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AR047732A1 - Nitrooxiderivados de drogas antihipertensivas - Google Patents

Nitrooxiderivados de drogas antihipertensivas

Info

Publication number
AR047732A1
AR047732A1 ARP040104485A ARP040104485A AR047732A1 AR 047732 A1 AR047732 A1 AR 047732A1 AR P040104485 A ARP040104485 A AR P040104485A AR P040104485 A ARP040104485 A AR P040104485A AR 047732 A1 AR047732 A1 AR 047732A1
Authority
AR
Argentina
Prior art keywords
group
integer
formula
ono2
formulas
Prior art date
Application number
ARP040104485A
Other languages
English (en)
Original Assignee
Nicox Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nicox Sa filed Critical Nicox Sa
Publication of AR047732A1 publication Critical patent/AR047732A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/14—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C219/06—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/30—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C07C233/33—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/04—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C235/08—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton being acyclic and saturated having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/82—Carbazoles; Hydrogenated carbazoles
    • C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/10—One of the condensed rings being a six-membered aromatic ring the other ring being six-membered, e.g. tetraline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Ophthalmology & Optometry (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Nitooxiderivados de bloqueadores b-adrenérgicos y enantiomeros y diastereoisomeros y sus sales aceptables para uso farmacéutico de los mismos. Composiciones farmacéuticas que los contienen y su uso para el tratamiento de hipertension, enfermedades cardiovasculares, glaucoma, migrana y enfermedades vasculares. Reivindicacion 1: Un compuesto caracterizado porque es de formula general A-(Y-ONO2)s (1) y los enantiomeros, diastereoisomeros y sales aceptables para uso farmacéutico del mismo donde: s es un entero igual a 1 o 2; A se selecciona ente los siguientes residuos bloqueadores beta-adrenérgicos de formula (2), donde R1 se selecciona entre el grupo que comprende: las formulas (2a) a (2i) y (2l) a (2n); R2 se selecciona entre el grupo que comprende: -CH(CH2)2, -C(CH3)3 o las formulas 3a y 3b cuando el radical R1 se selecciona entre las formulas (2a), (2c), (2d), (2g), (2h), (2i), (2m), R2 es -CH(CH3)2; cuando el radical R1 se selecciona entre las formulas (2e), (2f) o (2n), R2 es -C(CH3)3; cuando R1 es el radical (2b), R2 es (3a); cuando R1 es el radical (2l), R2 es (3b); Z es H o es u grupo capaz de unirse a Y seleccionado entre el grupo que comprende -C(O)-, -C(O)O- o como se muestra en la formula (4) donde R??y Rö son iguales o distintos, y son H o C1-4 alquilo lineal o ramificado; Z1 es H o un grupo -C(O)- capaz de unirse a Y; con la condicion de que cuando s de formula (1) es 1, Z o Z1 es H; Y es un radical bivalente con el siguiente significado: a) -C1-20 alquileno lineal o ramificado que está opcionalmente sustituido con uno más de los sustituyentes seleccionados entre el grupo que comprende: átomos de halogeno, hidroxi, -ONO2 o T es -OC(O)(C1-10 alquil)-ONO2, -O(C1-10 alquil)-ONO2; b) cicloalquileno con entre 5 y 7 átomos de C en el anillo cicloalquileno, donde el anillo está opcionalmente sustituido con cadenas laterales T1, donde T1 es alquilo lineal o ramificado con entre 1 y 10 átomos de C; c) formula (5) donde: n es un entero entre 0 y 20 y n1 es un entero entre 1 y 20; n2, n3, n4 y n5 son enteros iguales o distintos entre sí, igual a 0 o 1; R3 y R4 se seleccionan en forma independiente entre H o CH3; Y1 es -CH2- o -(CH2)na-CH= CH- donde na es un entero entre 0 y 20; X1 es -WC(O)- o -C(O)W-, donde W es O, S o NH; d) formula (6) donde: n1 y X1 son como se ha definido; n6 es un entero entre 1 uy 20 y n7 es un entero entre 0 y 20, R5 y R5?? R6 y R6?? se selecc ionan en forma independiente entre el grupo que comprende H, CH3, OH, NH2, NHCOCH3, COOH, CH2SH y C(CH3)2SH; cuando el enlace entre los C CA Y CB es un doble enlace R5 y R6 o R6?? y R5?? están ausentes; con la condicion de que cuando Y se selecciona entre los radicales bivalentes mencionados en c)- d), el grupo -ONO2 está unido al grupo -(CH2)n1-; e)formula (7) y formula (8) donde X2 es O o S, n10a, n10 y n12 son enteros seleccionados en forma independiente entre 0 y 20, n11 es un entero entre 0 y 6; R11 es H, CH3 o nitrooxi; R11a es CH3 o grupo nitrooxi; f) formula (9) donde n8 es un entero entre 0 y 10; n9 es un entero entre 1 y 10; R9, R10, R8, R7 son iguales o distintos, y son H o C1-4 alquilo lineal o ramificado; donde el grupo -ONO2 está unido a =[C]-n9 donde n9 es como se ha definido Y2 es un anillo heterocíclico saturado, insaturado o aromático de 5 o 6 miembros, con uno o más heteroátomos seleccionados entre N, O, S, y se selecciona entre el grupo que comprende: las formulas (Y1) a (Y13).
ARP040104485A 2003-12-02 2004-12-01 Nitrooxiderivados de drogas antihipertensivas AR047732A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03104484 2003-12-02

Publications (1)

Publication Number Publication Date
AR047732A1 true AR047732A1 (es) 2006-02-15

Family

ID=34639309

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040104485A AR047732A1 (es) 2003-12-02 2004-12-01 Nitrooxiderivados de drogas antihipertensivas

Country Status (22)

Country Link
US (1) US7825263B2 (es)
EP (1) EP1691804B1 (es)
JP (1) JP2007513114A (es)
KR (1) KR20060120677A (es)
CN (1) CN1886132A (es)
AR (1) AR047732A1 (es)
AT (1) ATE358478T1 (es)
AU (1) AU2004294297A1 (es)
BR (1) BRPI0416584A (es)
CA (1) CA2548129A1 (es)
DE (1) DE602004005748T2 (es)
DK (1) DK1691804T3 (es)
ES (1) ES2285549T3 (es)
HR (1) HRP20070283T3 (es)
IL (1) IL174959A0 (es)
NO (1) NO20063057L (es)
PL (2) PL380065A1 (es)
PT (1) PT1691804E (es)
RU (1) RU2006119528A (es)
SI (1) SI1691804T1 (es)
WO (1) WO2005053685A1 (es)
ZA (1) ZA200604458B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2446064A1 (en) 2001-05-02 2002-11-07 Nitromed, Inc. Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use
EP1981852A1 (en) 2006-02-06 2008-10-22 NicOx S.A. Nitrooxy-comprising derivatives of apraclonidine and brimodnidine as al pha2 -adrenergic receptor agonists
WO2007090733A1 (en) * 2006-02-06 2007-08-16 Nicox S.A. Nitrooxy derivatives suitable as alpha2 adrenergic receptor agonists
US9782488B2 (en) 2007-03-12 2017-10-10 Nektar Therapeutics Oligomer-beta blocker conjugates
US8425972B2 (en) 2007-05-14 2013-04-23 Covidien Lp Antimicrobial materials and coatings
US8062653B2 (en) * 2009-02-18 2011-11-22 Bezwada Biomedical, Llc Controlled release of nitric oxide and drugs from functionalized macromers and oligomers
WO2018161039A1 (en) 2017-03-03 2018-09-07 Synovo Gmbh Novel anti-infective and anti-inflammatory compounds
CN115246774A (zh) * 2021-04-27 2022-10-28 南昌弘益科技有限公司 一类新型双羰基类阿魏酸衍生物

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2805404A1 (de) * 1978-02-09 1979-08-16 Merck Patent Gmbh 1-aryloxy-3-nitratoalkylamino-2-propanole und verfahren zu ihrer herstellung
DE3443998A1 (de) * 1984-12-01 1986-06-05 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel sowie zwischenprodukte
DE3512627A1 (de) * 1985-04-06 1986-10-09 Boehringer Mannheim Gmbh, 6800 Mannheim Amino-propanol-derivate, verfahren zu deren herstellung, verwendung derselben und diese enthaltende arzneimittel
ES2065291B1 (es) * 1993-07-30 1995-10-01 Prodesfarma Sa "nitrato esteres de 1-ariloxi-3-alquilamino-2-propanoles, utilizacion y composicion farmaceutica correspondiente"
US5932538A (en) * 1996-02-02 1999-08-03 Nitromed, Inc. Nitrosated and nitrosylated α-adrenergic receptor antagonist compounds, compositions and their uses
IT1295694B1 (it) * 1996-11-14 1999-05-27 Nicox Sa Nitrossi derivati per la preparazione di medicamenti ad attivita antitrombinica
PE20001302A1 (es) * 1998-11-27 2000-11-30 Hoffmann La Roche Preparaciones de una combinacion farmaceutica que contiene carvedilol e hidroclorotiazida
IT1311924B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IT1311923B1 (it) * 1999-04-13 2002-03-20 Nicox Sa Composti farmaceutici.
IT1314184B1 (it) * 1999-08-12 2002-12-06 Nicox Sa Composizioni farmaceutiche per la terapia di condizioni di stressossidativo
EP1385509A4 (en) * 2001-04-02 2004-06-30 Smithkline Beecham Corp TREATMENT METHOD
US7119229B2 (en) * 2001-05-28 2006-10-10 Chemtech Research Incorporation Alkaloid derivative and a pharmaceutical composition containing the same
ITMI20020148A1 (it) * 2002-01-29 2003-07-29 Nicox Sa Nuovi corticosteroidi

Also Published As

Publication number Publication date
EP1691804A1 (en) 2006-08-23
AU2004294297A1 (en) 2005-06-16
PL380065A1 (pl) 2006-12-11
KR20060120677A (ko) 2006-11-27
DE602004005748D1 (de) 2007-05-16
NO20063057L (no) 2006-06-30
CA2548129A1 (en) 2005-06-16
HRP20070283T3 (en) 2007-11-30
DE602004005748T2 (de) 2007-12-27
BRPI0416584A (pt) 2007-01-30
SI1691804T1 (sl) 2007-10-31
PL1691804T3 (pl) 2007-08-31
PT1691804E (pt) 2007-07-04
US7825263B2 (en) 2010-11-02
IL174959A0 (en) 2006-08-20
US20070072854A1 (en) 2007-03-29
ES2285549T3 (es) 2007-11-16
WO2005053685A1 (en) 2005-06-16
ATE358478T1 (de) 2007-04-15
DK1691804T3 (da) 2007-07-16
JP2007513114A (ja) 2007-05-24
RU2006119528A (ru) 2008-01-10
ZA200604458B (en) 2007-04-25
CN1886132A (zh) 2006-12-27
EP1691804B1 (en) 2007-04-04

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