AR059296A1 - Compuesto de l-tartrato de s-zopiclona y proceso para resolver los enantiomeros de zopiclona. - Google Patents
Compuesto de l-tartrato de s-zopiclona y proceso para resolver los enantiomeros de zopiclona.Info
- Publication number
- AR059296A1 AR059296A1 ARP070100446A ARP070100446A AR059296A1 AR 059296 A1 AR059296 A1 AR 059296A1 AR P070100446 A ARP070100446 A AR P070100446A AR P070100446 A ARP070100446 A AR P070100446A AR 059296 A1 AR059296 A1 AR 059296A1
- Authority
- AR
- Argentina
- Prior art keywords
- tartrate
- zoplicone
- zopiclone
- tartaric acid
- zopiclona
- Prior art date
Links
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 title abstract 4
- GBBSUAFBMRNDJC-UHFFFAOYSA-N zopiclone Chemical class C1CN(C)CCN1C(=O)OC1C2=NC=CN=C2C(=O)N1C1=CC=C(Cl)C=N1 GBBSUAFBMRNDJC-UHFFFAOYSA-N 0.000 title abstract 2
- 229960000820 zopiclone Drugs 0.000 title abstract 2
- 239000002131 composite material Substances 0.000 title 1
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 6
- -1 zopiclone ions Chemical class 0.000 abstract 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-L L-tartrate(2-) Chemical compound [O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O FEWJPZIEWOKRBE-JCYAYHJZSA-L 0.000 abstract 2
- 239000012453 solvate Substances 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 abstract 1
- WOUIIWAEGRSUHQ-ZVGUSBNCSA-N acetonitrile;(2r,3r)-2,3-dihydroxybutanedioic acid Chemical compound CC#N.OC(=O)[C@H](O)[C@@H](O)C(O)=O WOUIIWAEGRSUHQ-ZVGUSBNCSA-N 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000001376 precipitating effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 235000002906 tartaric acid Nutrition 0.000 abstract 1
- 239000011975 tartaric acid Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Anesthesiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Un proceso, que comprende hacer reaccionar una mezcla de R- y/o S-zoplicona y/o una sal de los mismos con ácido L-tartárico en un solvente para formar una solucion que contiene iones zopiclona e iones ácido L-tartárico, y a un proceso para incrementar la pureza enantiomérica de S-zoplicona, que comprende: (a) hacer precipitar selectivamente a partir de una solucion, que contiene zoplicona y ácido tartárico como solutos y acetonitrilo como un solvente, un solvato L-tartrato de S- zoplicona acetonitrilo; y (b) tratar dicho solvato L-tartrato de S-zoplicona acetonitrilo con una base de manera de formar S-zoplicona enriquecida, y al uso de ácido L-tartárico en la produccion de S-zoplicona enriquecida y/o de su compuesto L- tartrato. Reivindicacion 1: Un compuesto, caracterizado porque es L-tartrato de S-zopiclona.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US76492706P | 2006-02-03 | 2006-02-03 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR059296A1 true AR059296A1 (es) | 2008-03-26 |
Family
ID=37904886
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP070100446A AR059296A1 (es) | 2006-02-03 | 2007-02-02 | Compuesto de l-tartrato de s-zopiclona y proceso para resolver los enantiomeros de zopiclona. |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US20070203145A1 (es) |
| EP (1) | EP1984371A1 (es) |
| AR (1) | AR059296A1 (es) |
| WO (1) | WO2007088073A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2671800B1 (fr) * | 1991-01-17 | 1993-03-12 | Rhone Poulenc Rorer Sa | Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent. |
| US7476737B2 (en) * | 2005-09-05 | 2009-01-13 | Dr. Reddy's Laboratories Limited | Eszopiclone process |
| WO2007109799A2 (en) * | 2006-03-23 | 2007-09-27 | Teva Pharmaceutical Industries Ltd. | Polymorphs of eszopiclone malate |
| US20070270590A1 (en) * | 2006-04-20 | 2007-11-22 | Marioara Mendelovici | Methods for preparing eszopiclone crystalline form a, substantially pure eszopiclone and optically enriched eszopiclone |
| EP1904499A1 (en) * | 2006-06-26 | 2008-04-02 | Teva Pharmaceutical Industries Ltd | Process for the preparation of zopiclone |
| US20080287447A1 (en) * | 2007-01-31 | 2008-11-20 | Nina Finkelstein | Methods for preparing eszopiclone |
| US20090018336A1 (en) * | 2007-06-25 | 2009-01-15 | Nina Finkelstein | Racemization process of R-zopiclone |
| EP2020403A1 (en) | 2007-08-02 | 2009-02-04 | Esteve Quimica, S.A. | Process for the resolution of zopiclone and intermediate compounds |
| ES2324136B1 (es) * | 2007-10-11 | 2010-05-31 | Apotecnia S.A. | Nuevo procedimiento de sintesis y purificacion de (s)-zopiclone cristalino anhidro. |
| WO2009085988A1 (en) * | 2007-12-19 | 2009-07-09 | Sepracor Inc. | Salts of 6-(5-chloro-2-pyridyl)-5-[(4-methyl-1-piperazinyl)carbonyloxy]-7-oxo-6,7- dihydro-5h-pyrrolo[3,4-b]pyrazine |
| CN101607961B (zh) * | 2008-06-18 | 2011-08-10 | 天津天士力集团有限公司 | 一种右佐匹克隆结晶及其组合物 |
| WO2010052475A1 (en) * | 2008-11-07 | 2010-05-14 | Cipla Limited | Process for resolving zopiclone |
| CN103193779B (zh) * | 2012-01-05 | 2016-04-20 | 成都弘达药业有限公司 | 一种右佐匹克隆的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| OA04285A (fr) * | 1972-01-07 | 1979-12-31 | Rhone Poulenc Sa | Nouveaux dérivés de la pyrrolo (3,4-b) pyrazine et leur préparation. |
| FR2671800B1 (fr) * | 1991-01-17 | 1993-03-12 | Rhone Poulenc Rorer Sa | Derive de la 5h-pyrrolo[3,4-b]pyrazine optiquement actif, sa preparation et les compositions pharmaceutiques qui le contiennent. |
-
2007
- 2007-02-02 US US11/670,657 patent/US20070203145A1/en not_active Abandoned
- 2007-02-02 AR ARP070100446A patent/AR059296A1/es unknown
- 2007-02-02 WO PCT/EP2007/000985 patent/WO2007088073A1/en not_active Ceased
- 2007-02-02 EP EP07703294A patent/EP1984371A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2007088073A1 (en) | 2007-08-09 |
| EP1984371A1 (en) | 2008-10-29 |
| US20070203145A1 (en) | 2007-08-30 |
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