AR015727A1 - Derivados de cetolida de eritromicina 3'-n-modificada 6-o-sustituida, composicion farmaceutica que los contiene, procedimiento para su preparacion y metodopara tratar las infecciones bacterianas. - Google Patents
Derivados de cetolida de eritromicina 3'-n-modificada 6-o-sustituida, composicion farmaceutica que los contiene, procedimiento para su preparacion y metodopara tratar las infecciones bacterianas.Info
- Publication number
- AR015727A1 AR015727A1 ARP980104856A ARP980104856A AR015727A1 AR 015727 A1 AR015727 A1 AR 015727A1 AR P980104856 A ARP980104856 A AR P980104856A AR P980104856 A ARP980104856 A AR P980104856A AR 015727 A1 AR015727 A1 AR 015727A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- substituted
- aryl
- heteroaryl
- group
- Prior art date
Links
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical class O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 title abstract 2
- 208000035143 Bacterial infection Diseases 0.000 title 1
- 208000022362 bacterial infectious disease Diseases 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 20
- 125000001072 heteroaryl group Chemical group 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003118 aryl group Chemical group 0.000 abstract 5
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- 125000003107 substituted aryl group Chemical group 0.000 abstract 3
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 229960003276 erythromycin Drugs 0.000 abstract 1
- -1 erythromycin ketone Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 229940002612 prodrug Drugs 0.000 abstract 1
- 239000000651 prodrug Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Derivados de cetolida de eritromicina 6-O-sustituida 3-N-modificada y sus sales y ésteres farmacéuticamente aceptables que tienen una actividadantibacteriana que tiene la formula (I), (II), (III), (IV) y (V) o su sal, éster o prodroga farmacéuticamente aceptable, donde R1 y R2, con la condicion de queR1 y R2 no sean ambos metilo, se seleccionan independientemente del grupo formado por: (3)hidrogeno, (4) alquilo de C1-6 opcionalmente sustituido por halogeno,cicloalquilo C3-6, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, -CHO, -C(O)-alquilo C1-6, y -C(O)-NRR, donde R y R se seleccionanindependientemente del grupo formado por hidrogeno, alquilo C1-3, alquilo C1-3 sustituido con arilo, arilo sustituido, heteroarilo y heteroarilo sustituido,(3) alquilo C2-6 opcionalmente sustituido con un sustituyente seleccionado del grupo formado por: alcoxi C1-6, -NRR, donde R y R son como definimosanteriormente, -NH-C(O)alquilo C1-6, -NH-C(O)-O-alquilo C1-6, -O-C(O)-O-alquilo C1-6, -O-C(O)-alquilo C1-6, -CH-(=N-O-alquilo C1-6),-C(=N-O-alquiloC1-6)-alquilo C1-6, -CH(=N-NH-alquilo C1-6) y -C(=N-NH-alquilo C1-6)-alquilo C1-6, (4) alquenilo de C3-6 opcionalmente sustituido con unsustituyente seleccionado del grupo formado por halogeno,cicloalquilo C3-6, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, -NH-C(O)-alquiloC1-6, -NH-C-(O)-O-alquilo C1-6, -O-C(O)-O-alquilo C1-6, -O-C(O)-alquilo C1-6, -CHO,-C(O)-alquilo C1-6, -C(O)-NRR, donde R y R son como definimosanteriormente, -CH(=N-O-alquilo C1-6, -C(=N-O-alquilo C1-6)-alquilo C1-6, -CH(=N-NH alquilo C1-6, -C(=N-NH-alquilo C1-6, y -C(O)-O-alquilo C1-6, (5) alquiniloC3-6 opcionalmente sustituido con un sustituyente seleccionado del grupo formado por:halogeno, cicloalquilo C3-6, arilo, arilo sustituido, heteroarilo, yheteroarilo sustituido, cicloalquilo C3-6, -CHO, -CC(O)-alquilo C1-6, -C(O)-NRR, donde R y R son como definimos anteriormente, y -C(O)-O-alquilo C1-6, oR1 y R2 tomados juntos pueden ser -(CH)2p-, donde p es entre 3 y 7, que tomado junto con el átomo de nitrogeno al que está unido, forman un anillo
