AR013217A1 - COMPUESTOS DERIVADOS DE 24a, 24b-DIHOMO-9,10-SECOCOLESTANO POLINSATURADO, SU USO, PROCEDIMIENTO PARA PREPARARLOS, COMPUESTOS UTILES COMO INTERMEDIARIOS,Y UNA COMPOSICION FARMACEUTICA QUE COMPRENDE DICHO COMPUESTO DERIVADO - Google Patents
COMPUESTOS DERIVADOS DE 24a, 24b-DIHOMO-9,10-SECOCOLESTANO POLINSATURADO, SU USO, PROCEDIMIENTO PARA PREPARARLOS, COMPUESTOS UTILES COMO INTERMEDIARIOS,Y UNA COMPOSICION FARMACEUTICA QUE COMPRENDE DICHO COMPUESTO DERIVADOInfo
- Publication number
- AR013217A1 AR013217A1 ARP980103432A ARP980103432A AR013217A1 AR 013217 A1 AR013217 A1 AR 013217A1 AR P980103432 A ARP980103432 A AR P980103432A AR P980103432 A ARP980103432 A AR P980103432A AR 013217 A1 AR013217 A1 AR 013217A1
- Authority
- AR
- Argentina
- Prior art keywords
- compounds
- derivative
- dihomo
- prepare
- procedure
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 7
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 230000001419 dependent effect Effects 0.000 abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 2
- 208000035475 disorder Diseases 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- 208000032116 Autoimmune Experimental Encephalomyelitis Diseases 0.000 abstract 1
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 206010004146 Basal cell carcinoma Diseases 0.000 abstract 1
- 208000009329 Graft vs Host Disease Diseases 0.000 abstract 1
- 206010020649 Hyperkeratosis Diseases 0.000 abstract 1
- 201000002980 Hyperparathyroidism Diseases 0.000 abstract 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 abstract 1
- 208000001126 Keratosis Diseases 0.000 abstract 1
- 208000001132 Osteoporosis Diseases 0.000 abstract 1
- 201000004681 Psoriasis Diseases 0.000 abstract 1
- 208000001647 Renal Insufficiency Diseases 0.000 abstract 1
- 206010040070 Septic Shock Diseases 0.000 abstract 1
- 206010052779 Transplant rejections Diseases 0.000 abstract 1
- 206010067584 Type 1 diabetes mellitus Diseases 0.000 abstract 1
- 229930003316 Vitamin D Natural products 0.000 abstract 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000000816 ethylene group Chemical group [H]C([H])([*:1])C([H])([H])[*:2] 0.000 abstract 1
- 208000024908 graft versus host disease Diseases 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000003780 keratinization Effects 0.000 abstract 1
- 201000006370 kidney failure Diseases 0.000 abstract 1
- 208000032839 leukemia Diseases 0.000 abstract 1
- 201000006417 multiple sclerosis Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 206010039073 rheumatoid arthritis Diseases 0.000 abstract 1
- 230000036303 septic shock Effects 0.000 abstract 1
- 208000035408 type 1 diabetes mellitus 1 Diseases 0.000 abstract 1
- 235000019166 vitamin D Nutrition 0.000 abstract 1
- 239000011710 vitamin D Substances 0.000 abstract 1
- 150000003710 vitamin D derivatives Chemical class 0.000 abstract 1
- 229940046008 vitamin d Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/02—Nutrients, e.g. vitamins, minerals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Compuestos derivados de 24a,24b-dihomo-9,10-secocolestano poliinsaturado de formula(I), donde: A es un enlace simple o doble; B1 y B2 son, cada unoindependientemente, CH=CH o C=C; T es CH2 o CH2CH2; X es -CH2- o >C=CH2; R1 es H, F u OH; R2 y R3 son, cada uno independientemente, alquilo inferior o CF3, oC(R2,R3) es cicloalquilo C3-6; su uso; procedimiento para prepararlos; compuestos utiles como intermediarios y composiciones farmacéuticas quecomprenden a los compuestos de formula (I). Los compuestos de formula (I) son utiles para el tratamiento o prevencion de desordenes dependientes de lavitamina D y enfermedades autoinmunes dependientes de IL-12, particularmente soriasis, carcinomas de célula basal, desordenes de laqueratinizacion yqueratosis, leucemia, osteoporosis, hiperparatiroidismo asociado con la insuficiencia renal, esclerosis multiple, rechazo de trasplantes, enfermedadde injerto contra huésped, artritis reumatoidea, diabetes mellitus insulinodependiente, enfermedad intestinal inflamatoria, choque séptico yencefalomielitis alérgica.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97112225 | 1997-07-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR013217A1 true AR013217A1 (es) | 2000-12-13 |
Family
ID=8227074
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980103432A AR013217A1 (es) | 1997-07-17 | 1998-07-15 | COMPUESTOS DERIVADOS DE 24a, 24b-DIHOMO-9,10-SECOCOLESTANO POLINSATURADO, SU USO, PROCEDIMIENTO PARA PREPARARLOS, COMPUESTOS UTILES COMO INTERMEDIARIOS,Y UNA COMPOSICION FARMACEUTICA QUE COMPRENDE DICHO COMPUESTO DERIVADO |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5994569A (es) |
| EP (1) | EP0998455B1 (es) |
| JP (1) | JP2001510183A (es) |
| AR (1) | AR013217A1 (es) |
| AU (1) | AU8860298A (es) |
| CA (1) | CA2296145A1 (es) |
| DE (1) | DE69818673T2 (es) |
| ES (1) | ES2206981T3 (es) |
| WO (1) | WO1999003828A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0957098A1 (en) * | 1998-05-14 | 1999-11-17 | F. Hoffmann-La Roche Ag | Intermediates for the synthesis of 3-epi vitamin D3 metabolites and analogs |
| ATE305506T1 (de) * | 1998-12-09 | 2005-10-15 | Protein Design Labs Inc | Verwendung von il-12 antikörpern zur behandlung von psoriasis |
| CA2390859A1 (en) * | 1999-12-02 | 2001-06-14 | The Penn State Research Foundation | Treatment of inflammatory bowel disease with vitamin d compounds |
| WO2008091686A2 (en) * | 2007-01-25 | 2008-07-31 | Bioxell S.P.A. | SYNTHESIS OF 1α-FLUORO-25-HYDROXY-16-23E-DIENE-26,27-BISHOMO-20-EPI-CHOLECALCIFEROL |
| CN114276284A (zh) * | 2021-12-30 | 2022-04-05 | 正大制药（青岛）有限公司 | 一种氟骨化醇的制备方法 |
| CN114957068A (zh) * | 2022-04-19 | 2022-08-30 | 正大制药（青岛）有限公司 | 一种氟骨化醇20s异构体的制备方法 |
| CN117018000B (zh) * | 2023-08-29 | 2025-01-28 | 东莞市东南部中心医院(东莞市东南部中医医疗服务中心) | 4-胆甾烯-3-酮在制备预防或治疗炎症性肠病药物中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8915770D0 (en) * | 1989-07-10 | 1989-08-31 | Leo Pharm Prod Ltd | Chemical compounds |
| US5532228A (en) * | 1990-02-06 | 1996-07-02 | Schering Aktiengesellschaft | Side-chain homologous vitamin D derivatives, process for their production, pharmaceutical preparations containing these derivatives and their use as pharmaceutical agents |
| EP0441467B1 (de) * | 1990-02-06 | 1994-06-01 | Schering Aktiengesellschaft | Seitenketten-homologe Vitamin-D-Derivate, Verfahren zu ihrer Herstellung, diese enthaltende pharmazeutische Präparate, sowie deren Verwendung als Arzneimittel |
| GB9017890D0 (en) * | 1990-08-15 | 1990-09-26 | Leo Pharm Prod Ltd | Chemical compounds i |
| GB9314400D0 (en) * | 1993-07-12 | 1993-08-25 | Leo Pharm Prod Ltd | Produktionsaktieselskab) chemical compounds |
| IL118156A (en) * | 1995-05-09 | 2001-08-26 | Duphar Int Res | Vitamin d compounds, their preparation and pharmaceutical compositions containing them |
| DE69606680T2 (de) * | 1995-10-30 | 2000-08-17 | F. Hoffmann-La Roche Ag, Basel | 1-Alpha, 26-dihydroxy-D-homo-vitamin D3 |
| WO1998018754A1 (en) * | 1996-10-28 | 1998-05-07 | Versicor, Inc. | Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof |
| GB9622590D0 (en) * | 1996-10-30 | 1997-01-08 | Leo Pharm Prod Ltd | Chemical compounds |
-
1998
- 1998-07-10 WO PCT/EP1998/004293 patent/WO1999003828A1/en not_active Ceased
- 1998-07-10 EP EP98940201A patent/EP0998455B1/en not_active Expired - Lifetime
- 1998-07-10 DE DE69818673T patent/DE69818673T2/de not_active Expired - Fee Related
- 1998-07-10 CA CA002296145A patent/CA2296145A1/en not_active Abandoned
- 1998-07-10 AU AU88602/98A patent/AU8860298A/en not_active Abandoned
- 1998-07-10 JP JP2000503057A patent/JP2001510183A/ja active Pending
- 1998-07-10 ES ES98940201T patent/ES2206981T3/es not_active Expired - Lifetime
- 1998-07-14 US US09/115,188 patent/US5994569A/en not_active Expired - Fee Related
- 1998-07-15 AR ARP980103432A patent/AR013217A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1999003828A1 (en) | 1999-01-28 |
| EP0998455A1 (en) | 2000-05-10 |
| ES2206981T3 (es) | 2004-05-16 |
| DE69818673T2 (de) | 2004-08-05 |
| AU8860298A (en) | 1999-02-10 |
| CA2296145A1 (en) | 1999-01-28 |
| DE69818673D1 (de) | 2003-11-06 |
| US5994569A (en) | 1999-11-30 |
| JP2001510183A (ja) | 2001-07-31 |
| EP0998455B1 (en) | 2003-10-01 |
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