736098B2 (ja) | 2007-08-21 | 2015-06-17 | アッヴィ・インコーポレイテッド | 中枢神経系障害を治療するための医薬組成物 |
| CA2704628C (en) | 2007-11-16 | 2016-11-29 | Boehringer Ingelheim International Gmbh | Aryl- and heteroarylcarbonyl derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| CA2708303A1 (en) | 2007-12-11 | 2009-06-18 | Vitae Pharmaceuticals, Inc. | Cyclic urea inhibitors of 11.beta.-hydroxysteroid dehydrogenase 1 |
| US20110028445A1 (en) * | 2008-02-12 | 2011-02-03 | Boehringer Ingelheim International Gmbh | Urea derivatives of benzomorphanes and related scaffolds, medicaments containing such compounds and their use |
| US8124636B2 (en) * | 2008-04-30 | 2012-02-28 | Hoffmann-La Roche Inc. | Imidazolidinone derivatives as 11B-HSD1 inhibitors |
| PL2300461T3 (pl) | 2008-05-01 | 2013-09-30 | Vitae Pharmaceuticals Inc | Cykliczne inhibitory dehydrogenazy 11beta-hydroksysteroidów 1 |
| CL2009001151A1 (es) | 2008-05-13 | 2010-08-13 | Boehringer Ingelheim Int | Compuestos derivados de acidos carbociclicos aliciclicos de benzomorfanos, procedimiento de preparacion, composicion farmaceutica, utiles para tratar enfermedades influenciadas por la inhibicion de la enzima 11beta-hidroxiesteroide deshidrogenasa, como trastornos metabolicos. |
| TW201016691A (en) | 2008-07-25 | 2010-05-01 | Boehringer Ingelheim Int | Inhibitors of 11beta-hydroxysteroid dehydrogenase 1 |
| WO2010010150A1 (en) | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Synthesis of inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 |
| JP5379160B2 (ja) | 2008-07-25 | 2013-12-25 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | １１β−ヒドロキシステロイドデヒドロゲナーゼ１の環状インヒビター |
| TW201022266A (en) | 2008-10-23 | 2010-06-16 | Boehringer Ingelheim Int | Urea derivatives of substituted nortropanes, medicaments containing such compounds and their use |
| EP2393807B1 (en) | 2009-02-04 | 2013-08-14 | Boehringer Ingelheim International GmbH | Cyclic inhibitors of 11 -hydroxysteroid dehydrogenase 1 |
| CN103772239B (zh) * | 2009-04-20 | 2017-04-12 | Abbvie 公司 | 酰胺和脒衍生物和其用途 |
| US8507493B2 (en) | 2009-04-20 | 2013-08-13 | Abbvie Inc. | Amide and amidine derivatives and uses thereof |
| US8546377B2 (en) * | 2009-04-23 | 2013-10-01 | Abbvie Inc. | Modulators of 5-HT receptors and methods of use thereof |
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-
2005
- 2005-08-26 KR KR1020077007047A patent/KR101197672B1/ko not_active Expired - Fee Related
- 2005-08-26 US US11/661,468 patent/US8563591B2/en not_active Expired - Fee Related
- 2005-08-26 AU AU2005279209A patent/AU2005279209B2/en not_active Ceased
- 2005-08-26 CA CA2576850A patent/CA2576850C/en not_active Expired - Fee Related
- 2005-08-26 ES ES05792007T patent/ES2334246T3/es not_active Expired - Lifetime
- 2005-08-26 AT AT05792007T patent/ATE445600T1/de not_active IP Right Cessation
- 2005-08-26 JP JP2007528862A patent/JP5137574B2/ja not_active Expired - Fee Related
- 2005-08-26 EP EP05792007A patent/EP1786774B1/en not_active Expired - Lifetime
- 2005-08-26 WO PCT/EP2005/054198 patent/WO2006024628A1/en not_active Ceased
- 2005-08-26 RU RU2007111711/04A patent/RU2386617C2/ru not_active IP Right Cessation
- 2005-08-26 MY MYPI20054028A patent/MY141198A/en unknown
- 2005-08-26 CN CN2005800354382A patent/CN101039908B/zh not_active Expired - Fee Related
- 2005-08-29 TW TW094129418A patent/TWI365871B/zh not_active IP Right Cessation
- 2005-08-29 AR ARP050103613A patent/AR050540A1/es unknown
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Also Published As
| Publication number | Publication date |
|---|---|
| TWI365871B (en) | 2012-06-11 |
| RU2386617C2 (ru) | 2010-04-20 |
| HK1112618A1 (en) | 2008-09-12 |
| JP5137574B2 (ja) | 2013-02-06 |
| CN101039908B (zh) | 2010-06-23 |
| ATE445600T1 (de) | 2009-10-15 |
| CN101039908A (zh) | 2007-09-19 |
| WO2006024628A1 (en) | 2006-03-09 |
| IL181581A0 (en) | 2007-07-04 |
| AU2005279209A1 (en) | 2006-03-09 |
| MY141198A (en) | 2010-03-31 |
| EP1786774A1 (en) | 2007-05-23 |
| CA2576850C (en) | 2013-06-25 |
| CA2576850A1 (en) | 2006-03-09 |
| US20080214597A1 (en) | 2008-09-04 |
| EP1786774B1 (en) | 2009-10-14 |
| KR101197672B1 (ko) | 2012-11-07 |
| US8563591B2 (en) | 2013-10-22 |
| ES2334246T3 (es) | 2010-03-08 |
| KR20070067111A (ko) | 2007-06-27 |
| JP2008511581A (ja) | 2008-04-17 |
| RU2007111711A (ru) | 2008-10-10 |
| AU2005279209B2 (en) | 2011-03-24 |
| TW200626549A (en) | 2006-08-01 |
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