AR034658A1 - Derivados de indol - Google Patents
Derivados de indolInfo
- Publication number
- AR034658A1 AR034658A1 ARP020102449A ARP020102449A AR034658A1 AR 034658 A1 AR034658 A1 AR 034658A1 AR P020102449 A ARP020102449 A AR P020102449A AR P020102449 A ARP020102449 A AR P020102449A AR 034658 A1 AR034658 A1 AR 034658A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- cycloalkyl
- independently represent
- represent hydrogen
- acyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Nutrition Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
Abstract
Un derivado de heteroarilo que tiene la fórmula (1) en la cual A representa O u S; n es 2, 3, 4, 5, 6, 7, 8, 9, o 10; m es 2 o 3; W representa N, C o CH; Q representa N, C o CH; y la línea punteada representa un enlace opcional; R1 representa hidrógeno, alquilo, C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquil C3-8-alquilo C1-6, aril-alquilo C1-6 o acilo; R2, R3, R4, R5 y R6 representan independientemente, hidrógeno, halógeno, ciano, nitro, alquilo C1-6, alcoxi C1-6, alquilsulfanilo C1-6, alquilsulfonilo C1-6, hidroxi, hidroxi-alquilo C1-6, alcoxicarbonilo C1-6, acilo, cicloalquilo C3-8, cicloalquilo C3-8-alquilo C1-6, trifluorometilo, trifluorometoxi, NR15R16 en donde R15 y R16 representan independientemente hidrógeno, alquilo C1-6, cicloalquilo C3-8 o fenilo; o R15 y R16 junto con el nitrógeno al cual están unidos forman un anillo de 5 o 6 miembros que contiene optativamente un heteroátomo adicional; R7 y R7' representan independientemente hidrógeno, alquilo C1-6 o pueden formar en conjunto un puente que consiste en dos o tres grupos metileno; R8, R9, R10 y R11 son cada uno independientemente seleccionados entre hidrógeno, halógeno, nitro, ciano, trifluorometilo, trifluorometoxi, alquilo C1-6, alquenilo C2-6, alquinilo C2-6, cicloalquilo C3-8, cicloalquil C3-8-alquilo, fenilo, tiofenilo, alcoxi C1-6, alquilsulfanilo C1-6, alquilsulfonilo C1-6, hidroxi, formilo, acilo, acilamino, aminocarbonilo, alcoxi C1-6carbonilamino, aminocarbonilamino, alquil C1-6aminocarbonilamino y di(alquil-C1-6)aminocarbonilamino, NR13R14 en donde R13 y R14 representan independientemente hidrógeno alquilo C1-6, cicloalquilo C3-8 o fenilo; o R13 y R14 junto con el nitrógeno al cual están adheridos forman un anillo de 5 o 6 miembros que contiene optativamente un heteroátomo adicional; sus enantiómeros, y su sal de adición de ácido farmacéuticamente aceptable. Los compuestos de la invención son considerados útiles para el tratamiento de trastornos afectivos como ser el trastorno de ansiedad general, trastorno de pánico, trastorno obsesivo compulsivo, depresión, fobia social, y trastornos de la alimentación y trastornos neurológicos como ser la sicosis.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DKPA200101037 | 2001-06-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR034658A1 true AR034658A1 (es) | 2004-03-03 |
Family
ID=8160599
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP020102449A AR034658A1 (es) | 2001-06-29 | 2002-06-28 | Derivados de indol |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US7342015B2 (es) |
| EP (1) | EP1399434B1 (es) |
| JP (1) | JP2004535448A (es) |
| KR (1) | KR20040019027A (es) |
| CN (1) | CN100338058C (es) |
| AR (1) | AR034658A1 (es) |
| AT (1) | ATE304007T1 (es) |
| AU (1) | AU2002344950B2 (es) |
| BG (1) | BG108538A (es) |
| BR (1) | BR0210407A (es) |
| CA (1) | CA2451229C (es) |
| CZ (1) | CZ2004155A3 (es) |
| DE (1) | DE60206043T2 (es) |
| DK (1) | DK1399434T3 (es) |
| EA (1) | EA006104B1 (es) |
| ES (1) | ES2247347T3 (es) |
| HU (1) | HUP0400834A2 (es) |
| IL (1) | IL158830A0 (es) |
| IS (1) | IS2431B (es) |
| MX (1) | MXPA03011766A (es) |
| NO (1) | NO326513B1 (es) |
| NZ (1) | NZ529461A (es) |
| PL (1) | PL366520A1 (es) |
| SK (1) | SK642004A3 (es) |
| UA (1) | UA74651C2 (es) |
| WO (1) | WO2003002552A1 (es) |
| ZA (1) | ZA200308848B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040248883A1 (en) * | 2001-06-29 | 2004-12-09 | Mario Rottlander | Novel heteroaryl derivatives, their preparation and use |
| DE602005016836D1 (de) | 2004-11-26 | 2009-11-05 | Janssen Pharmaceutica Nv | Chotischer und anxiolytischer aktivität |
| TWI329641B (en) * | 2005-08-31 | 2010-09-01 | Otsuka Pharma Co Ltd | (benzo[b]thiophen-4-yl)piperazine compounds, pharmaceutical compositions comprising the same, uses of the same and processes for preparing the same |
| JP4785881B2 (ja) * | 2007-02-27 | 2011-10-05 | 大塚製薬株式会社 | 医薬 |
| CN116554145B (zh) * | 2022-01-29 | 2025-06-03 | 江苏恩华药业股份有限公司 | 芳烷基-4-(1h)吲哚基哌嗪衍生物、其制备方法和应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0900792B1 (en) | 1997-09-02 | 2003-10-29 | Duphar International Research B.V | Piperazine and piperidine derivatives as 5-HT1A and dopamine D2-receptor (ant)agonists |
| EP1076647A2 (en) * | 1998-04-29 | 2001-02-21 | American Home Products Corporation | Antipsychotic indolyl derivatives |
| AR027134A1 (es) * | 1999-12-30 | 2003-03-12 | Lundbeck & Co As H | Derivados de indol. |
| US20040248883A1 (en) | 2001-06-29 | 2004-12-09 | Mario Rottlander | Novel heteroaryl derivatives, their preparation and use |
-
2002
- 2002-06-27 KR KR10-2003-7017127A patent/KR20040019027A/ko not_active Ceased
- 2002-06-27 HU HU0400834A patent/HUP0400834A2/hu unknown
- 2002-06-27 BR BR0210407-5A patent/BR0210407A/pt not_active IP Right Cessation
- 2002-06-27 NZ NZ529461A patent/NZ529461A/en unknown
- 2002-06-27 JP JP2003508933A patent/JP2004535448A/ja active Pending
- 2002-06-27 PL PL02366520A patent/PL366520A1/xx not_active Application Discontinuation
- 2002-06-27 CA CA002451229A patent/CA2451229C/en not_active Expired - Fee Related
- 2002-06-27 EA EA200400104A patent/EA006104B1/ru not_active IP Right Cessation
- 2002-06-27 AU AU2002344950A patent/AU2002344950B2/en not_active Ceased
- 2002-06-27 SK SK64-2004A patent/SK642004A3/sk unknown
- 2002-06-27 IL IL15883002A patent/IL158830A0/xx unknown
- 2002-06-27 DE DE60206043T patent/DE60206043T2/de not_active Expired - Fee Related
- 2002-06-27 US US10/482,762 patent/US7342015B2/en not_active Expired - Fee Related
- 2002-06-27 ES ES02742850T patent/ES2247347T3/es not_active Expired - Lifetime
- 2002-06-27 AT AT02742850T patent/ATE304007T1/de not_active IP Right Cessation
- 2002-06-27 CZ CZ2004155A patent/CZ2004155A3/cs unknown
- 2002-06-27 CN CNB028131878A patent/CN100338058C/zh not_active Expired - Fee Related
- 2002-06-27 WO PCT/DK2002/000436 patent/WO2003002552A1/en not_active Ceased
- 2002-06-27 DK DK02742850T patent/DK1399434T3/da active
- 2002-06-27 MX MXPA03011766A patent/MXPA03011766A/es active IP Right Grant
- 2002-06-27 EP EP02742850A patent/EP1399434B1/en not_active Expired - Lifetime
- 2002-06-27 UA UA20031211983A patent/UA74651C2/uk unknown
- 2002-06-28 AR ARP020102449A patent/AR034658A1/es unknown
-
2003
- 2003-11-10 IS IS7022A patent/IS2431B/is unknown
- 2003-11-13 ZA ZA200308848A patent/ZA200308848B/en unknown
- 2003-12-18 NO NO20035672A patent/NO326513B1/no unknown
-
2004
- 2004-01-21 BG BG108538A patent/BG108538A/bg unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |