AR039955A1 - Preparados con principio activo en forma de pelicula con mejora de la estabilidad quimica, y procedimiento para su fabricacion - Google Patents
Preparados con principio activo en forma de pelicula con mejora de la estabilidad quimica, y procedimiento para su fabricacionInfo
- Publication number
- AR039955A1 AR039955A1 ARP030101977A ARP030101977A AR039955A1 AR 039955 A1 AR039955 A1 AR 039955A1 AR P030101977 A ARP030101977 A AR P030101977A AR P030101977 A ARP030101977 A AR P030101977A AR 039955 A1 AR039955 A1 AR 039955A1
- Authority
- AR
- Argentina
- Prior art keywords
- cellulose
- preparation
- polymers
- formulation
- prepared according
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 239000004615 ingredient Substances 0.000 abstract 6
- 239000000203 mixture Substances 0.000 abstract 6
- 238000002360 preparation method Methods 0.000 abstract 6
- 238000009472 formulation Methods 0.000 abstract 5
- 229920000642 polymer Polymers 0.000 abstract 5
- 150000002978 peroxides Chemical class 0.000 abstract 4
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 abstract 3
- 239000001863 hydroxypropyl cellulose Substances 0.000 abstract 3
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 abstract 3
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 3
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 3
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 3
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 3
- 239000011159 matrix material Substances 0.000 abstract 3
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 102000004169 proteins and genes Human genes 0.000 abstract 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 abstract 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 abstract 2
- 239000004372 Polyvinyl alcohol Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000013543 active substance Substances 0.000 abstract 2
- 229920000615 alginic acid Polymers 0.000 abstract 2
- 235000010443 alginic acid Nutrition 0.000 abstract 2
- 229920002678 cellulose Polymers 0.000 abstract 2
- 239000001913 cellulose Substances 0.000 abstract 2
- 229920003086 cellulose ether Polymers 0.000 abstract 2
- 239000006185 dispersion Substances 0.000 abstract 2
- 239000000499 gel Substances 0.000 abstract 2
- 210000000214 mouth Anatomy 0.000 abstract 2
- 229920000058 polyacrylate Polymers 0.000 abstract 2
- 229920002689 polyvinyl acetate Polymers 0.000 abstract 2
- 239000011118 polyvinyl acetate Substances 0.000 abstract 2
- 229920002451 polyvinyl alcohol Polymers 0.000 abstract 2
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 2
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 2
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 abstract 2
- 235000010262 sodium metabisulphite Nutrition 0.000 abstract 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 abstract 2
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 abstract 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 abstract 1
- KUNNUNBSGQSGDY-UHFFFAOYSA-N 2-butyl-6-methylphenol Chemical compound CCCCC1=CC=CC(C)=C1O KUNNUNBSGQSGDY-UHFFFAOYSA-N 0.000 abstract 1
- GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 abstract 1
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 abstract 1
- 229920002307 Dextran Polymers 0.000 abstract 1
- 239000001856 Ethyl cellulose Substances 0.000 abstract 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 abstract 1
- 108010010803 Gelatin Proteins 0.000 abstract 1
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 abstract 1
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 abstract 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 abstract 1
- 229920002125 Sokalan® Polymers 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 abstract 1
- 229930003427 Vitamin E Natural products 0.000 abstract 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 230000003078 antioxidant effect Effects 0.000 abstract 1
- 235000006708 antioxidants Nutrition 0.000 abstract 1
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 235000010323 ascorbic acid Nutrition 0.000 abstract 1
- 229960005070 ascorbic acid Drugs 0.000 abstract 1
- 239000011668 ascorbic acid Substances 0.000 abstract 1
- 235000010385 ascorbyl palmitate Nutrition 0.000 abstract 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 abstract 1
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 abstract 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 abstract 1
- 238000005266 casting Methods 0.000 abstract 1
- 229920002301 cellulose acetate Polymers 0.000 abstract 1
- 238000001816 cooling Methods 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- -1 especially pululane Polymers 0.000 abstract 1
- 229920001249 ethyl cellulose Polymers 0.000 abstract 1
- 235000019325 ethyl cellulose Nutrition 0.000 abstract 1
- 238000001125 extrusion Methods 0.000 abstract 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 abstract 1
- 239000008273 gelatin Substances 0.000 abstract 1
- 229920000159 gelatin Polymers 0.000 abstract 1
- 235000019322 gelatine Nutrition 0.000 abstract 1
- 235000011852 gelatine desserts Nutrition 0.000 abstract 1
- 150000004676 glycans Chemical class 0.000 abstract 1
- 235000015110 jellies Nutrition 0.000 abstract 1
- 239000008274 jelly Substances 0.000 abstract 1
- 229920000609 methyl cellulose Polymers 0.000 abstract 1
- 239000001923 methylcellulose Substances 0.000 abstract 1
- 235000010981 methylcellulose Nutrition 0.000 abstract 1
- PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 abstract 1
- 239000001814 pectin Substances 0.000 abstract 1
- 235000010987 pectin Nutrition 0.000 abstract 1
- 229920001277 pectin Polymers 0.000 abstract 1
- 239000004584 polyacrylic acid Substances 0.000 abstract 1
- 229920000193 polymethacrylate Polymers 0.000 abstract 1
- 229920001282 polysaccharide Polymers 0.000 abstract 1
- 239000005017 polysaccharide Substances 0.000 abstract 1
- 229920002635 polyurethane Polymers 0.000 abstract 1
- 239000004814 polyurethane Substances 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- 238000007761 roller coating Methods 0.000 abstract 1
- 229940001584 sodium metabisulfite Drugs 0.000 abstract 1
- 235000010265 sodium sulphite Nutrition 0.000 abstract 1
- 238000005507 spraying Methods 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000000758 substrate Substances 0.000 abstract 1
- 229940035024 thioglycerol Drugs 0.000 abstract 1
- 229930003799 tocopherol Natural products 0.000 abstract 1
- 239000011732 tocopherol Substances 0.000 abstract 1
- 229940042585 tocopherol acetate Drugs 0.000 abstract 1
- 235000019149 tocopherols Nutrition 0.000 abstract 1
- 235000019155 vitamin A Nutrition 0.000 abstract 1
- 239000011719 vitamin A Substances 0.000 abstract 1
- 235000019165 vitamin E Nutrition 0.000 abstract 1
- 239000011709 vitamin E Substances 0.000 abstract 1
- 229940046009 vitamin E Drugs 0.000 abstract 1
- 229940045997 vitamin a Drugs 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
- 229920001285 xanthan gum Polymers 0.000 abstract 1
- QUEDXNHFTDJVIY-UHFFFAOYSA-N γ-tocopherol Chemical class OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 QUEDXNHFTDJVIY-UHFFFAOYSA-N 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
Landscapes
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Physiology (AREA)
- Nutrition Science (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
Un preparado en forma de película con principio activo para la aplicación en la cavidad bucal o para la aplicación transmucosal, caracterizado porque el preparado se ajusta a un índice de peróxidos de 40 como máximo. Reivindicación 4: Preparado según una de las reivindicaciones precedentes, caracterizado porque contiene al menos un antioxidante, seleccionado preferentemente del grupo que comprende ácido ascórbico, ascorbilpalmitato, sulfito sódico, disulfito de sodio, metabisulfito sódico, tocoferoles (vitamina E), tocoferolacetato, tioglicerol, ácido tioglicólico, vitamina A, propilgalato, octilgalato, butilhidroxianisol y butilhidroxitoluol. Reivindicación 6: Preparado según una de las reivindicaciones precedentes, caracterizado porque tiene una matriz de polímeros de una o varias capas, en que al menos una capa contiene sustancia activa. Reivindicación 7:Preparado según la reivindicación 6, caracterizado por que la matriz contiene uno o varios polímeros, que se elige o eligen del grupo que comprende éteres de celulosa, en especial etilcelulosa, propilcelulosa, carboximetilcelulosa (CMC), hidroxipropilcelulosa (HPC), hidroxipropilmetilcelulosa (HPMC), mezclas de éteres de celulosa, así como acetato de celulosa, polivinilalcohol, polivinilacetato, polivinilpirrolidonas, polímeros de óxido de polietileno, poliuretano, ácido poliacrílico, poliacrilatos, polimetacrilatos, alginatos, pectinas, gelatina, almidones y gomas naturales. Reivindicación 8: Preparado según la reivindicación 6, caracterizado por que la matriz contiene uno o varios polímeros, que se selecciona(n) del grupo de los polímeros hidrófilos, solubles en agua o descomponibles en medios acuosos, preferentemente del grupo que comprende: derivados de celulosa, en especial hidroxipropilmetilcelulosa, carboximetilcelulosa, hidroxipropilcelulosa y metilcelulosa, así como alcohol polivinílico, acetato de polivinilo, polivinilpirrolidona, poliacrilatos, polisacáridos solubles en agua, en especial pululano, xantano, alginatos, dextranos y pectinas, proteínas, con preferencia proteínas que forman geles, en especial gelatina. Reivindicación 15: Procedimiento para la fabricación de un preparado en forma de película con principio activo para la aplicación en la cavidad bucal o para la aplicación transmucosal, caracterizado por las siguientes etapas de trabajo: a) Determinación del índice de peróxidos de cada uno de los ingredientes de la formulación previstos en la fabricación del preparado según la fórmula. (b) Selección de los ingredientes de la formulación de manera que la suma de los índices de peróxidos de los distintos ingredientes de la formulación sea de 40 como máximo, donde el índice de peróxidos de cada ingrediente de la formulación se pondera en función de la fracción porcentual de dicho ingrediente en el preparado. (c) Generación de una disolución, dispersión o colada, que contenga los ingredientes de la formulación seleccionada junto con la(s) sustancia(s) activa(s) a liberar; (d) Extensión de esta disolución, dispersión o colada sobre un substrato inerte mediante rasqueta, recubrimiento por rodillos, rociado o extrusión y el consiguiente secado o refrigerado, de manera que se forme una capa laminar.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10224612A DE10224612A1 (de) | 2002-06-04 | 2002-06-04 | Wirkstoffhaltige filmförmige Zubereitungen mit verbesserter chemischer Stabilität, und Verfahren zu deren Herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR039955A1 true AR039955A1 (es) | 2005-03-09 |
Family
ID=29594232
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP030101977A AR039955A1 (es) | 2002-06-04 | 2003-06-04 | Preparados con principio activo en forma de pelicula con mejora de la estabilidad quimica, y procedimiento para su fabricacion |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US20050226823A1 (es) |
| EP (1) | EP1509201B1 (es) |
| JP (1) | JP2005528427A (es) |
| KR (1) | KR20050010024A (es) |
| CN (1) | CN1658833A (es) |
| AR (1) | AR039955A1 (es) |
| AT (1) | ATE426400T1 (es) |
| AU (1) | AU2003236632B2 (es) |
| BR (1) | BR0311663A (es) |
| CA (1) | CA2487590C (es) |
| DE (2) | DE10224612A1 (es) |
| ES (1) | ES2324909T3 (es) |
| RU (1) | RU2311900C2 (es) |
| TW (1) | TWI344373B (es) |
| WO (1) | WO2003101421A1 (es) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200514579A (en) * | 2003-07-24 | 2005-05-01 | Smithkline Beecham Corp | Orally dissolving films |
| DE10361306A1 (de) * | 2003-12-24 | 2005-07-28 | Lts Lohmann Therapie-Systeme Ag | Wundauflage und Wundschnellverband mit einem vasokonstriktorischen Inhaltsstoff, sowie Herstellungsverfahren hierfür |
| PE20060935A1 (es) | 2004-10-21 | 2006-10-26 | Novartis Ag | Composicion farmaceutica que comprende diclofenaco |
| DE102005005974A1 (de) * | 2005-02-09 | 2006-08-10 | Basf Ag | Verfahren zur Stabilisierung von Polyvinylpyrrolidonen |
| EP1888025B1 (en) * | 2005-06-08 | 2020-08-12 | Basf Corporation | Medicament carrier composition and method of forming a film therefrom |
| EP1937414A4 (en) * | 2005-09-19 | 2013-01-02 | Univ Witwatersrand Jhb | OROMUCOSAL DRUG ADMINISTRATIVE FORM |
| KR100742432B1 (ko) * | 2005-12-27 | 2007-07-24 | 한미약품 주식회사 | 암로디핀 캠실레이트 및 심바스타틴을 포함하는 복합제제,및 이의 제조방법 |
| FR2902655B1 (fr) * | 2006-06-23 | 2008-11-28 | Oreal | Compositon topique a effet froid |
| RU2418574C2 (ru) * | 2007-02-08 | 2011-05-20 | Медтроник Ксомед Инк. | Сольватирующая система и герметик для медицинского применения |
| JP5138765B2 (ja) | 2008-03-18 | 2013-02-06 | 日本たばこ産業株式会社 | シガレット主流煙成分吸着剤およびシガレット用フィルタ |
| EP2320739B1 (en) * | 2008-08-01 | 2019-11-27 | Chiesi Farmaceutici S.p.A. | Pharmaceutical compositions and methods for stabilizing the same |
| US9044475B2 (en) | 2009-06-12 | 2015-06-02 | Cynapsus Therapeutics, Inc. | Sublingual apomorphine |
| ES2791715T3 (es) | 2010-12-16 | 2020-11-05 | Sunovion Pharmaceuticals Inc | Películas sublinguales |
| JP5725940B2 (ja) * | 2011-04-01 | 2015-05-27 | 日東電工株式会社 | ニコチン含有貼付製剤 |
| CN103788552B (zh) * | 2012-10-26 | 2016-12-21 | 厦门加岩高分子材料有限公司 | 聚乙烯醇共混物 |
| US10045993B2 (en) * | 2014-06-20 | 2018-08-14 | Ctc Bio, Inc. | Pharmaceutical preparation containing entecavir as active ingredient, and preparation method therefor |
| WO2016172095A1 (en) | 2015-04-21 | 2016-10-27 | Cynapsus Therapeutics, Inc. | Methods of treating parkinson's disease by administration of apomorphine to an oral mucosa |
| WO2017081725A1 (ja) * | 2015-11-09 | 2017-05-18 | 花王株式会社 | 口腔用組成物 |
| US11648212B2 (en) * | 2016-02-03 | 2023-05-16 | Intelgenx Corp. | Loxapine film oral dosage form |
| DE102017127452A1 (de) * | 2017-11-21 | 2019-05-23 | Lts Lohmann Therapie-Systeme Ag | Wasserlösliche Polymerklebschichten |
| WO2019171843A1 (ja) * | 2018-03-05 | 2019-09-12 | パナソニックＩｐマネジメント株式会社 | 化粧料または医療材料 |
| IT201800011125A1 (it) | 2018-12-14 | 2020-06-14 | Dpl Pharma S P A | Composizioni farmaceutiche orali solide comprendenti matrici monolitiche complesse per la somministrazione cronotropica di medicamenti nel tratto gastroenterico |
| CN110339118B (zh) * | 2019-08-19 | 2022-08-16 | 广州明辉化妆品有限公司 | 具有美白保湿功效的美白霜 |
| SE544672C2 (en) | 2020-05-07 | 2022-10-11 | Liw Innovation Ab | New compositions for oral or nasal use |
| IT202000011050A1 (it) | 2020-05-14 | 2021-11-14 | Mogon Pharmaceuticals Sagl | Composizioni orali solide comprendenti matrici monolitiche composite per la somministrazione cronotropica nel tratto gastroenterico di ingredienti attivi |
| IT202000011053A1 (it) | 2020-05-14 | 2021-11-14 | Int Health Science S R L | Composizioni orali solide comprendenti matrici monolitiche composite per la somministrazione cronotropica nel tratto gastroenterico di alimenti, integratori alimentari, nutraceutici, dispositivi medici |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63501794A (ja) * | 1985-10-09 | 1988-07-21 | デジテイン アルツナイミツテル ゲ−エムベ−ハ− | 医薬有効物質，試薬，その他の作用物質の提供ないし投与形態の製造法 |
| US5032384A (en) * | 1989-01-27 | 1991-07-16 | Block Drug Company, Inc. | Compositions and method for the treatment of disease |
| IL97930A (en) * | 1991-04-23 | 1996-06-18 | Perio Prod Ltd | Preparations for whitening two controlled release products that contain a super-oxygen compound |
| JP2671248B2 (ja) * | 1991-10-23 | 1997-10-29 | ブロック・ドラッグ・カンパニー・インコーポレイテッド | 薬効または化粧効果成分の浸透性増進方法 |
| EP0648114B1 (de) * | 1992-07-08 | 1997-09-17 | DIANORM G. Maierhofer GmbH | Liposomen, verfahren zu ihrer herstellung und ihre verwendung zur herstellung eines arzneimittels |
| HU224035B1 (hu) * | 1996-05-13 | 2005-05-30 | Novartis Consumer Health S.A. | Bukkális adagolórendszer |
| US6375963B1 (en) * | 1999-06-16 | 2002-04-23 | Michael A. Repka | Bioadhesive hot-melt extruded film for topical and mucosal adhesion applications and drug delivery and process for preparation thereof |
| RU2155071C1 (ru) * | 1999-08-10 | 2000-08-27 | Мизина Прасковья Георгиевна | Способ получения лекарственной фитопленки |
| AU779523B2 (en) * | 1999-11-29 | 2005-01-27 | Lts Lohmann Therapie-Systeme Ag | Transdermal therapeutic systems with improved stability and a method for the production thereof |
| DE10018834A1 (de) * | 2000-04-15 | 2001-10-25 | Lohmann Therapie Syst Lts | Transdermale oder transmucosale Darreichungsformen mit einer nicotinhaltigen Wirkstoffkombination zur Raucherentwöhnung |
| DE10107659B4 (de) * | 2001-02-19 | 2008-03-13 | Lts Lohmann Therapie-Systeme Ag | Mucoadhäsive zerfallsfähige Arzneizubereitung zur Wirkstoffverabreichung in der Veterinär- und Humanmedizin |
| RU2195545C1 (ru) * | 2001-08-14 | 2002-12-27 | Хаминов Николай Иванович | Способ изоляции промытых зон в добывающей и нагнетательной скважинах |
-
2002
- 2002-06-04 DE DE10224612A patent/DE10224612A1/de not_active Withdrawn
-
2003
- 2003-05-08 AT AT03735367T patent/ATE426400T1/de not_active IP Right Cessation
- 2003-05-08 BR BR0311663-8A patent/BR0311663A/pt not_active Application Discontinuation
- 2003-05-08 JP JP2004508779A patent/JP2005528427A/ja active Pending
- 2003-05-08 CA CA2487590A patent/CA2487590C/en not_active Expired - Fee Related
- 2003-05-08 KR KR10-2004-7019688A patent/KR20050010024A/ko not_active Ceased
- 2003-05-08 CN CN03812839XA patent/CN1658833A/zh active Pending
- 2003-05-08 EP EP03735367A patent/EP1509201B1/de not_active Expired - Lifetime
- 2003-05-08 US US10/517,087 patent/US20050226823A1/en not_active Abandoned
- 2003-05-08 DE DE50311338T patent/DE50311338D1/de not_active Expired - Lifetime
- 2003-05-08 WO PCT/EP2003/004816 patent/WO2003101421A1/de not_active Ceased
- 2003-05-08 RU RU2004136576/15A patent/RU2311900C2/ru not_active IP Right Cessation
- 2003-05-08 ES ES03735367T patent/ES2324909T3/es not_active Expired - Lifetime
- 2003-05-08 AU AU2003236632A patent/AU2003236632B2/en not_active Ceased
- 2003-05-26 TW TW092114186A patent/TWI344373B/zh not_active IP Right Cessation
- 2003-06-04 AR ARP030101977A patent/AR039955A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2004136576A (ru) | 2005-08-27 |
| CA2487590C (en) | 2011-01-11 |
| TWI344373B (en) | 2011-07-01 |
| AU2003236632B2 (en) | 2008-07-31 |
| BR0311663A (pt) | 2005-06-28 |
| AU2003236632A1 (en) | 2003-12-19 |
| ATE426400T1 (de) | 2009-04-15 |
| DE10224612A1 (de) | 2003-12-24 |
| DE50311338D1 (de) | 2009-05-07 |
| WO2003101421A1 (de) | 2003-12-11 |
| WO2003101421A8 (de) | 2005-04-21 |
| CA2487590A1 (en) | 2003-12-11 |
| CN1658833A (zh) | 2005-08-24 |
| JP2005528427A (ja) | 2005-09-22 |
| RU2311900C2 (ru) | 2007-12-10 |
| US20050226823A1 (en) | 2005-10-13 |
| TW200307566A (en) | 2003-12-16 |
| KR20050010024A (ko) | 2005-01-26 |
| EP1509201A1 (de) | 2005-03-02 |
| ES2324909T3 (es) | 2009-08-19 |
| EP1509201B1 (de) | 2009-03-25 |
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