AR001767A1 - Derivados de ciclolignanos utiles como inmunosupresores composiciones farmaceuticas que los contienen y procedimiento para preparar dichos derivados - Google Patents
Derivados de ciclolignanos utiles como inmunosupresores composiciones farmaceuticas que los contienen y procedimiento para preparar dichos derivadosInfo
- Publication number
- AR001767A1 AR001767A1 AR33423295A AR33423295A AR001767A1 AR 001767 A1 AR001767 A1 AR 001767A1 AR 33423295 A AR33423295 A AR 33423295A AR 33423295 A AR33423295 A AR 33423295A AR 001767 A1 AR001767 A1 AR 001767A1
- Authority
- AR
- Argentina
- Prior art keywords
- derivatives
- alkyl
- immunosuppressants
- preparing
- pharmaceutical compositions
- Prior art date
Links
- 229960003444 immunosuppressant agent Drugs 0.000 title abstract 2
- 239000003018 immunosuppressive agent Substances 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 125000006823 (C1-C6) acyl group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 1
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 abstract 1
- 125000006577 C1-C6 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000001301 oxygen Chemical group 0.000 abstract 1
- 229910052760 oxygen Chemical group 0.000 abstract 1
- -1 thiocarbamoyl Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/92—Naphthofurans; Hydrogenated naphthofurans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/60—Naphtho [b] pyrroles; Hydrogenated naphtho [b] pyrroles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Transplantation (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Furan Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Abstract
Se trata de derivados de ciclolignante o de fórmula (I) o de la fórmula (II), donde: R1 es hidrógeno, hidroxi, alcoxi: (C1-C6),R2 y R3 son hidrógeno,alquilo (C1-C6), acilo (C1-C6) o juntos R2 y R3 forman un grupo -CHR4, donde R4 es:hidrógeno, alquilo (C1-C6), alquenilo (C3-C6), hidroxialquilo (C1-C6),polihalo-alquilo (C1-C6), arilo, aciloxi (C1-C20)alquilo (C1-C6), alcoxi (C1-C6),carboxi-alquilo (C1-C6), alcoxi(C1-C6) carbonilo, carbamoilo, R5,cuandoestá presente, eshidrógeno, al quilo(C1-C6), alquenilo, (C3-C6) arilo, (poli) haloalquilo, (C1-C6)acilo, (C1-C20)carbamoilo, o tiocarbamoilo; R6 es alquilo,(C1-C6)hidroxialquilo, (C1-C6)haloalquilo, (C1-C6) acilo, (C1-C20) aciloxi (C1-C20)alquilo (C1-C6),carboxi, o alcoxi ( C1-C6) carbonilo. Ar es 3,4,5-trialcoxi(C1-C6)fenilo o 4-hidroxi-3,5-dialcoxi(C1-C6)fenilo; X es nitrógeno u oxígeno. Dichos compuestos son útiles como inmunosupresores. Se proponentambién composiciones farmacéuticasformuladas con dichos derivados y un proceso para prepararlos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9422947A GB9422947D0 (en) | 1994-11-14 | 1994-11-14 | Immunosuppressive cyclolignan derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR001767A1 true AR001767A1 (es) | 1997-12-10 |
Family
ID=10764358
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR33423295A AR001767A1 (es) | 1994-11-14 | 1995-11-14 | Derivados de ciclolignanos utiles como inmunosupresores composiciones farmaceuticas que los contienen y procedimiento para preparar dichos derivados |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US5739114A (es) |
