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AR058982A1 - Vector de expresion de la proteina bicunina y metodo para producir dicha proteina - Google Patents

Vector de expresion de la proteina bicunina y metodo para producir dicha proteina

Info

Publication number
AR058982A1
AR058982A1 ARP070100116A ARP070100116A AR058982A1 AR 058982 A1 AR058982 A1 AR 058982A1 AR P070100116 A ARP070100116 A AR P070100116A AR P070100116 A ARP070100116 A AR P070100116A AR 058982 A1 AR058982 A1 AR 058982A1
Authority
AR
Argentina
Prior art keywords
protein
cysteine
bicunin
produce
expression vector
Prior art date
Application number
ARP070100116A
Other languages
English (en)
Original Assignee
Aerovance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aerovance Inc filed Critical Aerovance Inc
Publication of AR058982A1 publication Critical patent/AR058982A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • C07K14/8117—Bovine/basic pancreatic trypsin inhibitor (BPTI, aprotinin)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • C07K14/8114—Kunitz type inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Psychiatry (AREA)
  • Plant Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)

Abstract

Métodos tanto para producir la proteína como para inhibir la actividad de serina proteasa. Reivindicacion 1: Un vector autoreplicante de expresion de proteína caracterizado porque contiene una secuencia de ácido nucleico que codifica para y es capaz de expresar proteínas seleccionadas de al menos una de las siguientes secuencias proteicas. (Ver dibujo)à, donde los aminoácidos de las secuencias están numerados de acuerdo con la secuencia de aminoácidos de la bicunina placentaria humana mostrada en la SEC.ID. N°49; o donde dicha proteína está glicosilada, o contiene al menos un enlace de disulfuro cisteína-cisteína dentro de la cadena, o está glicosilada y también contiene al menos un enlace de disulfuro cisteína-cisteína dentro de la cadena; y un vehículo farmacéuticamente aceptable.
ARP070100116A 1996-03-11 2007-01-11 Vector de expresion de la proteina bicunina y metodo para producir dicha proteina AR058982A1 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US1310696P 1996-03-11 1996-03-11
US1979396P 1996-06-14 1996-06-14
US72525196A 1996-10-04 1996-10-04

Publications (1)

Publication Number Publication Date
AR058982A1 true AR058982A1 (es) 2008-03-05

Family

ID=27359773

Family Applications (3)

Application Number Title Priority Date Filing Date
ARP970100967A AR006188A1 (es) 1996-03-11 1997-03-11 "composicion farmaceutica para inhibir la actividad de serinproteasa, metodo in vitro para inhibir la actividad de serinproteasa y metodo para preparar dicha composicion".
ARP060101562A AR053063A2 (es) 1996-03-11 2006-04-20 Proteina sustancialmente purificada y composicion farmaceutica que la comprende
ARP070100116A AR058982A1 (es) 1996-03-11 2007-01-11 Vector de expresion de la proteina bicunina y metodo para producir dicha proteina

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ARP970100967A AR006188A1 (es) 1996-03-11 1997-03-11 "composicion farmaceutica para inhibir la actividad de serinproteasa, metodo in vitro para inhibir la actividad de serinproteasa y metodo para preparar dicha composicion".
ARP060101562A AR053063A2 (es) 1996-03-11 2006-04-20 Proteina sustancialmente purificada y composicion farmaceutica que la comprende

Country Status (27)

Country Link
US (3) US6583108B1 (es)
EP (1) EP0891426B1 (es)
JP (2) JP3469584B2 (es)
KR (1) KR100356956B1 (es)
AR (3) AR006188A1 (es)
AT (1) ATE328083T1 (es)
AU (1) AU716923B2 (es)
BR (1) BR9708021A (es)
CA (1) CA2247888A1 (es)
CO (1) CO4600683A1 (es)
DE (1) DE69735996T2 (es)
DK (1) DK0891426T3 (es)
ES (1) ES2263174T3 (es)
HR (1) HRP970144B1 (es)
HU (1) HU226419B1 (es)
ID (1) ID16224A (es)
IL (1) IL126115A (es)
IN (1) IN192874B (es)
MY (1) MY120693A (es)
NZ (1) NZ331540A (es)
PA (1) PA8426301A1 (es)
PL (1) PL188387B1 (es)
PT (1) PT891426E (es)
SV (1) SV1997000018A (es)
TR (1) TR199801794T2 (es)
WO (1) WO1997033996A2 (es)
YU (1) YU8997A (es)

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Also Published As

Publication number Publication date
PL188387B1 (pl) 2005-01-31
BR9708021A (pt) 1999-07-27
ID16224A (id) 1997-09-11
HUP9902698A2 (hu) 1999-11-29
EP0891426B1 (en) 2006-05-31
PA8426301A1 (es) 2000-05-24
KR100356956B1 (ko) 2003-03-15
WO1997033996A2 (en) 1997-09-18
PL328822A1 (en) 1999-02-15
JP3469584B2 (ja) 2003-11-25
AU716923B2 (en) 2000-03-09
AR006188A1 (es) 1999-08-11
IN192874B (es) 2004-05-29
US7452859B2 (en) 2008-11-18
JP2004000208A (ja) 2004-01-08
WO1997033996A3 (en) 1997-11-13
ATE328083T1 (de) 2006-06-15
CA2247888A1 (en) 1997-09-18
DK0891426T3 (da) 2006-10-02
DE69735996T2 (de) 2007-02-15
KR19990087697A (ko) 1999-12-27
SV1997000018A (es) 1999-01-14
YU8997A (sh) 1999-09-27
US20030194398A1 (en) 2003-10-16
AR053063A2 (es) 2007-04-18
EP0891426A2 (en) 1999-01-20
US6583108B1 (en) 2003-06-24
HUP9902698A3 (en) 2001-06-28
DE69735996D1 (de) 2006-07-06
HRP970144A2 (en) 1998-04-30
HRP970144B1 (en) 2004-10-31
CO4600683A1 (es) 1998-05-08
IL126115A (en) 2007-03-08
PT891426E (pt) 2006-10-31
US7019123B2 (en) 2006-03-28
NZ331540A (en) 1999-10-28
HU226419B1 (en) 2008-12-29
TR199801794T2 (xx) 2000-07-21
JP2001521367A (ja) 2001-11-06
AU2207797A (en) 1997-10-01
US20060172946A1 (en) 2006-08-03
MY120693A (en) 2005-11-30
IL126115A0 (en) 1999-05-09
ES2263174T3 (es) 2006-12-01

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