AR003985A1 - SWITTERIONICA CRYSTALLINE FORM OF TROVAFLOXACIN, PROCEDURE FOR ITS PREPARATION AND COMPOSITIONS THAT CONTAIN THEM. - Google Patents
SWITTERIONICA CRYSTALLINE FORM OF TROVAFLOXACIN, PROCEDURE FOR ITS PREPARATION AND COMPOSITIONS THAT CONTAIN THEM.Info
- Publication number
- AR003985A1 AR003985A1 ARP960104121A AR10412196A AR003985A1 AR 003985 A1 AR003985 A1 AR 003985A1 AR P960104121 A ARP960104121 A AR P960104121A AR 10412196 A AR10412196 A AR 10412196A AR 003985 A1 AR003985 A1 AR 003985A1
- Authority
- AR
- Argentina
- Prior art keywords
- trovafloxacin
- preparation
- switterionica
- compositions
- procedure
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- WVPSKSLAZQPAKQ-CDMJZVDBSA-N trovafloxacin Chemical compound C([C@H]1[C@@H]([C@H]1C1)N)N1C(C(=CC=1C(=O)C(C(O)=O)=C2)F)=NC=1N2C1=CC=C(F)C=C1F WVPSKSLAZQPAKQ-CDMJZVDBSA-N 0.000 title abstract 3
- 229960000497 trovafloxacin Drugs 0.000 title abstract 3
- 239000000203 mixture Substances 0.000 title 1
- 150000004686 pentahydrates Chemical class 0.000 abstract 2
- 208000035143 Bacterial infection Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 208000022362 bacterial infectious disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Physical Water Treatments (AREA)
- Processing Of Solid Wastes (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Una forma zwitteriónica de trovafloxacina de fórmula (I) seleccionada de entre el grupo formado por sus polimorfos higróscopicos y no higroscópicos ypentahidratos cristalinos y los procedimientos para su preparación. Dichos polímorfos comprenden un primer polimorfo PI no higroscópico, un segundopolimorfo PII higroscópico, y un pentahidrato del zwitterión de trovafloxacina tal como se describen en la memoria. La invención se refiere además aprocedimientos de uso, y composiciones farmacéuticas que los comprenden. Los compuestos de la invención se utilizan para el tratamiento de infeccionesbacterianas en mamíferos.A zwitterionic form of trovafloxacin of formula (I) selected from the group consisting of its hygro and non-hygroscopic polymorphs and crystalline pentahydrates and the processes for their preparation. Said polymorphs comprise a first non-hygroscopic PI polymorph, a second hygroscopic PII polymorph, and a trovafloxacin zwitterion pentahydrate as described in the specification. The invention further relates to methods of use, and pharmaceutical compositions comprising them. The compounds of the invention are used for the treatment of bacterial infections in mammals.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US297595P | 1995-08-29 | 1995-08-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR003985A1 true AR003985A1 (en) | 1998-09-30 |
Family
ID=21703460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960104121A AR003985A1 (en) | 1995-08-29 | 1996-08-26 | SWITTERIONICA CRYSTALLINE FORM OF TROVAFLOXACIN, PROCEDURE FOR ITS PREPARATION AND COMPOSITIONS THAT CONTAIN THEM. |
Country Status (30)
| Country | Link |
|---|---|
| EP (1) | EP0850060A1 (en) |
| JP (1) | JP3188476B2 (en) |
| KR (1) | KR100343909B1 (en) |
| CN (1) | CN1190889A (en) |
| AP (1) | AP636A (en) |
| AR (1) | AR003985A1 (en) |
| AU (1) | AU704115B2 (en) |
| BR (1) | BR9609998A (en) |
| CA (1) | CA2229786C (en) |
| CO (1) | CO4480739A1 (en) |
| CZ (1) | CZ56698A3 (en) |
| DZ (1) | DZ2087A1 (en) |
| GT (1) | GT199600072A (en) |
| HR (1) | HRP960395B1 (en) |
| HU (1) | HUP9900170A3 (en) |
| IL (1) | IL122651A (en) |
| MA (1) | MA23966A1 (en) |
| MY (1) | MY113874A (en) |
| NO (1) | NO309814B1 (en) |
| NZ (1) | NZ312199A (en) |
| OA (1) | OA10669A (en) |
| PE (1) | PE12598A1 (en) |
| PL (1) | PL325170A1 (en) |
| RU (1) | RU2144921C1 (en) |
| SK (1) | SK23898A3 (en) |
| TN (1) | TNSN96109A1 (en) |
| TR (1) | TR199800339T1 (en) |
| WO (1) | WO1997007800A1 (en) |
| YU (1) | YU48396A (en) |
| ZA (1) | ZA967282B (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HN1998000106A (en) | 1997-08-01 | 1999-01-08 | Pfizer Prod Inc | PARENTERAL COMPOSITIONS OF ALATROFLAXACINO |
| US7019142B2 (en) | 1998-01-16 | 2006-03-28 | Pfizer Inc. | Process for preparing naphthyridones and intermediates |
| PA8466701A1 (en) * | 1998-01-21 | 2000-09-29 | Pfizer Prod Inc | TROVAFLOXACINO MESYLATE TABLET |
| US6114531A (en) * | 1998-07-28 | 2000-09-05 | Pfizer Inc. | Process for preparing quinolone and naphthyridone carboxylic acids |
| HN1999000141A (en) * | 1998-09-03 | 2000-06-19 | Pfizer Prod Inc | PROCEDURE FOR PREPARING SALTS OF TROVAFLOXACIN FOR ADDITION OF ACIDS. |
| US6239141B1 (en) | 1999-06-04 | 2001-05-29 | Pfizer Inc. | Trovafloxacin oral suspensions |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CS274601B2 (en) * | 1983-07-27 | 1991-09-15 | Dainippon Pharmaceutical Co | Method of 1,8-naphthyridine derivative production |
| NZ232091A (en) * | 1989-01-16 | 1990-12-21 | Bellon Labor Sa Roger | 7-fluoro-8-(piperazin-1-yl)-4-oxo-1,4-dihydro-benzo(b)(1,8)naphthyridine-3-carboxylic acid derivatives, preparation and pharmaceutical compositions thereof |
| US5164402A (en) * | 1989-08-16 | 1992-11-17 | Pfizer Inc | Azabicyclo quinolone and naphthyridinone carboxylic acids |
| JP3029293B2 (en) | 1995-06-15 | 2000-04-04 | ファイザー・インコーポレーテッド | Method for preparing derivatives of azabicyclonaphthyridine carboxylic acid, including dipeptides |
-
1996
- 1996-07-29 EP EP96923020A patent/EP0850060A1/en not_active Withdrawn
- 1996-07-29 NZ NZ312199A patent/NZ312199A/en unknown
- 1996-07-29 WO PCT/IB1996/000756 patent/WO1997007800A1/en not_active Ceased
- 1996-07-29 AU AU63676/96A patent/AU704115B2/en not_active Ceased
- 1996-07-29 PL PL96325170A patent/PL325170A1/en unknown
- 1996-07-29 CA CA002229786A patent/CA2229786C/en not_active Expired - Fee Related
- 1996-07-29 SK SK238-98A patent/SK23898A3/en unknown
- 1996-07-29 KR KR10-1998-0701468A patent/KR100343909B1/en not_active Expired - Fee Related
- 1996-07-29 RU RU98103873/04A patent/RU2144921C1/en not_active IP Right Cessation
- 1996-07-29 IL IL12265196A patent/IL122651A/en not_active IP Right Cessation
- 1996-07-29 JP JP50343697A patent/JP3188476B2/en not_active Expired - Fee Related
- 1996-07-29 CN CN96195624A patent/CN1190889A/en active Pending
- 1996-07-29 CZ CZ98566A patent/CZ56698A3/en unknown
- 1996-07-29 HU HU9900170A patent/HUP9900170A3/en unknown
- 1996-07-29 TR TR1998/00339T patent/TR199800339T1/en unknown
- 1996-07-29 BR BR9609998A patent/BR9609998A/en unknown
- 1996-08-23 GT GT199600072A patent/GT199600072A/en unknown
- 1996-08-26 PE PE1996000633A patent/PE12598A1/en not_active Application Discontinuation
- 1996-08-26 AR ARP960104121A patent/AR003985A1/en unknown
- 1996-08-28 ZA ZA9607282A patent/ZA967282B/en unknown
- 1996-08-28 MY MYPI96003579A patent/MY113874A/en unknown
- 1996-08-28 MA MA24344A patent/MA23966A1/en unknown
- 1996-08-28 DZ DZ960131A patent/DZ2087A1/en active
- 1996-08-28 TN TNTNSN96109A patent/TNSN96109A1/en unknown
- 1996-08-28 YU YU48396A patent/YU48396A/en unknown
- 1996-08-29 HR HR960395A patent/HRP960395B1/en not_active IP Right Cessation
- 1996-08-29 CO CO96046149A patent/CO4480739A1/en unknown
- 1996-08-29 AP APAP/P/1996/000853A patent/AP636A/en active
-
1998
- 1998-02-27 OA OA9800026A patent/OA10669A/en unknown
- 1998-02-27 NO NO980862A patent/NO309814B1/en not_active Application Discontinuation
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