| EP (1) | EP0711765B9 (es) |
| JP (1) | JPH08225534A (es) |
| AR (1) | AR001767A1 (es) |
| AU (1) | AU3784695A (es) |
| BR (1) | BR9505178A (es) |
| CA (1) | CA2162760A1 (es) |
| DE (1) | DE69531586T2 (es) |
| ES (1) | ES2206481T3 (es) |
| GB (1) | GB9422947D0 (es) |
| IL (1) | IL115982A (es) |
| NZ (1) | NZ280455A (es) |
| ZA (1) | ZA959665B (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU775373B2 (en) | 1999-10-01 | 2004-07-29 | Immunogen, Inc. | Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents |
| KR100433679B1 (ko) * | 2000-11-20 | 2004-06-09 | 김송배 | 신규의 4'-데메틸-4'-ｏ-치환-1-데옥시포도필로톡신유도체 및 그의 기하 이성체, 그의 제조방법 및 그를포함하는 항암제 |
| SE0102168D0 (sv) | 2001-06-19 | 2001-06-19 | Karolinska Innovations Ab | New use and new compounds |
| WO2009100349A1 (en) * | 2008-02-09 | 2009-08-13 | The Trustees Of Columbia University In The City Of New York | Analogues of (-)-picropodophyllin, synthesis and uses thereof |
| WO2009157858A1 (en) * | 2008-06-23 | 2009-12-30 | Axelar Ab | Use of cyclolignans for the treatment of a hyperactive immune system |
| CA2912254C (en) | 2013-05-10 | 2021-06-08 | M. Alphabet 2, L.L.C. | Methods of treating skin conditions using cyclolignan compounds |
| JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4567253A (en) * | 1984-02-03 | 1986-01-28 | Tony Durst | 2-Substituted derivatives of podophyllotoxin and etoposide |
| HU201672B (en) * | 1984-12-28 | 1990-12-28 | Conpharm Ab | Process for producing pharmaceutical compositions comprising podophyllotoxin |
| US4644072A (en) * | 1985-04-12 | 1987-02-17 | Bristol-Myers Company | Intermediates for the production of epipodophyllotoxin and related compounds and processes for the preparation and use thereof |
-
1994
- 1994-11-14 GB GB9422947A patent/GB9422947D0/en active Pending
-
1995
- 1995-11-13 DE DE69531586T patent/DE69531586T2/de not_active Expired - Fee Related
- 1995-11-13 US US08/558,127 patent/US5739114A/en not_active Expired - Fee Related
- 1995-11-13 NZ NZ280455A patent/NZ280455A/xx unknown
- 1995-11-13 EP EP95308102A patent/EP0711765B9/en not_active Expired - Lifetime
- 1995-11-13 ES ES95308102T patent/ES2206481T3/es not_active Expired - Lifetime
- 1995-11-14 CA CA002162760A patent/CA2162760A1/en not_active Abandoned
- 1995-11-14 ZA ZA959665A patent/ZA959665B/xx unknown
- 1995-11-14 JP JP7295695A patent/JPH08225534A/ja active Pending
- 1995-11-14 AR AR33423295A patent/AR001767A1/es unknown
- 1995-11-14 IL IL11598295A patent/IL115982A/xx active IP Right Review Request
- 1995-11-14 AU AU37846/95A patent/AU3784695A/en not_active Abandoned
- 1995-11-14 BR BR9505178A patent/BR9505178A/pt not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA959665B (en) | 1996-05-29 |
| DE69531586T2 (de) | 2004-06-24 |
| IL115982A (en) | 1999-10-28 |
| US5739114A (en) | 1998-04-14 |
| IL115982A0 (en) | 1996-01-31 |
| EP0711765A1 (en) | 1996-05-15 |
| NZ280455A (en) | 1998-09-24 |
| CA2162760A1 (en) | 1996-05-15 |
| JPH08225534A (ja) | 1996-09-03 |
| EP0711765B1 (en) | 2003-08-27 |
| DE69531586D1 (de) | 2003-10-02 |
| BR9505178A (pt) | 1997-10-28 |
| EP0711765B9 (en) | 2004-03-03 |
| GB9422947D0 (en) | 1995-01-04 |
| AU3784695A (en) | 1996-05-23 |
| ES2206481T3 (es) | 2004-05-16 |
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