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US94087197A | 1997-09-30 | 1997-09-30 | |
| US13312198A | 1998-08-12 | 1998-08-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR015727A1 true AR015727A1 (es) | 2001-05-16 |
Family
ID=26831064
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP980104856A AR015727A1 (es) | 1997-09-30 | 1998-09-29 | Derivados de cetolida de eritromicina 3'-n-modificada 6-o-sustituida, composicion farmaceutica que los contiene, procedimiento para su preparacion y metodopara tratar las infecciones bacterianas. |
Country Status (22)
| Country | Link |
|---|---|
| EP (1) | EP1025114B1 (es) |
| JP (1) | JP2001518476A (es) |
| KR (1) | KR20010030807A (es) |
| CN (1) | CN1271363A (es) |
| AR (1) | AR015727A1 (es) |
| AT (1) | ATE260293T1 (es) |
| AU (1) | AU737310B2 (es) |
| BG (1) | BG104340A (es) |
| BR (1) | BR9812577A (es) |
| CA (1) | CA2303930A1 (es) |
| CO (1) | CO4990958A1 (es) |
| DE (1) | DE69821964T2 (es) |
| DK (1) | DK1025114T3 (es) |
| ES (1) | ES2217579T3 (es) |
| HU (1) | HUP0004579A3 (es) |
| IL (1) | IL134608A0 (es) |
| NO (1) | NO20001439L (es) |
| PL (1) | PL339575A1 (es) |
| PT (1) | PT1025114E (es) |
| SK (1) | SK4562000A3 (es) |
| TR (1) | TR200000805T2 (es) |
| WO (1) | WO1999016779A1 (es) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4573925B2 (ja) * | 1998-07-09 | 2010-11-04 | アベンティス・ファーマ・ソシエテ・アノニム | 新規のエリスロマイシン誘導体、その製造方法及びその薬剤としての使用 |
| ATE340183T1 (de) * | 1999-04-16 | 2006-10-15 | Kosan Biosciences Inc | Antiinfektiöse makrolidderivate |
| US6355620B1 (en) * | 1999-05-14 | 2002-03-12 | Abbott Laboratories | C-2 modified erythromycin derivatives |
| US6437106B1 (en) | 1999-06-24 | 2002-08-20 | Abbott Laboratories | Process for preparing 6-o-substituted erythromycin derivatives |
| CN1197870C (zh) * | 2000-08-14 | 2005-04-20 | 大正制药株式会社 | 一种红霉素衍生物的制备方法及其中间体 |
| US20020111317A1 (en) * | 2000-09-25 | 2002-08-15 | Leonard Katz | Sixteen-membered macrolide compounds |
| ITMI20021726A1 (it) | 2002-08-01 | 2004-02-02 | Zambon Spa | Macrolidi ad attivita' antiinfiammatoria. |
| US7091196B2 (en) | 2002-09-26 | 2006-08-15 | Rib-X Pharmaceuticals, Inc. | Bifunctional heterocyclic compounds and methods of making and using same |
| EP1723159B1 (en) * | 2004-02-27 | 2019-06-12 | Melinta Therapeutics, Inc. | Macrocyclic compounds and methods of making and using the same |
| CN1950388A (zh) * | 2004-02-27 | 2007-04-18 | 瑞伯-X医药品有限公司 | 大环化合物以及其制作和使用方法 |
| BRPI0513903A (pt) * | 2004-07-28 | 2008-05-20 | Ranbaxy Lab Ltd | derivados de cetolìdeos úteis como agentes antimicrobianos, seus processos de preparação e composições farmacêuticas compreendendo os mesmos |
| WO2006046112A2 (en) * | 2004-10-25 | 2006-05-04 | Ranbaxy Laboratories Limited | Ketolide derivatives as antibacterial agents |
| WO2006129257A2 (en) * | 2005-05-30 | 2006-12-07 | Ranbaxy Laboratories Limited | Ketolide derivatives as antibacterial agents |
| US8470985B2 (en) | 2005-08-24 | 2013-06-25 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
| WO2007025098A2 (en) * | 2005-08-24 | 2007-03-01 | Rib-X Pharmaceuticals, Inc. | Triazole compounds and methods of making and using the same |
| EP1957508A2 (en) * | 2005-11-23 | 2008-08-20 | Ranbaxy Laboratories Limited | Ketolide derivatives as antibacterial agents |
| US8124744B2 (en) * | 2006-05-01 | 2012-02-28 | Taisho Pharmaceutical Co., Ltd. | Macrolide derivatives |
| WO2008099368A1 (en) * | 2007-02-15 | 2008-08-21 | Ranbaxy Laboratories Limited | Macrolide derivatives as antibacterial agents |
| WO2008111020A2 (en) * | 2007-03-14 | 2008-09-18 | Ranbaxy Laboratories Limited | Macrolide derivatives as antibacterial agents |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL114589A (en) * | 1990-11-21 | 1999-12-22 | Roussel Uclaf | Intermediates for the preparation of erythromycin derivatives |
| ATE259823T1 (de) * | 1995-11-08 | 2004-03-15 | Abbott Lab | Tricyclische erythromycinderivate |
-
1998
- 1998-09-16 PL PL98339575A patent/PL339575A1/xx unknown
- 1998-09-16 AT AT98946087T patent/ATE260293T1/de not_active IP Right Cessation
- 1998-09-16 PT PT98946087T patent/PT1025114E/pt unknown
- 1998-09-16 DK DK98946087T patent/DK1025114T3/da active
- 1998-09-16 ES ES98946087T patent/ES2217579T3/es not_active Expired - Lifetime
- 1998-09-16 TR TR2000/00805T patent/TR200000805T2/xx unknown
- 1998-09-16 JP JP2000513861A patent/JP2001518476A/ja not_active Withdrawn
- 1998-09-16 KR KR1020007003408A patent/KR20010030807A/ko not_active Withdrawn
- 1998-09-16 DE DE69821964T patent/DE69821964T2/de not_active Expired - Fee Related
- 1998-09-16 EP EP98946087A patent/EP1025114B1/en not_active Expired - Lifetime
- 1998-09-16 CN CN98809567A patent/CN1271363A/zh active Pending
- 1998-09-16 IL IL13460898A patent/IL134608A0/xx unknown
- 1998-09-16 CA CA002303930A patent/CA2303930A1/en not_active Abandoned
- 1998-09-16 AU AU93176/98A patent/AU737310B2/en not_active Ceased
- 1998-09-16 BR BR9812577-0A patent/BR9812577A/pt not_active IP Right Cessation
- 1998-09-16 WO PCT/US1998/019311 patent/WO1999016779A1/en not_active Ceased
- 1998-09-16 HU HU0004579A patent/HUP0004579A3/hu unknown
- 1998-09-16 SK SK456-2000A patent/SK4562000A3/sk unknown
- 1998-09-28 CO CO98056259A patent/CO4990958A1/es unknown
- 1998-09-29 AR ARP980104856A patent/AR015727A1/es unknown
-
2000
- 2000-03-20 NO NO20001439A patent/NO20001439L/no not_active Application Discontinuation
- 2000-04-14 BG BG104340A patent/BG104340A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NO20001439L (no) | 2000-05-29 |
| AU737310B2 (en) | 2001-08-16 |
| TR200000805T2 (tr) | 2000-10-23 |
| KR20010030807A (ko) | 2001-04-16 |
| CO4990958A1 (es) | 2000-12-26 |
| JP2001518476A (ja) | 2001-10-16 |
| AU9317698A (en) | 1999-04-23 |
| SK4562000A3 (en) | 2000-09-12 |
| PT1025114E (pt) | 2004-07-30 |
| PL339575A1 (en) | 2000-12-18 |
| IL134608A0 (en) | 2001-04-30 |
| WO1999016779A1 (en) | 1999-04-08 |
| HUP0004579A2 (hu) | 2001-05-28 |
| ES2217579T3 (es) | 2004-11-01 |
| EP1025114A1 (en) | 2000-08-09 |
| NO20001439D0 (no) | 2000-03-20 |
| CA2303930A1 (en) | 1999-04-08 |
| BG104340A (en) | 2001-01-31 |
| DE69821964T2 (de) | 2004-12-30 |
| HUP0004579A3 (en) | 2001-11-28 |
| DK1025114T3 (da) | 2004-07-05 |
| ATE260293T1 (de) | 2004-03-15 |
| EP1025114B1 (en) | 2004-02-25 |
| CN1271363A (zh) | 2000-10-25 |
| DE69821964D1 (de) | 2004-04-01 |
| BR9812577A (pt) | 2000-10-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR015727A1 (es) | Derivados de cetolida de eritromicina 3'-n-modificada 6-o-sustituida, composicion farmaceutica que los contiene, procedimiento para su preparacion y metodopara tratar las infecciones bacterianas. | |
| AR046297A1 (es) | Inhibidores de la dpp - iv metodos para prepararlos y composiciones farmaceuticas que los contienen como agente activo | |
| ES2143526T3 (es) | Derivados de amida que tienen actividad antihipercolesterolemica, su preparacion y sus usos terapeuticos. | |
| EA199700267A1 (ru) | Применение фумагиллола и его производных для приготовления антиинфекционных интестинальных препаратов и фармацевтическая композиция на их основе | |
| YU48073B (sh) | Postupak za dobijanje heterocikličnih jedinjenja | |
| MX9300579A (es) | Derivados de pirazol, procedimientos para la preparacion de los mismos y a las composiciones farmaceuticas que comprenden a los mismos. | |
| PE20020058A1 (es) | Derivados de piperidina tetrahidroquinolina, tetrahidroisoquinolina como inhibidores de caspasas | |
| CO4970702A1 (es) | Quinolonas antimicrobianas, sus composiciones y sus usos | |
| CO5021213A1 (es) | INHIBIDORES DE FACTOR DE TRANSCRIPCION NF-k8 | |
| GB1069343A (en) | Propanolamine derivatives | |
| IE782493L (en) | Phosphonoformic acid derivatives | |
| EA200000700A2 (ru) | НОВЫЕ β- КАРБОЛИНОВЫЕ СОЕДИНЕНИЯ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ, СОДЕРЖАЩАЯ ИХ | |
| AR015994A1 (es) | Derivados de cetolidos 2-halo-6-o-sustituidos, composiciones farmaceuticas que los contienen, su uso para la manufactura de un medicamento y procesos parasu preparacion | |
| ES2058173T3 (es) | Dioxialquilenaril-dihidropiridinas, productos intermedios para su fabricacion, procedimientos para su fabricacion y su utilizacion. | |
| AR010984A1 (es) | Nuevos esteres de la pleuromutilina, y el acido 1-azabiciclo-4- carbanilcarbanico; procedimiento para su preparacion y composicionesfarmaceuticas que los contienen. | |
| GB1531963A (en) | Pyrido(1,2alpha)pyrimidine derivatives | |
| MX9304820A (es) | Derivados de 1, 4-benzodioxano, procedimiento para su preparacion y composiciones farmaceuticas que los contienen. | |
| EA199800155A1 (ru) | Новое соединение | |
| NO960441L (no) | Benzopyraner og farmasöytiske forbindelser inneholdende dem | |
| ATE122669T1 (de) | Zearalanol-derivate mit anabolytischer wirkung. | |
| WO2000051589A3 (en) | VACUOLAR-TYPE (H+)-ATPase-INHIBITING COMPOUNDS, COMPOSITIONS, AND USES THEREOF | |
| EA199800701A1 (ru) | БЕНЗО[С]ХИНОЛИЗИНОВЫЕ ПРОИЗВОДНЫЕ, ИХ ПОЛУЧЕНИЕ И ИСПОЛЬЗОВАНИЕ В КАЧЕСТВЕ ИНГИБИТОРОВ 5a-РЕДУКТАЗ | |
| IL276901B1 (en) | History of 10-(di(phenyl)methyl)-4-hydroxy-8,9,10,9A-tetrahydro-H7-pyrrolo[1',2':4,5]pyrazino[1,2-B]pyridazine-3 5-Dion and related compounds as inhibitors of orthomyxovirus replication for the treatment of influenza | |
| KR930006024A (ko) | 이미다조 인돌리진 유도체 및 그의 제조방법 | |
| ES445489A1 (es) | Procedimiento para la preparacion de nuevos compuestos de macrolida. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |