AR026362A1 - Procedimiento quimico - Google Patents
Procedimiento quimicoInfo
- Publication number
- AR026362A1 AR026362A1 ARP000105817A ARP000105817A AR026362A1 AR 026362 A1 AR026362 A1 AR 026362A1 AR P000105817 A ARP000105817 A AR P000105817A AR P000105817 A ARP000105817 A AR P000105817A AR 026362 A1 AR026362 A1 AR 026362A1
- Authority
- AR
- Argentina
- Prior art keywords
- reduction
- acid
- procedure
- formula
- indoles
- Prior art date
Links
- 238000000034 method Methods 0.000 abstract 6
- 150000002475 indoles Chemical class 0.000 abstract 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- PAYRUJLWNCNPSJ-UHFFFAOYSA-N Aniline Chemical compound NC1=CC=CC=C1 PAYRUJLWNCNPSJ-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 abstract 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 239000012954 diazonium Substances 0.000 abstract 2
- 150000001989 diazonium salts Chemical class 0.000 abstract 2
- 230000007613 environmental effect Effects 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 abstract 2
- FWPIDFUJEMBDLS-UHFFFAOYSA-L tin(II) chloride dihydrate Chemical compound O.O.Cl[Sn]Cl FWPIDFUJEMBDLS-UHFFFAOYSA-L 0.000 abstract 2
- BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 abstract 1
- WKEMJKQOLOHJLZ-UHFFFAOYSA-N Almogran Chemical compound C1=C2C(CCN(C)C)=CNC2=CC=C1CS(=O)(=O)N1CCCC1 WKEMJKQOLOHJLZ-UHFFFAOYSA-N 0.000 abstract 1
- 229940121710 HMGCoA reductase inhibitor Drugs 0.000 abstract 1
- 208000019695 Migraine disease Diseases 0.000 abstract 1
- ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical class [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 abstract 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical group [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 229960002133 almotriptan Drugs 0.000 abstract 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 abstract 1
- 150000001450 anions Chemical class 0.000 abstract 1
- 229940054051 antipsychotic indole derivative Drugs 0.000 abstract 1
- 229950002360 avitriptan Drugs 0.000 abstract 1
- WRZVGHXUPBWIOO-UHFFFAOYSA-N avitriptan Chemical compound C12=CC(CS(=O)(=O)NC)=CC=C2NC=C1CCCN(CC1)CCN1C1=NC=NC=C1OC WRZVGHXUPBWIOO-UHFFFAOYSA-N 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- GRWZHXKQBITJKP-UHFFFAOYSA-L dithionite(2-) Chemical class [O-]S(=O)S([O-])=O GRWZHXKQBITJKP-UHFFFAOYSA-L 0.000 abstract 1
- 229960002472 eletriptan Drugs 0.000 abstract 1
- PWVXXGRKLHYWKM-LJQANCHMSA-N eletriptan Chemical compound CN1CCC[C@@H]1CC(C1=C2)=CNC1=CC=C2CCS(=O)(=O)C1=CC=CC=C1 PWVXXGRKLHYWKM-LJQANCHMSA-N 0.000 abstract 1
- 230000008030 elimination Effects 0.000 abstract 1
- 238000003379 elimination reaction Methods 0.000 abstract 1
- 229960002284 frovatriptan Drugs 0.000 abstract 1
- SIBNYOSJIXCDRI-SECBINFHSA-N frovatriptan Chemical compound C1=C(C(N)=O)[CH]C2=C(C[C@H](NC)CC3)C3=NC2=C1 SIBNYOSJIXCDRI-SECBINFHSA-N 0.000 abstract 1
- 206010027599 migraine Diseases 0.000 abstract 1
- 229960005254 naratriptan Drugs 0.000 abstract 1
- AMKVXSZCKVJAGH-UHFFFAOYSA-N naratriptan Chemical compound C12=CC(CCS(=O)(=O)NC)=CC=C2NC=C1C1CCN(C)CC1 AMKVXSZCKVJAGH-UHFFFAOYSA-N 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229940127557 pharmaceutical product Drugs 0.000 abstract 1
- 150000004031 phenylhydrazines Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229960000425 rizatriptan Drugs 0.000 abstract 1
- ULFRLSNUDGIQQP-UHFFFAOYSA-N rizatriptan Chemical compound C1=C2C(CCN(C)C)=CNC2=CC=C1CN1C=NC=N1 ULFRLSNUDGIQQP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229960003708 sumatriptan Drugs 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 239000010891 toxic waste Substances 0.000 abstract 1
- 229960001360 zolmitriptan Drugs 0.000 abstract 1
- ULSDMUVEXKOYBU-ZDUSSCGKSA-N zolmitriptan Chemical compound C1=C2C(CCN(C)C)=CNC2=CC=C1C[C@H]1COC(=O)N1 ULSDMUVEXKOYBU-ZDUSSCGKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
- C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
- C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9926250.3A GB9926250D0 (en) | 1999-11-06 | 1999-11-06 | Chemical process |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR026362A1 true AR026362A1 (es) | 2003-02-05 |
Family
ID=10864031
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000105817A AR026362A1 (es) | 1999-11-06 | 2000-11-03 | Procedimiento quimico |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP1226116A1 (fr) |
| JP (1) | JP2003513953A (fr) |
| AR (1) | AR026362A1 (fr) |
| AU (1) | AU1145201A (fr) |
| CA (1) | CA2389514A1 (fr) |
| GB (1) | GB9926250D0 (fr) |
| IL (1) | IL148640A0 (fr) |
| WO (1) | WO2001034561A1 (fr) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2204303B2 (es) | 2002-08-07 | 2004-12-16 | Laboratorios Vita, S.A. | Procedimiento para la obtencion de un compuesto farmaceuticamente activo. |
| US7645886B2 (en) | 2002-12-20 | 2010-01-12 | Ciba Specialty Corporation | Synthesis of amines and intermediates for the synthesis thereof |
| US20070054953A1 (en) * | 2003-05-12 | 2007-03-08 | Potluri Ramesh B | A novel process for preparation of indole derivatives |
| KR100566562B1 (ko) | 2004-04-23 | 2006-03-31 | 주식회사 카이로제닉스 | 수마트립탄의 제조방법 |
| WO2005103035A1 (fr) * | 2004-04-23 | 2005-11-03 | Pfizer Limited | Preparation d'eletriptan consistant en une synthese modifiee d'indole par la methode de fischer |
| WO2009016414A1 (fr) * | 2007-08-02 | 2009-02-05 | Generics [Uk] Limited | Nouveau procédé |
| CN102351754A (zh) * | 2011-08-03 | 2012-02-15 | 山东新华制药股份有限公司 | 4-氨基-n-甲基苯甲磺酰胺的制备工艺 |
| CN102432519B (zh) * | 2011-11-21 | 2013-12-11 | 山东新华制药股份有限公司 | 3-(2-氨乙基)-n-甲基-1h-吲哚-5-甲烷磺酰胺的制备方法 |
| CN102964287B (zh) * | 2012-11-13 | 2014-04-09 | 苏州永健生物医药有限公司 | 一种3-（4-氯丁基）-5-氰基吲哚的合成方法 |
| CN106397359B (zh) * | 2016-08-31 | 2017-12-05 | 重庆华森制药股份有限公司 | 阿莫曲坦中间体4‑(1‑吡咯烷基磺酰甲基)‑苯肼的制备方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR79215B (fr) * | 1982-06-07 | 1984-10-22 | Glaxo Group Ltd | |
| GB8332435D0 (en) * | 1983-12-06 | 1984-01-11 | Glaxo Group Ltd | Chemical compounds |
| GB2162522B (en) * | 1984-08-01 | 1988-02-24 | Glaxo Group Ltd | An indole derivative |
| DE3531658A1 (de) * | 1985-09-05 | 1987-03-12 | Boehringer Mannheim Gmbh | Heterocyclisch substituierte indole, zwischenprodukte, verfahren zu ihrer herstellung und arzneimittel |
| US5272145A (en) * | 1989-08-22 | 1993-12-21 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
| GB9026998D0 (en) * | 1990-12-12 | 1991-01-30 | Glaxo Group Ltd | Medicaments |
-
1999
- 1999-11-06 GB GBGB9926250.3A patent/GB9926250D0/en not_active Ceased
-
2000
- 2000-10-27 EP EP00972875A patent/EP1226116A1/fr not_active Withdrawn
- 2000-10-27 CA CA002389514A patent/CA2389514A1/fr not_active Abandoned
- 2000-10-27 AU AU11452/01A patent/AU1145201A/en not_active Abandoned
- 2000-10-27 IL IL14864000A patent/IL148640A0/xx unknown
- 2000-10-27 JP JP2001536510A patent/JP2003513953A/ja not_active Withdrawn
- 2000-10-27 WO PCT/EP2000/010581 patent/WO2001034561A1/fr not_active Ceased
- 2000-11-03 AR ARP000105817A patent/AR026362A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU1145201A (en) | 2001-06-06 |
| GB9926250D0 (en) | 2000-01-12 |
| JP2003513953A (ja) | 2003-04-15 |
| CA2389514A1 (fr) | 2001-05-17 |
| IL148640A0 (en) | 2002-09-12 |
| EP1226116A1 (fr) | 2002-07-31 |
| WO2001034561A1 (fr) | 2001-05-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR026362A1 (es) | Procedimiento quimico | |
| US3629284A (en) | Process for the preparation of 3-indolyl aliphatic acid derivatives | |
| NO165146B (no) | 1h-imidazo-(4,5-c)-kinolin-4-klorforbindelser. | |
| KR900018080A (ko) | 말레인이미드 유도체 및 약제로서 그의 용도 | |
| DK1029861T3 (da) | Benzisothiazol-piperazinylderivat og dets anvendelse som neuroleptikum | |
| PE20000055A1 (es) | Compuestos de indol 2,3-sustituidos como agentes anti-inflamatorios y analgesicos | |
| US3852338A (en) | N-substituted phenylalanine derivatives | |
| ES8201572A1 (es) | Procedimiento de preparar derivados propanolaminicos | |
| US3564009A (en) | Process for producing 1-acylindole derivatives | |
| GB873925A (en) | Improvements in or relating to aralkylbenzmorphan derivatives | |
| HRP950304B1 (en) | Palladium catalyzed ring closure of triazolyl tryptamine | |
| KR970001215A (ko) | 특정 결정 형태의 질파테롤 히드로클로라이드, 그의 제조 방법 및 이에 사용되는 중간 생성물 | |
| DK168434B1 (da) | Beta-alkylmelatoniner, fremgangsmåde til fremstilling deraf samt farmaceutiske præparater indeholdende disse forbindelser | |
| Sawada et al. | 4-(1-Benzoylindol-3-yl) butyric acids and FK143: novel nonsteroidal inhibitors of steroid 5α-reductase (II) | |
| FR2536072A1 (fr) | Nouveaux derives de la quinazoline, leur preparation et leur utilisation comme medicaments | |
| SE7909367L (sv) | Sett att framstella piperidyl-indol-derivat, ny framstelld forening och dess salter samt anvendning derav sasom lekemedel och farmaceutiska kompositioner innehallande dessa foreningar | |
| PT89469A (pt) | Processo para a preparacao de derivados de acido 1h-indazole-3-acetico uteis como inibidores da aldose reductase | |
| US7307099B2 (en) | 4-(1-(sulfonyl)-1h-indol-2-yl)-4-(hydroxy)-cyclohexa-2,5-dienone compounds and analogs thereof as therapeutic agents | |
| ES2188482T3 (es) | Procedimiento para la preparacion de indoles acilados en la posicion 3. | |
| US3637747A (en) | 3-(2-aminophenyl) indole derivatives | |
| NO142018B (no) | Fremgangsmaate for fremstilling av en isolasjon for hoeyspenningsaggregat | |
| RU94019424A (ru) | Способ получения кристаллического моногидрата лоракарбефа из кристаллического дигидрата лоракарбефа | |
| HU198694B (en) | Process for producing azol derivatives and pharmaceutical compositions containing them as active components | |
| ES2003629A6 (es) | Procedimiento para preparar nuevos derivados de acidos fenilaceticos | |
| US3453286A (en) | Process for preparing cycloheptimidazolinium halides |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |