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AR015147A1 - Compuestos de 1-bis-trifluorometilbenzoil-2-indolilmetil-4-bencilamino-metil-piperazina, medicamentos que los contienen, y procedimiento para supreparacion - Google Patents

Compuestos de 1-bis-trifluorometilbenzoil-2-indolilmetil-4-bencilamino-metil-piperazina, medicamentos que los contienen, y procedimiento para supreparacion

Info

Publication number
AR015147A1
AR015147A1 ARP980103945A ARP980103945A AR015147A1 AR 015147 A1 AR015147 A1 AR 015147A1 AR P980103945 A ARP980103945 A AR P980103945A AR P980103945 A ARP980103945 A AR P980103945A AR 015147 A1 AR015147 A1 AR 015147A1
Authority
AR
Argentina
Prior art keywords
compounds
piperazine
bis
methyl
trifluorometilbenzoil
Prior art date
Application number
ARP980103945A
Other languages
English (en)
Original Assignee
Solvay Pharm Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharm Gmbh filed Critical Solvay Pharm Gmbh
Publication of AR015147A1 publication Critical patent/AR015147A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Se describen compuestos de 1-bis-trifluorometilbenzoil-2-indolilmetil-4-bencilamino-metil-piperazina, de la formula general (I), en la que R1 significahidrogeno o alquilo inferior, R2 significa hidrogeno o halogeno y R3 significa hidrogeno o alcoxi inferior y sus sales por adicion de ácidos fisiologicamentecompatibles, y medicamentos que contienen estos compuestos, así como procedimientos para la preparacion de estos compuestos.
ARP980103945A 1997-08-27 1998-08-10 Compuestos de 1-bis-trifluorometilbenzoil-2-indolilmetil-4-bencilamino-metil-piperazina, medicamentos que los contienen, y procedimiento para supreparacion AR015147A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19737274 1997-08-27

Publications (1)

Publication Number Publication Date
AR015147A1 true AR015147A1 (es) 2001-04-18

Family

ID=7840297

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP980103945A AR015147A1 (es) 1997-08-27 1998-08-10 Compuestos de 1-bis-trifluorometilbenzoil-2-indolilmetil-4-bencilamino-metil-piperazina, medicamentos que los contienen, y procedimiento para supreparacion

Country Status (23)

Country Link
US (1) US6001833A (es)
JP (1) JP4250228B2 (es)
KR (1) KR19990023605A (es)
CN (1) CN1108290C (es)
AR (1) AR015147A1 (es)
AU (1) AU744104B2 (es)
BR (1) BR9803237B1 (es)
CA (1) CA2245484C (es)
CZ (1) CZ267198A3 (es)
DE (1) DE19824865A1 (es)
DZ (1) DZ2597A1 (es)
HU (1) HUP9801889A1 (es)
ID (1) ID20787A (es)
IL (1) IL125885A (es)
NO (1) NO314939B1 (es)
NZ (1) NZ331524A (es)
PL (1) PL193724B1 (es)
RU (1) RU2198883C2 (es)
SK (1) SK111098A3 (es)
TR (1) TR199801683A2 (es)
TW (1) TW520368B (es)
UA (1) UA60300C2 (es)
ZA (1) ZA986721B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10036818A1 (de) * 2000-07-28 2002-02-07 Solvay Pharm Gmbh Neue N-Triazolylmethyl-Piperazinderivate als Neurokininrezeptor-Antagonisten
UA75425C2 (en) * 2001-07-09 2006-04-17 Piperazine oxime derivatives with antagonistic activity to nk-1 receptor, use thereof, a pharmaceutical composition based thereon, a method for producing and a method for producing intermediary compounds
UA77515C2 (en) * 2002-04-04 2006-12-15 Diazabicyclo alkane derivatives possessing neuroldnin-nk1 receptor antagonistic activity
ITBO20020198A1 (it) * 2002-04-12 2003-10-13 Univ Bologna Derivati 2 , 5 bis diammino 1 , 4 benzochenionici utili per il trattamento della malattia di alzheimer , metodo per la loro preparazione ed
US20070082905A1 (en) * 2005-05-27 2007-04-12 De Vries Michiel H Pharmaceutical compositions comprising n-triazolymethyl-piperazine compounds and methods of using same

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL111730A (en) * 1993-11-29 1998-12-06 Fujisawa Pharmaceutical Co Piperazine derivatives processes for the preparation thereof and pharmaceutical compositions containing the same
KR19990021857A (ko) * 1995-05-25 1999-03-25 후지야마 아키라 뉴로키닌 수용체 길항물질로서 1-벤조일-2-(인돌일-3-알킬)-피페라진 유도체
GB9519077D0 (en) * 1995-09-18 1995-11-15 Fujisawa Pharmaceutical Co New heterocyclic compounds
FR2744449B1 (fr) * 1996-02-02 1998-04-24 Pf Medicament Nouvelles piperazines aromatiques derivees de cycloazanes substitues, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments
JP4189043B2 (ja) * 1996-09-30 2008-12-03 株式会社資生堂 Ｎ−アシルピペラジン誘導体及び抗菌剤、抗潰瘍剤

Also Published As

Publication number Publication date
NZ331524A (en) 2000-02-28
JPH11140082A (ja) 1999-05-25
CN1218044A (zh) 1999-06-02
HU9801889D0 (en) 1998-10-28
NO983918D0 (no) 1998-08-26
KR19990023605A (ko) 1999-03-25
DZ2597A1 (fr) 2003-03-01
PL328221A1 (en) 1999-03-01
NO314939B1 (no) 2003-06-16
SK111098A3 (en) 1999-05-07
TW520368B (en) 2003-02-11
BR9803237B1 (pt) 2009-05-05
BR9803237A (pt) 2000-02-08
RU2198883C2 (ru) 2003-02-20
CZ267198A3 (cs) 1999-03-17
PL193724B1 (pl) 2007-03-30
AU744104B2 (en) 2002-02-14
JP4250228B2 (ja) 2009-04-08
ID20787A (id) 1999-03-04
HUP9801889A1 (hu) 2000-11-28
UA60300C2 (uk) 2003-10-15
CN1108290C (zh) 2003-05-14
AU8189998A (en) 1999-03-11
DE19824865A1 (de) 1999-03-04
ZA986721B (en) 1999-02-02
TR199801683A3 (tr) 1999-03-22
US6001833A (en) 1999-12-14
CA2245484C (en) 2008-04-29
CA2245484A1 (en) 1999-02-27
TR199801683A2 (xx) 1999-03-22
HK1019604A1 (en) 2000-02-18
IL125885A (en) 2000-08-13
NO983918L (no) 1999-03-01
IL125885A0 (en) 1999-04-11

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