AR045100A1 - Pirimidinas sustituidas, procedimiento para su obtencion y su uso en productos pesticidas - Google Patents
Pirimidinas sustituidas, procedimiento para su obtencion y su uso en productos pesticidasInfo
- Publication number
- AR045100A1 AR045100A1 ARP040102631A ARP040102631A AR045100A1 AR 045100 A1 AR045100 A1 AR 045100A1 AR P040102631 A ARP040102631 A AR P040102631A AR P040102631 A ARP040102631 A AR P040102631A AR 045100 A1 AR045100 A1 AR 045100A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkenyl
- alkynyl
- cyano
- alkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Pirimidinas sustituidas, procedimiento para su obtención, productos pesticidas que las contienen y el uso de las mismas como pesticidas. Reivindicación 1: Pirimidinas 2-sustituidas, caracterizadas porque la fórmula (1) en la que el índice y los sustituyentes tienen los significados siguientes: n es un número entero de 1 a 5; L es halógeno, ciano, cianato (OCN), -alquilo C1-8, alquenilo C2-8, alquinilo C2-8, alcoxi C1-6, alqueniloxi C2-8, alquiniloxi C2-8, cicloalquilo C3-6, cicloalquenilo C4-6, cicloalquiloxi C3-6, cicloalqueniloxi C4-6, nitro, -C(=O)-A, -C(=O)-O-A, -C(=O)-N(A´)A, C(A´)(=N-OA), N(A´)A, N(A´)-C(=O)-A, N(A")-C(=O)-N(A´)A, S(=O)m-A, S(=O)m-O-A o S(=O)m-N(A´)A, m es 0, 1 o 2; A, A´, A" significan, independientemente, H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-8, cicloalquenilo C3-8, fenilo, pudiendo los radicales orgánicos estar parcial o completamente halogenados o sustituidos por nitro, cianato, ciano o alcoxi C1-4: o pudiendo A y A´ formar juntos con los átomos a los que están ligados un heterociclo saturado, parcialmente insaturado o aromático de cinco a seis miembros que contiene uno a cuatro heteroátomos del grupo O, N o S; pudiendo los grupos alifáticos de las demás definiciones de L estar parcial o completamente halogenados o llevar uno a cuatro grupos Ru; Ru significa ciano, alcoxi C1-6, cicloalquilo C3-6, alqueniloxi C2-8, alquiniloxi C2-8, cicloalquenilo C4-6, cicloalquiloxi C3-6, cicloalqueniloxi C4-6, -C(=O)-A, -C(=O)-O-A, -C(=O)-N(A´)A, C(A´)(=N-OA), N(A´)A, N(A´)-C(=O)-A, N(A")-C(=O)-N(A´)A, S(=O)m-A, S(=O)m-O-A o S(=O)m-N(A´)A; R1, R2 significan, independientemente, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, halógenocicloalquilo C3-6, pudiendo los grupos alifáticos de las definiciones de los radicales R1 y R2 a su parte estar parcial o completamente halogenados o llevar uno a cuatro grupos Rv; Rv ciano, cicloalquilo C3-6, cicloalquenilo C4-6, hidroxi, alcoxi C1-6-, alqueniloxi C2-8, alquiniloxi C2-8, cicloalquiloxi C3-6cicloalqueniloxi C4-6, alquiltio C1-6, -C(=O)-A, -C(=O)-O-A, -C(=O)-N(A´)A, C(A´)(=N-OA), N(A´)A, N(A´)-C(=O)-A, N(A")-C(=O)-N(A´)A, S(=O)m-A, S(=O)m-O-A o S(=O)m-N(A´)A o fenilo, pudiendo la parte de fenilo llevar uno a tres radicales seleccionados del grupo halógeno, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-6, halógenoalquilo C1-6, alcoxi C1-6, ciano, nitro, -C(=O)-A, -C(=O)-O-A, -C(=O)-N(A´)A, C(A´)(=N-OA), N(A´)A; R2 puede significar, adicionalmente H; R1 y R2 pueden formar junto con el átomo de N al que están ligados un anillo saturado o no saturado de cinco o seis miembros, que puede estar interrumpido por un grupo éter-(-O-), carbonilo-(C=O), tio-(-S-), sulfóxido -(-S[=O]-) o sulfenilo-(-SO2-) o un grupo amino -(-N(Ra) adicional, donde Ra es H o alquilo C1-6, y/o contener uno o varios sustituyentes del grupo: halógeno, alquilo C1-6halógenoalquiloC1-6- y oxi- alquilenoxi C1-3; R3 es halógeno, ciano, alquilo C1-4, alquenilo C2-4, alquinilo C2-4, cicloalquilo C3-6, alcoxi C1-4, alqueniloxi C3-4, alquiniloxi C3-4, alquiltio C1-6, di-(alquil C1-6)amino o alquilamino C1-6, pudiendo los radicales alquilo, alquenilo y alquinilo de R3 estar sustituidos por halógeno, ciano, nitro, alcoxi C1-2 o alcoxicarbonilo C1-4; R4 corresponde a una de las fórmulas (2) donde X significa un enlace directo, -(C=O), -(C=O)-NH, -(C=O)-O, -O, -NRc, -CH2-O-(C=O), -C=C-(C=O), estando cada vez el átomo izquierdo del miembro de puente ligado con el átomo de N; Ra significa H, alquilo C1-6, alquenilo C2-8, alquinilo C2-8 o bencilo; Rb es H, alquilo C1-6, alquenilo C2-6 o alquinilo C2-6; Rc es H, alquilo C1-6, alquenilo C2-6, alquinilo C2-6,bencilo o acilo C1-6 pudiendo los grupos alifáticos, alicíclicos o aromáticos de las definiciones de los radicales de Ra, Rb y/o Rc a su vez llevar uno a dos grupos Rw; Rw significa halógeno, ciano, ORx, NHRx, SRx, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, alcoxi C1-6, alcoxicarbonilo C1-4, acilamino C1-4, [1,3]dioxolanoalquilo C1-4, [1,3]dioxano-alquilo C1-4, donde Rx significa H, alquilo C1-6, alquenilo C2-8,alquinilo C2-8 o bencilo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10333857 | 2003-07-24 | ||
| DE10357714 | 2003-12-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR045100A1 true AR045100A1 (es) | 2005-10-12 |
Family
ID=34117367
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP040102631A AR045100A1 (es) | 2003-07-24 | 2004-07-23 | Pirimidinas sustituidas, procedimiento para su obtencion y su uso en productos pesticidas |
Country Status (30)
| Country | Link |
|---|---|
| US (1) | US7375108B2 (es) |
| EP (1) | EP1651618B1 (es) |
| JP (1) | JP2006528603A (es) |
| KR (1) | KR20060052857A (es) |
| AP (1) | AP2157A (es) |
| AR (1) | AR045100A1 (es) |
| AT (1) | ATE350370T1 (es) |
| AU (1) | AU2004261373B8 (es) |
| BR (1) | BRPI0412891A (es) |
| CA (1) | CA2532718A1 (es) |
| CO (1) | CO5660292A2 (es) |
| CR (1) | CR8184A (es) |
| CY (1) | CY1106391T1 (es) |
| DE (1) | DE502004002570D1 (es) |
| DK (1) | DK1651618T3 (es) |
| EA (1) | EA010566B1 (es) |
| EC (1) | ECSP066278A (es) |
| ES (1) | ES2279395T3 (es) |
| HR (1) | HRP20070057T3 (es) |
| IL (1) | IL172848A0 (es) |
| MA (1) | MA27949A1 (es) |
| MX (1) | MXPA06000038A (es) |
| NZ (1) | NZ545103A (es) |
| PE (1) | PE20050882A1 (es) |
| PL (1) | PL1651618T3 (es) |
| PT (1) | PT1651618E (es) |
| SI (1) | SI1651618T1 (es) |
| TW (1) | TW200516075A (es) |
| UY (1) | UY28436A1 (es) |
| WO (1) | WO2005012261A1 (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080132522A1 (en) * | 2004-07-14 | 2008-06-05 | Basf Aktiengesellschaft | 2-Substituted Pyrimidines, Method for Their Production and Their Use for Controlling Pathogenic Fungi |
| CL2007002231A1 (es) * | 2006-08-02 | 2008-04-11 | Basf Ag | Uso de compuestos derivados de 5-(het) arilpirimidina para combatir hongos daninos; compuestos derivados de 5-(het) arilpirimidina; agente fungicida; y agente farmaceutico. |
| NZ710405A (en) * | 2010-11-16 | 2017-04-28 | Acetylon Pharmaceuticals Inc | Pyrimidine hydroxy amide compounds as protein deacetylase inhibitors and methods of use thereof |
| ES2929576T3 (es) | 2013-10-08 | 2022-11-30 | Acetylon Pharmaceuticals Inc | Combinaciones de inhibidores de histona deacetilasa 6 y el inhibidor de Her2 lapatinib para el uso en el tratamiento del cáncer de mama |
| EP3055299B1 (en) | 2013-10-10 | 2021-01-06 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as histone deacetylase inhibitors |
| US10660890B2 (en) | 2013-10-24 | 2020-05-26 | National Institutes Of Health (Nih), U.S. Dept. Of Health And Human Services (Dhhs), U.S. Government Nih Division Of Extramural Inventions And Technology Resources (Deitr) | Treatment of polycystic diseases with an HDAC6 inhibitor |
| KR20160092018A (ko) | 2013-12-03 | 2016-08-03 | 에이스틸론 파마수티컬스 인코포레이티드 | 히스톤 탈아세틸화효소 저해제 및 면역조절 약물의 조합 |
| US9464073B2 (en) | 2014-02-26 | 2016-10-11 | Acetylon Pharmaceuticals, Inc. | Pyrimidine hydroxy amide compounds as HDAC6 selective inhibitors |
| AU2015288060A1 (en) | 2014-07-07 | 2017-02-09 | Acetylon Pharmaceuticals, Inc. | Treatment of leukemia with histone deacetylase inhibitors |
| AU2015356779A1 (en) | 2014-12-05 | 2017-07-13 | University of Modena and Reggio Emilia | Combinations of histone deacetylase inhibitors and bendamustine for use in the treatment of lymphoma |
| US10272084B2 (en) | 2015-06-01 | 2019-04-30 | Regenacy Pharmaceuticals, Llc | Histone deacetylase 6 selective inhibitors for the treatment of cisplatin-induced peripheral neuropathy |
| EP3445364A4 (en) | 2016-04-19 | 2019-11-27 | Acetylon Pharmaceuticals, Inc. | HDAC INHIBITORS, ONLY OR IN COMBINATION WITH BTK INHIBITORS, FOR THE TREATMENT OF CHRONIC LYMPHOCYTIC LEUKEMIA |
| WO2018016596A1 (ja) * | 2016-07-20 | 2018-01-25 | 国立大学法人東北大学 | ＰＰＡＲαアゴニストを含有する、肺高血圧症の予防又は治療剤 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL362551A1 (en) | 2000-06-13 | 2004-11-02 | Basf Aktiengesellschaft | Fungicidal 5-phenyl substituted 2-(cyanoamino) pyrimidines |
| HUP0400210A3 (en) * | 2001-03-15 | 2005-11-28 | Basf Ag | 5-phenylpyrimidine, methods and intermediate products for the production thereof and use of the same for controlling pathogenic fungi |
| CA2467683C (en) | 2001-11-19 | 2011-09-27 | Basf Aktiengesellschaft | 5-phenylpyrimidines, agents comprising the same, method for production and use thereof |
-
2004
- 2004-07-15 WO PCT/EP2004/007877 patent/WO2005012261A1/de not_active Ceased
- 2004-07-15 AT AT04741053T patent/ATE350370T1/de not_active IP Right Cessation
- 2004-07-15 ES ES04741053T patent/ES2279395T3/es not_active Expired - Lifetime
- 2004-07-15 DK DK04741053T patent/DK1651618T3/da active
- 2004-07-15 DE DE502004002570T patent/DE502004002570D1/de not_active Expired - Lifetime
- 2004-07-15 EA EA200600212A patent/EA010566B1/ru not_active IP Right Cessation
- 2004-07-15 JP JP2006520743A patent/JP2006528603A/ja active Pending
- 2004-07-15 EP EP04741053A patent/EP1651618B1/de not_active Expired - Lifetime
- 2004-07-15 CA CA002532718A patent/CA2532718A1/en not_active Abandoned
- 2004-07-15 HR HR20070057T patent/HRP20070057T3/xx unknown
- 2004-07-15 BR BRPI0412891-5A patent/BRPI0412891A/pt not_active IP Right Cessation
- 2004-07-15 AP AP2006003497A patent/AP2157A/xx active
- 2004-07-15 MX MXPA06000038A patent/MXPA06000038A/es active IP Right Grant
- 2004-07-15 PT PT04741053T patent/PT1651618E/pt unknown
- 2004-07-15 NZ NZ545103A patent/NZ545103A/en unknown
- 2004-07-15 SI SI200430228T patent/SI1651618T1/sl unknown
- 2004-07-15 AU AU2004261373A patent/AU2004261373B8/en not_active Ceased
- 2004-07-15 KR KR1020067001493A patent/KR20060052857A/ko not_active Ceased
- 2004-07-15 US US10/564,013 patent/US7375108B2/en not_active Expired - Fee Related
- 2004-07-15 PL PL04741053T patent/PL1651618T3/pl unknown
- 2004-07-22 PE PE2004000707A patent/PE20050882A1/es not_active Application Discontinuation
- 2004-07-23 TW TW093122163A patent/TW200516075A/zh unknown
- 2004-07-23 AR ARP040102631A patent/AR045100A1/es active IP Right Grant
- 2004-07-23 UY UY28436A patent/UY28436A1/es unknown
-
2005
- 2005-12-27 IL IL172848A patent/IL172848A0/en not_active IP Right Cessation
-
2006
- 2006-01-11 CR CR8184A patent/CR8184A/es unknown
- 2006-01-11 EC EC2006006278A patent/ECSP066278A/es unknown
- 2006-01-24 CO CO06006393A patent/CO5660292A2/es not_active Application Discontinuation
- 2006-02-15 MA MA28806A patent/MA27949A1/fr unknown
-
2007
- 2007-03-16 CY CY20071100372T patent/CY1106391T1/el unknown
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Legal Events
| Date | Code | Title | Description |
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| FG | Grant, registration |