AR029729A1 - DERIVATIVES OF POLIFLUOROALQUILTRIAZOL, ITS PREPARATION AND ITS USE IN THERAPEUTICS - Google Patents
DERIVATIVES OF POLIFLUOROALQUILTRIAZOL, ITS PREPARATION AND ITS USE IN THERAPEUTICSInfo
- Publication number
- AR029729A1 AR029729A1 ARP010103375A ARP010103375A AR029729A1 AR 029729 A1 AR029729 A1 AR 029729A1 AR P010103375 A ARP010103375 A AR P010103375A AR P010103375 A ARP010103375 A AR P010103375A AR 029729 A1 AR029729 A1 AR 029729A1
- Authority
- AR
- Argentina
- Prior art keywords
- therapeutics
- group
- polifluoroalquiltriazol
- derivatives
- preparation
- Prior art date
Links
- 239000003814 drug Substances 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
- 108091005482 5-HT4 receptors Proteins 0.000 abstract 1
- 102000017925 CHRM3 Human genes 0.000 abstract 1
- 101150060249 CHRM3 gene Proteins 0.000 abstract 1
- 229910006074 SO2NH2 Inorganic materials 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000005043 dihydropyranyl group Chemical group O1C(CCC=C1)* 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000004677 hydrates Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 1
- 125000002883 imidazolyl group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000004309 pyranyl group Chemical group O1C(C=CC=C1)* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- -1 salts N-oxides Chemical class 0.000 abstract 1
- 125000000565 sulfonamide group Chemical group 0.000 abstract 1
- 125000000335 thiazolyl group Chemical group 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
- C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D249/12—Oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
Compuesto de formula general 1 en la cual R1 es un grupo de formula CnHxFy, donde n =1 o 2 , x = 0 a 4, y = 1 a 5 y x + y = 2n + 1; R representa un grupo alquenilo, fenilo, tienilo, furilo, piridilo, imidazolilo, tiazolilo, piranilo o dihidropiranilo C2-4, eventualmente sustituido por uno o dos grupos R3; R2 y R3 representan independientemente entre sí, un átomo de hidrogeno, un átomo de halogeno, un grupo alquilo C1-4, alcoxi C1-4, un hidroxi un amino, un ciano, un nitro, un alquiltio C1-4, un SO2NH2 o un hidroximetilo; y sus sales N-oxidos e hidratos. Aplicacion en terapéutica, como antagonistas de receptores 5-HT4 y M3. También se reivindica compuestos intermediarios.Compound of general formula 1 in which R1 is a group of formula CnHxFy, where n = 1 or 2, x = 0 to 4, y = 1 to 5 and x + y = 2n + 1; R represents an alkenyl, phenyl, thienyl, furyl, pyridyl, imidazolyl, thiazolyl, pyranyl or C2-4 dihydropyranyl group, optionally substituted by one or two R3 groups; R2 and R3 independently represent each other, a hydrogen atom, a halogen atom, a C1-4 alkyl group, C1-4 alkoxy, a hydroxy an amino, a cyano, a nitro, a C1-4 alkylthio, a SO2NH2 or a hydroxymethyl; and its salts N-oxides and hydrates. Application in therapeutics, as antagonists of 5-HT4 and M3 receptors. Intermediate compounds are also claimed.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0009418A FR2811989A1 (en) | 2000-07-18 | 2000-07-18 | POLYFLUOROALKYTRIAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC USE |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR029729A1 true AR029729A1 (en) | 2003-07-10 |
Family
ID=8852646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP010103375A AR029729A1 (en) | 2000-07-18 | 2001-07-16 | DERIVATIVES OF POLIFLUOROALQUILTRIAZOL, ITS PREPARATION AND ITS USE IN THERAPEUTICS |
Country Status (4)
| Country | Link |
|---|---|
| AR (1) | AR029729A1 (en) |
| AU (1) | AU2001284084A1 (en) |
| FR (1) | FR2811989A1 (en) |
| WO (1) | WO2002006272A1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR039385A1 (en) | 2002-04-19 | 2005-02-16 | Astrazeneca Ab | THIOXANTINE DERIVATIVES AS INHIBITORS OF MIELOPEROXIDASA |
| FR2846559B1 (en) | 2002-10-31 | 2007-06-15 | Centre Nat Rech Scient | PHARMACEUTICAL COMPOSITION FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT AND / OR PREVENTION OF A PATHOLOGY RELATED TO OBSESSIVE DRIVING |
| MY140748A (en) | 2004-12-06 | 2010-01-15 | Astrazeneca Ab | Novel pyrrolo [3,2-d] pyrimidin-4-one derivatives and their use in therapy |
| TW200804383A (en) | 2006-06-05 | 2008-01-16 | Astrazeneca Ab | New compounds |
| EP3092231B1 (en) | 2013-12-11 | 2018-06-27 | Ironwood Pharmaceuticals, Inc. | Sgc stimulators |
| CN117143013A (en) * | 2023-11-01 | 2023-12-01 | 苏州开元民生科技股份有限公司 | Synthesis method of 2-chloronicotinic acid |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4225778A1 (en) * | 1992-08-04 | 1994-02-17 | Hoechst Ag | New 1-aryl-1,2,4-triazolyl-3-carboxylic acid 4-amino-piperidide cpds. - useful as pesticides, esp. fungicides to protect plants, e.g. against Oomycetes, and industrial materials, e.g. wood, paint and oils |
| FR2751647B1 (en) * | 1996-07-25 | 1998-09-11 | Synthelabo | BENZIMIDAZOLE DERIVATIVES, THEIR PREPARATIONS AND THEIR THERAPEUTIC APPLICATIONS |
| FR2766485B1 (en) * | 1997-07-23 | 2002-05-24 | Synthelabo | 2,4-DIHYDRO-3H-1,2,4-TRIAZOL-3-ONE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
| FR2789077A1 (en) * | 1999-02-02 | 2000-08-04 | Synthelabo | PERAZOLE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION |
-
2000
- 2000-07-18 FR FR0009418A patent/FR2811989A1/en active Pending
-
2001
- 2001-07-16 AR ARP010103375A patent/AR029729A1/en unknown
- 2001-07-17 AU AU2001284084A patent/AU2001284084A1/en not_active Abandoned
- 2001-07-17 WO PCT/FR2001/002315 patent/WO2002006272A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| WO2002006272A1 (en) | 2002-01-24 |
| AU2001284084A1 (en) | 2002-01-30 |
| FR2811989A1 (en) | 2002-01-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |