AR025902A1 - Agonistas del receptor 3 (r3) del peptido activador de la adenilato ciclasa de la pituitaria y sus metodos de uso farmacologico - Google Patents
Agonistas del receptor 3 (r3) del peptido activador de la adenilato ciclasa de la pituitaria y sus metodos de uso farmacologicoInfo
- Publication number
- AR025902A1 AR025902A1 ARP000105130A AR025902A1 AR 025902 A1 AR025902 A1 AR 025902A1 AR P000105130 A ARP000105130 A AR P000105130A AR 025902 A1 AR025902 A1 AR 025902A1
- Authority
- AR
- Argentina
- Prior art keywords
- peptides
- pituitary
- cycling
- insulin
- use methods
- Prior art date
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 8
- 238000000034 method Methods 0.000 title abstract 3
- 230000003213 activating effect Effects 0.000 title 1
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 title 1
- 239000000556 agonist Substances 0.000 title 1
- 230000001351 cycling effect Effects 0.000 title 1
- 230000000144 pharmacologic effect Effects 0.000 title 1
- 230000001817 pituitary effect Effects 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 7
- 230000003914 insulin secretion Effects 0.000 abstract 3
- 229940122199 Insulin secretagogue Drugs 0.000 abstract 2
- 241000124008 Mammalia Species 0.000 abstract 2
- 229920001184 polypeptide Polymers 0.000 abstract 2
- 210000002237 B-cell of pancreatic islet Anatomy 0.000 abstract 1
- 102000002808 Pituitary adenylate cyclase-activating polypeptide Human genes 0.000 abstract 1
- 108010004684 Pituitary adenylate cyclase-activating polypeptide Proteins 0.000 abstract 1
- 241000700159 Rattus Species 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 208000016097 disease of metabolism Diseases 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 210000004153 islets of langerhan Anatomy 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
Esta presenta novedosos péptidos que funcionan in vivo para estimular la liberacion de insulina de las células beta pancreáticas en forma dependiente de laglucosa. Se ha demostrado que estos péptidos secretagogos de insulina estimulan la liberacion de insulina en las células de islotes de ratas in vitro e invivo. Los péptidos de la presente proporcionan una nueva terapia para pacientes con secrecion de insulina disminuida, en especial diabéticos de tipo 2. Enespecial, la presente es un polipéptido seleccionado entre un grupo específico de polipéptidos relacionados con VIP/PACAP, o equivalentes funcionales delmismo. La presente se refiere asimismo a un método para tratar una enfermedad metabolica en un mamífero que comprende administrar unacantidad terapéuticamenteefectiva de los péptidos secretagogos de insulina a dicho mamífero. También se describen métodos para preparar los péptidos, tanto recombinantes comosintéticos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40783299A | 1999-09-28 | 1999-09-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR025902A1 true AR025902A1 (es) | 2002-12-18 |
Family
ID=45570861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP000105130 AR025902A1 (es) | 1999-09-28 | 2000-09-28 | Agonistas del receptor 3 (r3) del peptido activador de la adenilato ciclasa de la pituitaria y sus metodos de uso farmacologico |
Country Status (1)
| Country | Link |
|---|---|
| AR (1) | AR025902A1 (es) |
-
2000
- 2000-09-28 AR ARP000105130 patent/AR025902A1/es not_active Application Discontinuation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |