AR020326A1 - Proteina homologa a poli (adp-ribosa) polimerasa (parp), acido nucleico, vector recombinante, mamifero o celula eucariota parp-deficiente, metodo dedeteccion in vitro para inhibidores parp, composicion farmaceutica - Google Patents
Proteina homologa a poli (adp-ribosa) polimerasa (parp), acido nucleico, vector recombinante, mamifero o celula eucariota parp-deficiente, metodo dedeteccion in vitro para inhibidores parp, composicion farmaceuticaInfo
- Publication number
- AR020326A1 AR020326A1 ARP990102655A ARP990102655A AR020326A1 AR 020326 A1 AR020326 A1 AR 020326A1 AR P990102655 A ARP990102655 A AR P990102655A AR P990102655 A ARP990102655 A AR P990102655A AR 020326 A1 AR020326 A1 AR 020326A1
- Authority
- AR
- Argentina
- Prior art keywords
- parp
- protein
- adp
- ribose
- polymerase
- Prior art date
Links
- 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 title abstract 10
- 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 title abstract 10
- 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 title abstract 9
- 238000000338 in vitro Methods 0.000 title abstract 3
- 108020004707 nucleic acids Proteins 0.000 title abstract 3
- 102000039446 nucleic acids Human genes 0.000 title abstract 3
- 150000007523 nucleic acids Chemical class 0.000 title abstract 3
- 239000012661 PARP inhibitor Substances 0.000 title abstract 2
- 229940121906 Poly ADP ribose polymerase inhibitor Drugs 0.000 title abstract 2
- 238000001514 detection method Methods 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 108090000623 proteins and genes Proteins 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 abstract 3
- 238000000034 method Methods 0.000 abstract 3
- 241000124008 Mammalia Species 0.000 abstract 2
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003275 alpha amino acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000002950 deficient Effects 0.000 abstract 1
- 239000012636 effector Substances 0.000 abstract 1
- 210000003527 eukaryotic cell Anatomy 0.000 abstract 1
- 238000001415 gene therapy Methods 0.000 abstract 1
- 244000005700 microbiome Species 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000009261 transgenic effect Effects 0.000 abstract 1
- 239000011701 zinc Substances 0.000 abstract 1
- 229910052725 zinc Inorganic materials 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1048—Glycosyltransferases (2.4)
- C12N9/1077—Pentosyltransferases (2.4.2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving transferase
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y204/00—Glycosyltransferases (2.4)
- C12Y204/02—Pentosyltransferases (2.4.2)
- C12Y204/0203—NAD+ ADP-ribosyltransferase (2.4.2.30), i.e. tankyrase or poly(ADP-ribose) polymerase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/91—Transferases (2.)
- G01N2333/91091—Glycosyltransferases (2.4)
- G01N2333/91142—Pentosyltransferases (2.4.2)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Saccharide Compounds (AREA)
Abstract
Una homologa de la poli(ADP-ribosa)polimerasa (PARP) que posee una secuencia de aminoácidos que posee: a) un dominio funcional de union con NAD+yb) ningunpatron de secuencia tipo dado de zinc de formula general CX2CXmHX2C en el cual m es un numero entero entre 28 y 30 y los radicales X son independientemente unodel otro, aminoácidos cualesquiera, y los equivalentes funcionales de los mismos. Ligando para dicha proteína homologa, ácido nucleico, casete de expresion,vector recombinante, microorganismo recombinante, mamífero transgénico, mamífero o célula eucariota PARP-deficiente, método de deteccion in vitro parainhibidores PARP, método de busqueda in vitro para ligandos de una molécula de PARP, método para la determinacion cualitativa o cuantitava de ácidosnucleicos que codifican a una homologa de PARP,método para determinar la eficiencia de los efectores de PARP, composicion para terapia génica que comprende unaproteína PARP, composicion farmacéutica y uso de ligandos de PARP.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19825213 | 1998-06-05 | ||
| DE19908837 | 1999-03-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR020326A1 true AR020326A1 (es) | 2002-05-08 |
Family
ID=26046644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990102655A AR020326A1 (es) | 1998-06-05 | 1999-06-04 | Proteina homologa a poli (adp-ribosa) polimerasa (parp), acido nucleico, vector recombinante, mamifero o celula eucariota parp-deficiente, metodo dedeteccion in vitro para inhibidores parp, composicion farmaceutica |
Country Status (24)
| Country | Link |
|---|---|
| US (3) | US7754459B1 (es) |
| EP (1) | EP1082416B1 (es) |
| JP (1) | JP2002517231A (es) |
| KR (1) | KR20010052582A (es) |
| CN (1) | CN1304446A (es) |
| AR (1) | AR020326A1 (es) |
| AT (1) | ATE358175T1 (es) |
| AU (1) | AU4605999A (es) |
| BG (1) | BG105018A (es) |
| BR (1) | BR9910967A (es) |
| CA (1) | CA2330206C (es) |
| CO (1) | CO5070700A1 (es) |
| DE (1) | DE59914280D1 (es) |
| ES (1) | ES2285842T3 (es) |
| HK (1) | HK1038591A1 (es) |
| HR (1) | HRP20010013A2 (es) |
| HU (1) | HUP0103190A2 (es) |
| ID (1) | ID27819A (es) |
| IL (1) | IL139750A0 (es) |
| NO (1) | NO20006153L (es) |
| PL (1) | PL345334A1 (es) |
| SK (1) | SK17892000A3 (es) |
| TR (1) | TR200003624T2 (es) |
| WO (1) | WO1999064572A2 (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19921567A1 (de) | 1999-05-11 | 2000-11-16 | Basf Ag | Verwendung von Phthalazine-Derivaten |
| EP1192258A2 (en) * | 1999-06-16 | 2002-04-03 | Icos Corporation | Human poly(adp-ribose) polymerase 2 materials and methods |
| US7041675B2 (en) | 2000-02-01 | 2006-05-09 | Abbott Gmbh & Co. Kg | Heterocyclic compounds and their use as PARP inhibitors |
| SG164368A1 (en) | 2005-07-18 | 2010-09-29 | Bipar Sciences Inc | Treatment of cancer |
| CA2662517A1 (en) | 2006-09-05 | 2008-03-13 | Jerome Moore | Treatment of cancer |
| CA2662337A1 (en) | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof |
| RU2480211C2 (ru) | 2007-11-12 | 2013-04-27 | Байпар Сайенсиз, Инк. | Лечение рака молочной железы с помощью соединения 4-иод-3-нитробензамид в комбинации с противоопухолевыми средствами |
| GB201102857D0 (en) | 2011-02-18 | 2011-04-06 | Danisco | Feed additive composition |
| WO2012110776A2 (en) | 2011-02-18 | 2012-08-23 | Dupont Nutrition Biosciences Aps | Feed additive composition |
| GB201102865D0 (en) | 2011-02-18 | 2011-04-06 | Danisco | Feed additive composition |
| GB201213801D0 (en) | 2012-08-03 | 2012-09-12 | Dupont Nutrition Biosci Aps | Feed additive composition |
| AU2013308770B2 (en) | 2012-08-29 | 2019-01-17 | Sangamo Therapeutics, Inc. | Methods and compositions for treatment of a genetic condition |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5162508A (en) * | 1987-12-18 | 1992-11-10 | Compagnie Oris Industrie | Rare earth cryptates, processes for their preparation, synthesis intermediates and application as fluorescent tracers |
| US5272057A (en) | 1988-10-14 | 1993-12-21 | Georgetown University | Method of detecting a predisposition to cancer by the use of restriction fragment length polymorphism of the gene for human poly (ADP-ribose) polymerase |
| FR2707011A1 (en) * | 1993-06-25 | 1994-12-30 | Pasteur Sanofi Diagnostics | Immunological process for the detection and assay of antibodies directed against poly(ADP-ribose) polymerase, application to diagnosis, kit for its implementation |
| DE4444949C1 (de) * | 1994-12-16 | 1996-11-21 | Deutsches Krebsforsch | Vektoren und Viren zur Gentherapie |
-
1999
- 1999-06-02 CO CO99034565A patent/CO5070700A1/es unknown
- 1999-06-04 AR ARP990102655A patent/AR020326A1/es unknown
- 1999-06-04 DE DE59914280T patent/DE59914280D1/de not_active Expired - Lifetime
- 1999-06-04 US US09/701,586 patent/US7754459B1/en not_active Expired - Fee Related
- 1999-06-04 HR HR20010013A patent/HRP20010013A2/hr not_active Application Discontinuation
- 1999-06-04 BR BR9910967-0A patent/BR9910967A/pt not_active IP Right Cessation
- 1999-06-04 CA CA2330206A patent/CA2330206C/en not_active Expired - Fee Related
- 1999-06-04 KR KR1020007013762A patent/KR20010052582A/ko not_active Ceased
- 1999-06-04 SK SK1789-2000A patent/SK17892000A3/sk unknown
- 1999-06-04 EP EP99929144A patent/EP1082416B1/de not_active Expired - Lifetime
- 1999-06-04 TR TR2000/03624T patent/TR200003624T2/xx unknown
- 1999-06-04 HU HU0103190A patent/HUP0103190A2/hu unknown
- 1999-06-04 JP JP2000553562A patent/JP2002517231A/ja active Pending
- 1999-06-04 ID IDW20002542A patent/ID27819A/id unknown
- 1999-06-04 PL PL99345334A patent/PL345334A1/xx not_active Application Discontinuation
- 1999-06-04 IL IL13975099A patent/IL139750A0/xx unknown
- 1999-06-04 AU AU46059/99A patent/AU4605999A/en not_active Abandoned
- 1999-06-04 WO PCT/EP1999/003889 patent/WO1999064572A2/de not_active Ceased
- 1999-06-04 ES ES99929144T patent/ES2285842T3/es not_active Expired - Lifetime
- 1999-06-04 HK HK02100014.0A patent/HK1038591A1/zh unknown
- 1999-06-04 AT AT99929144T patent/ATE358175T1/de not_active IP Right Cessation
- 1999-06-04 CN CN99807043A patent/CN1304446A/zh active Pending
-
2000
- 2000-12-04 NO NO20006153A patent/NO20006153L/no not_active Application Discontinuation
- 2000-12-04 BG BG105018A patent/BG105018A/xx unknown
-
2010
- 2010-05-12 US US12/778,692 patent/US9051553B2/en not_active Expired - Fee Related
-
2015
- 2015-06-05 US US14/732,603 patent/US20160010067A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20110107444A1 (en) | 2011-05-05 |
| PL345334A1 (en) | 2001-12-17 |
| IL139750A0 (en) | 2002-02-10 |
| US7754459B1 (en) | 2010-07-13 |
| US9051553B2 (en) | 2015-06-09 |
| JP2002517231A (ja) | 2002-06-18 |
| CN1304446A (zh) | 2001-07-18 |
| EP1082416A2 (de) | 2001-03-14 |
| CA2330206A1 (en) | 1999-12-16 |
| HRP20010013A2 (en) | 2001-12-31 |
| NO20006153L (no) | 2001-02-02 |
| SK17892000A3 (sk) | 2001-09-11 |
| BG105018A (en) | 2001-12-31 |
| ES2285842T3 (es) | 2007-11-16 |
| HK1038591A1 (zh) | 2002-03-22 |
| NO20006153D0 (no) | 2000-12-04 |
| US20160010067A1 (en) | 2016-01-14 |
| BR9910967A (pt) | 2001-02-13 |
| ID27819A (id) | 2001-04-26 |
| AU4605999A (en) | 1999-12-30 |
| KR20010052582A (ko) | 2001-06-25 |
| WO1999064572A3 (de) | 2000-06-08 |
| TR200003624T2 (tr) | 2001-06-21 |
| CA2330206C (en) | 2010-04-13 |
| WO1999064572A2 (de) | 1999-12-16 |
| DE59914280D1 (en) | 2007-05-10 |
| EP1082416B1 (de) | 2007-03-28 |
| ATE358175T1 (de) | 2007-04-15 |
| HUP0103190A2 (hu) | 2001-12-28 |
| CO5070700A1 (es) | 2001-08-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |