AR037878A1 - Procedimientos para preparar inhibidores de tipo-1 de intercambiador sodio-hidrogeno - Google Patents
Procedimientos para preparar inhibidores de tipo-1 de intercambiador sodio-hidrogenoInfo
- Publication number
- AR037878A1 AR037878A1 ARP020104909A ARP020104909A AR037878A1 AR 037878 A1 AR037878 A1 AR 037878A1 AR P020104909 A ARP020104909 A AR P020104909A AR P020104909 A ARP020104909 A AR P020104909A AR 037878 A1 AR037878 A1 AR 037878A1
- Authority
- AR
- Argentina
- Prior art keywords
- hydrogen
- formula
- mixture
- compound
- sodium
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 102000052126 Sodium-Hydrogen Exchangers Human genes 0.000 title abstract 2
- 108091006672 Sodium–hydrogen antiporter Proteins 0.000 title abstract 2
- 239000000203 mixture Substances 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- 229910052739 hydrogen Chemical group 0.000 abstract 4
- 239000001257 hydrogen Chemical group 0.000 abstract 4
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 abstract 2
- 102100030980 Sodium/hydrogen exchanger 1 Human genes 0.000 abstract 2
- 108010093115 growth factor-activatable Na-H exchanger NHE-1 Proteins 0.000 abstract 2
- 229910052736 halogen Chemical group 0.000 abstract 2
- 150000002367 halogens Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical group [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Epidemiology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a procedimientos de preparación de inhibidores de tipo 1 (NHE-1) de intercambiador sodio-hidrógeno de fórmula (1), y a procedimientos de preparación de composiciones farmacéuticas que comprenden tales inhibidores NHE-1. Reivindicaciones 1: Un método de preparación de un compuesto de fórmula (1), caracterizado porque comprende: combinar una mezcla de acetonitrilo y un compuesto de la fórmula (2), con cloruro de tionilo para formar una mezcla que comprende un compuesto de fórmula (3), evaporar el exceso de cloruro de tionilo de dicha mezcla para formar una mezcla evaporada; y combinar dicha mezcla evaporada con guanidina para formar un compuesto de fórmula (1), enla que R1 es metilsulfonilo o hidrógeno; R2 es hidrógeno o un halógeno; R3 es hidrógeno; R4 es hidrógeno o un halógeno; o R3 y R4, junto con los átomos de carbono a los que están unidos, forman un anillo de seis miembros completamente insaturado que tiene un heteroátomo que es nitrógeno.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34288801P | 2001-12-19 | 2001-12-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR037878A1 true AR037878A1 (es) | 2004-12-09 |
Family
ID=23343711
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020104909A AR037878A1 (es) | 2001-12-19 | 2002-12-17 | Procedimientos para preparar inhibidores de tipo-1 de intercambiador sodio-hidrogeno |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6627643B2 (es) |
| EP (1) | EP1456181A1 (es) |
| JP (1) | JP2005511787A (es) |
| AR (1) | AR037878A1 (es) |
| AU (1) | AU2002337460A1 (es) |
| BR (1) | BR0215002A (es) |
| CA (1) | CA2469305A1 (es) |
| MX (1) | MXPA04004685A (es) |
| TW (1) | TW200304819A (es) |
| WO (1) | WO2003051845A1 (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4975641B2 (ja) * | 2004-12-27 | 2012-07-11 | コリア リサーチ インスティテュート オブ ケミカル テクノロジー | ベンゾチオフェン−２−カルボニルグアニジン誘導体、その製造方法およびその誘導体を含む薬学的組成物 |
| BRPI0610459A2 (pt) | 2005-04-05 | 2010-06-22 | Hoffmann La Roche | composto, processo para a sua preparação, composições farmacêuticas que o compreendem, método para o tratamento terapêutico e/ou profilático de enfermidades que são moduladas por inibidores de deidrogenase de hidroxiesteróides-11b e utilização do composto |
| ES2548002T3 (es) | 2006-03-22 | 2015-10-13 | F. Hoffmann-La Roche Ag | Pirazoles como 11beta-SD1 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1289326A (zh) | 1998-02-27 | 2001-03-28 | 辉瑞产品公司 | 用于治疗局部缺血的n－[(取代的五元二氮杂或三氮杂二不饱和环)羰基]胍衍生物 |
| US6441176B1 (en) * | 1999-10-29 | 2002-08-27 | Pfizer Inc. | Method for preparing sodium-hydrogen exchanger type 1 inhibitor |
| IL152075A0 (en) * | 2000-04-28 | 2003-05-29 | Pfizer Prod Inc | Sodium-hydrogen exchanger type 1 inhibitor (nhe-1) |
| AU2002210839A1 (en) | 2000-11-28 | 2002-06-11 | Pfizer Products Inc. | Preparation of sodium-hydrogen exchanger type-1 inhibitors |
-
2002
- 2002-10-10 BR BR0215002-6A patent/BR0215002A/pt not_active IP Right Cessation
- 2002-10-10 CA CA002469305A patent/CA2469305A1/en not_active Abandoned
- 2002-10-10 WO PCT/IB2002/004191 patent/WO2003051845A1/en not_active Ceased
- 2002-10-10 JP JP2003552731A patent/JP2005511787A/ja active Pending
- 2002-10-10 AU AU2002337460A patent/AU2002337460A1/en not_active Abandoned
- 2002-10-10 MX MXPA04004685A patent/MXPA04004685A/es unknown
- 2002-10-10 EP EP02772734A patent/EP1456181A1/en not_active Withdrawn
- 2002-12-13 TW TW091136093A patent/TW200304819A/zh unknown
- 2002-12-16 US US10/320,186 patent/US6627643B2/en not_active Expired - Fee Related
- 2002-12-17 AR ARP020104909A patent/AR037878A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| MXPA04004685A (es) | 2004-08-12 |
| JP2005511787A (ja) | 2005-04-28 |
| WO2003051845A1 (en) | 2003-06-26 |
| BR0215002A (pt) | 2004-11-09 |
| EP1456181A1 (en) | 2004-09-15 |
| CA2469305A1 (en) | 2003-06-26 |
| US6627643B2 (en) | 2003-09-30 |
| TW200304819A (en) | 2003-10-16 |
| US20030119873A1 (en) | 2003-06-26 |
| AU2002337460A1 (en) | 2003-06-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CL2012000999A1 (es) | Compuestos derivados de pirazoloespirocetona sustituida, inhibidores de acetil-coa carboxilasa; composicion farmaceutica que los comprende; uso para tratar o retrasar la progresion o el inicio de diabetes tipo 2, higado graso no alcoholico (hgna) o la resistencia hepatica a la insulina. | |
| AR077416A2 (es) | Compuesto polimorfo estable de flibanserina , procedimiento industrial para su preparacion y uso del mismo para preparar medicamentos | |
| CR10145A (es) | Derivados de tropano útiles en terapia (divisional exp. 6800) | |
| PE20040373A1 (es) | Composiciones herbicidas que comprenden derivados de isoxazolina | |
| CO5170534A1 (es) | Derivados de fenil propionamida como activadores de la glucoquinasa | |
| CO5660262A2 (es) | Composicion farmaceutica que contiene un inhibidor de histona deacetilasa | |
| KR930016389A (ko) | No 신타제 및 시클로옥시게나제의 이중 억제제, 이들의 제조방법 및 이들을 함유하는 치료 조성물 | |
| CO5150164A1 (es) | Derivados de pirazolopiridina | |
| EA200971100A1 (ru) | Производные фталазинона в качестве ингибиторов поли(адф-рибоза)полимеразы (parp-1) | |
| AR049578A1 (es) | Derivados de hidantoina, procesos de obtencion y composiciones farmaceuticas | |
| DK1485377T5 (da) | Pyranoner egnede som ATM-inhibitorer | |
| CO5580821A2 (es) | 4-cetolactamas y -lactonas 3-fenil-3-substituidas, espirociclicas | |
| PA8654501A1 (es) | Derivados de quinazolina inhibidores de quinasas dirigidos a multiples blancos | |
| BR112017015958A2 (pt) | material de base transdermicamente absorvível contendo composto lípido-péptido | |
| AR012732A1 (es) | Derivados de fenilquinolinas, procedimientos para su preparacion, composiciones farmaceuticas, y su uso para la fabricacion de medicamentos | |
| AR009572A1 (es) | Derivados de 3,4,5,6,7,8-hexahidro pirido (4',3':4,5) tieno (2,3-d) pirimidina sustituidos en posicion 3 y su uso | |
| AR057855A1 (es) | Derivados de pirazina y composicion farmaceutica | |
| CO5080727A1 (es) | Ligandos azabiciclicos de receptores 5 ht1 | |
| PA8534001A1 (es) | Derivados de piperazina 1,4-disustituida utiles como bloqueadores alfa1,-adrenoceptores uro-selectivos | |
| AR037878A1 (es) | Procedimientos para preparar inhibidores de tipo-1 de intercambiador sodio-hidrogeno | |
| CR20250098A (es) | Inhibidores de sik novedosos | |
| NO912298D0 (no) | Fremgangsmaate for fremstilling av terapeutisk aktive 1,3-dioksanderivater. | |
| AR035601A1 (es) | Procesos de preparacion de inhibidores del intercambiador de sodio-hidrogeno de tipo 1, inhibidores, sales de dichos compuestos, composiciones farmaceuticas y uso de los mismos en la preparación de medicamentos | |
| AR046768A1 (es) | Derivados de piridin-tetrazol, metodos de obtencion y composiciones farmaceuticas | |
| PE20030724A1 (es) | Compuestos azapoliciclicos condensados con arilo |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |