AR015776A1 - Compuestos derivados de 2''-desoxi-higromicina, composicion farmaceutica, procedimiento de tratamiento y de preparacion - Google Patents
Compuestos derivados de 2''-desoxi-higromicina, composicion farmaceutica, procedimiento de tratamiento y de preparacionInfo
- Publication number
- AR015776A1 AR015776A1 ARP990102023A ARP990102023A AR015776A1 AR 015776 A1 AR015776 A1 AR 015776A1 AR P990102023 A ARP990102023 A AR P990102023A AR P990102023 A ARP990102023 A AR P990102023A AR 015776 A1 AR015776 A1 AR 015776A1
- Authority
- AR
- Argentina
- Prior art keywords
- aryl
- alkyl
- varies
- integer
- cycloalkyl
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 238000000034 method Methods 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000000041 C6-C10 aryl group Chemical group 0.000 abstract 5
- 125000000623 heterocyclic group Chemical group 0.000 abstract 5
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 abstract 3
- 125000004429 atom Chemical group 0.000 abstract 3
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 2
- 125000004434 sulfur atom Chemical group 0.000 abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 abstract 1
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000004786 difluoromethoxy group Chemical group [H]C(F)(F)O* 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/20—Carbocyclic rings
- C07H15/203—Monocyclic carbocyclic rings other than cyclohexane rings; Bicyclic carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Un compuesto de la formula 1 o una sal farmacéuticamente aceptable, profármaco o solvato del mismo, en la que: R1 es H y R2 es -NR3R4, -NR4C(O)R3,-OC(O)NR3R4 u -OR3; o R1 y R2 se toman conjuntamente para formar =O, =N-OR3, =CR3R4, =CR4C(O)R3, =CR4C(O)OR3 o =CR4C(O)NR3R4; cada R3 se seleccionaindependientemente entre H, alquilo C1-10, alquenilo C2-10, -(CH2)t(cicloalquilo C3-10), -(CH2)(arilo C6-10) y -(CH2)t(heterociclo de 4-10 eslabones), donde tes un numero entero que varía entre 0 y 5, dichogrupo alquilo opcionalmente contiene 1 o 2 heteroradicales seleccionados entre O, -S(O)j- donde j es un numeroentero que varía entre 0 y 2, y -N(R7)-, con la condicion de que dos átomos O, dos átomos S o un átomo O y un átomo de S no estén unidos directamente entre sí;dichos grupos R3 cicloalquilo, arilo y heterocíclico están opcionalmente condensados con un anillo de benceno, un grupo cíclico saturado C5-8 o un grupoheterocíclico de 4-10 miembros; los radicales -(CH2)t de los grupos R3 anteriores incluyen opcionalmente un doble o triple enlace C-C donde t es un numeroentero entre 2 y 5; y los grupos R3 anteriores, excepto H, pero que incluyen cualquier anillo condensado opcional mencionado anteriormente, están opcionalmentesustituidos con1 a 5 grupos R5; cada R4 es independientemente H o alquilo C1-10; cada R5 se selecciona independientemente entre alquilo C1-10, cicloalquiloC3-10, halo, ciano, nitro, trifluorometilo, difluorometoxi, azido, -OR6, -C(O)R6, -C(O)OR6, -NR7C(O)OR9, -OC(O)R6, -NR7SO2R9, -SO2NR6R7, -NR7C(O)R6,-C(O)NR6R7, -NR6R7, -S(O)j(CH2)m(arilo C6-10), -S(O)j(alquilo C1-6),donde j es un numero entero que varía entre 0 y 2, -(CH2)m(arilo C6-10), -O(CH2)m(arilo C6-10),-NR7(CH2)m(ariloC6-10) y -(CH2)m(heterociclo de 4-10 eslabones), donde m es un numero entero que varía entre 0 y 4; dicho grupo alquilo contieneopcionalmente 1 o 2 heteroaradicales seleccionados entre O, -S(O)j-,donde j es un numero entero que varía entre 0 y 2; y -N(R7)-, con la condicion de que dosátomos de O, dos átomos de S o un átomo de O y otro de S no esté unidos directamente entre sí; dichos grupos R5 cicloalquilo, arilo y heterocíclico están
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8405898P | 1998-05-04 | 1998-05-04 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR015776A1 true AR015776A1 (es) | 2001-05-16 |
Family
ID=22182624
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990102023A AR015776A1 (es) | 1998-05-04 | 1999-04-30 | Compuestos derivados de 2''-desoxi-higromicina, composicion farmaceutica, procedimiento de tratamiento y de preparacion |
Country Status (38)
| Country | Link |
|---|---|
| US (1) | US6342497B1 (es) |
| EP (1) | EP1077984B1 (es) |
| JP (1) | JP2002513798A (es) |
| KR (1) | KR100396099B1 (es) |
| CN (1) | CN1299367A (es) |
| AP (1) | AP1069A (es) |
| AR (1) | AR015776A1 (es) |
| AT (1) | ATE243218T1 (es) |
| AU (1) | AU762302B2 (es) |
| BG (1) | BG104995A (es) |
| BR (1) | BR9910232A (es) |
| CA (1) | CA2331261C (es) |
| DE (1) | DE69908936T2 (es) |
| DK (1) | DK1077984T3 (es) |
| DZ (1) | DZ2779A1 (es) |
| EA (1) | EA004374B1 (es) |
| ES (1) | ES2199559T3 (es) |
| GT (1) | GT199900058A (es) |
| HN (1) | HN1999000064A (es) |
| HR (1) | HRP20000748A2 (es) |
| HU (1) | HUP0102412A3 (es) |
| ID (1) | ID26368A (es) |
| IL (1) | IL139020A0 (es) |
| IS (1) | IS5680A (es) |
| MA (1) | MA26626A1 (es) |
| NO (1) | NO20005551L (es) |
| NZ (1) | NZ507450A (es) |
| OA (1) | OA11507A (es) |
| PA (1) | PA8471901A1 (es) |
| PE (1) | PE20000440A1 (es) |
| PL (1) | PL344085A1 (es) |
| PT (1) | PT1077984E (es) |
| SK (1) | SK16442000A3 (es) |
| TN (1) | TNSN99084A1 (es) |
| TR (1) | TR200003249T2 (es) |
| WO (1) | WO1999057127A1 (es) |
| YU (1) | YU64300A (es) |
| ZA (1) | ZA993063B (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL348063A1 (en) * | 1998-12-02 | 2002-05-06 | Pfizer Prod Inc | Hygromycin a derivatives as antibacterial agents |
| GB9923078D0 (en) * | 1999-09-29 | 1999-12-01 | Phytopharm Plc | Sapogenin derivatives and their use |
| SK16612002A3 (sk) * | 2000-06-02 | 2004-04-06 | Pfizer Products Inc. | Deriváty hygromycínu A na použitie na liečenie bakteriálnych a protozoálnych infekcií |
| CN102168034B (zh) * | 2010-11-29 | 2012-12-05 | 中国科学院南海海洋研究所 | 一种海洋链霉菌以及利用该菌制备替达霉素a和b的方法 |
| US12233081B2 (en) | 2018-08-20 | 2025-02-25 | Northeastern University | Hygromycin a compounds and methods of treating spirochete diseases |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2832356B2 (ja) * | 1988-03-31 | 1998-12-09 | 武田薬品工業株式会社 | ハイグロマイシン類の合成中間体および製造法 |
-
1999
- 1999-04-08 PL PL99344085A patent/PL344085A1/xx unknown
- 1999-04-08 EA EA200001028A patent/EA004374B1/ru not_active IP Right Cessation
- 1999-04-08 EP EP99909164A patent/EP1077984B1/en not_active Expired - Lifetime
- 1999-04-08 KR KR10-2000-7012222A patent/KR100396099B1/ko not_active Expired - Fee Related
- 1999-04-08 HU HU0102412A patent/HUP0102412A3/hu unknown
- 1999-04-08 PT PT99909164T patent/PT1077984E/pt unknown
- 1999-04-08 NZ NZ507450A patent/NZ507450A/en unknown
- 1999-04-08 DK DK99909164T patent/DK1077984T3/da active
- 1999-04-08 DE DE69908936T patent/DE69908936T2/de not_active Expired - Fee Related
- 1999-04-08 SK SK1644-2000A patent/SK16442000A3/sk unknown
- 1999-04-08 US US09/380,718 patent/US6342497B1/en not_active Expired - Fee Related
- 1999-04-08 CN CN99805810A patent/CN1299367A/zh active Pending
- 1999-04-08 WO PCT/IB1999/000611 patent/WO1999057127A1/en not_active Ceased
- 1999-04-08 ES ES99909164T patent/ES2199559T3/es not_active Expired - Lifetime
- 1999-04-08 TR TR2000/03249T patent/TR200003249T2/xx unknown
- 1999-04-08 IL IL13902099A patent/IL139020A0/xx unknown
- 1999-04-08 CA CA002331261A patent/CA2331261C/en not_active Expired - Fee Related
- 1999-04-08 AU AU28508/99A patent/AU762302B2/en not_active Ceased
- 1999-04-08 JP JP2000547096A patent/JP2002513798A/ja active Pending
- 1999-04-08 HR HR20000748A patent/HRP20000748A2/hr not_active Application Discontinuation
- 1999-04-08 AT AT99909164T patent/ATE243218T1/de not_active IP Right Cessation
- 1999-04-08 ID IDW20002256A patent/ID26368A/id unknown
- 1999-04-08 YU YU64300A patent/YU64300A/sh unknown
- 1999-04-08 BR BR9910232-3A patent/BR9910232A/pt not_active IP Right Cessation
- 1999-04-16 GT GT199900058A patent/GT199900058A/es unknown
- 1999-04-29 AP APAP/P/1999/001525A patent/AP1069A/en active
- 1999-04-29 PE PE1999000355A patent/PE20000440A1/es not_active Application Discontinuation
- 1999-04-30 AR ARP990102023A patent/AR015776A1/es not_active Application Discontinuation
- 1999-05-03 MA MA25566A patent/MA26626A1/fr unknown
- 1999-05-03 DZ DZ990079A patent/DZ2779A1/xx active
- 1999-05-03 TN TNTNSN99084A patent/TNSN99084A1/fr unknown
- 1999-05-03 HN HN1999000064A patent/HN1999000064A/es unknown
- 1999-05-03 ZA ZA9903063A patent/ZA993063B/xx unknown
- 1999-05-04 PA PA19998471901A patent/PA8471901A1/es unknown
-
2000
- 2000-10-24 IS IS5680A patent/IS5680A/is unknown
- 2000-10-27 OA OA1200000298A patent/OA11507A/en unknown
- 2000-11-03 NO NO20005551A patent/NO20005551L/no not_active Application Discontinuation
- 2000-11-28 BG BG104995A patent/BG104995A/bg unknown
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |